Theoretical description of chromosome architecture after multiple back-crossing

Rodolphe, François, Juliette Martin and Emmanuelle Della-Chiesa

Theoretical Population Biology, 2008, vol. 73, issue 2, 289-299

Abstract: This paper provides a theoretical description of the chromosome architecture resulting from a given number of generations in a back-cross. It is worth considering chromosome architecture as being dependent on a marked point process, whose properties themselves depend on the crossing-over model used. The resulting architecture is presented here for two different models, one without interference, the other with complete interference. Exact distributions, with easy-to-compute formulae, are derived for quantities of interest, as the lengths of donor or receiver fragments, for any chromosome length and for both crossing-over models. Examples are presented to illustrate the use of these distributions in introgression programs.

Keywords: Back-cross; Introgression; Crossing-over; Interference; Poisson process; Ehrenfest promenade (search for similar items in EconPapers)
Date: 2008
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Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:73:y:2008:i:2:p:289-299

DOI: 10.1016/j.tpb.2007.11.004

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