Viral diversity limits immune diversity in asymptomatic phase of HIV infection

Shingo Iwami, Shinji Nakaoka and Yasuhiro Takeuchi

Theoretical Population Biology, 2008, vol. 73, issue 3, 332-341

Abstract: We propose a new diversity threshold theory which states that the specific CTLs to the viral strain become inactivated (that is, some HIV strain can escape from its specific immune response) when the diversity of HIV strains exceeds some threshold number. We call this number “immune diversity threshold†. Our theory can explain the inactivation of specific immune response and a limit of maximum immune diversity. We can conclude that the accumulation of viral diversity eventually leads to AIDS.

Keywords: HIV; Viral diversity; Immune diversity threshold; Frequency dependence (search for similar items in EconPapers)
Date: 2008
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Citations: View citations in EconPapers (1)

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Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:73:y:2008:i:3:p:332-341

DOI: 10.1016/j.tpb.2008.01.003

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