An analytical model for genetic hitchhiking in the evolution of antimalarial drug resistance

Kristan A. Schneider and Yuseob Kim

Theoretical Population Biology, 2010, vol. 78, issue 2, 93-108

Abstract: We analytically study a deterministic model for the spread of drug resistance among human malaria parasites. The model incorporates all major characteristics of the complex malaria transmission cycle and accounts for the fact that only a fraction α of infected hosts receive drug treatment. Furthermore, the model incorporates that hosts can be co-infected. The number m of parasites co-infecting a host is either a constant or, more generally, follows a given frequency distribution.

Keywords: Selective sweep; Quasi-fixation; Co-infections; Drug concentration; Relative heterozygosity; Host heterogeneity; Malaria; Plasmodium falciparum (search for similar items in EconPapers)
Date: 2010
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Persistent link: https://EconPapers.repec.org/RePEc:eee:thpobi:v:78:y:2010:i:2:p:93-108

DOI: 10.1016/j.tpb.2010.06.005

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