Progress of m 6 A Methylation in Lipid Metabolism in Humans and Animals

Zimeng Xin, Tianying Zhang, Qinyue Lu, Zhangping Yang and Zhi Chen ()
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Zimeng Xin: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Tianying Zhang: Shaanxi Key Laboratory of Brain Disorders & Institute of Basic and Translational Medicine, Xi’an Medical University, No.1 Xinwang Road, Xi’an 710021, China
Qinyue Lu: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Zhangping Yang: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Zhi Chen: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Agriculture, 2022, vol. 12, issue 10, 1-18

Abstract: N6-methyladenosine (m 6 A) methylation is a type of methylation modification discovered on RNA molecules, mainly on mRNAs, as well as on other RNAs. Similar to DNA methylation, m 6 A methylation regulates the post-transcriptional expression level of genes without altering their base sequences. It modulates gene expression mainly by affecting the binding of mRNAs to reader proteins, thereby regulating variable splicing, translation efficiency, and stability of mRNAs. Early in the research, the study of m 6 A-related biological functions was greatly hindered due to the lack of effective detection methods. As second-generation sequencing and bioinformatics develop, several methods have been available to detect and predict m 6 A methylation sites in recent years. Moreover, m 6 A methylation is also closely related to the development of lipid metabolism, as shown in current studies. Combined with recent research, this paper reviews the concept, detection, and prediction means of m 6 A methylation, especially the relationship between m 6 A and lipid metabolism, providing a new clue to enrich the molecular mechanism of lipid metabolism.

Keywords: m 6 A methylation; lipid metabolism; molecular mechanism; detection tools (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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