CRISPR/Cas9 for Insect Pests Management: A Comprehensive Review of Advances and Applications

Sanchita Singh, Somnath Rahangdale, Shivali Pandita, Gauri Saxena, Santosh Kumar Upadhyay, Geetanjali Mishra and Praveen C. Verma ()
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Sanchita Singh: CSIR-National Botanical Research Institute, (Council of Scientific and Industrial Research) Rana Pratap Marg, Lucknow 226001, UP, India
Somnath Rahangdale: CSIR-National Botanical Research Institute, (Council of Scientific and Industrial Research) Rana Pratap Marg, Lucknow 226001, UP, India
Shivali Pandita: CSIR-National Botanical Research Institute, (Council of Scientific and Industrial Research) Rana Pratap Marg, Lucknow 226001, UP, India
Gauri Saxena: Department of Botany, University of Lucknow, Lucknow 226007, UP, India
Santosh Kumar Upadhyay: Department of Botany, Panjab University, Chandigarh 160014, UP, India
Geetanjali Mishra: Department of Zoology, University of Lucknow, Lucknow 226007, UP, India
Praveen C. Verma: CSIR-National Botanical Research Institute, (Council of Scientific and Industrial Research) Rana Pratap Marg, Lucknow 226001, UP, India

Agriculture, 2022, vol. 12, issue 11, 1-20

Abstract: Insect pests impose a serious threat to agricultural productivity. Initially, for pest management, several breeding approaches were applied which have now been gradually replaced by genome editing (GE) strategies as they are more efficient and less laborious. CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat/CRISPR-associated system) was discovered as an adaptive immune system of bacteria and with the scientific advancements, it has been improvised into a revolutionary genome editing technique. Due to its specificity and easy handling, CRISPR/Cas9-based genome editing has been applied to a wide range of organisms for various research purposes. For pest control, diverse approaches have been applied utilizing CRISPR/Cas9-like systems, thereby making the pests susceptible to various insecticides, compromising the reproductive fitness of the pest, hindering the metamorphosis of the pest, and there have been many other benefits. This article reviews the efficiency of CRISPR/Cas9 and proposes potential research ideas for CRISPR/Cas9-based integrated pest management. CRISPR/Cas9 technology has been successfully applied to several insect pest species. However, there is no review available which thoroughly summarizes the application of the technique in insect genome editing for pest control. Further, authors have highlighted the advancements in CRISPR/Cas9 research and have discussed its future possibilities in pest management.

Keywords: CRISPR/Cas9; insect pest; integrated pest management; genome editing (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2022
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