OTUD7A Regulates Inflammation- and Immune-Related Gene Expression in Goose Fatty Liver

Minmeng Zhao, Kang Wen, Xiang Fan, Qingyun Sun, Diego Jauregui, Mawahib K. Khogali, Long Liu, Tuoyu Geng and Daoqing Gong
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Minmeng Zhao: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Kang Wen: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Xiang Fan: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Qingyun Sun: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Diego Jauregui: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Mawahib K. Khogali: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Long Liu: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Tuoyu Geng: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Daoqing Gong: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Agriculture, 2022, vol. 12, issue 1, 1-13

Abstract: OTU deubiquitinase 7A ( OTUD7A ) can suppress inflammation signaling pathways, but it is unclear whether the gene can inhibit inflammation in goose fatty liver. In order to investigate the functions of OTUD7A and identify the genes and pathways subjected to the regulation of OTUD7A in the formation of goose fatty liver, we conducted transcriptomic analysis of cells, which revealed several genes related to inflammation and immunity that were significantly differentially expressed after OTUD7A overexpression. Moreover, the expression of interferon-induced protein with tetratricopeptide repeats 5 ( IFIT5 ), tumor necrosis factor ligand superfamily member 8 ( TNFSF8 ), sterile alpha motif domain-containing protein 9 ( SAMD9 ), radical S -adenosyl methionine domain-containing protein 2 ( RSAD2 ), interferon-induced GTP-binding protein Mx1 ( MX1 ), and interferon-induced guanylate binding protein 1-like ( GBP1 ) was inhibited by OTUD7A overexpression but induced by OTUD7A knockdown with small interfering RNA in goose hepatocytes. Furthermore, the mRNA expression of IFIT5 , TNFSF8 , SAMD9 , RSAD2 , MX1 , and GBP1 was downregulated, whereas OTUD7A expression was upregulated in goose fatty liver after 12 days of overfeeding. In contrast, the expression patterns of these genes showed nearly the opposite trend after 24 days of overfeeding. Taken together, these findings indicate that OTUD7A regulates the expression of inflammation- and immune-related genes in the development of goose fatty liver.

Keywords: OTUD7A; goose; inflammation; immune; nonalcoholic fatty liver disease (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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