Multi-Residue Determination of 244 Chemical Contaminants in Chicken Eggs by Liquid Chromatography-Tandem Mass Spectrometry after Effective Lipid Clean-Up

Lin Zhang, Qi Jia, Guangqin Liao, Yongzhong Qian and Jing Qiu
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Lin Zhang: Key Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Qi Jia: Key Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Guangqin Liao: Key Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Yongzhong Qian: Key Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China
Jing Qiu: Key Laboratory of Agro-Product Quality and Safety, Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China

Agriculture, 2022, vol. 12, issue 6, 1-21

Abstract: In this study, we aimed to establish a multi-residue analytical method for the simultaneous detection of chemical contaminants in eggs. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we developed an analytical method that can separate 244 compounds (including β-agonists (25), imidazole and benzimidazoles (31), sulfonamides (22), antihistamines (10), β-lactam (5), insecticides (7), quinolones (24), non-steroidal anti-inflammatory drugs (13), and steroidal hormones (38)) within 30 min. A new enhanced matrix removal-lipid (EMR-Lipid) material was used as a purified sorbent in the QuEChERS clean-up method. Excellent linearity (r > 0.9905) was achieved. Additionally, recoveries ranged between 51.33% and 118.28%, with repeatability (RSD r ) and reproducibility (RSD wR ) in the range of 1.01–14.22% and 1.08–14.96%, respectively. In all of the compounds, low limits of quantification (LOQs) ≤ 5 μg kg −1 were found. Meanwhile, the detection limit (CCα) and detection capability (CCβ) were 1.88–40.60 μg kg −1 and 2.85–407.19 μg kg −1 , respectively. In conclusion, the evaluated method was shown to provide reliable screening, quantification, and identification of 244 multi-class chemicals in eggs and was successfully applied in real samples.

Keywords: eggs; multi-residue; EMR-Lipid; LC-MS/MS (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2022
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