The Overlooked Transformation Mechanisms of VLCFAs: Peroxisomal β-Oxidation

Qinyue Lu, Weicheng Zong, Mingyixing Zhang, Zhi Chen and Zhangping Yang
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Qinyue Lu: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Weicheng Zong: College of Veterinary Medcine, Yangzhou University, Yangzhou 225009, China
Mingyixing Zhang: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Zhi Chen: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Zhangping Yang: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China

Agriculture, 2022, vol. 12, issue 7, 1-21

Abstract: Beta-oxidation(β-oxidation) is an important metabolic process involving multiple steps by which fatty acid molecules are broken down to produce energy. The very long-chain fatty acids (VLCFAs), a type of fatty acid (FA), are usually highly toxic when free in vivo, and their oxidative metabolism depends on the peroxisomal β-oxidation. For a long time, although β-oxidation takes place in both mitochondria and peroxisomes, most studies have been keen to explore the mechanism of β-oxidation in mitochondria while ignoring the importance of peroxisomal β-oxidation. However, current studies indicate that it is hard to provide effective treatment for diseases caused by the disorder of peroxisomal β-oxidation, such as X-ALD, SCOX deficiency, and D-BP deficiency; thus, actions should be taken to solve this problem. Based on existing research results, this review will summarize the importance of peroxisomal β-oxidation and help further learning.

Keywords: peroxisome; very long-chain fatty acids; beta-oxidation (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2022
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