Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid Profile

Tasneem S. Abu Ghazal, Hadil S. Subih, Belal S. Obeidat () and Mofleh S. Awawdeh
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Tasneem S. Abu Ghazal: Department of Nutrition, Faculty of Agriculture, Jordan University of Science and Technology, Irbid 22110, Jordan
Hadil S. Subih: Department of Nutrition, Faculty of Agriculture, Jordan University of Science and Technology, Irbid 22110, Jordan
Belal S. Obeidat: Department of Animal Production, Faculty of Agriculture, Jordan University of Science and Technology, Irbid 22110, Jordan
Mofleh S. Awawdeh: Department of Pathology and Public Health, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan

Agriculture, 2023, vol. 13, issue 2, 1-9

Abstract: Background: The prevalence of obesity is increasing dramatically worldwide. Obesity injuries have been linked to the alteration of many health biomarkers in humans. Consuming a 2.5:1 ratio of omega-6 and omega-3 helps to restore standard health biomarkers. Hemp, the non-psychoactive variety of Cannabis Sativa L., has a long history of being used as a source of food, fiber, and medicine. One of its attractive features is the favorable omega-6:omega-3 ratio found in its seed oil (HSO), making it a promising functional food for mitigating obesity-related injuries. Methods: A total of 84 female Wistar rats were randomly allocated into four groups. Two control groups ( n = 21 each) were fed with a standard diet supplemented with 10% HSO. Two other equivalent groups consumed a high-fat diet, and one was supplemented with 10% HSO. Rats were euthanized from each group at 5, 10, or 15 weeks to measure body weight change, food intake, and several health biomarkers. Results: The results demonstrated that body weight gain and triglycerides were lower ( p ≤ 0.05) for the control group supplemented with HSO compared with the other groups. Adiponectin concentration was lower ( p ≤ 0.05) in both the control and high-fat treated groups. Other biomarkers were comparable among treatment diets. Conclusion: Our results suggest the usefulness of HSO supplementation for the overall health status.

Keywords: hemp seed oil (HSO); obesity; lipid profile; omega-6:omega-3 ratio; adiponectin (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2023
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