In Vivo Hypolipidemic Effects and Antioxidant Capacity of Pinus morrisonicola Hay Extracts by Supercritical Carbon Dioxide Extraction

Ying-Jang Lai, Ming-Ching Cheng, Hsin-Chun Chen, Chien-Lin Chen and Tuzz-Ying Song ()
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Ying-Jang Lai: Department of Food Science, National Quemoy University, Jinning Township, Kinmen County 892, Taiwan
Ming-Ching Cheng: Department of Health Food, Chung Chou University of Science and Technology, Changhua 510, Taiwan
Hsin-Chun Chen: Department of Cosmeceutics, China Medical University, Taichung 406, Taiwan
Chien-Lin Chen: Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Changhua 515, Taiwan
Tuzz-Ying Song: Department of Medicinal Botanicals and Foods on Health Applications, Da-Yeh University, Changhua 515, Taiwan

Agriculture, 2023, vol. 13, issue 3, 1-13

Abstract: Pinus morrisonicola hay (PM) is a pine tree unique to Taiwan, whose needles are used as traditional medicine and as functional drink. PME3-1 was made using supercritical extraction to evaluate the prevention of hyperlipidemia. This study explored the hypolipidemic effect of PME3-1 on hamsters on a high fat and cholesterol (HFC) diet. Three groups of hamsters were fed with PME3-1 (0.2, 1.0, and 5.0 mg/kg bw). After feeding for eight weeks, PME3-1 reduced the serum cholesterol, triglyceride levels, the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL/HDL) ratio, and the swelling of the liver and kidney significantly ( p < 0.05). In addition, feeding the hamsters with 5.0 mg/kg bw of PME3-1 could significantly reduce their total lipid (TL) content, total cholesterol (TC) content, total triglyceride (TG) content, and the HMG-CoA reductase activity in the liver ( p < 0.05). Meanwhile, the antioxidant enzymes in the liver, glutathione peroxidase (GPx) and glutathione S-transferase (GST), can also improve, promoting the excretion of triglycerides (TG) and total cholesterol (TC) in the feces ( p < 0.05). Therefore, these results confirm that PME3-1 hypolipidemic and antioxidant regulating functions in vivo .

Keywords: high fat and cholesterol diet; atherosclerotic index; lipid peroxidation product; reactive oxygen species; HMG-CoA reductase (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2023
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