When an Intruder Comes Home: GM and GE Strategies to Combat Virus Infection in Plants

Adeeb Rahman and Neeti Sanan-Mishra ()
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Adeeb Rahman: Plant RNAi Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India
Neeti Sanan-Mishra: Plant RNAi Biology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India

Agriculture, 2024, vol. 14, issue 2, 1-26

Abstract: Viruses are silent enemies that intrude and take control of the plant cell’s machinery for their own multiplication. Infection by viruses and the resulting damage is still a major challenge in the agriculture sector. Plants have the capability to fight back, but the ability of viruses to mutate at a fast rate helps them to evade the host’s response. Therefore, classical approaches for introgressing resistance genes by breeding have obtained limited success in counteracting the virus menace. Genetic modification (GM)-based strategies have been successful in engineering artificial resistance in plants. Several different approaches based on pathogen-derived resistance, antisense constructs, hairpin RNAs, double-stranded RNA, etc., have been used to enhance plants’ resistance to viruses. Recently, genome editing (GE) strategies mainly involving the CRISPR/Cas-mediated modifications are being used for virus control. In this review, we discuss the developments and advancements in GM- and GE-based methods for tackling viral infection in plants.

Keywords: pathogen-derived resistance; RNA silencing; artificial miRNA; tasiRNA; epigenetic editing; prime editing; multiplexing CRISPR/Cas editing (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2024
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