Effect of Algae Supplementation on the Gene Expression of Liver Lipid Metabolism in Dairy Goat Bucks

Mengke Ni, Zhen Zhang, Xinran Luo, Min Tian, Yifan Zhu, Meiwen Song, Huan Lei, Zhi Chen and Cong Li ()
Additional contact information
Mengke Ni: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Zhen Zhang: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Xinran Luo: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Min Tian: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Yifan Zhu: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Meiwen Song: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Huan Lei: Xi’an Baiyue Goat Milk Co., Ltd., Xi’an 710000, China
Zhi Chen: College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China
Cong Li: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Agriculture, 2024, vol. 14, issue 5, 1-14

Abstract: This study aimed to investigate how diets supplemented with DHA-rich algae affect the expression of liver lipid synthesis genes in dairy goat bucks. The results revealed that when supplemented with DHA-rich algae, liver weight and serum HDL-C were significantly increased ( p < 0.05), as well as serum LDL-C was significantly decreased ( p < 0.05). Transcriptome sequencing indicated that algae supplementation alters liver gene expression. The differentially expressed genes were predominantly enriched in fatty acid metabolism and the biosynthesis of unsaturated fatty acids. The expression of fatty acid desaturation and transcription factors ( SCD , FADS1 , INSIG1 ), de novo synthesis fatty acids ( FASN ), fatty acid transport ( LDLR ), and cholesterol and steroid synthesis ( HMGCR , HMGCS1 , SQLE ) genes were significantly increased ( p < 0.05), and fatty acid oxidation ( ALDH3B1 ) genes were significantly decreased ( p < 0.05). In conclusion, this research provided preliminary evidence that supplementation with algae in dietary supplements altered the expression of the liver lipid synthesis genes in the Saanen dairy goat bucks.

Keywords: algae; RNA-Seq; liver; lipid metabolism; dairy goat bucks (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2024
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/2077-0472/14/5/685/pdf (application/pdf)
https://www.mdpi.com/2077-0472/14/5/685/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jagris:v:14:y:2024:i:5:p:685-:d:1384344

Access Statistics for this article

Agriculture is currently edited by Ms. Leda Xuan

More articles in Agriculture from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().