Enhancing Genomic Prediction Accuracy in Beef Cattle Using WMGBLUP and SNP Pre-Selection

Huqiong Zhao, Xueyuan Xie, Haoran Ma, Peinuo Zhou, Boran Xu, Yuanqing Zhang, Lingyang Xu, Huijiang Gao, Junya Li, Zezhao Wang () and Xiaoyan Niu ()
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Huqiong Zhao: College of Animal Science, Shanxi Agricultural University, Jinzhong 030801, China
Xueyuan Xie: College of Animal Science, Shanxi Agricultural University, Jinzhong 030801, China
Haoran Ma: State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Peinuo Zhou: Inner Mongolia Autonomous Region Agriculture and Animal Husbandry Technology Extension Center, Hohhot 010020, China
Boran Xu: Tongliao Agriculture and Animal Husbandry Development Center, Tongliao 028000, China
Yuanqing Zhang: College of Animal Science, Shanxi Agricultural University, Jinzhong 030801, China
Lingyang Xu: State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Huijiang Gao: State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Junya Li: State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Zezhao Wang: State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China
Xiaoyan Niu: College of Animal Science, Shanxi Agricultural University, Jinzhong 030801, China

Agriculture, 2025, vol. 15, issue 10, 1-17

Abstract: Genomic selection (GS) plays a crucial role in livestock breeding. However, its implementation in Chinese beef cattle breeding is constrained by a limited reference population and incomplete data records. To address these challenges, this study aimed to identify more effective models for multi-population genomic selection. We simulated five different beef cattle populations and selected three populations with varying levels of kinship to investigate the impact of population relationships on genomic prediction. Utilizing results from a genome-wide association study (GWAS), we preselected different proportions of single nucleotide polymorphism (SNP). Subsequently, we employed three models—genomic best linear unbiased prediction (GBLUP), multi-genomic best linear unbiased prediction (MGBLUP), and weighted multi-genomic best linear unbiased prediction (WMGBLUP)—for within-population and multi-population genomic prediction. Our results showed that increasing the size of the training set improved within-population prediction accuracy. Furthermore, both MGBLUP and WMGBLUP outperformed GBLUP in terms of prediction accuracy for both within-population and multi-population analyses. Among the models evaluated, the WMGBLUP model, which utilized the top 5% of preselected SNPs based on GWAS findings, demonstrated superior performance, yielding an improvement of up to 11.1% in within-population prediction and 16.5% in multi-population prediction. In summary, both WMGBLUP and MGBLUP models exhibit enhanced efficacy in improving genomic prediction accuracy, and the incorporation of GWAS results can further optimize their performance.

Keywords: GWAS; beef cattle; multi-population genomic prediction; simulation (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2025
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