Detection of Copy Number Variations from HIF1A and HIF2A Gene as Genetic Determinants of Bovine Carcass Traits

Enhui Jiang, Yingjie Zhou, Yunan He, Zhuoyuan He, Hongyang Wang, Leijing Zhu, Chuanying Pan, Chuzhao Lei, Fugui Jiang () and Xianyong Lan ()
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Enhui Jiang: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Yingjie Zhou: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Yunan He: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Zhuoyuan He: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Hongyang Wang: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Leijing Zhu: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Chuanying Pan: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Chuzhao Lei: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China
Fugui Jiang: Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan 250100, China
Xianyong Lan: College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Agriculture, 2025, vol. 15, issue 12, 1-15

Abstract: The beef cattle industry has seen rapid expansion, necessitating the optimization of slaughter traits for enhanced economic benefits. Copy number variation (CNV) has emerged as a pivotal molecular marker in marker-assisted selection (MAS) for genetic improvement in livestock. In this study, we focused on CNVs within the HIF1A and HIF2A genes, which play crucial roles in hypoxic signaling and energy metabolism. Four CNVs were identified in the bovine HIF1A gene and three in HIF2A using the AAOD database. In Gaoqing Black cattle (GQB), the distribution of CNVs for both genes was investigated, revealing predominantly median copy numbers. Association analysis showed a significant relation between CNVs in HIF1A and carcass traits such as cervical vertebrae (CNV1), initial weight and beef diaphragm (CNV2), slaughter weight and chuck (CNV3), and femur and chuck (CNV4) ( p < 0.05 or p < 0.01). Similarly, CNVs in HIF2A are associated with traits like beef diaphragm, beef knuckle bone, and beef tendon (CNV1), longissimus dorsi width and beef diaphragm (CNV2), and slaughter weight and limb weights (CNV3) ( p < 0.05 or p < 0.01). These findings provide insights into the potential influence of CNVs in HIF1A and HIF2A on carcass traits in Gaoqing Black cattle, offering a theoretical basis for genetic improvement in beef cattle breeding.

Keywords: beef cattle; HIF1A; HIF2A; CNV; carcass traits (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2025
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