Rebound of Antibiotic Resistance Genes in Composting: Mechanisms, Challenges, and Control Strategies

Xinyuan Zhang, Xuan Wang (), Yazhan Ren, Zihan Wang, Zhaohai Bai and Lin Ma ()
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Xinyuan Zhang: Key Laboratory of Agricultural Water Resources, Hebei Key Laboratory of Soil Ecology, Center for Agricultural Resources Research, Institute of Genetic and Developmental Biology, Chinese Academy of Sciences, 286 Huaizhong Road, Shijiazhuang 050021, China
Xuan Wang: Key Laboratory of Agricultural Water Resources, Hebei Key Laboratory of Soil Ecology, Center for Agricultural Resources Research, Institute of Genetic and Developmental Biology, Chinese Academy of Sciences, 286 Huaizhong Road, Shijiazhuang 050021, China
Yazhan Ren: Key Laboratory of Agricultural Water Resources, Hebei Key Laboratory of Soil Ecology, Center for Agricultural Resources Research, Institute of Genetic and Developmental Biology, Chinese Academy of Sciences, 286 Huaizhong Road, Shijiazhuang 050021, China
Zihan Wang: College of Environmental Sciences and Engineering, Hebei University of Science and Technology, 26 Yuxiang Street, Shijiazhuang 050018, China
Zhaohai Bai: Key Laboratory of Agricultural Water Resources, Hebei Key Laboratory of Soil Ecology, Center for Agricultural Resources Research, Institute of Genetic and Developmental Biology, Chinese Academy of Sciences, 286 Huaizhong Road, Shijiazhuang 050021, China
Lin Ma: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China

Agriculture, 2025, vol. 15, issue 22, 1-20

Abstract: The proliferation of antibiotic resistance genes (ARGs) in livestock manure has raised growing environmental and public health concerns. Composting is widely recognized as an effective method to mitigate ARG dissemination; however, recent studies have increasingly reported a rebound in ARG abundance during the curing stage of composting, undermining its long-term effectiveness. Here, “rebound” refers to a renewed increase in ARG abundance—either in absolute terms or relative to the 16S rRNA gene—following its decline to a minimum during the thermophilic phase. This review systematically summarizes the dynamic changes in ARGs throughout the composting process, with a particular focus on the mechanisms and drivers underlying ARG rebound. Vertical and horizontal gene transfer, along with microbial succession, are discussed as key contributors to this phenomenon. Current strategies to suppress ARG rebound, including microbial community manipulation, hyperthermophilic composting, and exogenous amendments, are evaluated. Furthermore, the roles of heavy metals and extracellular polymeric substances in promoting ARG persistence are examined, highlighting their potential involvement in ARG rebound. This review aims to provide a comprehensive understanding of ARG rebound in composting and to inform the development of more effective, integrated mitigation strategies.

Keywords: ARGs; composting; rebound effect; heavy metals; extracellular polymeric substances; mitigation strategies (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2025
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