Whole Genome Analysis of Proteus mirabilis in a Poultry Breeder Farm Reveals the Dissemination of bla NDM and bla CTX-M Mediated by Diverse Mobile Genetic Elements

Haibin Hu, Ke Wu, Tiejun Zhang, Yuhuan Mou, Luya Liu, Xiaoqin Wang, Wei Xu, Wenping Chen, Xiaojiao Chen, Hongning Wang and Changwei Lei ()
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Haibin Hu: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China
Ke Wu: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China
Tiejun Zhang: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China
Yuhuan Mou: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China
Luya Liu: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China
Xiaoqin Wang: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China
Wei Xu: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China
Wenping Chen: Beijing Huadu Yukou Poultry Industry Co., Ltd., Beijing 101206, China
Xiaojiao Chen: Beijing Huadu Yukou Poultry Industry Co., Ltd., Beijing 101206, China
Hongning Wang: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China
Changwei Lei: Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu 610065, China

Agriculture, 2025, vol. 15, issue 5, 1-10

Abstract: Proteus mirabilis is a significant foodborne opportunistic pathogen associated with various nosocomial infections. Chicken farms may serve as an important reservoir for P. mirabilis . However, research on antibiotic resistance and genomic features of P. mirabilis in China’s poultry industry is limited. This study isolates P. mirabilis from a breeder farm in China and investigates the dissemination of P. mirabilis and clinically significant antibiotic resistance genes (ARGs), including bla NDM and bla CTX-M . From 510 samples, 69 isolates were obtained, classified into 11 sequence types (STs), with ST135 and ST175 predominating. A total of 39 ARGs were detected, including fosA3 , floR , bla CTX-M-3 , bla CTX-M-65 , and bla NDM-1 . Genetic analysis revealed that bla NDM-1 was exclusively located on Salmonella genomic island 1 (SGI1), while bla CTX-M was found in various mobile genetic elements (MGEs), including Tn 7 , SXT/R391 integrative conjugative elements (ICEs), Proteus mirabilis genomic resistance island 1 (PmGRI1), and SGI1. Notably, many isolates carried multiple MGEs, suggesting frequent horizontal transfer of ARGs in P. mirabilis . These findings underscore the role of P. mirabilis in carrying and spreading antibiotic resistance, posing significant risks to the poultry industry and public health.

Keywords: Proteus mirabilis; antibiotic resistance; bla NDM; bla CTX-M; breeder farm (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2025
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