Nematocidal Potential of Synthetic Phenyl Azide Derivatives Against False Root-Knot Nematode ( Nacobbus aberrans ) Under In Vitro Conditions

Julio Cruz-Arévalo, Alonzo González-González, Eyra Ortiz-Pérez, Lenci K. Vázquez-Jiménez, Timoteo Delgado-Maldonado, Alma D. Paz-González, Jesús Antonio Pineda-Alegría, Gildardo Rivera () and Liliana Aguilar-Marcelino ()
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Julio Cruz-Arévalo: División Agroalimentaria, Universidad Tecnológica de la Selva, Entronque Toniná Km. 0.5 Carretera Ocosingo- Altamirano, Ocosingo 29950, CS, Mexico
Alonzo González-González: Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, TM, Mexico
Eyra Ortiz-Pérez: Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, TM, Mexico
Lenci K. Vázquez-Jiménez: Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, TM, Mexico
Timoteo Delgado-Maldonado: Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, TM, Mexico
Alma D. Paz-González: Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, TM, Mexico
Jesús Antonio Pineda-Alegría: CENID-Salud Animal e Inocuidad, Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias, Jiutepec 62550, MR, Mexico
Gildardo Rivera: Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politécnico Nacional, Reynosa 88710, TM, Mexico
Liliana Aguilar-Marcelino: CENID-Salud Animal e Inocuidad, Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias, Jiutepec 62550, MR, Mexico

Agriculture, 2025, vol. 15, issue 7, 1-11

Abstract: The primary strategy for managing Nacobbus aberrans has traditionally relied on synthetic chemicals. However, increasing regulatory pressure on unsafe products has led to a growing research focus on nematicides. Despite this, chemical nematicides remain more effective than other control methods. Consequently, there is a pressing need to develop novel nematicides that are both effective and environmentally safer. This study aimed to evaluate the nematocidal efficacy of various synthetic molecules against the second-stage juveniles of N. aberrans , the false root-knot nematode. A total of fifty-eight synthetic derivatives were obtained and tested in vitro at a concentration of 500 µg/mL. The results identified the AGAz family as the most promising, with AGAz-3 (LC 50 : 52.7 µg/mL) and AGAz-4 (LC 50 : 103.22 µg/mL) surpassing the efficacy of chitosan. Our findings emphasize the strong potential of AGAz-3 and AGAz-4 as nematocidal agents, particularly for in situ applications in agricultural settings. Additionally, AGAz-3 demonstrates potential not only as a nematocidal agent but also as an incentive for related research exploring its analogs as effective ovicidal compounds and investigating its efficacy against other phytonematodes. Furthermore, compounds from the N -Sulfonyl-hydrazone and N -acyl-hydrazone series showed efficacy (>50%), warranting additional experiments to assess their effectiveness across the most important pest phytonematodes.

Keywords: novel nematicides; phytonematodes; nematode management; agriculture (search for similar items in EconPapers)
JEL-codes: Q1 Q10 Q11 Q12 Q13 Q14 Q15 Q16 Q17 Q18 (search for similar items in EconPapers)
Date: 2025
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