Effectiveness of Paliperidone Palmitate in Reducing Acute Psychiatric Service Use for Patients Suffering from Psychosis—A Retrospective Mirror-Image Study

Chun Ting Chan (), Swapna Verma, Mythily Subramaniam, Edimansyah Abdin and Jenny Tay
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Chun Ting Chan: Institute of Mental Health, Singapore 539747, Singapore
Swapna Verma: Institute of Mental Health, Singapore 539747, Singapore
Mythily Subramaniam: Institute of Mental Health, Singapore 539747, Singapore
Jenny Tay: Institute of Mental Health, Singapore 539747, Singapore

IJERPH, 2023, vol. 20, issue 4, 1-10

Abstract: Poor adherence to antipsychotic treatment is a leading cause of relapse for patients suffering from psychotic disorders and the use of long-acting injectable antipsychotics (LAI) may lead to improved clinical outcomes. This was a 1-year mirror-image study examining the clinical outcomes after monthly administration of paliperidone palmitate (PP1M). The primary outcome measure was the total days of psychiatric hospitalization in the 1-year before and 1-year after initiation of PP1M. Data from 158 patients were included in the study. Most of the patients suffered from schizophrenia. In the year after initiation of PP1M, the mean number of hospitalization days fell from 106.53 to 19.10 ( p < 0.001). There were significant reductions in the mean number of hospitalizations and emergency room visits. The use of paliperidone palmitate is associated with significant reduction in both the number of admissions and days of psychiatric hospitalization.

Keywords: psychosis; long-acting antipsychotic; paliperidone palmitate; outcome; mirror-image study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2023
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