Formation of supramolecular channels by reversible unwinding-rewinding of bis(indole) double helix via ion coordination

Debashis Mondal, Manzoor Ahmad (), Bijoy Dey, Abhishek Mondal and Pinaki Talukdar ()
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Debashis Mondal: Indian Institute of Science Education and Research Pune
Bijoy Dey: Tata Institute of Fundamental Research
Abhishek Mondal: Indian Institute of Science Education and Research Pune
Pinaki Talukdar: Indian Institute of Science Education and Research Pune

Nature Communications, 2022, vol. 13, issue 1, 1-11

Abstract: Abstract Stimulus-responsive reversible transformation between two structural conformers is an essential process in many biological systems. An example of such a process is the conversion of amyloid-β peptide into β-sheet-rich oligomers, which leads to the accumulation of insoluble amyloid in the brain, in Alzheimer’s disease. To reverse this unique structural shift and prevent amyloid accumulation, β-sheet breakers are used. Herein, we report a series of bis(indole)-based biofunctional molecules, which form a stable double helix structure in the solid and solution state. In presence of chloride anion, the double helical structure unwinds to form an anion-coordinated supramolecular polymeric channel, which in turn rewinds upon the addition of Ag+ salts. Moreover, the formation of the anion-induced supramolecular ion channel results in efficient ion transport across lipid bilayer membranes with excellent chloride selectivity. This work demonstrates anion-cation-assisted stimulus-responsive unwinding and rewinding of artificial double-helix systems, paving way for smart materials with better biomedical applications.

Date: 2022
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DOI: 10.1038/s41467-022-34159-y

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