Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J. Ramus, Qiyuan Li, Melissa K. Delgado, Janet M. Lee, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K. Arun, Brita Arver, Elisa V. Bandera, Monica Barile, Rosa B. Barkardottir, Daniel Barrowdale, Matthias W. Beckmann, Javier Benitez, Andrew Berchuck, Maria Bisogna, Line Bjorge, Carl Blomqvist, William Blot, Natalia Bogdanova, Anders Bojesen, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Fiona Bruinsma, Joan Brunet, Shaik Ahmad Buhari, Barbara Burwinkel, Ralf Butzow, Saundra S. Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Rikki Canniotto, Jenny Chang-Claude, Jocelyne Chiquette, Ji-Yeob Choi, Kathleen B. M. Claes, Linda S. Cook, Angela Cox, Daniel W. Cramer, Simon S. Cross, Cezary Cybulski, Kamila Czene, Mary B. Daly, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Joe Dennis, Peter Devilee, Orland Diez, Jennifer A. Doherty, Susan M. Domchek, Cecilia M. Dorfling, Thilo Dörk, Martine Dumont, Hans Ehrencrona, Bent Ejlertsen, Steve Ellis, Christoph Engel, Eunjung Lee, D. Gareth Evans, Peter A. Fasching, Lidia Feliubadalo, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lenka Foretova, Florentia Fostira, William D. Foulkes, Brooke L. Fridley, Eitan Friedman, Debra Frost, Gaetana Gambino, Patricia A. Ganz, Judy Garber, Montserrat García-Closas, Aleksandra Gentry-Maharaj, Maya Ghoussaini, Graham G. Giles, Rosalind Glasspool, Andrew K. Godwin, Mark S. Goldberg, David E. Goldgar, Anna González-Neira, Ellen L. Goode, Marc T. Goodman, Mark H. Greene, Jacek Gronwald, Pascal Guénel, Christopher A. Haiman, Per Hall, Emily Hallberg, Ute Hamann, Thomas V. O. Hansen, Patricia A. Harrington, Mikael Hartman, Norhashimah Hassan, Sue Healey, Florian Heitz, Josef Herzog, Estrid Høgdall, Claus K. Høgdall, Frans B. L. Hogervorst, Antoinette Hollestelle, John L. Hopper, Peter J. Hulick, Tomasz Huzarski, Evgeny N. Imyanitov, Claudine Isaacs, Hidemi Ito, Anna Jakubowska, Ramunas Janavicius, Allan Jensen, Esther M. John, Nichola Johnson, Maria Kabisch, Daehee Kang, Miroslav Kapuscinski, Beth Y. Karlan, Sofia Khan, Lambertus A. Kiemeney, Susanne Kruger Kjaer, Julia A. Knight, Irene Konstantopoulou, Veli-Matti Kosma, Vessela Kristensen, Jolanta Kupryjanczyk, Ava Kwong, Miguel de la Hoya, Yael Laitman, Diether Lambrechts, Nhu Le, Kim De Leeneer, Jenny Lester, Douglas A. Levine, Jingmei Li, Annika Lindblom, Jirong Long, Artitaya Lophatananon, Jennifer T. Loud, Karen Lu, Jan Lubinski, Arto Mannermaa, Siranoush Manoukian, Loic Le Marchand, Sara Margolin, Frederik Marme, Leon F. A. G. Massuger, Keitaro Matsuo, Sylvie Mazoyer, Lesley McGuffog, Catriona McLean, Iain McNeish, Alfons Meindl, Usha Menon, Arjen R. Mensenkamp, Roger L. Milne, Marco Montagna, Kirsten B. Moysich, Kenneth Muir, Anna Marie Mulligan, Katherine L. Nathanson, Roberta B. Ness, Susan L. Neuhausen, Heli Nevanlinna, Silje Nord, Robert L. Nussbaum, Kunle Odunsi, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Janet E. Olson, Curtis Olswold, David O’Malley, Irene Orlow, Nick Orr, Ana Osorio, Sue Kyung Park, Celeste L. Pearce, Tanja Pejovic, Paolo Peterlongo, Georg Pfeiler, Catherine M. Phelan, Elizabeth M. Poole, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Valerie Rhenius, Kerstin Rhiem, Harvey A. Risch, Gus Rodriguez, Mary Anne Rossing, Anja Rudolph, Helga B. Salvesen, Suleeporn Sangrajrang, Elinor J. Sawyer, Joellen M. Schildkraut, Marjanka K. Schmidt, Rita K. Schmutzler, Thomas A. Sellers, Caroline Seynaeve, Mitul Shah, Chen-Yang Shen, Xiao-Ou Shu, Weiva Sieh, Christian F. Singer, Olga M. Sinilnikova, Susan Slager, Honglin Song, Penny Soucy, Melissa C. Southey, Marie Stenmark-Askmalm, Dominique Stoppa-Lyonnet, Christian Sutter, Anthony Swerdlow, Sandrine Tchatchou, Manuel R. Teixeira, Soo H. Teo, Kathryn L. Terry, Mary Beth Terry, Mads Thomassen, Maria Grazia Tibiletti, Laima Tihomirova, Silvia Tognazzo, Amanda Ewart Toland, Ian Tomlinson, Diana Torres, Thérèse Truong, Chiu-chen Tseng, Nadine Tung, Shelley S. Tworoger, Celine Vachon, Ans M. W. van den Ouweland, Helena C. van Doorn, Elizabeth J. van Rensburg, Laura J. Van't Veer, Adriaan Vanderstichele, Ignace Vergote, Joseph Vijai, Qin Wang, Shan Wang-Gohrke, Jeffrey N. Weitzel, Nicolas Wentzensen, Alice S. Whittemore, Hans Wildiers, Robert Winqvist, Anna H. Wu, Drakoulis Yannoukakos, Sook-Yee Yoon, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Kum Kum Khanna, Jacques Simard, Alvaro N. Monteiro, Juliet D. French, Fergus J. Couch, Matthew L. Freedman, Douglas F. Easton, Alison M. Dunning, Paul D. Pharoah, Stacey L. Edwards, Georgia Chenevix-Trench, Antonis C. Antoniou () and Simon A. Gayther
Additional contact information
Kate Lawrenson: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Siddhartha Kar: Centre for Cancer Genetic Epidemiology, University of Cambridge
Karen McCue: QIMR Berghofer Medical Research Institute
Karoline Kuchenbaeker: Centre for Cancer Genetic Epidemiology, University of Cambridge
Kyriaki Michailidou: Centre for Cancer Genetic Epidemiology, University of Cambridge
Jonathan Tyrer: Centre for Cancer Genetic Epidemiology, University of Cambridge
Jonathan Beesley: QIMR Berghofer Medical Research Institute
Susan J. Ramus: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Qiyuan Li: Medical College, Xiamen University
Melissa K. Delgado: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Janet M. Lee: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Kristiina Aittomäki: Helsinki University Hospital, University of Helsinki
Irene L. Andrulis: Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
Hoda Anton-Culver: Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine
Volker Arndt: German Cancer Research Center (DKFZ)
Banu K. Arun: University of Texas MD Anderson Cancer Center
Brita Arver: Karolinska University Hospital
Elisa V. Bandera: Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey
Monica Barile: Istituto Europeo di Oncologia
Rosa B. Barkardottir: Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland
Daniel Barrowdale: Centre for Cancer Genetic Epidemiology, University of Cambridge
Matthias W. Beckmann: University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
Javier Benitez: Human Cancer Genetics Program, Spanish National Cancer Research Centre
Andrew Berchuck: Duke University Medical Center
Maria Bisogna: Gynecology Service, Memorial Sloan-Kettering Cancer Center
Line Bjorge: Haukeland University Hospital
Carl Blomqvist: Helsinki University Hospital, University of Helsinki
William Blot: Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Natalia Bogdanova: Gynaecology Research Unit, Hannover Medical School
Anders Bojesen: Vejle Hospital
Stig E. Bojesen: Faculty of Health and Medical Sciences, University of Copenhagen
Manjeet K. Bolla: Centre for Cancer Genetic Epidemiology, University of Cambridge
Bernardo Bonanni: Istituto Europeo di Oncologia
Anne-Lise Børresen-Dale: Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
Hiltrud Brauch: Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology
Paul Brennan: International Agency for Research on Cancer
Hermann Brenner: German Cancer Research Center (DKFZ)
Fiona Bruinsma: Cancer Epidemiology Centre, Cancer Council Victoria
Joan Brunet: Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology
Shaik Ahmad Buhari: National University Health System
Barbara Burwinkel: Molecular Epidemiology Group, German Cancer Research Center (DKFZ)
Ralf Butzow: University of Helsinki and Helsinki University Central Hospital
Saundra S. Buys: Huntsman Cancer Institute, University of Utah School of Medicine
Qiuyin Cai: Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Trinidad Caldes: Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Ian Campbell: Cancer Genetics Laboratory, Peter MacCallum Cancer Centre
Rikki Canniotto: Cancer Pathology & Prevention, Roswell Park Cancer Institute
Jenny Chang-Claude: German Cancer Research Center (DKFZ)
Jocelyne Chiquette: Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec
Ji-Yeob Choi: Cancer Research Institute, Seoul National University
Kathleen B. M. Claes: Center for Medical Genetics, Ghent University
Linda S. Cook: University of New Mexico
Angela Cox: Sheffield Cancer Research, University of Sheffield
Daniel W. Cramer: Harvard HT Chan School of Public Health
Simon S. Cross: Academic Unit of Pathology, University of Sheffield
Cezary Cybulski: Pomeranian Medical University
Kamila Czene: Karolinska Institutet
Mary B. Daly: Fox Chase Cancer Center
Francesca Damiola: INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon
Agnieszka Dansonka-Mieszkowska: Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology
Hatef Darabi: Karolinska Institutet
Joe Dennis: Centre for Cancer Genetic Epidemiology, University of Cambridge
Peter Devilee: Leiden University Medical Center
Orland Diez: Oncogenetics Group, University Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona
Jennifer A. Doherty: Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth
Susan M. Domchek: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Cecilia M. Dorfling: University of Pretoria
Thilo Dörk: Gynaecology Research Unit, Hannover Medical School
Martine Dumont: Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University
Hans Ehrencrona: Genetics and Pathology, Uppsala University
Bent Ejlertsen: Rigshospitalet, Copenhagen University Hospital
Steve Ellis: Centre for Cancer Genetic Epidemiology, University of Cambridge
Eunjung Lee: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
D. Gareth Evans: Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust
Peter A. Fasching: University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
Lidia Feliubadalo: Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology
Jonine Figueroa: National Cancer Institute
Dieter Flesch-Janys: Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf
Olivia Fletcher: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research
Henrik Flyger: Herlev Hospital, Copenhagen University Hospital
Lenka Foretova: Masaryk Memorial Cancer Institute and Medical Faculty MU
Florentia Fostira: Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis
William D. Foulkes: Program in Cancer Genetics, McGill University, Montreal
Brooke L. Fridley: Biostatistics and Informatics Shared Resource, University of Kansas Medical Center
Eitan Friedman: Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center
Debra Frost: Centre for Cancer Genetic Epidemiology, University of Cambridge
Gaetana Gambino: Section of Genetic Oncology, University and University Hospital of Pisa
Patricia A. Ganz: UCLA Schools of Medicine and Public Health, Jonsson Comprehensive Cancer Center
Judy Garber: Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute
Montserrat García-Closas: National Cancer Institute
Aleksandra Gentry-Maharaj: Women's Cancer, UCL EGA Institute for Women's Health
Maya Ghoussaini: Centre for Cancer Genetic Epidemiology, University of Cambridge
Graham G. Giles: Cancer Epidemiology Centre, Cancer Council Victoria
Rosalind Glasspool: Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre
Andrew K. Godwin: University of Kansas Medical Center
Mark S. Goldberg: Royal Victoria Hospital, McGill University
David E. Goldgar: Huntsman Cancer Institute, University of Utah School of Medicine
Anna González-Neira: Human Cancer Genetics Program, Spanish National Cancer Research Centre
Ellen L. Goode: Mayo Clinic
Marc T. Goodman: Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Mark H. Greene: Clinical Genetics Branch, National Cancer Institute, National Institutes of Health
Jacek Gronwald: Pomeranian Medical University
Pascal Guénel: Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM
Christopher A. Haiman: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Per Hall: Karolinska Institutet
Emily Hallberg: Mayo Clinic
Ute Hamann: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
Thomas V. O. Hansen: Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital
Patricia A. Harrington: University of Cambridge, Strangeways Research Laboratory
Mikael Hartman: National University Health System
Norhashimah Hassan: Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre
Sue Healey: QIMR Berghofer Medical Research Institute
Florian Heitz: Kliniken Essen-Mitte
Josef Herzog: Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network
Estrid Høgdall: Molecular Unit, Herlev Hospital, University of Copenhagen
Claus K. Høgdall: Rigshospitalet, University of Copenhagen
Frans B. L. Hogervorst: Family Cancer Clinic, Netherlands Cancer Institute
Antoinette Hollestelle: Family Cancer Clinic, Erasmus MC Cancer Institute
John L. Hopper: Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
Peter J. Hulick: Center for Medical Genetics, NorthShore University Health System
Tomasz Huzarski: Pomeranian Medical University
Evgeny N. Imyanitov: N.N. Petrov Institute of Oncology
Claudine Isaacs: Lombardi Comprehensive Cancer Center, Georgetown University
Hidemi Ito: Aichi Cancer Center Research Institute
Anna Jakubowska: Pomeranian Medical University
Ramunas Janavicius: State Research Institute Centre for Innovative Medicine
Allan Jensen: Rigshospitalet, University of Copenhagen
Esther M. John: Cancer Prevention Institute of California
Nichola Johnson: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research
Maria Kabisch: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
Daehee Kang: Cancer Research Institute, Seoul National University
Miroslav Kapuscinski: Centre for Epidemiology and Biostatistics, University of Melbourne
Beth Y. Karlan: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Sofia Khan: University of Helsinki and Helsinki University Central Hospital
Lambertus A. Kiemeney: Radboud University Medical Centre, Radboud Institute for Health Sciences
Susanne Kruger Kjaer: Lifestyle and Genes, Danish Cancer Society Research Center
Julia A. Knight: Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
Irene Konstantopoulou: Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis
Veli-Matti Kosma: Imaging Center, Kuopio University Hospital
Vessela Kristensen: Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
Jolanta Kupryjanczyk: Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology
Ava Kwong: The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital
Miguel de la Hoya: Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Yael Laitman: Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center
Diether Lambrechts: Vesalius Research Center, VIB
Nhu Le: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Kim De Leeneer: Center for Medical Genetics, Ghent University
Jenny Lester: Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
Douglas A. Levine: Gynecology Service, Memorial Sloan-Kettering Cancer Center
Jingmei Li: Karolinska Institutet
Annika Lindblom: Karolinska Institutet
Jirong Long: Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Artitaya Lophatananon: Warwick Medical School, Warwick University
Jennifer T. Loud: Clinical Genetics Branch, National Cancer Institute, National Institutes of Health
Karen Lu: The University of Texas MD Anderson Cancer Center
Jan Lubinski: Pomeranian Medical University
Arto Mannermaa: Imaging Center, Kuopio University Hospital
Siranoush Manoukian: Unit of Medical Genetics, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT)
Loic Le Marchand: University of Hawaii Cancer Center
Sara Margolin: Karolinska Institutet
Frederik Marme: University of Heidelberg
Leon F. A. G. Massuger: Radboud University Medical Centre
Keitaro Matsuo: Kyushu University Faculty of Medical Sciences
Sylvie Mazoyer: INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon
Lesley McGuffog: Centre for Cancer Genetic Epidemiology, University of Cambridge
Catriona McLean: Anatomical Pathology, The Alfred Hospital
Iain McNeish: Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research
Alfons Meindl: Technische Universität München
Usha Menon: Women's Cancer, UCL EGA Institute for Women's Health
Arjen R. Mensenkamp: Radboud University Medical Centre
Roger L. Milne: Cancer Epidemiology Centre, Cancer Council Victoria
Marco Montagna: Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS
Kirsten B. Moysich: Roswell Park Cancer Institute
Kenneth Muir: Warwick Medical School, Warwick University
Anna Marie Mulligan: Laboratory Medicine Program, University Health Network
Katherine L. Nathanson: Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
Roberta B. Ness: The University of Texas School of Public Health
Susan L. Neuhausen: Beckman Research Institute of City of Hope
Heli Nevanlinna: University of Helsinki and Helsinki University Central Hospital
Silje Nord: K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
Robert L. Nussbaum: University of California
Kunle Odunsi: Roswell Park Cancer Institute
Kenneth Offit: Memorial Sloan-Kettering Cancer Center
Edith Olah: National Institute of Oncology
Olufunmilayo I. Olopade: Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center
Janet E. Olson: Mayo Clinic
Curtis Olswold: Mayo Clinic
David O’Malley: The Ohio State University and the James Cancer Center
Irene Orlow: Memorial Sloan Kettering Cancer Center
Nick Orr: Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research
Ana Osorio: Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)
Sue Kyung Park: Seoul National University College of Medicine
Celeste L. Pearce: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Tanja Pejovic: Oregon Health and Science University
Paolo Peterlongo: IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology
Georg Pfeiler: Comprehensive Cancer Center, Medical University of Vienna
Catherine M. Phelan: Moffitt Cancer Center
Elizabeth M. Poole: Brigham and Women's Hospital and Harvard Medical School
Katri Pylkäs: Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab
Paolo Radice: Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT)
Johanna Rantala: Karolinska University Hospital
Muhammad Usman Rashid: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
Gad Rennert: Carmel Medical Center and B. Rappaport Faculty of Medicine
Valerie Rhenius: Centre for Cancer Genetic Epidemiology, University of Cambridge
Kerstin Rhiem: Centre of Familial Breast and Ovarian Cancer, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne
Harvey A. Risch: Yale School of Public Health
Gus Rodriguez: NorthShore University HealthSystem
Mary Anne Rossing: Program in Epidemiology, Fred Hutchinson Cancer Research Center
Anja Rudolph: German Cancer Research Center (DKFZ)
Helga B. Salvesen: Haukeland University Hospital
Suleeporn Sangrajrang: National Cancer Institute
Elinor J. Sawyer: Research Oncology, Guy’s Hospital, King's College London
Joellen M. Schildkraut: Duke University Medical Center
Marjanka K. Schmidt: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
Rita K. Schmutzler: University Hospital of Cologne
Thomas A. Sellers: Moffitt Cancer Center
Caroline Seynaeve: Family Cancer Clinic, Erasmus MC Cancer Institute
Mitul Shah: Centre for Cancer Genetic Epidemiology, University of Cambridge
Chen-Yang Shen: Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica
Xiao-Ou Shu: Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Weiva Sieh: Stanford University School of Medicine
Christian F. Singer: Comprehensive Cancer Center, Medical University of Vienna
Olga M. Sinilnikova: Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard
Susan Slager: Mayo Clinic
Honglin Song: Centre for Cancer Genetic Epidemiology, University of Cambridge
Penny Soucy: Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University
Melissa C. Southey: University of Melbourne
Marie Stenmark-Askmalm: Lund University Hospital
Dominique Stoppa-Lyonnet: Institut Curie, Paris, France
Christian Sutter: Institute of Human Genetics, University Hospital Heidelberg
Anthony Swerdlow: The Institute of Cancer Research
Sandrine Tchatchou: Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
Manuel R. Teixeira: Portuguese Oncology Institute
Soo H. Teo: Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre
Kathryn L. Terry: Harvard HT Chan School of Public Health
Mary Beth Terry: Mailman School of Public Health, Columbia University
Mads Thomassen: Odense University Hospital
Maria Grazia Tibiletti: UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria
Laima Tihomirova: Latvian Biomedical Research and Study Centre
Silvia Tognazzo: Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico)
Amanda Ewart Toland: Immunology and Medical Genetics, The Ohio State University
Ian Tomlinson: Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford
Diana Torres: Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
Thérèse Truong: Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM
Chiu-chen Tseng: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Nadine Tung: Beth Israel Deaconess Medical Center
Shelley S. Tworoger: Brigham and Women's Hospital and Harvard Medical School
Celine Vachon: Mayo Clinic
Ans M. W. van den Ouweland: Erasmus University Medical Center
Helena C. van Doorn: Family Cancer Clinic, Erasmus MC Cancer Institute
Elizabeth J. van Rensburg: University of Pretoria
Laura J. Van't Veer: Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
Adriaan Vanderstichele: University Hospitals Leuven
Ignace Vergote: University Hospitals Leuven
Joseph Vijai: Memorial Sloan-Kettering Cancer Center
Qin Wang: Centre for Cancer Genetic Epidemiology, University of Cambridge
Jeffrey N. Weitzel: Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network
Nicolas Wentzensen: National Cancer Institute
Alice S. Whittemore: Stanford University School of Medicine
Hans Wildiers: Multidisciplinary Breast Center, University Hospitals Leuven
Robert Winqvist: Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab
Anna H. Wu: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
Drakoulis Yannoukakos: Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos’
Sook-Yee Yoon: Cancer Research Initiatives Foundation, Sime Darby Medical Centre
Jyh-Cherng Yu: Tri-Service General Hospital, National Defense Medical Center
Wei Zheng: Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
Ying Zheng: Shanghai Center for Disease Control and Prevention
Kum Kum Khanna: QIMR Berghofer Medical Research Institute
Jacques Simard: Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University
Alvaro N. Monteiro: Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute
Juliet D. French: QIMR Berghofer Medical Research Institute
Fergus J. Couch: Mayo Clinic
Matthew L. Freedman: The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
Douglas F. Easton: Centre for Cancer Genetic Epidemiology, University of Cambridge
Alison M. Dunning: Centre for Cancer Genetic Epidemiology, University of Cambridge
Paul D. Pharoah: Centre for Cancer Genetic Epidemiology, University of Cambridge
Stacey L. Edwards: QIMR Berghofer Medical Research Institute
Georgia Chenevix-Trench: QIMR Berghofer Medical Research Institute
Antonis C. Antoniou: Centre for Cancer Genetic Epidemiology, University of Cambridge
Simon A. Gayther: Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center

Nature Communications, 2016, vol. 7, issue 1, 1-22

Abstract: Abstract A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10−20), ER-negative BC (P=1.1 × 10−13), BRCA1-associated BC (P=7.7 × 10−16) and triple negative BC (P-diff=2 × 10−5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10−3) and ABHD8 (P

Date: 2016
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DOI: 10.1038/ncomms12675

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