Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

Marina V. Rodnina, Andreas Savelsbergh, Vladimir I. Katunin and Wolfgang Wintermeyer
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Marina V. Rodnina: University of Witten/Herdecke
Andreas Savelsbergh: University of Witten/Herdecke
Vladimir I. Katunin: University of Witten/Herdecke
Wolfgang Wintermeyer: University of Witten/Herdecke

Nature, 1997, vol. 385, issue 6611, 37-41

Abstract: Abstract Elongation factor G (EF-G) is a GTPase that is involved in the translocation of bacterial ribosomes along messenger RNA during protein biosynthesis. In contrast to current models, EF-G-dependent GTP hydrolysis is shown to precede, and greatly accelerate, the rearrangement of the ribosome that leads to translocation. Domain IV of the EF-G structure is crucial for both rapid translocation and subsequent release of the factor from the ribosome. By coupling the free energy of GTP hydrolysis to translocation, EF-G serves as a motor protein to drive the directional movement of transfer and messenger RNAs on the ribosome.

Date: 1997
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DOI: 10.1038/385037a0

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