Nature

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2025, volume 643, articles 8071

How we’re rebuilding the Weizmann Institute — and our hopes for a better future pp. 306-306

Alon Chen

2025, volume 643, articles 8070

Why we need mandatory safeguards for emotionally responsive AI pp. 9-9

Ziv Ben-Zion

What we stand to lose when foreign students are seen as a threat pp. 10-10

Maia Chankseliani

Can AI build a virtual cell? Scientists race to model life’s smallest unit pp. 13-14

Ewen Callaway

These scientists re-enacted Stone Age voyage to Japan’s remote islands pp. 14-15

Katie Kavanagh

Does using ChatGPT change your brain activity? Study sparks debate pp. 15-16

Nicola Jones

How many PhDs does the world need? Doctoral graduates vastly outnumber jobs in academia pp. 16-17

Diana Kwon

DeepMind’s new AlphaGenome AI tackles the ‘dark matter’ in our DNA pp. 17-18

Ewen Callaway

First images from world’s largest digital camera leave astronomers in awe pp. 18-19

Davide Castelvecchi

Everyday painkiller made from plastic — by E. coli pp. 19-19

Rita Aksenfeld

Happy birthday Jaws! How the movie changed shark science pp. 20-20

Katie Kavanagh

What’s it like to work with an AI team of virtual scientists? pp. 22-25

Nicola Jones

Harvard vs Trump: what this epic battle means for science pp. 26-27

Jeff Tollefson

What do dolphins talk about? One biologist is trying to listen in pp. 28-29

Laela Sayigh

Niède Guidon obituary: Brazilian archaeologist who upended ideas on early human migration pp. 30-30

Meghie Rodrigues

Human embryo research: how to move towards a 28-day limit pp. 31-34

Alejandro De Los Angeles, Nissim Benvenisty, Hongkui Deng, Jacob H. Hanna, Julian Koplin, Tianqing Li, Pentao Liu, Yuin-Han Loh, Duanqing Pei, Ryohichi Sugimura, Timothy Theodore Ka Ki Tam, Tan Tao, Alan Trounson, Shao Xu, Leqian Yu, Elias Zambidis, Magdalena Zernicka-Goetz and Robin Lovell-Badge

Protect Iran’s scientists from attacks pp. 35-35

Navid Madani

Human space travel risks contaminating Mars pp. 35-35

Alberto G. Fairén

Global pandemic agreement needs sustained pressure to succeed pp. 35-35

WooJung Jon

It should be free to apply to graduate school pp. 35-35

Benjamin Fernando, Michael Cassidy, Angela Russell and Aris Katzourakis

Tunnelling photons challenge interpretation of quantum mechanics pp. 37-38

Alessandro Fedrizzi and Fabio Biancalana

A bile acid could explain how calorie restriction slows ageing pp. 38-40

David A. Sinclair

Natural nappers: monitoring the sleeping patterns of wild orangutans pp. 39-39

Mary Abraham

Computer-vision research is hiding its role in creating ‘Big Brother’ technologies pp. 41-42

Jathan Sadowski

Deciphering how dog roses with an odd chromosome copy number sexually reproduce pp. 42-43

Adrián Gonzalo and Joiselle B. Fernandes

Sticky membranes of dead red blood cells obstruct small vessels pp. 44-45

Elizabeth Iffrig and Wilbur A. Lam

Iron deficiency in pregnant mice causes XY embryos to develop with female characteristics pp. 45-46

Shannon Dupont and Blanche Capel

The Somatic Mosaicism across Human Tissues Network pp. 47-59

Tim H. H. Coorens, Ji Won Oh, Yujin Angelina Choi, Nam Seop Lim, Boxun Zhao, Adam Voshall, Alexej Abyzov, Lucinda Antonacci-Fulton, Samuel Aparicio, Kristin G. Ardlie, Thomas J. Bell, James T. Bennett, Bradley E. Bernstein, Thomas G. Blanchard, Alan P. Boyle, Jason D. Buenrostro, Kathleen H. Burns, Fei Chen, Rui Chen, Sangita Choudhury, Harsha V. Doddapaneni, Evan E. Eichler, Gilad D. Evrony, Melissa A. Faith, Thomas G. Fazzio, Robert S. Fulton, Manuel Garber, Nils Gehlenborg, Soren Germer, Gad Getz, Richard A. Gibbs, Raquel G. Hernandez, Fulai Jin, Jan O. Korbel, Dan A. Landau, Heather A. Lawson, Niall J. Lennon, Heng Li, Yan Li, Po-Ru Loh, Gabor Marth, Michael J. McConnell, Ryan E. Mills, Stephen B. Montgomery, Pradeep Natarajan, Peter J. Park, Rahul Satija, Fritz J. Sedlazeck, Diane D. Shao, Hui Shen, Andrew B. Stergachis, Hunter R. Underhill, Alexander E. Urban, Melissa W. VonDran, Christopher A. Walsh, Ting Wang, Tao P. Wu, Chenghang Zong, Eunjung Alice Lee and Flora M. Vaccarino

Carbonate formation and fluctuating habitability on Mars pp. 60-66

Edwin S. Kite, Benjamin M. Tutolo, Madison L. Turner, Heather B. Franz, David G. Burtt, Thomas F. Bristow, Woodward W. Fischer, Ralph E. Milliken, Abigail A. Fraeman and Daniel Y. Zhou

Energy–speed relationship of quantum particles challenges Bohmian mechanics pp. 67-72

Violetta Sharoglazova, Marius Puplauskis, Charlie Mattschas, Chris Toebes and Jan Klaers

Computer-vision research powers surveillance technology pp. 73-79

Pratyusha Ria Kalluri, William Agnew, Myra Cheng, Kentrell Owens, Luca Soldaini and Abeba Birhane

Ultrabroadband and band-selective thermal meta-emitters by machine learning pp. 80-88

Chengyu Xiao, Mengqi Liu, Kan Yao, Yifan Zhang, Mengqi Zhang, Max Yan, Ya Sun, Xianghui Liu, Xuanyu Cui, Tongxiang Fan, Changying Zhao, Wansu Hua, Yinqiao Ying, Yuebing Zheng, Di Zhang, Cheng-Wei Qiu and Han Zhou

Controlling diverse robots by inferring Jacobian fields with deep networks pp. 89-95

Sizhe Lester Li, Annan Zhang, Boyuan Chen, Hanna Matusik, Chao Liu, Daniela Rus and Vincent Sitzmann

Weakly space-confined all-inorganic perovskites for light-emitting diodes pp. 96-103

Chenchen Peng, Haitao Yao, Othman Ali, Wenjing Chen, Yingguo Yang, Zongming Huang, Hui Liu, Jianyu Li, Tao Chen, Zhijian Li, Mei Sun, Hongmin Zhou, Xiangru Tao, Nana Wang, Jianpu Wang and Zhengguo Xiao

Efficient near-infrared harvesting in perovskite–organic tandem solar cells pp. 104-110

Zhenrong Jia, Xiao Guo, Xinxing Yin, Ming Sun, Jiawei Qiao, Xinyu Jiang, Xi Wang, Yuduan Wang, Zijing Dong, Zhuojie Shi, Chun-Hsiao Kuan, Jingcong Hu, Qilin Zhou, Xiangkun Jia, Jinxi Chen, Zhouyin Wei, Shunchang Liu, Haoming Liang, Nengxu Li, Ling Kai Lee, Renjun Guo, Stephan V. Roth, Peter Müller-Buschbaum, Xiaotao Hao, Xiaoyan Du and Yi Hou

A cost-effective all-in-one halide material for all-solid-state batteries pp. 111-118

Jiamin Fu, Changhong Wang, Shuo Wang, Joel W. Reid, Jianwen Liang, Jing Luo, Jung Tae Kim, Yang Zhao, Xiaofei Yang, Feipeng Zhao, Weihan Li, Bolin Fu, Xiaoting Lin, Yang Hu, Han Su, Xiaoge Hao, Yingjie Gao, Shutao Zhang, Ziqing Wang, Jue Liu, Hamid Abdolvand, Tsun-Kong Sham, Yifei Mo and Xueliang Sun

Machine-learning design of ductile FeNiCoAlTa alloys with high strength pp. 119-124

Yasir Sohail, Chongle Zhang, Dezhen Xue, Jinyu Zhang, Dongdong Zhang, Shaohua Gao, Yang Yang, Xiaoxuan Fan, Hang Zhang, Gang Liu, Jun Sun and En Ma

Soft magnetic hysteresis in a dysprosium amide–alkene complex up to 100 kelvin pp. 125-129

Jack Emerson-King, Gemma K. Gransbury, Benjamin E. Atkinson, William J. A. Blackmore, George F. S. Whitehead, Nicholas F. Chilton and David P. Mills

One-carbon homologation of alkenes pp. 130-138

Marcus C. Grocott and Matthew J. Gaunt

Punic people were genetically diverse with almost no Levantine ancestors pp. 139-147

Harald Ringbauer, Ayelet Salman-Minkov, Dalit Regev, Iñigo Olalde, Tomer Peled, Luca Sineo, Gioacchino Falsone, Peter Dommelen, Alissa Mittnik, Iosif Lazaridis, Davide Pettener, Maria Bofill, Ana Mezquida, Benjamí Costa, Helena Jiménez, Patricia Smith, Stefania Vai, Alessandra Modi, Arie Shaus, Kim Callan, Elizabeth Curtis, Aisling Kearns, Ann Marie Lawson, Matthew Mah, Adam Micco, Jonas Oppenheimer, Lijun Qiu, Kristin Stewardson, J. Noah Workman, Nicholas Márquez-Grant, Antonio M. Sáez Romero, María Luisa Lavado Florido, Juan Manuel Jiménez-Arenas, Isidro Jorge Toro Moyano, Enrique Viguera, José Suárez Padilla, Sonia López Chamizo, Tomas Marques-Bonet, Esther Lizano, Alicia Rodero Riaza, Francesca Olivieri, Pamela Toti, Valentina Giuliana, Alon Barash, Liran Carmel, Elisabetta Boaretto, Marina Faerman, Michaela Lucci, Francesco Pastina, Alessia Nava, Francesco Genchi, Carla Vais, Gabriele Lauria, Francesca Meli, Paola Sconzo, Giulio Catalano, Elisabetta Cilli, Anna Chiara Fariselli, Francesco Fontani, Donata Luiselli, Brendan J. Culleton, Swapan Mallick, Nadin Rohland, Lorenzo Nigro, Alfredo Coppa, David Caramelli, Ron Pinhasi, Carles Lalueza-Fox, Ilan Gronau and David Reich

Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis pp. 148-157

V. Herklotz, M. Zhang, T. Nascimento, R. Kalfusová, J. Lunerová, J. Fuchs, D. Harpke, B. Huettel, U. Pfordt, V. Wissemann, A. Kovařík, A. Marques and C. M. Ritz

Comparative connectomics of Drosophila descending and ascending neurons pp. 158-172

Tomke Stürner, Paul Brooks, Laia Serratosa Capdevila, Billy J. Morris, Alexandre Javier, Siqi Fang, Marina Gkantia, Sebastian Cachero, Isabella R. Beckett, Elizabeth C. Marin, Philipp Schlegel, Andrew S. Champion, Ilina Moitra, Alana Richards, Finja Klemm, Leonie Kugel, Shigehiro Namiki, Han S. J. Cheong, Julie Kovalyak, Emily Tenshaw, Ruchi Parekh, Jasper S. Phelps, Brandon Mark, Sven Dorkenwald, Alexander S. Bates, Arie Matsliah, Szi-chieh Yu, Claire E. McKellar, Amy Sterling, H. Sebastian Seung, Mala Murthy, John C. Tuthill, Wei-Chung Allen Lee, Gwyneth M. Card, Marta Costa, Gregory S. X. E. Jefferis and Katharina Eichler

Regulation of PV interneuron plasticity by neuropeptide-encoding genes pp. 173-181

Martijn Selten, Clémence Bernard, Diptendu Mukherjee, Fursham Hamid, Alicia Hanusz-Godoy, Fazal Oozeer, Christoph Zimmer and Oscar Marín

Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy pp. 182-191

Mike C. L. Wu, Ethan Italiano, Rocko Jarvis-Child, Imala Alwis, Rhyll Smythe, Eduardo A. Albornoz, Jonathan Noonan, Marie Portelli, Marissa Baptista, Jessica Maclean, Pashtana Noori, Jinglu Yang, John D. Lee, James D. McFadyen, Alexandra F. Sharland, Trent M. Woodruff, Andre L. Samson, Amy Rapkiewicz, Tessa J. Barrett, Alan Pham, Simone M. Schoenwaelder, Yuping Yuan and Shaun P. Jackson

Lithocholic acid phenocopies anti-ageing effects of calorie restriction pp. 192-200

Qi Qu, Yan Chen, Yu Wang, Shating Long, Weiche Wang, Heng-Ye Yang, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, Shengrong Xu, Cixiong Zhang, Mingxia Zhu, Sin Man Lam, Jianfeng Wu, Chuyu Yun, Junjie Chen, Shengye Xue, Baoding Zhang, Zhong-Zheng Zheng, Hai-Long Piao, Changtao Jiang, Hao Guo, Guanghou Shui, Xianming Deng, Chen-Song Zhang and Sheng-Cai Lin

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing pp. 201-209

Qi Qu, Yan Chen, Yu Wang, Weiche Wang, Shating Long, Heng-Ye Yang, Jianfeng Wu, Mengqi Li, Xiao Tian, Xiaoyan Wei, Yan-Hui Liu, Shengrong Xu, Jinye Xiong, Chunyan Yang, Zhenhua Wu, Xi Huang, Changchuan Xie, Yaying Wu, Zheni Xu, Cixiong Zhang, Baoding Zhang, Jin-Wei Feng, Junjie Chen, Yuanji Feng, Huapan Fang, Liyun Lin, Xie Zk, Beibei Sun, Huayu Tian, Yong Yu, Hai-Long Piao, Xiao-Song Xie, Xianming Deng, Chen-Song Zhang and Sheng-Cai Lin

Targeting symbionts by apolipoprotein L proteins modulates gut immunity pp. 210-218

Tao Yang, Xiaohu Hu, Fei Cao, Fenglin Yun, Kaiwen Jia, Mingxiang Zhang, Gaohui Kong, Biyu Nie, Yuexing Liu, Haohao Zhang, Xiaoyu Li, Hongyan Gao, Jiantao Shi, Guanxiang Liang, Guohong Hu, Dennis L. Kasper, Xinyang Song and Youcun Qian

Glioblastoma-instructed astrocytes suppress tumour-specific T cell immunity pp. 219-229

Camilo Faust Akl, Brian M. Andersen, Zhaorong Li, Federico Giovannoni, Martin Diebold, Liliana M. Sanmarco, Michael Kilian, Luca Fehrenbacher, Florian Pernin, Joseph M. Rone, Hong-Gyun Lee, Gavin Piester, Jessica E. Kenison, Joon-Hyuk Lee, Tomer Illouz, Carolina M. Polonio, Léna Srun, Jazmin Martinez, Elizabeth N. Chung, Anton Schüle, Agustin Plasencia, Lucinda Li, Kylynne Ferrara, Mercedes Lewandrowski, Craig A. Strathdee, Lorena Lerner, Christophe Quéva, Iain C. Clark, Benjamin Deneen, Judy Lieberman, David H. Sherr, Jack P. Antel, Michael A. Wheeler, Keith L. Ligon, E. Antonio Chiocca, Marco Prinz, David A. Reardon and Francisco J. Quintana

Geographic and age variations in mutational processes in colorectal cancer pp. 230-240

Marcos Díaz-Gay, Wellington Santos, Sarah Moody, Mariya Kazachkova, Ammal Abbasi, Christopher D. Steele, Raviteja Vangara, Sergey Senkin, Jingwei Wang, Stephen Fitzgerald, Erik N. Bergstrom, Azhar Khandekar, Burçak Otlu, Behnoush Abedi-Ardekani, Ana Carolina Carvalho, Thomas Cattiaux, Ricardo Cortez Cardoso Penha, Valérie Gaborieau, Priscilia Chopard, Christine Carreira, Saamin Cheema, Calli Latimer, Jon W. Teague, Anush Mukeriya, David Zaridze, Riley Cox, Monique Albert, Larry Phouthavongsy, Steven Gallinger, Reza Malekzadeh, Ahmadreza Niavarani, Marko Miladinov, Katarina Erić, Sasa Milosavljevic, Suleeporn Sangrajrang, Maria Paula Curado, Samuel Aguiar, Rui Manuel Reis, Monise Tadin Reis, Luis Gustavo Romagnolo, Denise Peixoto Guimarães, Ivana Holcatova, Jaroslav Kalvach, Carlos Alberto Vaccaro, Tamara Alejandra Piñero, Beata Świątkowska, Jolanta Lissowska, Katarzyna Roszkowska-Purska, Antonio Huertas-Salgado, Tatsuhiro Shibata, Satoshi Shiba, Surasak Sangkhathat, Taned Chitapanarux, Gholamreza Roshandel, Patricia Ashton-Prolla, Daniel C. Damin, Francine Hehn Oliveira, Laura Humphreys, Trevor D. Lawley, Sandra Perdomo, Michael R. Stratton, Paul Brennan and Ludmil B. Alexandrov

Programmable control of spatial transcriptome in live cells and neurons pp. 241-251

Mengting Han, Maylin L. Fu, Yanyu Zhu, Alexander A. Choi, Emmy Li, Jon Bezney, Sa Cai, Leann Miles, Yitong Ma and Lei S. Qi

EndoMAP.v1 charts the structural landscape of human early endosome complexes pp. 252-261

Miguel A. Gonzalez-Lozano, Ernst W. Schmid, Enya Miguel Whelan, Yizhi Jiang, Joao A. Paulo, Johannes C. Walter and J. Wade Harper

Maternal iron deficiency causes male-to-female sex reversal in mouse embryos pp. 262-270

Naoki Okashita, Ryo Maeda, Shunsuke Kuroki, Kyona Sasaki, Yoko Uno, Peter Koopman and Makoto Tachibana

Substrate recognition and cleavage mechanism of the monkeypox virus core protease pp. 271-279

Yan Gao, Xiong Xie, Xiaoyu Zhang, Junyuan Cao, Weiqi Lan, Tian You, Dongxu Li, Xuxue Dong, Wenhao Dai, Yingchun Xiang, Shulei Hu, Weijuan Shang, Botao Wu, Yumin Zhang, Jin Xu, Xiaoce Liu, Haofeng Wang, Wanlong Hu, Mingjing Zhang, Yinkai Duan, Wen Cui, Hao Zhou, Shengjiang Mao, Handi Jia, Zhanqi Sun, Menghan Jia, Yue Yin, Henry C. Nguyen, Kailin Yang, Bei Yang, Xiuna Yang, Xiaoyun Ji, Gengfu Xiao, Wei Wang, Leike Zhang, Zihe Rao, Hong Liu and Haitao Yang

Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor pp. 280-287

Qiuyan Chen, Christopher T. Schafer, Somnath Mukherjee, Kai Wang, Martin Gustavsson, James R. Fuller, Katelyn Tepper, Thomas D. Lamme, Yasmin Aydin, Parth Agrawal, Genki Terashi, Xin-Qiu Yao, Daisuke Kihara, Anthony A. Kossiakoff, Tracy M. Handel and John J. G. Tesmer

Some US researchers want to leave the country. Can Europe take them? pp. 289-291

Jack Leeming

’We couldn’t live without it’: the UCSC Genome Browser turns 25 pp. 292-294

Michael Eisenstein

I pioneered my country’s newborn health-screening programme pp. 296-296

James Mitchell Crow