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2012, volume 490, articles 7421

Throw off the cloak of invisibility pp. 447-447

Athene Donald

High stakes for US science pp. 453-455

Jeff Tollefson and Heidi Ledford

Viral research faces clampdown pp. 456-456

Declan Butler

Website pitches solutions in search of problems pp. 457-457

Richard Van Noorden

Ocean-fertilization project off Canada sparks furore pp. 458-459

Jeff Tollefson

Texas cancer fund seeks fresh start pp. 459-460

Monya Baker

Toxicology: The learning curve pp. 462-465

Dan Fagin

Biology and ideology: The anatomy of politics pp. 466-468

Lizzie Buchen

Wall Street's thirst for water pp. 469-471

Frederick Kaufman

Why symmetry matters pp. 472-473

Mario Livio

Environmental sciences: Divided we save pp. 474-475

Peter Kareiva

Mathematics: A fractal life pp. 476-477

Mark Buchanan

Medical history: Stemming the red tide pp. 477-478

Stefan H. E. Kaufmann

Planetary science: The search for Earth's twin pp. 479-479

Sara Seager

Pseudoscience: A fringe too far pp. 480-481

David Morrison

Neuroscience: Encounters with the nonexistent pp. 481-482

Dominic Ffytche

Food security: Growing trouble pp. 483-484

Calestous Juma

Biotechnology: Random harvest pp. 484-485

Ian Wilmut

Reallocate funds to boost performance pp. 487-487

Andrew J. Tanentzap

Social insight rings true 125 years on pp. 487-487

Lee Altenberg

Beit fellowships forge a Nobel link pp. 487-487

Andrew McMichael and Cyril Chantler

Timely reminder to return to the Moon pp. 487-487

David A. Kring, Jack O. Burns and D. Ben J. Bussey

Bureaucracy bypass let research flourish pp. 487-487

Min-Liang Wong

Louise Johnson (1940–2012) pp. 488-488

Mark Sansom

Destiny from density pp. 490-491

Victoria L. Seewaldt

Signs of instability pp. 491-492

Juergen Mienert

Snapshot of an activated peptide receptor pp. 492-493

Felix Hausch and Florian Holsboer

The inner life of proteins pp. 493-494

Günter P. Wagner

Infrared light from wandering stars pp. 494-495

Andrea Ferrara

A map of rice genome variation reveals the origin of cultivated rice pp. 497-501

Xuehui Huang, Nori Kurata, Xinghua Wei, Zi-Xuan Wang, Ahong Wang, Qiang Zhao, Yan Zhao, Kunyan Liu, Hengyun Lu, Wenjun Li, Yunli Guo, Yiqi Lu, Congcong Zhou, Danlin Fan, Qijun Weng, Chuanrang Zhu, Tao Huang, Lei Zhang, Yongchun Wang, Lei Feng, Hiroyasu Furuumi, Takahiko Kubo, Toshie Miyabayashi, Xiaoping Yuan, Qun Xu, Guojun Dong, Qilin Zhan, Canyang Li, Asao Fujiyama, Atsushi Toyoda, Tingting Lu, Qi Feng, Qian Qian, Jiayang Li and Bin Han

Compensatory dendritic cell development mediated by BATF–IRF interactions pp. 502-507

Roxane Tussiwand, Wan-Ling Lee, Theresa L. Murphy, Mona Mashayekhi, Wumesh Kc, Jörn C. Albring, Ansuman T. Satpathy, Jeffrey A. Rotondo, Brian T. Edelson, Nicole M. Kretzer, Xiaodi Wu, Leslie A. Weiss, Elke Glasmacher, Peng Li, Wei Liao, Michael Behnke, Samuel S. K. Lam, Cora T. Aurthur, Warren J. Leonard, Harinder Singh, Christina L. Stallings, L. David Sibley, Robert D. Schreiber and Kenneth M. Murphy

Structure of the agonist-bound neurotensin receptor pp. 508-513

Jim F. White, Nicholas Noinaj, Yoko Shibata, James Love, Brian Kloss, Feng Xu, Jelena Gvozdenovic-Jeremic, Priyanka Shah, Joseph Shiloach, Christopher G. Tate and Reinhard Grisshammer

Near-infrared background anisotropies from diffuse intrahalo light of galaxies pp. 514-516

Asantha Cooray, Joseph Smidt, Francesco De Bernardis, Yan Gong, Daniel Stern, Matthew L. N. Ashby, Peter R. Eisenhardt, Christopher C. Frazer, Anthony H. Gonzalez, Christopher S. Kochanek, Szymon Kozłowski and Edward L. Wright

Quasi-periodic events in crystal plasticity and the self-organized avalanche oscillator pp. 517-521

Stefanos Papanikolaou, Dennis M. Dimiduk, Woosong Choi, James P. Sethna, Michael D. Uchic, Christopher F. Woodward and Stefano Zapperi

Forming all-carbon quaternary stereogenic centres in acyclic systems from alkynes pp. 522-526

Yury Minko, Morgane Pasco, Lukas Lercher, Mark Botoshansky and Ilan Marek

Recent changes to the Gulf Stream causing widespread gas hydrate destabilization pp. 527-530

Benjamin J. Phrampus and Matthew J. Hornbach

The origin of the terrestrial noble-gas signature pp. 531-534

Svyatoslav S. Shcheka and Hans Keppler

Epistasis as the primary factor in molecular evolution pp. 535-538

Michael S. Breen, Carsten Kemena, Peter K. Vlasov, Cedric Notredame and Fyodor A. Kondrashov

Phosphorylation of NLRC4 is critical for inflammasome activation pp. 539-542

Yan Qu, Shahram Misaghi, Anita Izrael-Tomasevic, Kim Newton, Laurie L. Gilmour, Mohamed Lamkanfi, Salina Louie, Nobuhiko Kayagaki, Jinfeng Liu, László Kömüves, James E. Cupp, David Arnott, Denise Monack and Vishva M. Dixit

BATF–JUN is critical for IRF4-mediated transcription in T cells pp. 543-546

Peng Li, Rosanne Spolski, Wei Liao, Lu Wang, Theresa L. Murphy, Kenneth M. Murphy and Warren J. Leonard

Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila pp. 547-551

Shizue Ohsawa, Yoshitaka Sato, Masato Enomoto, Mai Nakamura, Aya Betsumiya and Tatsushi Igaki

Black mamba venom peptides target acid-sensing ion channels to abolish pain pp. 552-555

Sylvie Diochot, Anne Baron, Miguel Salinas, Dominique Douguet, Sabine Scarzello, Anne-Sophie Dabert-Gay, Delphine Debayle, Valérie Friend, Abdelkrim Alloui, Michel Lazdunski and Eric Lingueglia

Structure-based prediction of protein–protein interactions on a genome-wide scale pp. 556-560

Qiangfeng Cliff Zhang, Donald Petrey, Lei Deng, Li Qiang, Yu Shi, Chan Aye Thu, Brygida Bisikirska, Celine Lefebvre, Domenico Accili, Tony Hunter, Tom Maniatis, Andrea Califano and Barry Honig

Clonal allelic predetermination of immunoglobulin-κ rearrangement pp. 561-565

Marganit Farago, Chaggai Rosenbluh, Maya Tevlin, Shira Fraenkel, Sharon Schlesinger, Hagit Masika, Masha Gouzman, Grace Teng, David Schatz, Yoach Rais, Jacob H. Hanna, Alexander Mildner, Steffen Jung, Gustavo Mostoslavsky, Howard Cedar and Yehudit Bergman

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans pp. 566-569

Mi Sun Jin, Michael L. Oldham, Qiuju Zhang and Jue Chen

Correction: Corrigendum: Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors pp. 570-570

Xiaocong Yu, Tshidi Tsibane, Patricia A. McGraw, Frances S. House, Christopher J. Keefer, Mark D. Hicar, Terrence M. Tumpey, Claudia Pappas, Lucy A. Perrone, Osvaldo Martinez, James Stevens, Ian A. Wilson, Patricia V. Aguilar, Eric L. Altschuler, Christopher F. Basler and James E. Crowe

Correction: Corrigendum: RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis pp. 570-570

Min Yu, David T. Ting, Shannon L. Stott, Ben S. Wittner, Fatih Ozsolak, Suchismita Paul, Jordan C. Ciciliano, Malgorzata E. Smas, Daniel Winokur, Anna J. Gilman, Matthew J. Ulman, Kristina Xega, Gianmarco Contino, Brinda Alagesan, Brian W. Brannigan, Patrice M. Milos, David P. Ryan, Lecia V. Sequist, Nabeel Bardeesy, Sridhar Ramaswamy, Mehmet Toner, Shyamala Maheswaran and Daniel A. Haber

Correction: Corrigendum: High-performance bulk thermoelectrics with all-scale hierarchical architectures pp. 570-570

Kanishka Biswas, Jiaqing He, Ivan D. Blum, Chun-IWu, Timothy P. Hogan, David N. Seidman, Vinayak P. Dravid and Mercouri G. Kanatzidis

Work experience: Stepping stones pp. 571-573

Amanda Mascarelli

Glass future pp. 576-576

Deborah Walker

2012, volume 490, articles 7420

The secrets of my prizewinning research pp. 311-311

Serge Haroche

Badger battle erupts in England pp. 317-318

Geoff Brumfiel

Politics holds back animal engineers pp. 318-319

Amy Maxmen

Nobel work boosts drug development pp. 320-320

Richard Van Noorden

Stem-cell fraud hits febrile field pp. 321-321

David Cyranoski

Drug firm to share raw trial data pp. 322-322

Declan Butler

The exoplanet next door pp. 323-323

Eric Hand

Antarctic seas in the balance pp. 324-324

Daniel Cressey

Global mobility: Science on the move pp. 326-329

Richard Van Noorden

The rise of research networks pp. 335-336

Jonathan Adams

Global challenges need global solutions pp. 337-338

Subra Suresh

Biophysics: Tales from the canopy pp. 339-340

Sandra Knapp

Zoology: The animal inside pp. 340-341

Josie Glausiusz

Rural factories won't fix Chinese pollution pp. 342-343

Hong Yang, Roger J. Flower and Julian R. Thompson

Citizens add to satellite forest maps pp. 342-342

Marijn van der Velde, Linda See and Steffen Fritz

Database for sharing costly equipment pp. 342-342

Luke Georghiou

Cash puts publishing ethics at risk in China pp. 342-342

Sarah Huggett

Metrics: a long-term threat to society pp. 343-343

Malgorzata Blicharska and Grzegorz Mikusinski

Metrics: a fetish for high-profile journals pp. 343-343

Ronald Rousseau and Xiaojun Hu

Metrics: allow more gradual progress pp. 343-343

Pedro Cintas

Librarians or science informationists? pp. 343-343

Ludmila Pollock

Clean stoves benefit climate and health pp. 343-343

Susan Anenberg

Galvanized lunacy pp. 346-347

Tim Elliott

Tumours switch to resist pp. 347-348

Antoni Ribas and Paul C. Tumeh

Bundles of insights into sugar transporters pp. 348-349

Peter J. F. Henderson and Stephen A. Baldwin

Design by trial pp. 350-351

David V. Glidden

Choose your protein partners pp. 351-352

Rahul S. Samant and Paul Workman

The big picture of marsh loss pp. 352-353

Steven C. Pennings

The aged niche disrupts muscle stem cell quiescence pp. 355-360

Joe V. Chakkalakal, Kieran M. Jones, M. Albert Basson and Andrew S. Brack

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4 pp. 361-366

Linfeng Sun, Xin Zeng, Chuangye Yan, Xiuyun Sun, Xinqi Gong, Yu Rao and Nieng Yan

Structure of AMP-PNP-bound vitamin B12 transporter BtuCD–F pp. 367-372

Vladimir M. Korkhov, Samantha A. Mireku and Kaspar P. Locher

Hard-X-ray emission lines from the decay of 44Ti in the remnant of supernova 1987A pp. 373-375

S. A. Grebenev, A. A. Lutovinov, S. S. Tsygankov and C. Winkler

Zinc isotopic evidence for the origin of the Moon pp. 376-379

Randal C. Paniello, James M. D. Day and Frédéric Moynier

Circuit quantum electrodynamics with a spin qubit pp. 380-383

K. D. Petersson, L. W. McFaul, M. D. Schroer, M. Jung, J. M. Taylor, A. A. Houck and J. R. Petta

Bonding and structure of a reconstructed (001) surface of SrTiO3 from TEM pp. 384-387

Guo-zhen Zhu, Guillaume Radtke and Gianluigi A. Botton

Coastal eutrophication as a driver of salt marsh loss pp. 388-392

Linda A. Deegan, David Samuel Johnson, R. Scott Warren, Bruce J. Peterson, John W. Fleeger, Sergio Fagherazzi and Wilfred M. Wollheim

Delayed build-up of Arctic ice sheets during 400,000-year minima in insolation variability pp. 393-396

Qingzhen Hao, Luo Wang, Frank Oldfield, Shuzhen Peng, Li Qin, Yang Song, Bing Xu, Yansong Qiao, Jan Bloemendal and Zhengtang Guo

Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo pp. 397-401

Maria Lavzin, Sophia Rapoport, Alon Polsky, Liora Garion and Jackie Schiller

Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive pp. 402-406

Julia C. Lemos, Matthew J. Wanat, Jeffrey S. Smith, Beverly A. S. Reyes, Nick G. Hollon, Elisabeth J. Van Bockstaele, Charles Chavkin and Paul E. M. Phillips

Androgenetic haploid embryonic stem cells produce live transgenic mice pp. 407-411

Wei Li, Ling Shuai, Haifeng Wan, Mingzhu Dong, Meng Wang, Lisi Sang, Chunjing Feng, Guan-Zheng Luo, Tianda Li, Xin Li, Libin Wang, Qin-Yuan Zheng, Chao Sheng, Hua-Jun Wu, Zhonghua Liu, Lei Liu, Liu Wang, Xiu-Jie Wang, Xiao-Yang Zhao and Qi Zhou

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation pp. 412-416

Jennifer Landsberg, Judith Kohlmeyer, Marcel Renn, Tobias Bald, Meri Rogava, Mira Cron, Martina Fatho, Volker Lennerz, Thomas Wölfel, Michael Hölzel and Thomas Tüting

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 pp. 417-420

Morgane Rolland, Paul T. Edlefsen, Brendan B. Larsen, Sodsai Tovanabutra, Eric Sanders-Buell, Tomer Hertz, Allan C. deCamp, Chris Carrico, Sergey Menis, Craig A. Magaret, Hasan Ahmed, Michal Juraska, Lennie Chen, Philip Konopa, Snehal Nariya, Julia N. Stoddard, Kim Wong, Hong Zhao, Wenjie Deng, Brandon S. Maust, Meera Bose, Shana Howell, Adam Bates, Michelle Lazzaro, Annemarie O’Sullivan, Esther Lei, Andrea Bradfield, Grace Ibitamuno, Vatcharain Assawadarachai, Robert J. O’Connell, Mark S. deSouza, Sorachai Nitayaphan, Supachai Rerks-Ngarm, Merlin L. Robb, Jason S. McLellan, Ivelin Georgiev, Peter D. Kwong, Jonathan M. Carlson, Nelson L. Michael, William R. Schief, Peter B. Gilbert, James I. Mullins and Jerome H. Kim

A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses pp. 421-425

Vladimir Litvak, Alexander V. Ratushny, Aaron E. Lampano, Frank Schmitz, Albert C. Huang, Ayush Raman, Alistair G. Rust, Andreas Bergthaler, John D. Aitchison and Alan Aderem

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes pp. 426-430

Carolina E. Hagberg, Annika Mehlem, Annelie Falkevall, Lars Muhl, Barbara C. Fam, Henrik Ortsäter, Pierre Scotney, Daniel Nyqvist, Erik Samén, Li Lu, Sharon Stone-Elander, Joseph Proietto, Sofianos Andrikopoulos, Åke Sjöholm, Andrew Nash and Ulf Eriksson

Initiation of transcription-coupled repair characterized at single-molecule resolution pp. 431-434

Kévin Howan, Abigail J. Smith, Lars F. Westblade, Nicolas Joly, Wilfried Grange, Sylvain Zorman, Seth A. Darst, Nigel J. Savery and Terence R. Strick

Innovation: Brushing up on business pp. 435-437

Neil Savage

Turning point: Craig Bennett pp. 437-437

Virginia Gewin

The tell-tale ear pp. 440-440

Alex Shvartsman

2012, volume 490, articles 7419

Physics masterclass pp. S1-S1

Michelle Grayson

Cosmology: Out of the darkness pp. S2-S4

Matthew Chalmers

Astronomy: A conversation about observation pp. S5-S7

John Mather and Minnie Mao

Finding fascination in nature pp. S8-S9

Dan Csontos

Coming to terms with the Higgs pp. S10-S11

Matthew Chalmers

In search of ignorance pp. S11-S12

Iulia Georgescu

From Los Alamos to Stockholm pp. S13-S13

Andreas Trabesinger

Socially responsible science pp. S14-S15

Olive Heffernan

Expert assessments can work if lessons are learned pp. 145-145

Ehsan Masood

Cell rewind wins medicine Nobel pp. 151-152

Alison Abbott

Physics Nobel for quantum optics pp. 152-152

Geoff Brumfiel

Boston scandal exposes backlog pp. 153-154

Eugenie Samuel Reich

Economics and genetics meet in uneasy union pp. 154-155

Ewen Callaway

Genome interpreter vies for place in clinical market pp. 157-157

Monya Baker

Hyped GM maize study faces growing scrutiny pp. 158-158

Declan Butler

US biologists decry funding changes pp. 159-159

Helen Shen

Stress and the city: Urban decay pp. 162-164

Alison Abbott

Stress: The roots of resilience pp. 165-167

Virginia Hughes

Too toxic to ignore pp. 169-171

Elizabeth H. Blackburn and Elissa S. Epel

Stress makes its molecular mark pp. 171-172

Eric J. Nestler

Sleep science: Broken dreams pp. 173-174

Meredith Wadman

Psychiatry: The dispossessed pp. 174-175

Amy Maxmen

Drop re-review for big grant holders pp. 176-176

Hemant K. Roy

EU scientific visa is a success in Ireland pp. 176-176

Conor O'Carroll

Who discovered Universe expansion? pp. 176-176

Ian Steer

Environment in Queensland at risk pp. 176-176

Andrew Chin, Jimmy White and Nick Dulvy

Promiscuous vesicles pp. 178-179

John T. Williams

Single molecules put a ring on it pp. 179-180

John T. S. Yeoman and Sarah E. Reisman

Cambrian nervous wrecks pp. 180-181

Graham E. Budd

Catching the wave pp. 182-183

John M. Fryxell and Tal Avgar

When an oceanic tectonic plate cracks pp. 183-185

Jean-Yves Royer

The neuron family tree remodelled pp. 185-186

Oscar Marín

A call for transparent reporting to optimize the predictive value of preclinical research pp. 187-191

Story C. Landis, Susan G. Amara, Khusru Asadullah, Chris P. Austin, Robi Blumenstein, Eileen W. Bradley, Ronald G. Crystal, Robert B. Darnell, Robert J. Ferrante, Howard Fillit, Robert Finkelstein, Marc Fisher, Howard E. Gendelman, Robert M. Golub, John L. Goudreau, Robert A. Gross, Amelie K. Gubitz, Sharon E. Hesterlee, David W. Howells, John Huguenard, Katrina Kelner, Walter Koroshetz, Dimitri Krainc, Stanley E. Lazic, Michael S. Levine, Malcolm R. Macleod, John M. McCall, Richard T. Moxley, Kalyani Narasimhan, Linda J. Noble, Steve Perrin, John D. Porter, Oswald Steward, Ellis Unger, Ursula Utz and Shai D. Silberberg

A roadmap for graphene pp. 192-200

K. S. Novoselov, V. I. Fal′ko, Luca Colombo, P. R. Gellert, M. G. Schwab and K. Kim

Molecular machines governing exocytosis of synaptic vesicles pp. 201-207

Reinhard Jahn and Dirk Fasshauer

The hexadehydro-Diels–Alder reaction pp. 208-212

Thomas R. Hoye, Beeraiah Baire, Dawen Niu, Patrick H. Willoughby and Brian P. Woods

Small heat-shock proteins protect from heat-stroke-associated neurodegeneration pp. 213-218

Nikos Kourtis, Vassiliki Nikoletopoulou and Nektarios Tavernarakis

Retinal waves coordinate patterned activity throughout the developing visual system pp. 219-225

James B. Ackman, Timothy J. Burbridge and Michael C. Crair

A neural circuit for spatial summation in visual cortex pp. 226-231

Hillel Adesnik, William Bruns, Hiroki Taniguchi, Z. Josh Huang and Massimo Scanziani

Unexpectedly large mass loss during the thermal pulse cycle of the red giant star R Sculptoris pp. 232-234

M. Maercker, S. Mohamed, W. H. T. Vlemmings, S. Ramstedt, M. A. T. Groenewegen, E. Humphreys, F. Kerschbaum, M. Lindqvist, H. Olofsson, C. Paladini, M. Wittkowski, I. de Gregorio-Monsalvo and L.-A. Nyman

Probing graphene grain boundaries with optical microscopy pp. 235-239

Dinh Loc Duong, Gang Hee Han, Seung Mi Lee, Fethullah Gunes, Eun Sung Kim, Sung Tae Kim, Heetae Kim, Quang Huy Ta, Kang Pyo So, Seok Jun Yoon, Seung Jin Chae, Young Woo Jo, Min Ho Park, Sang Hoon Chae, Seong Chu Lim, Jae Young Choi and Young Hee Lee

April 2012 intra-oceanic seismicity off Sumatra boosted by the Banda-Aceh megathrust pp. 240-244

Matthias Delescluse, Nicolas Chamot-Rooke, Rodolphe Cattin, Luce Fleitout, Olga Trubienko and Christophe Vigny

En échelon and orthogonal fault ruptures of the 11 April 2012 great intraplate earthquakes pp. 245-249

Han Yue, Thorne Lay and Keith D. Koper

The 11 April 2012 east Indian Ocean earthquake triggered large aftershocks worldwide pp. 250-253

Fred F. Pollitz, Ross S. Stein, Volkan Sevilgen and Roland Bürgmann

Closing yield gaps through nutrient and water management pp. 254-257

Nathaniel D. Mueller, James S. Gerber, Matt Johnston, Deepak K. Ray, Navin Ramankutty and Jonathan A. Foley

Complex brain and optic lobes in an early Cambrian arthropod pp. 258-261

Xiaoya Ma, Xianguang Hou, Gregory D. Edgecombe and Nicholas J. Strausfeld

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA pp. 262-266

Nicolas X. Tritsch, Jun B. Ding and Bernardo L. Sabatini

FTO genotype is associated with phenotypic variability of body mass index pp. 267-272

Jian Yang, Ruth J. F. Loos, Joseph E. Powell, Sarah E. Medland, Elizabeth K. Speliotes, Daniel I. Chasman, Lynda M. Rose, Gudmar Thorleifsson, Valgerdur Steinthorsdottir, Reedik Mägi, Lindsay Waite, Albert Vernon Smith, Laura M. Yerges-Armstrong, Keri L. Monda, David Hadley, Anubha Mahajan, Guo Li, Karen Kapur, Veronique Vitart, Jennifer E. Huffman, Sophie R. Wang, Cameron Palmer, Tõnu Esko, Krista Fischer, Jing Hua Zhao, Ayşe Demirkan, Aaron Isaacs, Mary F. Feitosa, Jian’an Luan, Nancy L. Heard-Costa, Charles White, Anne U. Jackson, Michael Preuss, Andreas Ziegler, Joel Eriksson, Zoltán Kutalik, Francesca Frau, Ilja M. Nolte, Jana V. Van Vliet-Ostaptchouk, Jouke-Jan Hottenga, Kevin B. Jacobs, Niek Verweij, Anuj Goel, Carolina Medina-Gomez, Karol Estrada, Jennifer Lynn Bragg-Gresham, Serena Sanna, Carlo Sidore, Jonathan Tyrer, Alexander Teumer, Inga Prokopenko, Massimo Mangino, Cecilia M. Lindgren, Themistocles L. Assimes, Alan R. Shuldiner, Jennie Hui, John P. Beilby, Wendy L. McArdle, Per Hall, Talin Haritunians, Lina Zgaga, Ivana Kolcic, Ozren Polasek, Tatijana Zemunik, Ben A. Oostra, M. Juhani Junttila, Henrik Grönberg, Stefan Schreiber, Annette Peters, Andrew A. Hicks, Jonathan Stephens, Nicola S. Foad, Jaana Laitinen, Anneli Pouta, Marika Kaakinen, Gonneke Willemsen, Jacqueline M. Vink, Sarah H. Wild, Gerjan Navis, Folkert W. Asselbergs, Georg Homuth, Ulrich John, Carlos Iribarren, Tamara Harris, Lenore Launer, Vilmundur Gudnason, Jeffrey R. O’Connell, Eric Boerwinkle, Gemma Cadby, Lyle J. Palmer, Alan L. James, Arthur W. Musk, Erik Ingelsson, Bruce M. Psaty, Jacques S. Beckmann, Gerard Waeber, Peter Vollenweider, Caroline Hayward, Alan F. Wright, Igor Rudan, Leif C. Groop, Andres Metspalu, Kay-Tee Khaw, Cornelia M. van Duijn, Ingrid B. Borecki, Michael A. Province, Nicholas J. Wareham, Jean-Claude Tardif, Heikki V. Huikuri, L. Adrienne Cupples, Larry D. Atwood, Caroline S. Fox, Michael Boehnke, Francis S. Collins, Karen L. Mohlke, Jeanette Erdmann, Heribert Schunkert, Christian Hengstenberg, Klaus Stark, Mattias Lorentzon, Claes Ohlsson, Daniele Cusi, Jan A. Staessen, Melanie M. Van der Klauw, Peter P. Pramstaller, Sekar Kathiresan, Jennifer D. Jolley, Samuli Ripatti, Marjo-Riitta Jarvelin, Eco J. C. de Geus, Dorret I. Boomsma, Brenda Penninx, James F. Wilson, Harry Campbell, Stephen J. Chanock, Pim van der Harst, Anders Hamsten, Hugh Watkins, Albert Hofman, Jacqueline C. Witteman, M. Carola Zillikens, André G. Uitterlinden, Fernando Rivadeneira, M. Carola Zillikens, Lambertus A. Kiemeney, Sita H. Vermeulen, Goncalo R. Abecasis, David Schlessinger, Sabine Schipf, Michael Stumvoll, Anke Tönjes, Tim D. Spector, Kari E. North, Guillaume Lettre, Mark I. McCarthy, Sonja I. Berndt, Andrew C. Heath, Pamela A. F. Madden, Dale R. Nyholt, Grant W. Montgomery, Nicholas G. Martin, Barbara McKnight, David P. Strachan, William G. Hill, Harold Snieder, Paul M. Ridker, Unnur Thorsteinsdottir, Kari Stefansson, Timothy M. Frayling, Joel N. Hirschhorn, Michael E. Goddard and Peter M. Visscher

Controlling interneuron activity in Caenorhabditis elegans to evoke chemotactic behaviour pp. 273-277

Askin Kocabas, Ching-Han Shen, Zengcai V. Guo and Sharad Ramanathan

Restoration of auditory evoked responses by human ES-cell-derived otic progenitors pp. 278-282

Wei Chen, Nopporn Jongkamonwiwat, Leila Abbas, Sarah Jacob Eshtan, Stuart L. Johnson, Stephanie Kuhn, Marta Milo, Johanna K. Thurlow, Peter W. Andrews, Walter Marcotti, Harry D. Moore and Marcelo N. Rivolta

HIV-infected T cells are migratory vehicles for viral dissemination pp. 283-287

Thomas T. Murooka, Maud Deruaz, Francesco Marangoni, Vladimir D. Vrbanac, Edward Seung, Ulrich H. von Andrian, Andrew M. Tager, Andrew D. Luster and Thorsten R. Mempel

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 pp. 288-291

Petr Broz, Thomas Ruby, Kamila Belhocine, Donna M. Bouley, Nobuhiko Kayagaki, Vishva M. Dixit and Denise M. Monack

Correction: Corrigendum: Past extreme warming events linked to massive carbon release from thawing permafrost pp. 292-292

Robert M. DeConto, Simone Galeotti, Mark Pagani, David Tracy, Kevin Schaefer, Tingjun Zhang, David Pollard and David J. Beerling

Erratum: Integrated genomic analyses of ovarian carcinoma pp. 292-292

The Cancer Genome Atlas Research Network

Correction: Corrigendum: Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure pp. 292-292

Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Manabu Taneike, Toshihiro Takeda, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Hiroyuki Nakayama, Kazuhiko Nishida, Shizuo Akira, Akitsugu Yamamoto, Issei Komuro and Kinya Otsu

Charting the brain's networks pp. 293-298

Vivien Marx

Mental health: Under a cloud pp. 299-301

Virginia Gewin

Advising on the edge pp. 301-301

Katherine Mackey

Temporal ventures robbed me pp. 304-304

Scott C. Mikula

2012, volume 490, articles 7418

Gene therapies need new development models pp. 7-7

Fulvio Mavilio

Malaria plan under scrutiny pp. 13-14

Amy Maxmen

New cures sought from old drugs pp. 15-15

Meredith Wadman

The telescopes that came in from the cold pp. 16-17

Eric Hand

Foundation opens TB lab in Africa pp. 19-19

Linda Nordling

SARS veterans tackle coronavirus pp. 20-20

Declan Butler

Misconduct is the main cause of life-sciences retractions pp. 21-21

Zoë Corbyn

Plant science: The chestnut resurrection pp. 22-23

Helen Thompson

Galaxy formation: The new Milky Way pp. 24-27

Ann Finkbeiner

Don't let copyright block data mining pp. 29-30

Matthew L. Jockers, Matthew Sag and Jason Schultz

What makes a great lab? pp. 31-32

William Bynum

Zoonosis: Fatal exchange pp. 33-33

Nathan Wolfe

Mars exploration: Roving the red planet pp. 34-35

Jim Bell

Network theory: The regularities of facts pp. 36-36

Carl Bergstrom

Biodiversity needs a scientific approach pp. 37-37

David A. Westcott, Frederieke J. Kroon and Andy W. Sheppard

Change of heart on nanoparticle risks pp. 37-37

Silvia Ribeiro

Fleischmann denied due credit pp. 37-37

Brian D. Josephson

European biodiesel can be sustainable pp. 37-37

Rod Snowdon and Wolfgang Friedt

Reviews turn facts into understanding pp. 37-37

Douglas B. Kell

The aerosol effect pp. 40-41

Bjorn Stevens and Olivier Boucher

Infection induces friendly fire pp. 41-43

David Masopust and Vaiva Vezys

Cruise control for a qubit pp. 43-44

Howard M. Wiseman

Resident risks pp. 44-46

Julia Oh and Julia A. Segre

Two black holes found in a star cluster pp. 46-47

Stefan Umbreit

Tolerating pregnancy pp. 47-48

Alexander G. Betz

The oyster genome reveals stress adaptation and complexity of shell formation pp. 49-54

Guofan Zhang, Xiaodong Fang, Ximing Guo, Li Li, Ruibang Luo, Fei Xu, Pengcheng Yang, Linlin Zhang, Xiaotong Wang, Haigang Qi, Zhiqiang Xiong, Huayong Que, Yinlong Xie, Peter W. H. Holland, Jordi Paps, Yabing Zhu, Fucun Wu, Yuanxin Chen, Jiafeng Wang, Chunfang Peng, Jie Meng, Lan Yang, Jun Liu, Bo Wen, Na Zhang, Zhiyong Huang, Qihui Zhu, Yue Feng, Andrew Mount, Dennis Hedgecock, Zhe Xu, Yunjie Liu, Tomislav Domazet-Lošo, Yishuai Du, Xiaoqing Sun, Shoudu Zhang, Binghang Liu, Peizhou Cheng, Xuanting Jiang, Juan Li, Dingding Fan, Wei Wang, Wenjing Fu, Tong Wang, Bo Wang, Jibiao Zhang, Zhiyu Peng, Yingxiang Li, Na Li, Jinpeng Wang, Maoshan Chen, Yan He, Fengji Tan, Xiaorui Song, Qiumei Zheng, Ronglian Huang, Hailong Yang, Xuedi Du, Li Chen, Mei Yang, Patrick M. Gaffney, Shan Wang, Longhai Luo, Zhicai She, Yao Ming, Wen Huang, Shu Zhang, Baoyu Huang, Yong Zhang, Tao Qu, Peixiang Ni, Guoying Miao, Junyi Wang, Qiang Wang, Christian E. W. Steinberg, Haiyan Wang, Ning Li, Lumin Qian, Guojie Zhang, Yingrui Li, Huanming Yang, Xiao Liu, Jian Wang, Ye Yin and Jun Wang

A metagenome-wide association study of gut microbiota in type 2 diabetes pp. 55-60

Junjie Qin, Yingrui Li, Zhiming Cai, Shenghui Li, Jianfeng Zhu, Fan Zhang, Suisha Liang, Wenwei Zhang, Yuanlin Guan, Dongqian Shen, Yangqing Peng, Dongya Zhang, Zhuye Jie, Wenxian Wu, Youwen Qin, Wenbin Xue, Junhua Li, Lingchuan Han, Donghui Lu, Peixian Wu, Yali Dai, Xiaojuan Sun, Zesong Li, Aifa Tang, Shilong Zhong, Xiaoping Li, Weineng Chen, Ran Xu, Mingbang Wang, Qiang Feng, Meihua Gong, Jing Yu, Yanyan Zhang, Ming Zhang, Torben Hansen, Gaston Sanchez, Jeroen Raes, Gwen Falony, Shujiro Okuda, Mathieu Almeida, Emmanuelle LeChatelier, Pierre Renault, Nicolas Pons, Jean-Michel Batto, Zhaoxi Zhang, Hua Chen, Ruifu Yang, Weimou Zheng, Songgang Li, Huanming Yang, Jian Wang, S. Dusko Ehrlich, Rasmus Nielsen, Oluf Pedersen, Karsten Kristiansen and Jun Wang

Two stellar-mass black holes in the globular cluster M22 pp. 71-73

Jay Strader, Laura Chomiuk, Thomas J. Maccarone, James C. A. Miller-Jones and Anil C. Seth

Comet-like mineralogy of olivine crystals in an extrasolar proto-Kuiper belt pp. 74-76

B. L. de Vries, B. Acke, J. A. D. L. Blommaert, C. Waelkens, L. B. F. M. Waters, B. Vandenbussche, M. Min, G. Olofsson, C. Dominik, L. Decin, M. J. Barlow, A. Brandeker, J. Di Francesco, A. M. Glauser, J. Greaves, P. M. Harvey, W. S. Holland, R. J. Ivison, R. Liseau, E. E. Pantin, G. L. Pilbratt, P. Royer and B. Sibthorpe

Stabilizing Rabi oscillations in a superconducting qubit using quantum feedback pp. 77-80

R. Vijay, C. Macklin, D. H. Slichter, S. J. Weber, K. W. Murch, R. Naik, A. N. Korotkov and I. Siddiqi

Sulphate–climate coupling over the past 300,000 years in inland Antarctica pp. 81-84

Yoshinori Iizuka, Ryu Uemura, Hideaki Motoyama, Toshitaka Suzuki, Takayuki Miyake, Motohiro Hirabayashi and Takeo Hondoh

Natural and anthropogenic variations in methane sources during the past two millennia pp. 85-88

C. J. Sapart, G. Monteil, M. Prokopiou, R. S. W. van de Wal, J. O. Kaplan, P. Sperlich, K. M. Krumhardt, C. van der Veen, S. Houweling, M. C. Krol, T. Blunier, T. Sowers, P. Martinerie, E. Witrant, D. Dahl-Jensen and T. Röckmann

Dynamical similarity of geomagnetic field reversals pp. 89-93

Jean-Pierre Valet, Alexandre Fournier, Vincent Courtillot and Emilio Herrero-Bervera

A Silurian armoured aplacophoran and implications for molluscan phylogeny pp. 94-97

Mark D. Sutton, Derek E. G. Briggs, David J. Siveter, Derek J. Siveter and Julia D. Sigwart

A transcriptomic hourglass in plant embryogenesis pp. 98-101

Marcel Quint, Hajk-Georg Drost, Alexander Gabel, Kristian Karsten Ullrich, Markus Bönn and Ivo Grosse

Pregnancy imprints regulatory memory that sustains anergy to fetal antigen pp. 102-106

Jared H. Rowe, James M. Ertelt, Lijun Xin and Sing Sing Way

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo pp. 107-111

Jakob von Moltke, Norver J. Trinidad, Mahtab Moayeri, Alexander F. Kintzer, Samantha B. Wang, Nico van Rooijen, Charles R. Brown, Bryan A. Krantz, Stephen H. Leppla, Karsten Gronert and Russell E. Vance

Paramutation in Drosophila linked to emergence of a piRNA-producing locus pp. 112-115

Augustin de Vanssay, Anne-Laure Bougé, Antoine Boivin, Catherine Hermant, Laure Teysset, Valérie Delmarre, Christophe Antoniewski and Stéphane Ronsseray

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics pp. 116-120

Roland Schmitz, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, Arthur L. Shaffer, Daniel J. Hodson, Eric Buras, Xuelu Liu, John Powell, Yandan Yang, Weihong Xu, Hong Zhao, Holger Kohlhammer, Andreas Rosenwald, Philip Kluin, Hans Konrad Müller-Hermelink, German Ott, Randy D. Gascoyne, Joseph M. Connors, Lisa M. Rimsza, Elias Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Martin D. Ogwang, Steven J. Reynolds, Richard I. Fisher, Rita M. Braziel, Raymond R. Tubbs, James R. Cook, Dennis D. Weisenburger, Wing C. Chan, Stefania Pittaluga, Wyndham Wilson, Thomas A. Waldmann, Martin Rowe, Sam M. Mbulaiteye, Alan B. Rickinson and Louis M. Staudt

Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p pp. 121-125

Anna L. Mallam, Mark Del Campo, Benjamin Gilman, David J. Sidote and Alan M. Lambowitz

Alternating-access mechanism in conformationally asymmetric trimers of the betaine transporter BetP pp. 126-130

Camilo Perez, Caroline Koshy, Özkan Yildiz and Christine Ziegler

Higher education: Beyond the farm pp. 131-132

Amy Maxmen

Turning point: Ethan Perlstein pp. 133-133

Virginia Gewin

Man's best friend pp. 136-136

Grace Tang