Enhancer loops appear stable during development and are associated with paused polymerase

Yad Ghavi-Helm, Felix A. Klein, Tibor Pakozdi, Lucia Ciglar, Daan Noordermeer, Wolfgang Huber and Eileen E. M. Furlong ()
Additional contact information
Yad Ghavi-Helm: European Molecular Biology Laboratory, Genome Biology Unit, D-69117 Heidelberg, Germany
Felix A. Klein: European Molecular Biology Laboratory, Genome Biology Unit, D-69117 Heidelberg, Germany
Tibor Pakozdi: European Molecular Biology Laboratory, Genome Biology Unit, D-69117 Heidelberg, Germany
Lucia Ciglar: European Molecular Biology Laboratory, Genome Biology Unit, D-69117 Heidelberg, Germany
Daan Noordermeer: Swiss Federal Institute of Technology, School of Life Sciences, CH-1015 Lausanne, Switzerland
Wolfgang Huber: European Molecular Biology Laboratory, Genome Biology Unit, D-69117 Heidelberg, Germany
Eileen E. M. Furlong: European Molecular Biology Laboratory, Genome Biology Unit, D-69117 Heidelberg, Germany

Nature, 2014, vol. 512, issue 7512, 96-100

Abstract: A high-resolution map of enhancer three-dimensional contacts during Drosophila embryogenesis shows that although local regulatory interactions are frequent, long-range interactions are also very common; unexpectedly, most interactions appear unchanged between tissues and across development and are formed prior to gene expression, indicating that transcription initiates from preformed enhancer–promoter loops, which are associated with paused polymerase.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (8)

Downloads: (external link)
https://www.nature.com/articles/nature13417 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:512:y:2014:i:7512:d:10.1038_nature13417

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature13417

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().