Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys

James B. Whitney, Alison L. Hill, Srisowmya Sanisetty, Pablo Penaloza-MacMaster, Jinyan Liu, Mayuri Shetty, Lily Parenteau, Crystal Cabral, Jennifer Shields, Stephen Blackmore, Jeffrey Y. Smith, Amanda L. Brinkman, Lauren E. Peter, Sheeba I. Mathew, Kaitlin M. Smith, Erica N. Borducchi, Daniel I. S. Rosenbloom, Mark G. Lewis, Jillian Hattersley, Bei Li, Joseph Hesselgesser, Romas Geleziunas, Merlin L. Robb, Jerome H. Kim, Nelson L. Michael and Dan H. Barouch ()
Additional contact information
James B. Whitney: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Alison L. Hill: Program for Evolutionary Dynamics, Harvard University
Srisowmya Sanisetty: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Pablo Penaloza-MacMaster: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Jinyan Liu: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Mayuri Shetty: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Lily Parenteau: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Crystal Cabral: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Jennifer Shields: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Stephen Blackmore: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Jeffrey Y. Smith: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Amanda L. Brinkman: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Lauren E. Peter: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Sheeba I. Mathew: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Kaitlin M. Smith: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Erica N. Borducchi: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
Daniel I. S. Rosenbloom: Program for Evolutionary Dynamics, Harvard University
Mark G. Lewis: Bioqual
Jillian Hattersley: Gilead Sciences
Bei Li: Gilead Sciences
Joseph Hesselgesser: Gilead Sciences
Romas Geleziunas: Gilead Sciences
Merlin L. Robb: US Military HIV Research Program, Walter Reed Army Institute of Research
Jerome H. Kim: US Military HIV Research Program, Walter Reed Army Institute of Research
Nelson L. Michael: US Military HIV Research Program, Walter Reed Army Institute of Research
Dan H. Barouch: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School

Nature, 2014, vol. 512, issue 7512, 74-77

Abstract: Reservoirs of virus infection represent the most important reason why HIV-1 cannot be cured with current antiretroviral drugs; now the refractory viral reservoir is shown to be seeded as early as 3 days after infection in a monkey model, even before the virus is detected in the blood.

Date: 2014
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DOI: 10.1038/nature13594

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