PVT1 dependence in cancer with MYC copy-number increase

Yuen-Yi Tseng, Branden S. Moriarity, Wuming Gong, Ryutaro Akiyama, Ashutosh Tiwari, Hiroko Kawakami, Peter Ronning, Brian Reuland, Kacey Guenther, Thomas C. Beadnell, Jaclyn Essig, George M. Otto, M. Gerard O’Sullivan, David A. Largaespada, Kathryn L. Schwertfeger, York Marahrens, Yasuhiko Kawakami and Anindya Bagchi ()
Additional contact information
Yuen-Yi Tseng: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Branden S. Moriarity: Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Wuming Gong: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Ryutaro Akiyama: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Ashutosh Tiwari: Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Hiroko Kawakami: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Peter Ronning: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Brian Reuland: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Kacey Guenther: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Thomas C. Beadnell: University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Jaclyn Essig: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
George M. Otto: Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
M. Gerard O’Sullivan: Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
David A. Largaespada: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Kathryn L. Schwertfeger: Masonic Cancer Center, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
York Marahrens: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Yasuhiko Kawakami: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
Anindya Bagchi: Cell Biology and Development, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA

Nature, 2014, vol. 512, issue 7512, 82-86

Abstract: Pvt1 overexpression in mice contributes to high Myc levels due to 8q24.21 gain and to MYC-driven tumorigenesis.

Date: 2014
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DOI: 10.1038/nature13311

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