Visualization of arrestin recruitment by a G-protein-coupled receptor

Arun K. Shukla, Gerwin H. Westfield, Kunhong Xiao, Rosana I. Reis, Li-Yin Huang, Prachi Tripathi-Shukla, Jiang Qian, Sheng Li, Adi Blanc, Austin N. Oleskie, Anne M. Dosey, Min Su, Cui-Rong Liang, Ling-Ling Gu, Jin-Ming Shan, Xin Chen, Rachel Hanna, Minjung Choi, Xiao Jie Yao, Bjoern U. Klink, Alem W. Kahsai, Sachdev S. Sidhu, Shohei Koide, Pawel A. Penczek, Anthony A. Kossiakoff, Virgil L. Woods, Brian K. Kobilka (), Georgios Skiniotis () and Robert J. Lefkowitz ()
Additional contact information
Arun K. Shukla: Duke University Medical Center
Gerwin H. Westfield: University of Michigan Medical School
Kunhong Xiao: Duke University Medical Center
Rosana I. Reis: Duke University Medical Center
Li-Yin Huang: Duke University Medical Center
Prachi Tripathi-Shukla: Duke University Medical Center
Jiang Qian: Duke University Medical Center
Sheng Li: University of California at San Diego
Adi Blanc: Duke University Medical Center
Austin N. Oleskie: University of Michigan Medical School
Anne M. Dosey: University of Michigan Medical School
Min Su: University of Michigan Medical School
Cui-Rong Liang: School of Pharmaceutical & Life Sciences, Changzhou University, Changzhou, Jiangsu 213164, China
Ling-Ling Gu: School of Pharmaceutical & Life Sciences, Changzhou University, Changzhou, Jiangsu 213164, China
Jin-Ming Shan: School of Pharmaceutical & Life Sciences, Changzhou University, Changzhou, Jiangsu 213164, China
Xin Chen: School of Pharmaceutical & Life Sciences, Changzhou University, Changzhou, Jiangsu 213164, China
Rachel Hanna: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
Minjung Choi: Duke University Medical Center
Xiao Jie Yao: Duke University Medical Center
Bjoern U. Klink: Duke University Medical Center
Alem W. Kahsai: Duke University Medical Center
Sachdev S. Sidhu: Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
Shohei Koide: University of Chicago
Pawel A. Penczek: The University of Texas Medical School at Houston
Anthony A. Kossiakoff: University of Chicago
Virgil L. Woods: University of California at San Diego
Brian K. Kobilka: Stanford University School of Medicine, 279 Campus Drive
Georgios Skiniotis: University of Michigan Medical School
Robert J. Lefkowitz: Duke University Medical Center

Nature, 2014, vol. 512, issue 7513, 218-222

Abstract: Single-particle electron microscopy and hydrogen–deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor–arrestin complex.

Date: 2014
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DOI: 10.1038/nature13430

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