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2017, volume 547, articles 7664

Can we predict protein from mRNA levels? pp. E19-E20

Nikolaus Fortelny, Christopher M. Overall, Paul Pavlidis and Gabriela V. Cohen Freue

Wilhelm et al. reply pp. E23-E23

Mathias Wilhelm, Hannes Hahne, Mikhail Savitski, Harald Marx, Simone Lemeer, Marcus Bantscheff and Bernhard Kuster

Don't run biomedical science as a business pp. 381-381

Michele Pagano

Iceland drilling project aims to unearth how islands form pp. 387-388

Alexandra Witze

US defence agencies grapple with gene drives pp. 388-389

Ewen Callaway

Brain’s stem cells slow ageing in mice pp. 389-389

Sara Reardon

Budding UK innovation agency gains cash — and clout pp. 390-391

Elizabeth Gibney

Giant radio telescope scaled back to contain costs pp. 391-392

Sarah Wild

China’s quest to become a space science superpower pp. 394-396

Jane Qiu

Metrology is key to reproducing results pp. 397-399

Martyn Sené, Ian Gilmore and Jan-Theodoor Janssen

Climate change: Al Gore gets inconvenient again pp. 400-401

Michael E. Mann

In retrospect: Das Kapital pp. 401-402

Gareth Stedman Jones

Open data: enforce materials sharing pp. 403-403

Joanne Kamens

Open data: support from Swiss funder pp. 403-403

Matthias Egger and Angelika Kalt

Factor in species' conservation value pp. 403-403

Axel Hochkirch

Alternative telescope site is a good back-up pp. 403-403

Sergio Bonaque-González

History's take on the atomic forge pp. 403-403

Michael Isaacson

How fish feel the flow pp. 406-407

John O. Dabiri

A new spin on nanoscale computing pp. 407-408

Frank Hoppensteadt

Synapses get together for vision pp. 408-410

Tobias Rose and Mark Hübener

Molecular structure assignment simplified pp. 410-411

Severin K. Thompson and Thomas R. Hoye

Towards polio eradication pp. 411-412

Jaime Sepúlveda

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target pp. 413-418

Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer, Flavian D. Brown, Kathleen B. Yates, Brian C. Miller, Natalie B. Collins, Kevin Bi, Martin W. LaFleur, Vikram R. Juneja, Sarah A. Weiss, Jennifer Lo, David E. Fisher, Diana Miao, Eliezer Van Allen, David E. Root, Arlene H. Sharpe, John G. Doench and W. Nicholas Haining

Maternal H3K27me3 controls DNA methylation-independent imprinting pp. 419-424

Azusa Inoue, Lan Jiang, Falong Lu, Tsukasa Suzuki and Yi Zhang

Significant and variable linear polarization during the prompt optical flash of GRB 160625B pp. 425-427

E. Troja, V. M. Lipunov, C. G. Mundell, N. R. Butler, A. M. Watson, S. Kobayashi, S. B. Cenko, F. E. Marshall, R. Ricci, A. Fruchter, M. H. Wieringa, E. S. Gorbovskoy, V. Kornilov, A. Kutyrev, W. H. Lee, V. Toy, N. V. Tyurina, N. M. Budnev, D. A. H. Buckley, J. González, O. Gress, A. Horesh, M. I. Panasyuk, J. X. Prochaska, E. Ramirez-Ruiz, R. Rebolo Lopez, M. G. Richer, C. Román-Zúñiga, M. Serra-Ricart, V. Yurkov and N. Gehrels

Neuromorphic computing with nanoscale spintronic oscillators pp. 428-431

Jacob Torrejon, Mathieu Riou, Flavio Abreu Araujo, Sumito Tsunegi, Guru Khalsa, Damien Querlioz, Paolo Bortolotti, Vincent Cros, Kay Yakushiji, Akio Fukushima, Hitoshi Kubota, Shinji Yuasa, Mark D. Stiles and Julie Grollier

Spontaneous breaking of rotational symmetry in copper oxide superconductors pp. 432-435

J. Wu, A. T. Bollinger, X. He and I. Božović

Synergy of synthesis, computation and NMR reveals correct baulamycin structures pp. 436-440

Jingjing Wu, Paula Lorenzo, Siying Zhong, Muhammad Ali, Craig P. Butts, Eddie L. Myers and Varinder K. Aggarwal

Global forest loss disproportionately erodes biodiversity in intact landscapes pp. 441-444

Matthew G. Betts, Christopher Wolf, William J. Ripple, Ben Phalan, Kimberley A. Millers, Adam Duarte, Stuart H. M. Butchart and Taal Levi

A novel mechanism for mechanosensory-based rheotaxis in larval zebrafish pp. 445-448

Pablo Oteiza, Iris Odstrcil, George Lauder, Ruben Portugues and Florian Engert

Synaptic organization of visual space in primary visual cortex pp. 449-452

M. Florencia Iacaruso, Ioana T. Gasler and Sonja B. Hofer

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway pp. 453-457

Vasanthi S. Viswanathan, Matthew J. Ryan, Harshil D. Dhruv, Shubhroz Gill, Ossia M. Eichhoff, Brinton Seashore-Ludlow, Samuel D. Kaffenberger, John K. Eaton, Kenichi Shimada, Andrew J. Aguirre, Srinivas R. Viswanathan, Shrikanta Chattopadhyay, Pablo Tamayo, Wan Seok Yang, Matthew G. Rees, Sixun Chen, Zarko V. Boskovic, Sarah Javaid, Cherrie Huang, Xiaoyun Wu, Yuen-Yi Tseng, Elisabeth M. Roider, Dong Gao, James M. Cleary, Brian M. Wolpin, Jill P. Mesirov, Daniel A. Haber, Jeffrey A. Engelman, Jesse S. Boehm, Joanne D. Kotz, Cindy S. Hon, Yu Chen, William C. Hahn, Mitchell P. Levesque, John G. Doench, Michael E. Berens, Alykhan F. Shamji, Paul A. Clemons, Brent R. Stockwell and Stuart L. Schreiber

Cysteine protease cathepsin B mediates radiation-induced bystander effects pp. 458-462

Yu Peng, Man Zhang, Lingjun Zheng, Qian Liang, Hanzeng Li, Jeng-Ting Chen, Hongyan Guo, Sawako Yoshina, Yu-Zen Chen, Xiang Zhao, Xiaoqi Wu, Bin Liu, Shohei Mitani, Jau-Song Yu and Ding Xue

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription pp. 463-467

Gloria Jih, Nahid Iglesias, Mark A. Currie, Natarajan V. Bhanu, Joao A. Paulo, Steven P. Gygi, Benjamin A. Garcia and Danesh Moazed

Crystal structures of agonist-bound human cannabinoid receptor CB1 pp. 468-471

Tian Hua, Kiran Vemuri, Spyros P. Nikas, Robert B. Laprairie, Yiran Wu, Lu Qu, Mengchen Pu, Anisha Korde, Shan Jiang, Jo-Hao Ho, Gye Won Han, Kang Ding, Xuanxuan Li, Haiguang Liu, Michael A. Hanson, Suwen Zhao, Laura M. Bohn, Alexandros Makriyannis, Raymond C. Stevens and Zhi-Jie Liu

The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture pp. 472-475

Changkeun Lee, Jiangtao Guo, Weizhong Zeng, Sunghoon Kim, Ji She, Chunlei Cang, Dejian Ren and Youxing Jiang

Erratum: Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage pp. 476-476

Stefano Stella, Pablo Alcón and Guillermo Montoya

Correction: Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans pp. 476-476

Caroline Heintz, Thomas K. Doktor, Anne Lanjuin, Caroline C. Escoubas, Yue Zhang, Heather J. Weir, Sneha Dutta, Carlos Giovanni Silva-García, Gitte H. Bruun, Ianessa Morantte, Gerta Hoxhaj, Brendan D. Manning, Brage S. Andresen and William B. Mair

Correction: Corrigendum: Molecular mechanism for the regulation of yeast separase by securin pp. 476-476

Shukun Luo and Liang Tong

How to hack the genome pp. 477-479

Jeffrey M. Perkel

Lab etiquette: The perils of pet peeves pp. 481-482

Amber Dance

Look for the leaders pp. 483-483

Toddi A. Steelman and Jeffrey J. McDonnell

Good news pp. 486-486

Jack McDevitt

2017, volume 547, articles 7663

The DeepMind debacle demands dialogue on data pp. 259-259

Hetan Shah

Satellite snafu masked true sea-level rise for decades pp. 265-266

Jeff Tollefson

Female astronomers of colour face daunting discrimination pp. 266-267

Rachael Lallensack

European Commission urges logging ban in ancient Białowieża Forest pp. 267-268

Quirin Schiermeier

US lawmakers seek $1.1-billion boost for the NIH pp. 268-268

Lauren Morello

Climate scientists flock to France’s call pp. 269-269

Declan Butler

Engineered cell therapy for cancer gets thumbs up from FDA advisers pp. 270-270

Heidi Ledford

The strange topology that is reshaping physics pp. 272-274

Davide Castelvecchi

Solve Antarctica’s sea-ice puzzle pp. 275-277

John Turner and Josefino Comiso

Environment: A journey on plastic seas pp. 278-279

Richard Thompson

Books in brief pp. 279-279

Barbara Kiser

History: Tracking down a doomed Arctic expedition pp. 280-280

Daniel Cressey

Paris neurosurgeon's map outwitted Nazis pp. 281-281

Pierre Bourdillon, Marc Lévêque and Caroline Apra

No cost crisis for space telescope pp. 281-281

Thomas H. Zurbuchen

Restrict bush fires used in animal hunts pp. 281-281

Mwazvita T. B. Dalu, Tatenda Dalu and Ryan J. Wasserman

Stellar palaeontology pp. 284-285

Ilya Mandel and Alison Farmer

Early signs of human presence in Australia pp. 285-286

Curtis W. Marean

Chemistry and physics happily wed pp. 287-288

Gregory A. Fiete

Nervous crosstalk to make antibodies pp. 288-290

Hai Qi

X-rays used to watch spins in 3D pp. 290-291

Peter Fischer

Keeping it real to kill glioblastoma pp. 291-292

Paul A. Northcott

Ribosomes are optimized for autocatalytic production pp. 293-297

Shlomi Reuveni, Måns Ehrenberg and Johan Paulsson

Topological quantum chemistry pp. 298-305

Barry Bradlyn, L. Elcoro, Jennifer Cano, M. G. Vergniory, Zhijun Wang, C. Felser, M. I. Aroyo and B. Andrei Bernevig

Human occupation of northern Australia by 65,000 years ago pp. 306-310

Chris Clarkson, Zenobia Jacobs, Ben Marwick, Richard Fullagar, Lynley Wallis, Mike Smith, Richard G. Roberts, Elspeth Hayes, Kelsey Lowe, Xavier Carah, S. Anna Florin, Jessica McNeil, Delyth Cox, Lee J. Arnold, Quan Hua, Jillian Huntley, Helen E. A. Brand, Tiina Manne, Andrew Fairbairn, James Shulmeister, Lindsey Lyle, Makiah Salinas, Mara Page, Kate Connell, Gayoung Park, Kasih Norman, Tessa Murphy and Colin Pardoe

The whole-genome landscape of medulloblastoma subtypes pp. 311-317

Paul A. Northcott, Ivo Buchhalter, A. Sorana Morrissy, Volker Hovestadt, Joachim Weischenfeldt, Tobias Ehrenberger, Susanne Gröbner, Maia Segura-Wang, Thomas Zichner, Vasilisa A. Rudneva, Hans-Jörg Warnatz, Nikos Sidiropoulos, Aaron H. Phillips, Steven Schumacher, Kortine Kleinheinz, Sebastian M. Waszak, Serap Erkek, David T. W. Jones, Barbara C. Worst, Marcel Kool, Marc Zapatka, Natalie Jäger, Lukas Chavez, Barbara Hutter, Matthias Bieg, Nagarajan Paramasivam, Michael Heinold, Zuguang Gu, Naveed Ishaque, Christina Jäger-Schmidt, Charles D. Imbusch, Alke Jugold, Daniel Hübschmann, Thomas Risch, Vyacheslav Amstislavskiy, Francisco German Rodriguez Gonzalez, Ursula D. Weber, Stephan Wolf, Giles W. Robinson, Xin Zhou, Gang Wu, David Finkelstein, Yanling Liu, Florence M. G. Cavalli, Betty Luu, Vijay Ramaswamy, Xiaochong Wu, Jan Koster, Marina Ryzhova, Yoon-Jae Cho, Scott L. Pomeroy, Christel Herold-Mende, Martin Schuhmann, Martin Ebinger, Linda M. Liau, Jaume Mora, Roger E. McLendon, Nada Jabado, Toshihiro Kumabe, Eric Chuah, Yussanne Ma, Richard A. Moore, Andrew J. Mungall, Karen L. Mungall, Nina Thiessen, Kane Tse, Tina Wong, Steven J. M. Jones, Olaf Witt, Till Milde, Andreas Von Deimling, David Capper, Andrey Korshunov, Marie-Laure Yaspo, Richard Kriwacki, Amar Gajjar, Jinghui Zhang, Rameen Beroukhim, Ernest Fraenkel, Jan O. Korbel, Benedikt Brors, Matthias Schlesner, Roland Eils, Marco A. Marra, Stefan M. Pfister, Michael D. Taylor and Peter Lichter

TFH-derived dopamine accelerates productive synapses in germinal centres pp. 318-323

Ilenia Papa, David Saliba, Maurilio Ponzoni, Sonia Bustamante, Pablo F. Canete, Paula Gonzalez-Figueroa, Hayley A. McNamara, Salvatore Valvo, Michele Grimbaldeston, Rebecca A. Sweet, Harpreet Vohra, Ian A. Cockburn, Michael Meyer-Hermann, Michael L. Dustin, Claudio Doglioni and Carola G. Vinuesa

Experimental signatures of the mixed axial–gravitational anomaly in the Weyl semimetal NbP pp. 324-327

Johannes Gooth, Anna C. Niemann, Tobias Meng, Adolfo G. Grushin, Karl Landsteiner, Bernd Gotsmann, Fabian Menges, Marcus Schmidt, Chandra Shekhar, Vicky Süß, Ruben Hühne, Bernd Rellinghaus, Claudia Felser, Binghai Yan and Kornelius Nielsch

Three-dimensional magnetization structures revealed with X-ray vector nanotomography pp. 328-331

Claire Donnelly, Manuel Guizar-Sicairos, Valerio Scagnoli, Sebastian Gliga, Mirko Holler, Jörg Raabe and Laura J. Heyderman

Nitrogen reduction and functionalization by a multimetallic uranium nitride complex pp. 332-335

Marta Falcone, Lucile Chatelain, Rosario Scopelliti, Ivica Živković and Marinella Mazzanti

Large-scale physical activity data reveal worldwide activity inequality pp. 336-339

Tim Althoff, Rok Sosič, Jennifer L. Hicks, Abby C. King, Scott L. Delp and Jure Leskovec

Infant viewing of social scenes is under genetic control and is atypical in autism pp. 340-344

John N. Constantino, Stefanie Kennon-McGill, Claire Weichselbaum, Natasha Marrus, Alyzeh Haider, Anne L. Glowinski, Scott Gillespie, Cheryl Klaiman, Ami Klin and Warren Jones

CRISPR–Cas encoding of a digital movie into the genomes of a population of living bacteria pp. 345-349

Seth L. Shipman, Jeff Nivala, Jeffrey D. Macklis and George M. Church

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration pp. 350-354

Alexander Raven, Wei-Yu Lu, Tak Yung Man, Sofia Ferreira-Gonzalez, Eoghan O’Duibhir, Benjamin J. Dwyer, John P. Thomson, Richard R. Meehan, Roman Bogorad, Victor Koteliansky, Yuri Kotelevtsev, Charles ffrench-Constant, Luke Boulter and Stuart J. Forbes

Transcription elongation factors represent in vivo cancer dependencies in glioblastoma pp. 355-359

Tyler E. Miller, Brian B. Liau, Lisa C. Wallace, Andrew R. Morton, Qi Xie, Deobrat Dixit, Daniel C. Factor, Leo J. Y. Kim, James J. Morrow, Qiulian Wu, Stephen C. Mack, Christopher G. Hubert, Shawn M. Gillespie, William A. Flavahan, Thomas Hoffmann, Rohit Thummalapalli, Michael T. Hemann, Patrick J. Paddison, Craig M. Horbinski, Johannes Zuber, Peter C. Scacheri, Bradley E. Bernstein, Paul J. Tesar and Jeremy N. Rich

Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike pp. 360-363

Gabriel Ozorowski, Jesper Pallesen, Natalia de Val, Dmitry Lyumkis, Christopher A. Cottrell, Jonathan L. Torres, Jeffrey Copps, Robyn L. Stanfield, Albert Cupo, Pavel Pugach, John P. Moore, Ian A. Wilson and Andrew B. Ward

K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site pp. 364-368

Marco Lolicato, Cristina Arrigoni, Takahiro Mori, Yoko Sekioka, Clifford Bryant, Kimberly A. Clark and Daniel L. Minor

Enterprise: Game on pp. 369-371

Roberta Kwok

Turning point: Soft-skills sculptor pp. 371-371

Virginia Gewin

Catalogue of Items in the Chess Exhibition at the Humanities Museum, Pre-Enlightenment Wing pp. 374-374

Alex Shvartsman

2017, volume 547, articles 7662

Conflicting evidence for ferroelectricity pp. E9-E10

Gabriele D’Avino, Manuel Souto, Matteo Masino, Jonas K. H. Fischer, Imma Ratera, Xavier Fontrodona, Gianluca Giovannetti, Matthieu J. Verstraete, Anna Painelli, Peter Lunkenheimer, Jaume Veciana and Alberto Girlando

Tayi et al. reply pp. E14-E15

Alok S. Tayi, Alexander K. Shveyd, Andrew C.-H. Sue, Jodi M. Szarko, Brian S. Rolczynski, Dennis Cao, T. Jackson Kennedy, Amy A. Sarjeant, Charlotte L. Stern, Walter F. Paxton, Wei Wu, Sanjeev K. Dey, Albert C. Fahrenbach, Jeffrey R. Guest, Hooman Mohseni, Lin X. Chen, Kang L. Wang, J. Fraser Stoddart and Samuel I. Stupp

Overestimate of committed warming pp. E16-E17

Gavin A. Schmidt, Jeff Severinghaus, Ayako Abe-Ouchi, Richard B. Alley, Wallace Broecker, Ed Brook, David Etheridge, Kenji Kawamura, Ralph F. Keeling, Margaret Leinen, Kate Marvel and Thomas F. Stocker

Snyder replies pp. E17-E18

Carolyn W. Snyder

Kill the myth of the miracle machine pp. 139-139

Daniel Sarewitz

White House’s dwindling science office leaves major research programmes in limbo pp. 145-146

Sara Reardon

Why planetary scientists want better fake space dirt pp. 146-147

Alexandra Witze

Massive database of 182,000 leaves is helping predict plants' family trees pp. 147-147

Heidi Ledford

Tricks to mute quantum noise aid hunt for gravitational waves pp. 148-148

Elizabeth Gibney

Ancient-genome studies grapple with Africa’s past pp. 149-149

Ewen Callaway

How poverty affects the brain pp. 150-152

Carina Storrs

Stop Alzheimer’s before it starts pp. 153-155

Eric McDade and Randall J. Bateman

Witness gravity’s quantum side in the lab pp. 156-158

Chiara Marletto and Vlatko Vedral

Information technology: A digital genius at play pp. 159-159

Vint Cerf

History: Science lessons from the Gulag pp. 160-161

Asif Siddiqi

Books in brief pp. 161-161

Barbara Kiser

Switch it off on eclipse day pp. 162-162

Steve Elgar

Philanthropic risks can hit home runs pp. 162-162

Melissa L. Stevens

Manage chemicals and waste globally pp. 162-162

Quanyin Tan and Jinhui Li

Taxonomy: refine rather than stabilize pp. 162-162

Fenton P. D. Cotterill, Colin P. Groves and Peter J. Taylor

CRISPR book review — Doudna responds pp. 162-162

Jennifer Doudna

Sensing past the quantum limit pp. 164-165

Christopher G. Baker and Warwick P. Bowen

Precision T-cell therapy targets tumours pp. 165-167

Cornelis J. M. Melief

Arctic plants take up mercury vapour pp. 167-168

William Shotyk

A liquid reservoir for silent chromatin pp. 168-169

Adam Klosin and Anthony A. Hyman

Taming tangled tau pp. 170-171

David S. Eisenberg and Michael R. Sawaya

Bile ducts regenerated pp. 171-172

Ludi Zhang and Lijian Hui

Fine-mapping inflammatory bowel disease loci to single-variant resolution pp. 173-178

Hailiang Huang, Ming Fang, Luke Jostins, Maša Umićević Mirkov, Gabrielle Boucher, Carl A. Anderson, Vibeke Andersen, Isabelle Cleynen, Adrian Cortes, François Crins, Mauro D’Amato, Valérie Deffontaine, Julia Dmitrieva, Elisa Docampo, Mahmoud Elansary, Kyle Kai-How Farh, Andre Franke, Ann-Stephan Gori, Philippe Goyette, Jonas Halfvarson, Talin Haritunians, Jo Knight, Ian C. Lawrance, Charlie W. Lees, Edouard Louis, Rob Mariman, Theo Meuwissen, Myriam Mni, Yukihide Momozawa, Miles Parkes, Sarah L. Spain, Emilie Théâtre, Gosia Trynka, Jack Satsangi, Suzanne van Sommeren, Severine Vermeire, Ramnik J. Xavier, Rinse K. Weersma, Richard H. Duerr, Christopher G. Mathew, John D. Rioux, Dermot P. B. McGovern, Judy H. Cho, Michel Georges, Mark J. Daly and Jeffrey C. Barrett

The extracellular matrix protein agrin promotes heart regeneration in mice pp. 179-184

Elad Bassat, Yara Eid Mutlak, Alex Genzelinakh, Ilya Y. Shadrin, Kfir Baruch Umansky, Oren Yifa, David Kain, Dana Rajchman, John Leach, Daria Riabov Bassat, Yael Udi, Rachel Sarig, Irit Sagi, James F. Martin, Nenad Bursac, Shenhav Cohen and Eldad Tzahor

Cryo-EM structures of tau filaments from Alzheimer’s disease pp. 185-190

Anthony W. P. Fitzpatrick, Benjamin Falcon, Shaoda He, Alexey G. Murzin, Garib Murshudov, Holly J. Garringer, R. Anthony Crowther, Bernardino Ghetti, Michel Goedert and Sjors H. W. Scheres

Quantum back-action-evading measurement of motion in a negative mass reference frame pp. 191-195

Christoffer B. Møller, Rodrigo A. Thomas, Georgios Vasilakis, Emil Zeuthen, Yeghishe Tsaturyan, Mikhail Balabas, Kasper Jensen, Albert Schliesser, Klemens Hammerer and Eugene S. Polzik

Catalytic allylic oxidation of internal alkenes to a multifunctional chiral building block pp. 196-200

Liela Bayeh, Phong Q. Le and Uttam K. Tambar

Tundra uptake of atmospheric elemental mercury drives Arctic mercury pollution pp. 201-204

Daniel Obrist, Yannick Agnan, Martin Jiskra, Christine L. Olson, Dominique P. Colegrove, Jacques Hueber, Christopher W. Moore, Jeroen E. Sonke and Detlev Helmig

The pyrite-type high-pressure form of FeOOH pp. 205-208

Masayuki Nishi, Yasuhiro Kuwayama, Jun Tsuchiya and Taku Tsuchiya

Pre-oral gut contributes to facial structures in non-teleost fishes pp. 209-212

Martin Minarik, Jan Stundl, Peter Fabian, David Jandzik, Brian D. Metscher, Martin Psenicka, David Gela, Adriana Osorio-Pérez, Lenin Arias-Rodriguez, Ivan Horácek and Robert Cerny

Nutrient sensing modulates malaria parasite virulence pp. 213-216

Liliana Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo, Ana Rita Grosso, Katarzyna K. Modrzynska, Iset Medina Vera, Joana Sales-Dias, Ana Rita Gomes, Cameron Ross MacPherson, Pierre Crozet, Mattia Adamo, Elena Baena-Gonzalez, Rita Tewari, Manuel Llinás, Oliver Billker and Maria M. Mota

An immunogenic personal neoantigen vaccine for patients with melanoma pp. 217-221

Patrick A. Ott, Zhuting Hu, Derin B. Keskin, Sachet A. Shukla, Jing Sun, David J. Bozym, Wandi Zhang, Adrienne Luoma, Anita Giobbie-Hurder, Lauren Peter, Christina Chen, Oriol Olive, Todd A. Carter, Shuqiang Li, David J. Lieb, Thomas Eisenhaure, Evisa Gjini, Jonathan Stevens, William J. Lane, Indu Javeri, Kaliappanadar Nellaiappan, Andres M. Salazar, Heather Daley, Michael Seaman, Elizabeth I. Buchbinder, Charles H. Yoon, Maegan Harden, Niall Lennon, Stacey Gabriel, Scott J. Rodig, Dan H. Barouch, Jon C. Aster, Gad Getz, Kai Wucherpfennig, Donna Neuberg, Jerome Ritz, Eric S. Lander, Edward F. Fritsch, Nir Hacohen and Catherine J. Wu

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer pp. 222-226

Ugur Sahin, Evelyna Derhovanessian, Matthias Miller, Björn-Philipp Kloke, Petra Simon, Martin Löwer, Valesca Bukur, Arbel D. Tadmor, Ulrich Luxemburger, Barbara Schrörs, Tana Omokoko, Mathias Vormehr, Christian Albrecht, Anna Paruzynski, Andreas N. Kuhn, Janina Buck, Sandra Heesch, Katharina H. Schreeb, Felicitas Müller, Inga Ortseifer, Isabel Vogler, Eva Godehardt, Sebastian Attig, Richard Rae, Andrea Breitkreuz, Claudia Tolliver, Martin Suchan, Goran Martic, Alexander Hohberger, Patrick Sorn, Jan Diekmann, Janko Ciesla, Olga Waksmann, Alexandra-Kemmer Brück, Meike Witt, Martina Zillgen, Andree Rothermel, Barbara Kasemann, David Langer, Stefanie Bolte, Mustafa Diken, Sebastian Kreiter, Romina Nemecek, Christoffer Gebhardt, Stephan Grabbe, Christoph Höller, Jochen Utikal, Christoph Huber, Carmen Loquai and Özlem Türeci

Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation pp. 227-231

Yuka Morikawa, Todd Heallen, John Leach, Yang Xiao and James F. Martin

Allelic reprogramming of 3D chromatin architecture during early mammalian development pp. 232-235

Zhenhai Du, Hui Zheng, Bo Huang, Rui Ma, Jingyi Wu, Xianglin Zhang, Jing He, Yunlong Xiang, Qiujun Wang, Yuanyuan Li, Jing Ma, Xu Zhang, Ke Zhang, Yang Wang, Michael Q. Zhang, Juntao Gao, Jesse R. Dixon, Xiaowo Wang, Jianyang Zeng and Wei Xie

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin pp. 236-240

Adam G. Larson, Daniel Elnatan, Madeline M. Keenen, Michael J. Trnka, Jonathan B. Johnston, Alma L. Burlingame, David A. Agard, Sy Redding and Geeta J. Narlikar

Phase separation drives heterochromatin domain formation pp. 241-245

Amy R. Strom, Alexander V. Emelyanov, Mustafa Mir, Dmitry V. Fyodorov, Xavier Darzacq and Gary H. Karpen

Correction: Corrigendum: Mineral supply for sustainable development requires resource governance pp. 246-246

Saleem H. Ali, Damien Giurco, Nicholas Arndt, Edmund Nickless, Graham Brown, Alecos Demetriades, Ray Durrheim, Maria Amélia Enriquez, Judith Kinnaird, Anna Littleboy, Lawrence D. Meinert, Roland Oberhänsli, Janet Salem, Richard Schodde, Gabi Schneider, Olivier Vidal and Natalia Yakovleva

Retraction Note: Oncogenic activity of Cdc6 through repression of the INK4/ARF locus pp. 246-246

Susana Gonzalez, Peter Klatt, Sonia Delgado, Esther Conde, Fernando Lopez-Rios, Montserrat Sanchez-Cespedes, Juan Mendez, Francisco Antequera and Manuel Serrano

Housing: A home on a budget pp. 247-249

Chris Woolston

Turning point: Tenacious chemist pp. 249-249

Virginia Gewin

Legs-11 pp. 252-252

Hugh Cartwright

2017, volume 547, articles 7661

Upholding a role for EMT in breast cancer metastasis pp. E1-E3

Xin Ye, Thomas Brabletz, Yibin Kang, Gregory D. Longmore, M. Angela Nieto, Ben Z. Stanger, Jing Yang and Robert A. Weinberg

Fischer et al. reply pp. E5-E6

Kari R. Fischer, Nasser K. Altorki, Vivek Mittal and Dingcheng Gao

Upholding a role for EMT in pancreatic cancer metastasis pp. E7-E8

Nicole M. Aiello, Thomas Brabletz, Yibin Kang, M. Angela Nieto, Robert A. Weinberg and Ben Z. Stanger

Our obsession with eminence warps research pp. 7-7

Simine Vazire

Google spin-off deploys wearable electronics for huge health study pp. 13-14

Amy Maxmen

Ebola outbreak in Africa ends — but gaps in public health leave region vulnerable pp. 14-15

Erika Check Hayden

Has Harry Potter mania cursed Indonesia's owls? pp. 15-15

Inga Vesper

Qatar blockade hits helium supply pp. 16-16

Declan Butler

Europe’s next big science-funding programme urged to double its budget pp. 17-17

Alison Abbott

The trickiest family tree in biology pp. 20-22

Ewen Callaway

Immunology, one cell at a time pp. 27-29

Amir Giladi and Ido Amit

Cybersecurity: The cold war online pp. 30-31

Steven Aftergood

Books in brief pp. 31-31

Barbara Kiser

AI zooms in on highly influential citations pp. 32-32

Oren Etzioni

Japan disregards whaling review again pp. 32-32

Phillip J. Clapham

Flagging gender bias doesn't always work pp. 32-32

Greta Faccio

Stop ruining Turkey's geological heritage pp. 32-32

A. M. Celal Şengör and Nalan Lom

Defend real science in the Balkans pp. 32-32

Jelena Kalinić

Continuous chromatin changes pp. 34-35

Robert A. Beagrie and Ana Pombo

Ice-sheet history revealed by fossils pp. 35-36

Jennifer Hertzberg

The patterns of T-cell target recognition pp. 36-38

Sai T. Reddy

3D integration advances computing pp. 38-39

Sherief Reda

Less is more in the hunt for driver mutations pp. 40-41

Sushant Kumar and Mark Gerstein

Stellar siblings grow closer with age pp. 41-42

Aaron M. Geller

West Antarctic Ice Sheet retreat driven by Holocene warm water incursions pp. 43-48

Claus-Dieter Hillenbrand, James A. Smith, David A. Hodell, Mervyn Greaves, Christopher R. Poole, Sev Kender, Mark Williams, Thorbjørn Joest Andersen, Patrycja E. Jernas, Henry Elderfield, Johann P. Klages, Stephen J. Roberts, Karsten Gohl, Robert D. Larter and Gerhard Kuhn

Climate change drives expansion of Antarctic ice-free habitat pp. 49-54

Jasmine R. Lee, Ben Raymond, Thomas J. Bracegirdle, Iadine Chadès, Richard A. Fuller, Justine D. Shaw and Aleks Terauds

Recurrent and functional regulatory mutations in breast cancer pp. 55-60

Esther Rheinbay, Prasanna Parasuraman, Jonna Grimsby, Grace Tiao, Jesse M. Engreitz, Jaegil Kim, Michael S. Lawrence, Amaro Taylor-Weiner, Sergio Rodriguez-Cuevas, Mara Rosenberg, Julian Hess, Chip Stewart, Yosef E. Maruvka, Petar Stojanov, Maria L. Cortes, Sara Seepo, Carrie Cibulskis, Adam Tracy, Trevor J. Pugh, Jesse Lee, Zongli Zheng, Leif W. Ellisen, A. John Iafrate, Jesse S. Boehm, Stacey B. Gabriel, Matthew Meyerson, Todd R. Golub, Jose Baselga, Alfredo Hidalgo-Miranda, Toshi Shioda, Andre Bernards, Eric S. Lander and Gad Getz

Cell-cycle dynamics of chromosomal organization at single-cell resolution pp. 61-67

Takashi Nagano, Yaniv Lubling, Csilla Várnai, Carmel Dudley, Wing Leung, Yael Baran, Netta Mendelson Cohen, Steven Wingett, Peter Fraser and Amos Tanay

Single-molecule analysis of ligand efficacy in β2AR–G-protein activation pp. 68-73

G. Glenn Gregorio, Matthieu Masureel, Daniel Hilger, Daniel S. Terry, Manuel Juette, Hong Zhao, Zhou Zhou, Jose Manuel Perez-Aguilar, Maria Hauge, Signe Mathiasen, Jonathan A. Javitch, Harel Weinstein, Brian K. Kobilka and Scott C. Blanchard

Three-dimensional integration of nanotechnologies for computing and data storage on a single chip pp. 74-78

Max M. Shulaker, Gage Hills, Rebecca S. Park, Roger T. Howe, Krishna Saraswat, H.-S. Philip Wong and Subhasish Mitra

Selective sp3 C–H alkylation via polarity-match-based cross-coupling pp. 79-83

Chip Le, Yufan Liang, Ryan W. Evans, Ximing Li and David W. C. MacMillan

Episodic kinematics in continental rifts modulated by changes in mantle melt fraction pp. 84-88

Simon Lamb, James D. P. Moore, Euan Smith and Tim Stern

Quantifiable predictive features define epitope-specific T cell receptor repertoires pp. 89-93

Pradyot Dash, Andrew J. Fiore-Gartland, Tomer Hertz, George C. Wang, Shalini Sharma, Aisha Souquette, Jeremy Chase Crawford, E. Bridie Clemens, Thi H. O. Nguyen, Katherine Kedzierska, Nicole L. La Gruta, Philip Bradley and Paul G. Thomas

Identifying specificity groups in the T cell receptor repertoire pp. 94-98

Jacob Glanville, Huang Huang, Allison Nau, Olivia Hatton, Lisa E. Wagar, Florian Rubelt, Xuhuai Ji, Arnold Han, Sheri M. Krams, Christina Pettus, Nikhil Haas, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Scott D. Boyd, Thomas J. Scriba, Olivia M. Martinez and Mark M. Davis

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin pp. 99-103

Yupeng Wang, Wenqing Gao, Xuyan Shi, Jingjin Ding, Wang Liu, Huabin He, Kun Wang and Feng Shao

Tracing the origins of relapse in acute myeloid leukaemia to stem cells pp. 104-108

Liran I. Shlush, Amanda Mitchell, Lawrence Heisler, Sagi Abelson, Stanley W. K. Ng, Aaron Trotman-Grant, Jessie J. F. Medeiros, Abilasha Rao-Bhatia, Ivana Jaciw-Zurakowsky, Rene Marke, Jessica L. McLeod, Monica Doedens, Gary Bader, Veronique Voisin, ChangJiang Xu, John D. McPherson, Thomas J. Hudson, Jean C. Y. Wang, Mark D. Minden and John E. Dick

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer pp. 109-113

Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Natalia Martín-Martín, Sonia Fernandez-Ruiz, James D. Sutherland, Michelle Clasquin, Julen Tomas-Cortazar, Jose Jimenez, Ines Torres, Phong Quang, Pilar Ximenez-Embun, Ruzica Bago, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Verónica Torrano, Diana Cabrera, Sebastiaan M. van Liempd, Ylenia Cendon, Elena Castro, Stuart Murray, Ajinkya Revandkar, Andrea Alimonti, Yinan Zhang, Amelia Barnett, Gina Lein, David Pirman, Ana R. Cortazar, Leire Arreal, Ludmila Prudkin, Ianire Astobiza, Lorea Valcarcel-Jimenez, Patricia Zuñiga-García, Itziar Fernandez-Dominguez, Marco Piva, Alfredo Caro-Maldonado, Pilar Sánchez-Mosquera, Mireia Castillo-Martín, Violeta Serra, Naiara Beraza, Antonio Gentilella, George Thomas, Mikel Azkargorta, Felix Elortza, Rosa Farràs, David Olmos, Alejo Efeyan, Juan Anguita, Javier Muñoz, Juan M. Falcón-Pérez, Rosa Barrio, Teresa Macarulla, Jose M. Mato, Maria L. Martinez-Chantar, Carlos Cordon-Cardo, Ana M. Aransay, Kevin Marks, José Baselga, Josep Tabernero, Paolo Nuciforo, Brendan D. Manning, Katya Marjon and Arkaitz Carracedo

RNase III nucleases from diverse kingdoms serve as antiviral effectors pp. 114-117

Lauren C. Aguado, Sonja Schmid, Jared May, Leah R. Sabin, Maryline Panis, Daniel Blanco-Melo, Jaehee V. Shim, David Sachs, Sara Cherry, Anne E. Simon, Jean-Pierre Levraud and Benjamin R. tenOever

Electron cryo-microscopy structure of the mechanotransduction channel NOMPC pp. 118-122

Peng Jin, David Bulkley, Yanmeng Guo, Wei Zhang, Zhenhao Guo, Walter Huynh, Shenping Wu, Shan Meltzer, Tong Cheng, Lily Yeh Jan, Yuh-Nung Jan and Yifan Cheng

Addendum: Immune clearance of highly pathogenic SIV infection pp. 123-124

Scott G. Hansen, Michael Piatak, Abigail B. Ventura, Colette M. Hughes, Roxanne M. Gilbride, Julia C. Ford, Kelli Oswald, Rebecca Shoemaker, Yuan Li, Matthew S. Lewis, Awbrey N. Gilliam, Guangwu Xu, Nathan Whizin, Benjamin J. Burwitz, Shannon L. Planer, John M. Turner, Alfred W. Legasse, Michael K. Axthelm, Jay A. Nelson, Klaus Früh, Jonah B. Sacha, Jacob D. Estes, Brandon F. Keele, Paul T. Edlefsen, Jeffrey D. Lifson and Louis J. Picker

Single-cell sequencing made simple pp. 125-126

Jeffrey M. Perkel

Glycobiology: Sweet success pp. 127-129

Esther Landhuis

Turning point: Single-cell mapper pp. 129-129

Virginia Gewin

The ghost in the machine pp. 132-132

Anna Novitzky