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2020, volume 587, articles 7835

Outlook: Multiple myeloma pp. S55-S55

Brian Owens

Will the reclassification of multiple myeloma change how people are treated? pp. S56-S57

Benjamin Plackett

Burning questions about smouldering myeloma pp. S58-S59

Sarah DeWeerdt

Scientists are harnessing viruses to treat tumours pp. S60-S62

Carolyn Brown

The screening imperative for multiple myeloma pp. S63-S63

S. Vincent Rajkumar

How researchers are addressing the racial imbalance in multiple myeloma pp. S64-S65

Cassandra Willyard

Immunotherapies target multiple myeloma pp. S66-S67

Dalmeet Singh Chawla

Research round-up: Multiple myeloma pp. S68-S69

Jyoti Madhusoodanan

German science is thriving, but diversity remains an issue pp. S103-S103

Bec Crew

How Germany retains one of the world’s strongest research reputations pp. S104-S105

Hristio Boytchev

Germany’s start-up scene is booming pp. S106-S109

Gemma Conroy, Natalie Parletta and Chris Woolston

Asifa Akhtar is a sign of new things to come at the Max Planck Society pp. S112-S112

Chris Woolston

Clusters of Excellence: the new ‘brains trusts’ of German science pp. S116-S117

Gemma Conroy, Bec Crew and Andy Tay

University rankings need a rethink pp. 523-523

Elizabeth Gadd

Legendary Arecibo telescope will close forever — scientists are reeling pp. 529-530

Alexandra Witze

Can dogs smell COVID? Here’s what the science says pp. 530-531

Holly Else

Prospects for life on Venus fade — but aren’t dead yet pp. 532-532

Alexandra Witze

Simulating the pandemic: What COVID forecasters can learn from climate models pp. 533-534

David Adam

What the data say about asymptomatic COVID infections pp. 534-535

Bianca Nogrady

California’s vote to revive controversial stem-cell institute sparks debate pp. 535-535

Nidhi Subbaraman

How Iceland hammered COVID with science pp. 536-539

Megan Scudellari

When is sorrow sickness? A history of depression pp. 541-542

China Mills

Book-burning through the ages, the Arctic laid bare, and capitalism under scrutiny: Books in brief pp. 542-542

Andrew Robinson

Reboot contraceptives research — it has been stuck for decades pp. 543-545

Sarah G. Chamberlain, Kirsten M. Vogelsong, Michelle Weinberger, Emily Serazin, Sarah Cairns-Smith and Stephen E. Gerrard

Memo for President Biden: Five steps to getting more from science pp. 546-547

Roger Pielke and Neal Lane

Explain ESA’s last-minute ditching of new space telescope pp. 548-548

David L. Clements, Stephen Serjeant and Shoko Jin

COVID-19: Panama stockpiles unproven drugs pp. 548-548

Ivonne Torres-Atencio, Amador Goodridge and Silvio Vega

Giant tortoises make a comeback in Madagascar pp. 548-548

Miguel Pedrono, Elodi Rambeloson and Alison Clausen

COVID-19: students caught in Pakistan’s digital divide pp. 548-548

Aziz Khan

Genetic variability of memory performance is explained by differences in the brain’s thalamus pp. 549-550

Michael M. Halassa

Neutrino detection gets to the core of the Sun pp. 550-552

Gabriel D. Orebi Gann

Neanderthal DNA highlights complexity of COVID risk factors pp. 552-553

Yang Luo

Isoforms of GPCR proteins combine for diverse signalling pp. 553-554

Joshua C. Snyder and Sudarshan Rajagopal

Fibrosis: from mechanisms to medicines pp. 555-566

Neil C. Henderson, Florian Rieder and Thomas A. Wynn

Discoveries in structure and physiology of mechanically activated ion channels pp. 567-576

J. M. Kefauver, A. B. Ward and A. Patapoutian

Observing the emergence of a quantum phase transition shell by shell pp. 583-587

Luca Bayha, Marvin Holten, Ralf Klemt, Keerthan Subramanian, Johannes Bjerlin, Stephanie M. Reimann, Georg M. Bruun, Philipp M. Preiss and Selim Jochim

Spin-enhanced nanodiamond biosensing for ultrasensitive diagnostics pp. 588-593

Benjamin S. Miller, Léonard Bezinge, Harriet D. Gliddon, Da Huang, Gavin Dold, Eleanor R. Gray, Judith Heaney, Peter J. Dobson, Eleni Nastouli, John J. L. Morton and Rachel A. McKendry

Lanthanide-doped inorganic nanoparticles turn molecular triplet excitons bright pp. 594-599

Sanyang Han, Renren Deng, Qifei Gu, Limeng Ni, Uyen Huynh, Jiangbin Zhang, Zhigao Yi, Baodan Zhao, Hiroyuki Tamura, Anton Pershin, Hui Xu, Zhiyuan Huang, Shahab Ahmad, Mojtaba Abdi-Jalebi, Aditya Sadhanala, Ming Lee Tang, Artem Bakulin, David Beljonne, Xiaogang Liu and Akshay Rao

Antarctic ice dynamics amplified by Northern Hemisphere sea-level forcing pp. 600-604

Natalya Gomez, Michael E. Weber, Peter U. Clark, Jerry X. Mitrovica and Holly K. Han

Sensory pollutants alter bird phenology and fitness across a continent pp. 605-609

Masayuki Senzaki, Jesse R. Barber, Jennifer N. Phillips, Neil H. Carter, Caren B. Cooper, Mark A. Ditmer, Kurt M. Fristrup, Christopher J. W. McClure, Daniel J. Mennitt, Luke P. Tyrrell, Jelena Vukomanovic, Ashley A. Wilson and Clinton D. Francis

The major genetic risk factor for severe COVID-19 is inherited from Neanderthals pp. 610-612

Hugo Zeberg and Svante Pääbo

Microglia-organized scar-free spinal cord repair in neonatal mice pp. 613-618

Yi Li, Xuelian He, Riki Kawaguchi, Yu Zhang, Qing Wang, Aboozar Monavarfeshani, Zhiyun Yang, Bo Chen, Zhongju Shi, Huyan Meng, Songlin Zhou, Junjie Zhu, Anne Jacobi, Vivek Swarup, Phillip G. Popovich, Daniel H. Geschwind and Zhigang He

A molecular cell atlas of the human lung from single-cell RNA sequencing pp. 619-625

Kyle J. Travaglini, Ahmad N. Nabhan, Lolita Penland, Rahul Sinha, Astrid Gillich, Rene V. Sit, Stephen Chang, Stephanie D. Conley, Yasuo Mori, Jun Seita, Gerald J. Berry, Joseph B. Shrager, Ross J. Metzger, Christin S. Kuo, Norma Neff, Irving L. Weissman, Stephen R. Quake and Mark A. Krasnow

Macrophage-derived glutamine boosts satellite cells and muscle regeneration pp. 626-631

Min Shang, Federica Cappellesso, Ricardo Amorim, Jens Serneels, Federico Virga, Guy Eelen, Stefania Carobbio, Melvin Y. Rincon, Pierre Maechler, Katrien Bock, Ping-Chih Ho, Marco Sandri, Bart Ghesquière, Peter Carmeliet, Mario Di Matteo, Emanuele Berardi and Massimiliano Mazzone

DNA targeting and interference by a bacterial Argonaute nuclease pp. 632-637

Anton Kuzmenko, Anastasiya Oguienko, Daria Esyunina, Denis Yudin, Mayya Petrova, Alina Kudinova, Olga Maslova, Maria Ninova, Sergei Ryazansky, David Leach, Alexei A. Aravin and Andrey Kulbachinskiy

Host ANP32A mediates the assembly of the influenza virus replicase pp. 638-643

Loïc Carrique, Haitian Fan, Alexander P. Walker, Jeremy R. Keown, Jane Sharps, Ecco Staller, Wendy S. Barclay, Ervin Fodor and Jonathan M. Grimes

Cell-type-specific 3D epigenomes in the developing human cortex pp. 644-649

Michael Song, Mark-Phillip Pebworth, Xiaoyu Yang, Armen Abnousi, Changxu Fan, Jia Wen, Jonathan D. Rosen, Mayank N. K. Choudhary, Xiekui Cui, Ian R. Jones, Seth Bergenholtz, Ugomma C. Eze, Ivan Juric, Bingkun Li, Lenka Maliskova, Jerry Lee, Weifang Liu, Alex A. Pollen, Yun Li, Ting Wang, Ming Hu, Arnold R. Kriegstein and Yin Shen

Combinatorial expression of GPCR isoforms affects signalling and drug responses pp. 650-656

Maria Marti-Solano, Stephanie E. Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Abigail Pearce, Tezz Quon, Amanda E. Mackenzie, Xusheng Wang, Junmin Peng, Andrew B. Tobin, Graham Ladds, Graeme Milligan, David E. Gloriam, Manojkumar A. Puthenveedu and M. Madan Babu

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity pp. 657-662

Donghyuk Shin, Rukmini Mukherjee, Diana Grewe, Denisa Bojkova, Kheewoong Baek, Anshu Bhattacharya, Laura Schulz, Marek Widera, Ahmad Reza Mehdipour, Georg Tascher, Paul P. Geurink, Alexander Wilhelm, Gerbrand J. Heden van Noort, Huib Ovaa, Stefan Müller, Klaus-Peter Knobeloch, Krishnaraj Rajalingam, Brenda A. Schulman, Jindrich Cinatl, Gerhard Hummer, Sandra Ciesek and Ivan Dikic

Site-specific RNA methylation by a methyltransferase ribozyme pp. 663-667

Carolin P. M. Scheitl, Mohammad Ghaem Maghami, Ann-Kathrin Lenz and Claudia Höbartner

Structural mechanism of cGAS inhibition by the nucleosome pp. 668-672

Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä and Andrea Ablasser

The molecular basis of tight nuclear tethering and inactivation of cGAS pp. 673-677

Baoyu Zhao, Pengbiao Xu, Chesley M. Rowlett, Tao Jing, Omkar Shinde, Yuanjiu Lei, A. Phillip West, Wenshe Ray Liu and Pingwei Li

Structural basis for sequestration and autoinhibition of cGAS by chromatin pp. 678-682

Sebastian Michalski, Carina C. de Oliveira Mann, Che A. Stafford, Gregor Witte, Joseph Bartho, Katja Lammens, Veit Hornung and Karl-Peter Hopfner

Structural basis for the final steps of human 40S ribosome maturation pp. 683-687

Michael Ameismeier, Ivo Zemp, Jasmin Heuvel, Matthias Thoms, Otto Berninghausen, Ulrike Kutay and Roland Beckmann

Postdocs under pressure: ‘Can I even do this any more?’ pp. 689-692

Chris Woolston

Flame thrower pp. 694-694

Kendall Powell

2020, volume 587, articles 7834

Publisher Correction: Innate and plastic mechanisms for maternal behaviour in auditory cortex pp. E2-E2

Jennifer K. Schiavo, Silvana Valtcheva, Chloe J. Bair-Marshall, Soomin C. Song, Kathleen A. Martin and Robert C. Froemke

Lung cancer pp. S7-S7

Herb Brody

Research round-up: lung cancer pp. S8-S9

Bianca Nogrady

New lung-cancer drugs extend survival times pp. S10-S12

Michael Eisenstein

Lung-cancer researchers and clinicians must pay more attention to women pp. S13-S13

Narjust Duma

Better treatments for lung cancer that spreads to the brain pp. S14-S15

Natalie Healey

Oncogene-specific advocacy groups bring a patient-centric perspective to studies of lung cancer pp. S16-S17

Elie Dolgin

How liquid biopsies allow smarter lung-cancer treatment pp. S18-S19

Benjamin Plackett

Artificial intelligence is improving the detection of lung cancer pp. S20-S22

Elizabeth Svoboda

What if tropical diseases had as much attention as COVID? pp. 331-331

Francine Ntoumi

COVID vaccine excitement builds as Moderna reports third positive result pp. 337-338

Ewen Callaway

Joe Biden’s COVID plan is taking shape — and researchers approve pp. 339-340

Nidhi Subbaraman

COVID mink analysis shows mutations are not dangerous — yet pp. 340-341

Smriti Mallapaty

Where did COVID come from? WHO investigation begins but faces challenges pp. 341-342

Smriti Mallapaty

Quantum computer race intensifies as alternative technology gains steam pp. 342-343

Elizabeth Gibney

How to stop restaurants from driving COVID infections pp. 344-344

David Cyranoski

Is facial recognition too biased to be let loose? pp. 347-349

Davide Castelvecchi

Resisting the rise of facial recognition pp. 350-353

Antoaneta Roussi

The ethical questions that haunt facial-recognition research pp. 354-358

Richard Van Noorden

What NASA missions can teach us about teamwork pp. 359-360

Alexandra Witze

The science of sliminess, the secrets of bones, and mathematicians who took to the air: Books in brief pp. 360-360

Andrew Robinson

Five rules for evidence communication pp. 362-364

Michael Blastland, Alexandra L. J. Freeman, Sander van der Linden, Theresa M. Marteau and David Spiegelhalter

COVID-19 disruptions to tech-metals supply are a wake-up call pp. 365-367

Ata Akcil, Zhi Sun and Sandeep Panda

Potentially harmful aerosols concentrate in European urban centres pp. 369-370

Rodney Weber

Universal assembly instructions for the placenta pp. 370-371

Jennifer L. Watts and Amy Ralston

Hierarchies defined through human mobility pp. 372-373

Elsa Arcaute

Identifying gut microbes that affect human health pp. 373-374

Sigal Leviatan and Eran Segal

Interferon deficiency can lead to severe COVID pp. 374-376

Eric Meffre and Akiko Iwasaki

LifeTime and improving European healthcare through cell-based interceptive medicine pp. 377-386

Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A. Gorski, Stein Aerts, Ido Amit, Michela G. Bertero, Christoph Bock, Annelien L. Bredenoord, Giacomo Cavalli, Susanna Chiocca, Hans Clevers, Bart De Strooper, Angelika Eggert, Jan Ellenberg, Xosé M. Fernández, Marek Figlerowicz, Susan M. Gasser, Norbert Hubner, Jørgen Kjems, Jürgen A. Knoblich, Grietje Krabbe, Peter Lichter, Sten Linnarsson, Jean-Christophe Marine, John C. Marioni, Marc A. Marti-Renom, Mihai G. Netea, Dörthe Nickel, Marcelo Nollmann, Halina R. Novak, Helen Parkinson, Stefano Piccolo, Inês Pinheiro, Ana Pombo, Christian Popp, Wolf Reik, Sergio Roman-Roman, Philip Rosenstiel, Joachim L. Schultze, Oliver Stegle, Amos Tanay, Giuseppe Testa, Dimitris Thanos, Fabian J. Theis, Maria-Elena Torres-Padilla, Alfonso Valencia, Céline Vallot, Alexander van Oudenaarden, Marie Vidal and Thierry Voet

A blue ring nebula from a stellar merger several thousand years ago pp. 387-391

Keri Hoadley, D. Christopher Martin, Brian D. Metzger, Mark Seibert, Andrew McWilliam, Ken J. Shen, James D. Neill, Gudmundur Stefansson, Andrew Monson and Bradley E. Schaefer

Observation of gauge invariance in a 71-site Bose–Hubbard quantum simulator pp. 392-396

Bing Yang, Hui Sun, Robert Ott, Han-Yi Wang, Torsten V. Zache, Jad C. Halimeh, Zhen-Sheng Yuan, Philipp Hauke and Jian-Wei Pan

The growth equation of cities pp. 397-401

Vincent Verbavatz and Marc Barthelemy

The scales of human mobility pp. 402-407

Laura Alessandretti, Ulf Aslak and Sune Lehmann

Key role of chemistry versus bias in electrocatalytic oxygen evolution pp. 408-413

Hong Nhan Nong, Lorenz J. Falling, Arno Bergmann, Malte Klingenhof, Hoang Phi Tran, Camillo Spöri, Rik Mom, Janis Timoshenko, Guido Zichittella, Axel Knop-Gericke, Simone Piccinin, Javier Pérez-Ramírez, Beatriz Roldan Cuenya, Robert Schlögl, Peter Strasser, Detre Teschner and Travis E. Jones

Sources of particulate-matter air pollution and its oxidative potential in Europe pp. 414-419

Kaspar R. Daellenbach, Gaëlle Uzu, Jianhui Jiang, Laure-Estelle Cassagnes, Zaira Leni, Athanasia Vlachou, Giulia Stefenelli, Francesco Canonaco, Samuël Weber, Arjo Segers, Jeroen J. P. Kuenen, Martijn Schaap, Olivier Favez, Alexandre Albinet, Sebnem Aksoyoglu, Josef Dommen, Urs Baltensperger, Marianne Geiser, Imad El Haddad, Jean-Luc Jaffrezo and André S. H. Prévôt

A yeast living ancestor reveals the origin of genomic introgressions pp. 420-425

Melania D’Angiolo, Matteo De Chiara, Jia-Xing Yue, Agurtzane Irizar, Simon Stenberg, Karl Persson, Agnès Llored, Benjamin Barré, Joseph Schacherer, Roberto Marangoni, Eric Gilson, Jonas Warringer and Gianni Liti

Innate and plastic mechanisms for maternal behaviour in auditory cortex pp. 426-431

Jennifer K. Schiavo, Silvana Valtcheva, Chloe J. Bair-Marshall, Soomin C. Song, Kathleen A. Martin and Robert C. Froemke

Spontaneous travelling cortical waves gate perception in behaving primates pp. 432-436

Zachary W. Davis, Lyle Muller, Julio Martinez-Trujillo, Terrence Sejnowski and John H. Reynolds

Persistent transcriptional programmes are associated with remote memory pp. 437-442

Michelle B. Chen, Xian Jiang, Stephen R. Quake and Thomas C. Südhof

Initiation of a conserved trophectoderm program in human, cow and mouse embryos pp. 443-447

Claudia Gerri, Afshan McCarthy, Gregorio Alanis-Lobato, Andrej Demtschenko, Alexandre Bruneau, Sophie Loubersac, Norah M. E. Fogarty, Daniel Hampshire, Kay Elder, Phil Snell, Leila Christie, Laurent David, Hilde Van de Velde, Ali A. Fouladi-Nashta and Kathy K. Niakan

Host variables confound gut microbiota studies of human disease pp. 448-454

Ivan Vujkovic-Cvijin, Jack Sklar, Lingjing Jiang, Loki Natarajan, Rob Knight and Yasmine Belkaid

Enteric neurons increase maternal food intake during reproduction pp. 455-459

Dafni Hadjieconomou, George King, Pedro Gaspar, Alessandro Mineo, Laura Blackie, Tomotsune Ameku, Chris Studd, Alex Mendoza, Fengqiu Diao, Benjamin H. White, André E. X. Brown, Pierre-Yves Plaçais, Thomas Préat and Irene Miguel-Aliaga

Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia pp. 460-465

Lucia M. Moreira, Abhijit Takawale, Mohit Hulsurkar, David A. Menassa, Agne Antanaviciute, Satadru K. Lahiri, Neelam Mehta, Neil Evans, Constantinos Psarros, Paul Robinson, Alexander J. Sparrow, Marc-Antoine Gillis, Neil Ashley, Patrice Naud, Javier Barallobre-Barreiro, Konstantinos Theofilatos, Angela Lee, Mary Norris, Michele V. Clarke, Patricia K. Russell, Barbara Casadei, Shoumo Bhattacharya, Jeffrey D. Zajac, Rachel A. Davey, Martin Sirois, Adam Mead, Alison Simmons, Manuel Mayr, Rana Sayeed, George Krasopoulos, Charles Redwood, Keith M. Channon, Jean-Claude Tardif, Xander H. T. Wehrens, Stanley Nattel and Svetlana Reilly

Exuberant fibroblast activity compromises lung function via ADAMTS4 pp. 466-471

David F. Boyd, E. Kaitlynn Allen, Adrienne G. Randolph, Xi-zhi J. Guo, Yunceng Weng, Catherine J. Sanders, Resha Bajracharya, Natalie K. Lee, Clifford S. Guy, Peter Vogel, Wenda Guan, Yimin Li, Xiaoqing Liu, Tanya Novak, Margaret M. Newhams, Thomas P. Fabrizio, Nicholas Wohlgemuth, Peter M. Mourani, Thomas N. Wight, Stacey Schultz-Cherry, Stephania A. Cormier, Kathryn Shaw-Saliba, Andrew Pekosz, Richard E. Rothman, Kuan-Fu Chen, Zifeng Yang, Richard J. Webby, Nanshan Zhong, Jeremy Chase Crawford and Paul G. Thomas

Gut-educated IgA plasma cells defend the meningeal venous sinuses pp. 472-476

Zachary Fitzpatrick, Gordon Frazer, Ashley Ferro, Simon Clare, Nicolas Bouladoux, John Ferdinand, Zewen Kelvin Tuong, Maria Luciana Negro-Demontel, Nitin Kumar, Ondrej Suchanek, Tamara Tajsic, Katherine Harcourt, Kirsten Scott, Rachel Bashford-Rogers, Adel Helmy, Daniel S. Reich, Yasmine Belkaid, Trevor D. Lawley, Dorian B. McGavern and Menna R. Clatworthy

Single-cell mutation analysis of clonal evolution in myeloid malignancies pp. 477-482

Linde A. Miles, Robert L. Bowman, Tiffany R. Merlinsky, Isabelle S. Csete, Aik T. Ooi, Robert Durruthy-Durruthy, Michael Bowman, Christopher Famulare, Minal A. Patel, Pedro Mendez, Chrysanthi Ainali, Benjamin Demaree, Cyrille L. Delley, Adam R. Abate, Manimozhi Manivannan, Sombeet Sahu, Aaron D. Goldberg, Kelly L. Bolton, Ahmet Zehir, Raajit Rampal, Martin P. Carroll, Sara E. Meyer, Aaron D. Viny and Ross L. Levine

Molecular dissection of amyloid disaggregation by human HSP70 pp. 483-488

Anne S. Wentink, Nadinath B. Nillegoda, Jennifer Feufel, Gabrielė Ubartaitė, Carolyn P. Schneider, Paolo De Los Rios, Janosch Hennig, Alessandro Barducci and Bernd Bukau

HSP40 proteins use class-specific regulation to drive HSP70 functional diversity pp. 489-494

Ofrah Faust, Meital Abayev-Avraham, Anne S. Wentink, Michael Maurer, Nadinath B. Nillegoda, Nir London, Bernd Bukau and Rina Rosenzweig

The native structure of the assembled matrix protein 1 of influenza A virus pp. 495-498

Julia Peukes, Xiaoli Xiong, Simon Erlendsson, Kun Qu, William Wan, Leslie J. Calder, Oliver Schraidt, Susann Kummer, Stefan M. V. Freund, Hans-Georg Kräusslich and John A. G. Briggs

Structural basis of GPBAR activation and bile acid recognition pp. 499-504

Fan Yang, Chunyou Mao, Lulu Guo, Jingyu Lin, Qianqian Ming, Peng Xiao, Xiang Wu, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C. Luca, Jiuyao Zhou, Changtao Jiang, Jin-Peng Sun, Xin Xie, Xiao Yu and Yan Zhang

Postdoc survey reveals disenchantment with working life pp. 505-508

Chris Woolston

How DIY technologies are democratizing science pp. 509-511

Sandeep Ravindran

Top banana: developing varieties that resist disease pp. 514-514

Abdullahi Tsanni

2020, volume 587, articles 7833

To counter conspiracy theories, boost well-being pp. 177-177

Aleksandra Cichocka

Scientists relieved as Joe Biden wins tight US presidential election pp. 183-184

Jeff Tollefson

China set to retrieve first Moon rocks in 40 years pp. 185-186

Smriti Mallapaty

UAE ramps up space ambitions with Arab world’s first Moon mission pp. 186-187

Elizabeth Gibney

Scientists criticize use of unproven COVID drugs in India pp. 187-188

Gayathri Vaidyanathan

Quantum-computing pioneer warns of complacency over Internet security pp. 189-189

Davide Castelvecchi

Why do COVID death rates seem to be falling? pp. 190-192

Heidi Ledford

Mario Molina (1943–2020) pp. 193-193

V. Faye McNeill

COVID vaccination logistics: five steps to take now pp. 194-196

Yot Teerawattananon and Saudamini Vishwanath Dabak

COVID-19: Canadian policy makes funding more fair pp. 197-197

Holly O. Witteman, Jenna Haverfield and Cara Tannenbaum

Long COVID: don’t consign ME/CFS to history pp. 197-197

Peter White

Pandemics: global biobanking for equitable testing pp. 197-197

Alison Jane Basile and Lee M. Hampton

NASA-backed launch for jobless postdocs pp. 197-197

Zélia Ferreira Worman, Rachael Dempsey, Catherine Domingo and Dorit Donoviel

DNA-binding proteins meet their mismatch pp. 199-200

Kale Kundert and James S. Fraser

Tropical cyclones could last longer after landfall in a warming world pp. 200-201

Dan Chavas and Jie Chen

Caspase-8 protein cuts a brake on immune defences pp. 201-203

Igor E. Brodsky

Primordial element production studied beneath a mountain pp. 203-204

Brian D. Fields

Bennu’s near-Earth lifetime of 1.75 million years inferred from craters on its boulders pp. 205-209

R.-L. Ballouz, K. J. Walsh, O. S. Barnouin, D. N. DellaGiustina, M. Al Asad, E. R. Jawin, M. G. Daly, W. F. Bottke, P. Michel, C. Avdellidou, M. Delbo, R. T. Daly, E. Asphaug, C. A. Bennett, E. B. Bierhaus, H. C. Connolly, D. R. Golish, J. L. Molaro, M. C. Nolan, M. Pajola, B. Rizk, S. R. Schwartz, D. Trang, C. W. V. Wolner and D. S. Lauretta

The baryon density of the Universe from an improved rate of deuterium burning pp. 210-213

V. Mossa, K. Stöckel, F. Cavanna, F. Ferraro, M. Aliotta, F. Barile, D. Bemmerer, A. Best, A. Boeltzig, C. Broggini, C. G. Bruno, A. Caciolli, T. Chillery, G. F. Ciani, P. Corvisiero, L. Csedreki, T. Davinson, R. Depalo, A. Leva, Z. Elekes, E. M. Fiore, A. Formicola, Zs. Fülöp, G. Gervino, A. Guglielmetti, C. Gustavino, G. Gyürky, G. Imbriani, M. Junker, A. Kievsky, I. Kochanek, M. Lugaro, L. E. Marcucci, G. Mangano, P. Marigo, E. Masha, R. Menegazzo, F. R. Pantaleo, V. Paticchio, R. Perrino, D. Piatti, O. Pisanti, P. Prati, L. Schiavulli, O. Straniero, T. Szücs, M. P. Takács, D. Trezzi, M. Viviani and S. Zavatarelli

Correlated insulating states at fractional fillings of moiré superlattices pp. 214-218

Yang Xu, Song Liu, Daniel A. Rhodes, Kenji Watanabe, Takashi Taniguchi, James Hone, Veit Elser, Kin Fai Mak and Jie Shan

Ultra-sensitive and resilient compliant strain gauges for soft machines pp. 219-224

Oluwaseun A. Araromi, Moritz A. Graule, Kristen L. Dorsey, Sam Castellanos, Jonathan R. Foster, Wen-Hao Hsu, Arthur E. Passy, Joost J. Vlassak, James C. Weaver, Conor J. Walsh and Robert J. Wood

Anatomy of cage formation in a two-dimensional glass-forming liquid pp. 225-229

Bo Li, Kai Lou, Walter Kob and Steve Granick

Slower decay of landfalling hurricanes in a warming world pp. 230-234

Lin Li and Pinaki Chakraborty

Dense and pleiotropic regulatory information in a developmental enhancer pp. 235-239

Timothy Fuqua, Jeff Jordan, Maria Elize Breugel, Aliaksandr Halavatyi, Christian Tischer, Peter Polidoro, Namiko Abe, Albert Tsai, Richard S. Mann, David L. Stern and Justin Crocker

Progressive Cactus is a multiple-genome aligner for the thousand-genome era pp. 246-251

Joel Armstrong, Glenn Hickey, Mark Diekhans, Ian T. Fiddes, Adam M. Novak, Alden Deran, Qi Fang, Duo Xie, Shaohong Feng, Josefin Stiller, Diane Genereux, Jeremy Johnson, Voichita Dana Marinescu, Jessica Alföldi, Robert S. Harris, Kerstin Lindblad-Toh, David Haussler, Elinor Karlsson, Erich D. Jarvis, Guojie Zhang and Benedict Paten

Dense sampling of bird diversity increases power of comparative genomics pp. 252-257

Shaohong Feng, Josefin Stiller, Yuan Deng, Joel Armstrong, Qi Fang, Andrew Hart Reeve, Duo Xie, Guangji Chen, Chunxue Guo, Brant C. Faircloth, Bent Petersen, Zongji Wang, Qi Zhou, Mark Diekhans, Wanjun Chen, Sergio Andreu-Sánchez, Ashot Margaryan, Jason Travis Howard, Carole Parent, George Pacheco, Mikkel-Holger S. Sinding, Lara Puetz, Emily Cavill, Ângela M. Ribeiro, Leopold Eckhart, Jon Fjeldså, Peter A. Hosner, Robb T. Brumfield, Les Christidis, Mads F. Bertelsen, Thomas Sicheritz-Ponten, Dieter Thomas Tietze, Bruce C. Robertson, Gang Song, Gerald Borgia, Santiago Claramunt, Irby J. Lovette, Saul J. Cowen, Peter Njoroge, John Philip Dumbacher, Oliver A. Ryder, Jérôme Fuchs, Michael Bunce, David W. Burt, Joel Cracraft, Guanliang Meng, Shannon J. Hackett, Peter G. Ryan, Knud Andreas Jønsson, Ian G. Jamieson, Rute R. Fonseca, Edward L. Braun, Peter Houde, Siavash Mirarab, Alexander Suh, Bengt Hansson, Suvi Ponnikas, Hanna Sigeman, Martin Stervander, Paul B. Frandsen, Henriette Zwan, Rencia Sluis, Carina Visser, Christopher N. Balakrishnan, Andrew G. Clark, John W. Fitzpatrick, Reed Bowman, Nancy Chen, Alison Cloutier, Timothy B. Sackton, Scott V. Edwards, Dustin J. Foote, Subir B. Shakya, Frederick H. Sheldon, Alain Vignal, André E. R. Soares, Beth Shapiro, Jacob González-Solís, Joan Ferrer-Obiol, Julio Rozas, Marta Riutort, Anna Tigano, Vicki Friesen, Love Dalén, Araxi O. Urrutia, Tamás Székely, Yang Liu, Michael G. Campana, André Corvelo, Robert C. Fleischer, Kim M. Rutherford, Neil J. Gemmell, Nicolas Dussex, Henrik Mouritsen, Nadine Thiele, Kira Delmore, Miriam Liedvogel, Andre Franke, Marc P. Hoeppner, Oliver Krone, Adam M. Fudickar, Borja Milá, Ellen D. Ketterson, Andrew Eric Fidler, Guillermo Friis, Ángela M. Parody-Merino, Phil F. Battley, Murray P. Cox, Nicholas Costa Barroso Lima, Francisco Prosdocimi, Thomas Lee Parchman, Barney A. Schlinger, Bette A. Loiselle, John G. Blake, Haw Chuan Lim, Lainy B. Day, Matthew J. Fuxjager, Maude W. Baldwin, Michael J. Braun, Morgan Wirthlin, Rebecca B. Dikow, T. Brandt Ryder, Glauco Camenisch, Lukas F. Keller, Jeffrey M. DaCosta, Mark E. Hauber, Matthew I. M. Louder, Christopher C. Witt, Jimmy A. McGuire, Joann Mudge, Libby C. Megna, Matthew D. Carling, Biao Wang, Scott A. Taylor, Glaucia Del-Rio, Alexandre Aleixo, Ana Tereza Ribeiro Vasconcelos, Claudio V. Mello, Jason T. Weir, David Haussler, Qiye Li, Huanming Yang, Jian Wang, Fumin Lei, Carsten Rahbek, M. Thomas P. Gilbert, Gary R. Graves, Erich D. Jarvis, Benedict Paten and Guojie Zhang

Parallel ascending spinal pathways for affective touch and pain pp. 258-263

Seungwon Choi, Junichi Hachisuka, Matthew A. Brett, Alexandra R. Magee, Yu Omori, Noor-ul-Aine Iqbal, Dawei Zhang, Michelle M. DeLisle, Rachel L. Wolfson, Ling Bai, Celine Santiago, Shiaoching Gong, Martyn Goulding, Nathaniel Heintz, H. Richard Koerber, Sarah E. Ross and David D. Ginty

Hippocampal CA2 sharp-wave ripples reactivate and promote social memory pp. 264-269

Azahara Oliva, Antonio Fernández-Ruiz, Felix Leroy and Steven A. Siegelbaum

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19 pp. 270-274

Julian Braun, Lucie Loyal, Marco Frentsch, Daniel Wendisch, Philipp Georg, Florian Kurth, Stefan Hippenstiel, Manuela Dingeldey, Beate Kruse, Florent Fauchere, Emre Baysal, Maike Mangold, Larissa Henze, Roland Lauster, Marcus A. Mall, Kirsten Beyer, Jobst Röhmel, Sebastian Voigt, Jürgen Schmitz, Stefan Miltenyi, Ilja Demuth, Marcel A. Müller, Andreas Hocke, Martin Witzenrath, Norbert Suttorp, Florian Kern, Ulf Reimer, Holger Wenschuh, Christian Drosten, Victor M. Corman, Claudia Giesecke-Thiel, Leif Erik Sander and Andreas Thiel

Integration of innate immune signalling by caspase-8 cleavage of N4BP1 pp. 275-280

Alexander D. Gitlin, Klaus Heger, Alexander F. Schubert, Rohit Reja, Donghong Yan, Victoria C. Pham, Eric Suto, Juan Zhang, Youngsu C. Kwon, Emily C. Freund, Jing Kang, Anna Pham, Roger Caothien, Natasha Bacarro, Trent Hinkle, Min Xu, Brent S. McKenzie, Benjamin Haley, Wyne P. Lee, Jennie R. Lill, Merone Roose-Girma, Monika Dohse, Joshua D. Webster, Kim Newton and Vishva M. Dixit

Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA pp. 281-284

Justin M. Wolter, Hanqian Mao, Giulia Fragola, Jeremy M. Simon, James L. Krantz, Hannah O. Bazick, Baris Oztemiz, Jason L. Stein and Mark J. Zylka

Chromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly pp. 285-290

Sara Cuylen-Haering, Mina Petrovic, Alberto Hernandez-Armendariz, Maximilian W. G. Schneider, Matthias Samwer, Claudia Blaukopf, Liam J. Holt and Daniel W. Gerlich

DNA mismatches reveal conformational penalties in protein–DNA recognition pp. 291-296

Ariel Afek, Honglue Shi, Atul Rangadurai, Harshit Sahay, Alon Senitzki, Suela Xhani, Mimi Fang, Raul Salinas, Zachery Mielko, Miles A. Pufall, Gregory M. K. Poon, Tali E. Haran, Maria A. Schumacher, Hashim M. Al-Hashimi and Raluca Gordân

Equilibrium between nascent and parental MCM proteins protects replicating genomes pp. 297-302

Hana Sedlackova, Maj-Britt Rask, Rajat Gupta, Chunaram Choudhary, Kumar Somyajit and Jiri Lukas

RAD51-dependent recruitment of TERRA lncRNA to telomeres through R-loops pp. 303-308

Marianna Feretzaki, Michaela Pospisilova, Rita Valador Fernandes, Thomas Lunardi, Lumir Krejci and Joachim Lingner

Structural basis for RIFIN-mediated activation of LILRB1 in malaria pp. 309-312

Thomas E. Harrison, Alexander M. Mørch, James H. Felce, Akihito Sakoguchi, Adam J. Reid, Hisashi Arase, Michael L. Dustin and Matthew K. Higgins

Structure of the human sodium leak channel NALCN pp. 313-318

Marc Kschonsak, Han Chow Chua, Cameron L. Noland, Claudia Weidling, Thomas Clairfeuille, Oskar Ørts Bahlke, Aishat Oluwanifemi Ameen, Zhong Rong Li, Christopher P. Arthur, Claudio Ciferri, Stephan Alexander Pless and Jian Payandeh

Why comparing yourself to other graduate students is counter-productive pp. 319-320

Julia Nolte

Spare a thought for longitudinal diversity pp. 320-320

Geoff Goodhill

‘I’ve never worked harder’: the race to develop a COVID-19 vaccine pp. 322-322

Chris Woolston

2020, volume 587, articles 7832

Making it in the megacity pp. S1-S5

Sarah O’Meara

Publisher Correction: A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation pp. E1-E1

Shantha K. Mahadevaiah, Mahesh N. Sangrithi, Takayuki Hirota and James M. A. Turner

Young scientists in Malaysia have made integrity training fun and relevant pp. 9-9

Chau De-Ming

New polio vaccine poised to get emergency WHO approval pp. 15-16

Aisling Irwin

Why schools probably aren’t COVID hotspots pp. 17-17

Dyani Lewis

The race to make COVID antibody therapies cheaper and more potent pp. 18-18

Heidi Ledford

How France overcame the odds to build a research mega-campus pp. 19-19

Barbara Casassus

Ancient dog DNA reveals 11,000 years of canine evolution pp. 20-20

Ewen Callaway

Wealthy funder pays reparations for use of HeLa cells pp. 20-21

Alexandra Witze

The next-generation bots interfering with the US election pp. 21-21

Giorgia Guglielmi

Are infections seeding some cases of Alzheimer’s disease? pp. 22-25

Alison Abbott

The false promise of herd immunity for COVID-19 pp. 26-28

Christie Aschwanden

Racism is baked into patent systems pp. 30-31

Shobita Parthasarathy

Timely book tells the CRISPR story so far pp. 31-33

Natalie Kofler

A deep-dive into ignorance, the man behind the Rubik’s Cube, and a controversial theory of life: Books in brief pp. 33-33

Andrew Robinson

James Randi (1928–2020) pp. 34-34

Philip Ball

Redesign open science for Asia, Africa and Latin America pp. 35-37

Sandersan Onie

Cryo-electron microscopy reaches atomic resolution pp. 39-40

Mark A. Herzik

Competition at nuclear extremes explains why neutrons drip off nuclei pp. 40-41

Calvin W. Johnson

Satellites could soon map every tree on Earth pp. 42-43

Niall P. Hanan and Julius Y. Anchang

A fast radio burst in our own Galaxy pp. 43-44

Amanda Weltman and Anthony Walters

The physical mechanisms of fast radio bursts pp. 45-53

Bing Zhang

A fast radio burst associated with a Galactic magnetar pp. 59-62

C. D. Bochenek, V. Ravi, K. V. Belov, G. Hallinan, J. Kocz, S. R. Kulkarni and D. L. McKenna

No pulsed radio emission during a bursting phase of a Galactic magnetar pp. 63-65

L. Lin, C. F. Zhang, P. Wang, H. Gao, X. Guan, J. L. Han, J. C. Jiang, P. Jiang, K. J. Lee, D. Li, Y. P. Men, C. C. Miao, C. H. Niu, J. R. Niu, C. Sun, B. J. Wang, Z. L. Wang, H. Xu, J. L. Xu, J. W. Xu, Y. H. Yang, Y. P. Yang, W. Yu, B. Zhang, B.-B. Zhang, D. J. Zhou, W. W. Zhu, A. J. Castro-Tirado, Z. G. Dai, M. Y. Ge, Y. D. Hu, C. K. Li, Y. Li, Z. Li, E. W. Liang, S. M. Jia, R. Querel, L. Shao, F. Y. Wang, X. G. Wang, X. F. Wu, S. L. Xiong, R. X. Xu, Y.-S. Yang, G. Q. Zhang, S. N. Zhang, T. C. Zheng and J.-H. Zou

The impact of nuclear shape on the emergence of the neutron dripline pp. 66-71

Naofumi Tsunoda, Takaharu Otsuka, Kazuo Takayanagi, Noritaka Shimizu, Toshio Suzuki, Yutaka Utsuno, Sota Yoshida and Hideki Ueno

Logic-in-memory based on an atomically thin semiconductor pp. 72-77

Guilherme Migliato Marega, Yanfei Zhao, Ahmet Avsar, Zhenyu Wang, Mukesh Tripathi, Aleksandra Radenovic and Andras Kis

An unexpectedly large count of trees in the West African Sahara and Sahel pp. 78-82

Martin Brandt, Compton J. Tucker, Ankit Kariryaa, Kjeld Rasmussen, Christin Abel, Jennifer Small, Jerome Chave, Laura Vang Rasmussen, Pierre Hiernaux, Abdoul Aziz Diouf, Laurent Kergoat, Ole Mertz, Christian Igel, Fabian Gieseke, Johannes Schöning, Sizhuo Li, Katherine Melocik, Jesse Meyer, Scott Sinno, Eric Romero, Erin Glennie, Amandine Montagu, Morgane Dendoncker and Rasmus Fensholt

150 million years of sustained increase in pterosaur flight efficiency pp. 83-86

Chris Venditti, Joanna Baker, Michael J. Benton, Andrew Meade and Stuart Humphries

Memory failure predicted by attention lapsing and media multitasking pp. 87-91

Kevin P. Madore, Anna M. Khazenzon, Cameron W. Backes, Jiefeng Jiang, Melina R. Uncapher, Anthony M. Norcia and Anthony D. Wagner

Quinone perception in plants via leucine-rich-repeat receptor-like kinases pp. 92-97

Anuphon Laohavisit, Takanori Wakatake, Nobuaki Ishihama, Hugh Mulvey, Kaori Takizawa, Takamasa Suzuki and Ken Shirasu

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis pp. 98-102

Wenfei Sun, Hua Dong, Miroslav Balaz, Michal Slyper, Eugene Drokhlyansky, Georgia Colleluori, Antonio Giordano, Zuzana Kovanicova, Patrik Stefanicka, Lucia Balazova, Lianggong Ding, Anna Sofie Husted, Gottfried Rudofsky, Jozef Ukropec, Saverio Cinti, Thue W. Schwartz, Aviv Regev and Christian Wolfrum

A single bacterial genus maintains root growth in a complex microbiome pp. 103-108

Omri M. Finkel, Isai Salas-González, Gabriel Castrillo, Jonathan M. Conway, Theresa F. Law, Paulo José Pereira Lima Teixeira, Ellie D. Wilson, Connor R. Fitzpatrick, Corbin D. Jones and Jeffery L. Dangl

Cytoplasmic control of intranuclear polarity by human cytomegalovirus pp. 109-114

Dean J. Procter, Colleen Furey, Arturo G. Garza-Gongora, Steven T. Kosak and Derek Walsh

TGF-β suppresses type 2 immunity to cancer pp. 115-120

Ming Liu, Fengshen Kuo, Kristelle J. Capistrano, Davina Kang, Briana G. Nixon, Wei Shi, Chun Chou, Mytrang H. Do, Efstathios G. Stamatiades, Shengyu Gao, Shun Li, Yingbei Chen, James J. Hsieh, A. Ari Hakimi, Ichiro Taniuchi, Timothy A. Chan and Ming O. Li

Cancer immunotherapy via targeted TGF-β signalling blockade in TH cells pp. 121-125

Shun Li, Ming Liu, Mytrang H. Do, Chun Chou, Efstathios G. Stamatiades, Briana G. Nixon, Wei Shi, Xian Zhang, Peng Li, Shengyu Gao, Kristelle J. Capistrano, Hong Xu, Nai-Kong V. Cheung and Ming O. Li

Pervasive chromosomal instability and karyotype order in tumour evolution pp. 126-132

Thomas B. K. Watkins, Emilia L. Lim, Marina Petkovic, Sergi Elizalde, Nicolai J. Birkbak, Gareth A. Wilson, David A. Moore, Eva Grönroos, Andrew Rowan, Sally M. Dewhurst, Jonas Demeulemeester, Stefan C. Dentro, Stuart Horswell, Lewis Au, Kerstin Haase, Mickael Escudero, Rachel Rosenthal, Maise Al Bakir, Hang Xu, Kevin Litchfield, Wei Ting Lu, Thanos P. Mourikis, Michelle Dietzen, Lavinia Spain, George D. Cresswell, Dhruva Biswas, Philippe Lamy, Iver Nordentoft, Katja Harbst, Francesc Castro-Giner, Lucy R. Yates, Franco Caramia, Fanny Jaulin, Cécile Vicier, Ian P. M. Tomlinson, Priscilla K. Brastianos, Raymond J. Cho, Boris C. Bastian, Lars Dyrskjøt, Göran B. Jönsson, Peter Savas, Sherene Loi, Peter J. Campbell, Fabrice Andre, Nicholas M. Luscombe, Neeltje Steeghs, Vivianne C. G. Tjan-Heijnen, Zoltan Szallasi, Samra Turajlic, Mariam Jamal-Hanjani, Peter Loo, Samuel F. Bakhoum, Roland F. Schwarz, Nicholas McGranahan and Charles Swanton

Modulating TRADD to restore cellular homeostasis and inhibit apoptosis pp. 133-138

Daichao Xu, Heng Zhao, Minzhi Jin, Hong Zhu, Bing Shan, Jiefei Geng, Slawomir A. Dziedzic, Palak Amin, Lauren Mifflin, Masanori Gomi Naito, Ayaz Najafov, Jing Xing, Lingjie Yan, Jianping Liu, Ying Qin, Xinqian Hu, Huibing Wang, Mengmeng Zhang, Vica Jean Manuel, Li Tan, Zhuohao He, Zhenyu J. Sun, Virginia M. Y. Lee, Gerhard Wagner and Junying Yuan

The landscape of RNA Pol II binding reveals a stepwise transition during ZGA pp. 139-144

Bofeng Liu, Qianhua Xu, Qiujun Wang, Su Feng, Fangnong Lai, Peizhe Wang, Fangyuan Zheng, Yunlong Xiang, Jingyi Wu, Junwei Nie, Cui Qiu, Weikun Xia, Lijia Li, Guang Yu, Zili Lin, Kai Xu, Zhuqing Xiong, Feng Kong, Ling Liu, Chunyi Huang, Yang Yu, Jie Na and Wei Xie

A protein assembly mediates Xist localization and gene silencing pp. 145-151

Amy Pandya-Jones, Yolanda Markaki, Jacques Serizay, Tsotne Chitiashvili, Walter R. Mancia Leon, Andrey Damianov, Constantinos Chronis, Bernadett Papp, Chun-Kan Chen, Robin McKee, Xiao-Jun Wang, Anthony Chau, Shan Sabri, Heinrich Leonhardt, Sika Zheng, Mitchell Guttman, Douglas. L. Black and Kathrin Plath

Single-particle cryo-EM at atomic resolution pp. 152-156

Takanori Nakane, Abhay Kotecha, Andrija Sente, Greg McMullan, Simonas Masiulis, Patricia M. G. E. Brown, Ioana T. Grigoras, Lina Malinauskaite, Tomas Malinauskas, Jonas Miehling, Tomasz Uchański, Lingbo Yu, Dimple Karia, Evgeniya V. Pechnikova, Erwin Jong, Jeroen Keizer, Maarten Bischoff, Jamie McCormack, Peter Tiemeijer, Steven W. Hardwick, Dimitri Y. Chirgadze, Garib Murshudov, A. Radu Aricescu and Sjors H. W. Scheres

Atomic-resolution protein structure determination by cryo-EM pp. 157-161

Ka Man Yip, Niels Fischer, Elham Paknia, Ashwin Chari and Holger Stark

Too intelligent for the life sciences in Brazil: how two female researchers fought back pp. 163-164

Luciana Leite and Luisa M. Diele-Viegas

Studying life at the extremes pp. 165-166

Amber Dance

Catching a wave to study coral pp. 168-168

Chris Woolston