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2018, volume 564, articles 7736

Elasticity of lower-mantle bridgmanite pp. E18-E26

Jung-Fu Lin, Zhu Mao, Jing Yang and Suyu Fu

Kurnosov et al. reply pp. E27-E31

A. Kurnosov, H. Marquardt, D. J. Frost, T. Boffa Ballaran and L. Ziberna

Concerns about modelling of the EDGES data pp. E32-E34

Richard Hills, Girish Kulkarni, P. Daniel Meerburg and Ewald Puchwein

Reply to Hills et al pp. E35-E35

Judd D. Bowman, Alan E. E. Rogers, Raul A. Monsalve, Thomas J. Mozdzen and Nivedita Mahesh

Author Correction: Rock fluidization during peak-ring formation of large impact structures pp. E36-E36

Ulrich Riller, Michael H. Poelchau, Auriol S. P. Rae, Felix M. Schulte, Gareth S. Collins, H. Jay Melosh, Richard A. F. Grieve, Joanna V. Morgan, Sean P. S. Gulick, Johanna Lofi, Abdoulaye Diaw, Naoma McCall and David A. Kring

Author Correction: The selective tRNA aminoacylation mechanism based on a single G•U pair pp. E37-E37

Masahiro Naganuma, Shun-ichi Sekine, Yeeting Esther Chong, Min Guo, Xiang-Lei Yang, Howard Gamper, Ya-Ming Hou, Paul Schimmel and Shigeyuki Yokoyama

Publisher Correction: Very-high-energy particle acceleration powered by the jets of the microquasar SS 433 pp. E38-E38

A. U. Abeysekara, A. Albert, R. Alfaro, C. Alvarez, J. D. Álvarez, R. Arceo, J. C. Arteaga-Velázquez, D. Avila Rojas, H. A. Ayala Solares, E. Belmont-Moreno, S. Y. BenZvi, C. Brisbois, K. S. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, M. Castillo, U. Cotti, J. Cotzomi, S. Coutiño de León, C. De León, E. De la Fuente, J. C. Díaz-Vélez, S. Dichiara, B. L. Dingus, M. A. DuVernois, R. W. Ellsworth, K. Engel, C. Espinoza, K. Fang, H. Fleischhack, N. Fraija, A. Galván-Gámez, J. A. García-González, F. Garfias, A. González-Muñoz, M. M. González, J. A. Goodman, Z. Hampel-Arias, J. P. Harding, S. Hernandez, J. Hinton, B. Hona, F. Hueyotl-Zahuantitla, C. M. Hui, P. Hüntemeyer, A. Iriarte, A. Jardin-Blicq, V. Joshi, S. Kaufmann, P. Kar, G. J. Kunde, R. J. Lauer, W. H. Lee, H. León Vargas, H. Li, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, R. López-Coto, K. Malone, S. S. Marinelli, O. Martinez, I. Martinez-Castellanos, J. Martínez-Castro, J. A. Matthews, P. Miranda-Romagnoli, E. Moreno, M. Mostafá, A. Nayerhoda, L. Nellen, M. Newbold, M. U. Nisa, R. Noriega-Papaqui, J. Pretz, E. G. Pérez-Pérez, Z. Ren, C. D. Rho, C. Rivière, D. Rosa-González, M. Rosenberg, E. Ruiz-Velasco, F. Salesa Greus, A. Sandoval, M. Schneider, H. Schoorlemmer, M. Seglar Arroyo, G. Sinnis, A. J. Smith, R. W. Springer, P. Surajbali, I. Taboada, O. Tibolla, K. Tollefson, I. Torres, G. Vianello, L. Villaseñor, T. Weisgarber, F. Werner, S. Westerhoff, J. Wood, T. Yapici, G. Yodh, A. Zepeda, H. Zhang and H. Zhou

Liver cirrhosis: scar wars pp. S73-S73

Liam Drew

Tipping the balance pp. S74-S75

Liam Drew

The 2019 Events Guide pp. S79-S79

Jack Leeming

The future of the scientific conference pp. S80-S82

Emily Sohn

How to give a great scientific talk pp. S84-S85

Nic Fleming

Milestone meetings pp. S86-S87

Virginia Gewin

How conferences are getting better at accommodating child-caring scientists pp. S88-S89

Julie Gould

Make it easier for me to deliver childcare at conferences pp. S89-S89

Eileen Parkes

How I stave off despair as a climate scientist pp. 303-303

Dave Reay

South Korean scientists protest treatment of university president accused of misusing funds pp. 309-310

Mark Zastrow

Italian scientists protest funding for vaccine-safety investigation pp. 310-311

Giorgia Guglielmi

Massive ocean carbon sink spotted burping CO2 on the sly pp. 311-312

Jeff Tollefson

China introduces ‘social’ punishments for scientific misconduct pp. 312-312

David Cyranoski

2018 in news: The science events that shaped the year pp. 314-317

Alison Abbott, Ewen Callaway, Davide Castelvecchi, Holly Else, Elizabeth Gibney, Heidi Ledford, Jane J. Lee, Lauren Morello, Jeff Tollefson and Alexandra Witze

The best science images of the year: 2018 in pictures pp. 318-323

Mico Tatalovic

Nature’s 10: Ten people who mattered in science in 2018 pp. 325-335

Elizabeth Gibney, Ewen Callaway, David Cyranoski, Nisha Gaind, Jeff Tollefson, Rachel Courtland, Yao-Hua Law, Brendan Maher, Holly Else and Davide Castelvecchi

Vaccine candidates for poor nations are going to waste pp. 337-339

David C. Kaslow, Steve Black, David E. Bloom, Mahima Datla, David Salisbury and Rino Rappuoli

Explorers at sea: centuries of science afloat pp. 340-342

Huw Lewis-Jones

CRISPR twins: a condemnation from Chinese academic societies pp. 345-345

Haoyi Wang, Jinsong Li, Wei Li, Caixia Gao and Wensheng Wei

Gene editing: sloppy definitions mislead pp. 345-345

Paul Knoepfler

Up for debate — WHO guidelines on prompt release of outbreak data pp. 345-345

Vasee Moorthy, Peter Salama and Soumya Swaminathan

Biodiversity loss is dire, don’t get distracted pp. 345-345

Jonathan Davies and Peter Stoett

King Faisal international prize a harbinger of Nobel winners? pp. 345-345

Sameen Ahmed Khan

Aaron Klug (1926-2018) pp. 346-346

Kenneth Holmes

Tiny crystals have big potential for determining structures of small molecules pp. 348-349

Alan Brown and Jon Clardy

Brain circuits of compulsive drug addiction identified pp. 349-350

Patricia Janak

Elusive torque sensed by liquid crystals pp. 350-351

Slobodan Žumer

Success for pig-to-baboon heart transplants pp. 352-353

Christoph Knosalla

An abundance of rare isotopes in a planetary nebula pp. 353-354

Amanda Karakas

Amyloid-β ‘seeds’ in old vials of growth hormone pp. 354-355

Tien-Phat V. Huynh and David M. Holtzman

Soft-tissue evidence for homeothermy and crypsis in a Jurassic ichthyosaur pp. 359-365

Johan Lindgren, Peter Sjövall, Volker Thiel, Wenxia Zheng, Shosuke Ito, Kazumasa Wakamatsu, Rolf Hauff, Benjamin P. Kear, Anders Engdahl, Carl Alwmark, Mats E. Eriksson, Martin Jarenmark, Sven Sachs, Per E. Ahlberg, Federica Marone, Takeo Kuriyama, Ola Gustafsson, Per Malmberg, Aurélien Thomen, Irene Rodríguez-Meizoso, Per Uvdal, Makoto Ojika and Mary H. Schweitzer

Stochastic synaptic plasticity underlying compulsion in a model of addiction pp. 366-371

Vincent Pascoli, Agnès Hiver, Ruud Zessen, Michaël Loureiro, Ridouane Achargui, Masaya Harada, Jérôme Flakowski and Christian Lüscher

Structure of native lens connexin 46/50 intercellular channels by cryo-EM pp. 372-377

Janette B. Myers, Bassam G. Haddad, Susan E. O’Neill, Dror S. Chorev, Craig C. Yoshioka, Carol V. Robinson, Daniel M. Zuckerman and Steve L. Reichow

Extreme 13C,15N and 17O isotopic enrichment in the young planetary nebula K4-47 pp. 378-381

D. R. Schmidt, N. J. Woolf, T. J. Zega and L. M. Ziurys

Impact of pear-shaped fission fragments on mass-asymmetric fission in actinides pp. 382-385

Guillaume Scamps and Cédric Simenel

Measurement of the Casimir torque pp. 386-389

David A. T. Somers, Joseph L. Garrett, Kevin J. Palm and Jeremy N. Munday

Electric-field-tuned topological phase transition in ultrathin Na3Bi pp. 390-394

James L. Collins, Anton Tadich, Weikang Wu, Lidia C. Gomes, Joao N. B. Rodrigues, Chang Liu, Jack Hellerstedt, Hyejin Ryu, Shujie Tang, Sung-Kwan Mo, Shaffique Adam, Shengyuan A. Yang, Michael S. Fuhrer and Mark T. Edmonds

Desymmetrization of cyclohexanes by site- and stereoselective C–H functionalization pp. 395-399

Jiantao Fu, Zhi Ren, John Bacsa, Djamaladdin G. Musaev and Huw M. L. Davies

Origin of spatial variation in US East Coast sea-level trends during 1900–2017 pp. 400-404

Christopher G. Piecuch, Peter Huybers, Carling C. Hay, Andrew C. Kemp, Christopher M. Little, Jerry X. Mitrovica, Rui M. Ponte and Martin P. Tingley

Chemical differentiation, cold storage and remobilization of magma in the Earth’s crust pp. 405-409

M. D. Jackson, J. Blundy and R. S. J. Sparks

Hemimastigophora is a novel supra-kingdom-level lineage of eukaryotes pp. 410-414

Gordon Lax, Yana Eglit, Laura Eme, Erin M. Bertrand, Andrew J. Roger and Alastair G. B. Simpson

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone pp. 415-419

Silvia A. Purro, Mark A. Farrow, Jacqueline Linehan, Tamsin Nazari, David X. Thomas, Zhicheng Chen, David Mengel, Takashi Saito, Takaomi Saido, Peter Rudge, Sebastian Brandner, Dominic M. Walsh and John Collinge

Distinct activity-gated pathways mediate attraction and aversion to CO2 in Drosophila pp. 420-424

Floris Breugel, Ainul Huda and Michael H. Dickinson

Complex mammalian-like haematopoietic system found in a colonial chordate pp. 425-429

Benyamin Rosental, Mark Kowarsky, Jun Seita, Daniel M. Corey, Katherine J. Ishizuka, Karla J. Palmeri, Shih-Yu Chen, Rahul Sinha, Jennifer Okamoto, Gary Mantalas, Lucia Manni, Tal Raveh, D. Nathaniel Clarke, Jonathan M. Tsai, Aaron M. Newman, Norma F. Neff, Garry P. Nolan, Stephen R. Quake, Irving L. Weissman and Ayelet Voskoboynik

Consistent success in life-supporting porcine cardiac xenotransplantation pp. 430-433

Matthias Längin, Tanja Mayr, Bruno Reichart, Sebastian Michel, Stefan Buchholz, Sonja Guethoff, Alexey Dashkevich, Andrea Baehr, Stefanie Egerer, Andreas Bauer, Maks Mihalj, Alessandro Panelli, Lara Issl, Jiawei Ying, Ann Kathrin Fresch, Ines Buttgereit, Maren Mokelke, Julia Radan, Fabian Werner, Isabelle Lutzmann, Stig Steen, Trygve Sjöberg, Audrius Paskevicius, Liao Qiuming, Riccardo Sfriso, Robert Rieben, Maik Dahlhoff, Barbara Kessler, Elisabeth Kemter, Mayuko Kurome, Valeri Zakhartchenko, Katharina Klett, Rabea Hinkel, Christian Kupatt, Almuth Falkenau, Simone Reu, Reinhard Ellgass, Rudolf Herzog, Uli Binder, Günter Wich, Arne Skerra, David Ayares, Alexander Kind, Uwe Schönmann, Franz-Josef Kaup, Christian Hagl, Eckhard Wolf, Nikolai Klymiuk, Paolo Brenner and Jan-Michael Abicht

The translation of non-canonical open reading frames controls mucosal immunity pp. 434-438

Ruaidhrí Jackson, Lina Kroehling, Alexandra Khitun, Will Bailis, Abigail Jarret, Autumn G. York, Omair M. Khan, J. Richard Brewer, Mathias H. Skadow, Coco Duizer, Christian C. D. Harman, Lelina Chang, Piotr Bielecki, Angel G. Solis, Holly R. Steach, Sarah Slavoff and Richard A. Flavell

Design of amidobenzimidazole STING receptor agonists with systemic activity pp. 439-443

Joshi M. Ramanjulu, G. Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Shu-Yun Zhang, Jean-Luc Tran, Patrick Moore, Stephanie Lehmann, H. Christian Eberl, Marcel Muelbaier, Jessica L. Schneck, Jim Clemens, Michael Adam, John Mehlmann, Joseph Romano, Angel Morales, James Kang, Lara Leister, Todd L. Graybill, Adam K. Charnley, Guosen Ye, Neysa Nevins, Kamelia Behnia, Amaya I. Wolf, Viera Kasparcova, Kelvin Nurse, Liping Wang, Ana C. Puhl, Yue Li, Michael Klein, Christopher B. Hopson, Jeffrey Guss, Marcus Bantscheff, Giovanna Bergamini, Michael A. Reilly, Yiqian Lian, Kevin J. Duffy, Jerry Adams, Kevin P. Foley, Peter J. Gough, Robert W. Marquis, James Smothers, Axel Hoos and John Bertin

Controlling orthogonal ribosome subunit interactions enables evolution of new function pp. 444-448

Wolfgang H. Schmied, Zakir Tnimov, Chayasith Uttamapinant, Christopher D. Rae, Stephen D. Fried and Jason W. Chin

Seven steps to boost your research career in 2019 pp. 449-450

Chris Woolston

Solstice pp. 462-462

John Gilbey

2018, volume 564, articles 7735

Gene therapy pp. S5-S5

Herb Brody

Prenatal gene therapy offers the earliest possible cure pp. S6-S8

Sarah DeWeerdt

Author Correction: Necroptosis microenvironment directs lineage commitment in liver cancer pp. E9-E9

Marco Seehawer, Florian Heinzmann, Luana D’Artista, Jule Harbig, Pierre-François Roux, Lisa Hoenicke, Hien Dang, Sabrina Klotz, Lucas Robinson, Grégory Doré, Nir Rozenblum, Tae-Won Kang, Rishabh Chawla, Thorsten Buch, Mihael Vucur, Mareike Roth, Johannes Zuber, Tom Luedde, Bence Sipos, Thomas Longerich, Mathias Heikenwälder, Xin Wei Wang, Oliver Bischof and Lars Zender

A genetically augmented future pp. S9-S9

Ellen Wright Clayton

Author Correction: Self-organization of a human organizer by combined Wnt and Nodal signalling pp. E10-E10

I. Martyn, T. Y. Kanno, A. Ruzo, E. D. Siggia and A. H. Brivanlou

Gene therapy targets epilepsy pp. S10-S11

Liam Drew

Author Correction: A global slowdown of tropical-cyclone translation speed pp. E11-E16

James P. Kossin

Gene therapy targets sickle-cell disease pp. S12-S13

Anna Nowogrodzki

Change the genes to fix the skin pp. S14-S15

Kat Arney

The genetic shortcut to antibody drugs pp. S16-S17

Amanda Keener

Publisher Correction: Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing pp. E17-E17

Binbin Lai, Weiwu Gao, Kairong Cui, Wanli Xie, Qingsong Tang, Wenfei Jin, Gangqing Hu, Bing Ni and Keji Zhao

Designer viruses could be the secret to cheaper and better gene therapy pp. S18-S19

Neil Savage

Regulating the gene-therapy revolution pp. S20-S22

Eric Bender

Access and affordability for all pp. S23-S23

Michael Sherman

How Indian biotech is driving innovation pp. S53-S55

Bianca Nogrady

All eyes on the prize pp. S57-S57

Catherine Armitage

Yielding results to feed a people pp. S62-S63

Hepeng Jia

China’s place among the stars pp. S64-S65

Mark Zastrow

Small science grows large in new hands pp. S65-S66

Sarah O’Meara

Engineering a biomedical revolution pp. S66-S68

Smriti Mallapaty

Strong spending compounds chemistry prowess pp. S68-S69

Hepeng Jia

Quality deficit belies the hype pp. S70-S71

Futao Huang

Citations strength begins at home pp. S70-S71

Vincent Larivière, Kaile Gong and Cassidy R. Sugimoto

Students need guidance in languages they speak pp. 163-163

Clarissa Rios Rojas

‘Little Foot’ hominin emerges from stone after millions of years pp. 169-170

Colin Barras

Machine learning helps to hunt down the cause of a paralysing illness pp. 170-171

Sara Reardon

China backs bold plan to tear down journal paywalls pp. 171-172

Quirin Schiermeier

Could the United Kingdom really build its own global satnav system? pp. 172-173

Declan Butler

Cancer researchers seek to harness mysterious DNA ‘super-enhancers’ pp. 173-174

Heidi Ledford

Ebola detectives race to identify hidden sources of infection as outbreak spreads pp. 174-175

Amy Maxmen

How the brain’s face code might unlock the mysteries of perception pp. 176-179

Alison Abbott

The hunt for life below Antarctic ice pp. 180-182

Douglas Fox

Debate ethics of embryo models from stem cells pp. 183-185

Nicolas Rivron, Martin Pera, Janet Rossant, Alfonso Martinez Arias, Magdalena Zernicka-Goetz, Jianping Fu, Susanne van den Brink, Annelien Bredenoord, Wybo Dondorp, Guido de Wert, Insoo Hyun, Megan Munsie and Rosario Isasi

India: a turbulent tale of rivers, floods and monsoons pp. 186-188

Philip Ball

The Wright brothers’ real story, cosmic chronology, and what happened to the megafauna: Books in brief pp. 187-187

Barbara Kiser

Science in hand: how art and craft can boost reproducibility pp. 188-189

Roger Kneebone, Claudia Schlegel and Alan Spivey

Gene editing: who should decide? pp. 190-190

Akira Akabayashi, Eisuke Nakazawa and Arthur L. Caplan

COP24 and SDGs — use same statistics please pp. 190-190

Francesco N. Tubiello

NIH dollars go to too few US states pp. 190-190

Wayne P. Wahls

No place for ‘trial by media’ in bullying allegations pp. 190-190

Grace Collord, Jyoti Nangalia and Luiza Moore

El Niño events will intensify under global warming pp. 192-193

Yoo-Geun Ham

How cells hush a viral invader pp. 193-194

Parinaz Fozouni and Melanie Ott

Adrenaline fuels a cytokine storm during immunotherapy pp. 194-196

Stanley R. RIddell

Darwin’s finches choose parent lookalikes as mates pp. 196-197

Lewis G. Spurgin and Tracey Chapman

An exciting tool for asymmetric synthesis pp. 197-199

Cheng Yang and Yoshihisa Inoue

Bacterial defence molecules target viral DNA pp. 199-200

Martha R. J. Clokie

Increased variability of eastern Pacific El Niño under greenhouse warming pp. 201-206

Wenju Cai, Guojian Wang, Boris Dewitte, Lixin Wu, Agus Santoso, Ken Takahashi, Yun Yang, Aude Carréric and Michael J. McPhaden

Widespread but heterogeneous responses of Andean forests to climate change pp. 207-212

Belén Fadrique, Selene Báez, Álvaro Duque, Agustina Malizia, Cecilia Blundo, Julieta Carilla, Oriana Osinaga-Acosta, Lucio Malizia, Miles Silman, William Farfán-Ríos, Yadvinder Malhi, Kenneth R. Young, Francisco Cuesta C., Jurgen Homeier, Manuel Peralvo, Esteban Pinto, Oswaldo Jadan, Nikolay Aguirre, Zhofre Aguirre and Kenneth J. Feeley

A circuit from hippocampal CA2 to lateral septum disinhibits social aggression pp. 213-218

Felix Leroy, Jung Park, Arun Asok, David H. Brann, Torcato Meira, Lara M. Boyle, Eric W. Buss, Eric R. Kandel and Steven A. Siegelbaum

Single-cell mapping of lineage and identity in direct reprogramming pp. 219-224

Brent A. Biddy, Wenjun Kong, Kenji Kamimoto, Chuner Guo, Sarah E. Waye, Tao Sun and Samantha A. Morris

An entanglement-based wavelength-multiplexed quantum communication network pp. 225-228

Sören Wengerowsky, Siddarth Koduru Joshi, Fabian Steinlechner, Hannes Hübel and Rupert Ursin

Experimental realization of on-chip topological nanoelectromechanical metamaterials pp. 229-233

Jinwoong Cha, Kun Woo Kim and Chiara Daraio

Reversible superdense ordering of lithium between two graphene sheets pp. 234-239

Matthias Kühne, Felix Börrnert, Sven Fecher, Mahdi Ghorbani-Asl, Johannes Biskupek, Dominik Samuelis, Arkady V. Krasheninnikov, Ute Kaiser and Jurgen H. Smet

Catalytic deracemization of chiral allenes by sensitized excitation with visible light pp. 240-243

Alena Hölzl-Hobmeier, Andreas Bauer, Alexandre Vieira Silva, Stefan M. Huber, Christoph Bannwarth and Thorsten Bach

Deconstructive diversification of cyclic amines pp. 244-248

Jose B. Roque, Yusuke Kuroda, Lucas T. Göttemann and Richmond Sarpong

Assessing the efficiency of changes in land use for mitigating climate change pp. 249-253

Timothy D. Searchinger, Stefan Wirsenius, Tim Beringer and Patrice Dumas

Palaeolithic cave art in Borneo pp. 254-257

M. Aubert, P. Setiawan, A. A. Oktaviana, A. Brumm, P. H. Sulistyarto, E. W. Saptomo, B. Istiawan, T. A. Ma’rifat, V. N. Wahyuono, F. T. Atmoko, J.-X. Zhao, J. Huntley, P. S. C. Taçon, D. L. Howard and H. E. A. Brand

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses pp. 258-262

Tara A. LeGates, Mark D. Kvarta, Jessica R. Tooley, T. Chase Francis, Mary Kay Lobo, Meaghan C. Creed and Scott M. Thompson

Trophoblast organoids as a model for maternal–fetal interactions during human placentation pp. 263-267

Margherita Y. Turco, Lucy Gardner, Richard G. Kay, Russell S. Hamilton, Malwina Prater, Michael S. Hollinshead, Alasdair McWhinnie, Laura Esposito, Ridma Fernando, Helen Skelton, Frank Reimann, Fiona M. Gribble, Andrew Sharkey, Steven G. E. Marsh, Stephen O’Rahilly, Myriam Hemberger, Graham J. Burton and Ashley Moffett

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer pp. 268-272

Lei Zhang, Xin Yu, Liangtao Zheng, Yuanyuan Zhang, Yansen Li, Qiao Fang, Ranran Gao, Boxi Kang, Qiming Zhang, Julie Y. Huang, Hiroyasu Konno, Xinyi Guo, Yingjiang Ye, Songyuan Gao, Shan Wang, Xueda Hu, Xianwen Ren, Zhanlong Shen, Wenjun Ouyang and Zemin Zhang

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome pp. 273-277

Verena Staedtke, Ren-Yuan Bai, Kibem Kim, Martin Darvas, Marco L. Davila, Gregory J. Riggins, Paul B. Rothman, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein and Shibin Zhou

NP220 mediates silencing of unintegrated retroviral DNA pp. 278-282

Yiping Zhu, Gary Z. Wang, Oya Cingöz and Stephen P. Goff

A chemical defence against phage infection pp. 283-286

Sarah Kronheim, Martin Daniel-Ivad, Zhuang Duan, Sungwon Hwang, Andrew I. Wong, Ian Mantel, Justin R. Nodwell and Karen L. Maxwell

Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks pp. 287-290

Yang Yu, Nhung Pham, Bo Xia, Alma Papusha, Guangyu Wang, Zhenxin Yan, Guang Peng, Kaifu Chen and Grzegorz Ira

The automatic-design tools that are changing synthetic biology pp. 291-292

Anna Nowogrodzki

The scientists who feed us pp. 293-294

David Payne

Cold heart pp. 296-296

Victoria Dixon

2018, volume 564, articles 7734

Computer logic meets cell biology: how cell science is getting an upgrade pp. S1-S3

Neil Savage

Stiff competition pp. E1-E1

G. W. Milton

Berger et al. reply pp. E2-E4

J. B. Berger, H. N. G. Wadley and R. M. McMeeking

Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes pp. E5-E5

Roshni Roy Chowdhury, Francesco Vallania, Qianting Yang, Cesar Joel Lopez Angel, Fatoumatta Darboe, Adam Penn-Nicholson, Virginie Rozot, Elisa Nemes, Stephanus T. Malherbe, Katharina Ronacher, Gerhard Walzl, Willem Hanekom, Mark M. Davis, Jill Winter, Xinchun Chen, Thomas J. Scriba, Purvesh Khatri and Yueh-hsiu Chien

Author Correction: Cryo-EM of the dynamin polymer assembled on lipid membrane pp. E6-E6

Leopold Kong, Kem A. Sochacki, Huaibin Wang, Shunming Fang, Bertram Canagarajah, Andrew D. Kehr, William J. Rice, Marie-Paule Strub, Justin W. Taraska and Jenny E. Hinshaw

How sure are you of your result? Put a number on it pp. 7-7

Steven N. Goodman

Publisher Correction: Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease pp. E7-E7

Sandro Da Mesquita, Antoine Louveau, Andrea Vaccari, Igor Smirnov, R. Chase Cornelison, Kathryn M. Kingsmore, Christian Contarino, Suna Onengut-Gumuscu, Emily Farber, Daniel Raper, Kenneth E. Viar, Romie D. Powell, Wendy Baker, Nisha Dabhi, Robin Bai, Rui Cao, Song Hu, Stephen S. Rich, Jennifer M. Munson, M. Beatriz Lopes, Christopher C. Overall, Scott T. Acton and Jonathan Kipnis

Publisher Correction: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys pp. E8-E8

Erica N. Borducchi, Jinyan Liu, Joseph P. Nkolola, Anthony M. Cadena, Wen-Han Yu, Stephanie Fischinger, Thomas Broge, Peter Abbink, Noe B. Mercado, Abishek Chandrashekar, David Jetton, Lauren Peter, Katherine McMahan, Edward T. Moseley, Elena Bekerman, Joseph Hesselgesser, Wenjun Li, Mark G. Lewis, Galit Alter, Romas Geleziunas and Dan H. Barouch

CRISPR-baby scientist fails to satisfy critics pp. 13-14

David Cyranoski

China set to launch first-ever spacecraft to the far side of the Moon pp. 15-15

Andrew Silver

Venice anti-flood gates could wreck lagoon ecosystem pp. 16-16

Lou Del Bello

Tehran’s drastic sinking exposed by satellite data pp. 17-18

Kate Ravilious

Geologists are measuring bullet damage to ancient Middle Eastern settlements pp. 18-19

Sarah Wild

These dusty young stars are changing the rules of planet-building pp. 20-23

Rebecca Boyle

The silent epidemic killing more people than HIV, malaria or TB pp. 24-26

Ian Graber-Stiehl

Emissions are still rising: ramp up the cuts pp. 27-30

Christiana Figueres, Corinne Le Quéré, Anand Mahindra, Oliver Bäte, Gail Whiteman, Glen Peters and Dabo Guan

Global warming will happen faster than we think pp. 30-32

Yangyang Xu, Veerabhadran Ramanathan and David G. Victor

Put more carbon in soils to meet Paris climate pledges pp. 32-34

Cornelia Rumpel, Farshad Amiraslani, Lydie-Stella Koutika, Pete Smith, David Whitehead and Eva Wollenberg

Do luxe labs shape science? pp. 36-38

Kendall Powell

Big oil in the dock, the influenza trail, and insects as icons: Books in brief pp. 37-37

Barbara Kiser

Plan S will hit some academic societies hard pp. 39-39

Michael Jennions, Rob Lanfear and Shinichi Nakagawa

Boost university voices at COP24 UN climate meeting pp. 39-39

Samantha Basile, Michael Lerner and Keyon Rostamnezhad

Brazil’s new government threatens food security and biodiversity pp. 39-39

Marina Demaria Venâncio, Kamila Pope and Stefan Sieber

Road charges in real time are not a silver bullet pp. 39-39

Geertje Schuitema and Linda Steg

Helmholtz mentored many Nobelists pp. 39-39

Sameen Ahmed Khan

The rocky road to biomolecules pp. 42-43

John A. Baross

Elusive spin textures discovered pp. 43-44

Seonghoon Woo

Exit route evolved into entry path in plants pp. 45-46

Danny J. Schnell

Long-sought decay of the Higgs boson seen pp. 46-47

Boris Tuchming

Reduced oxygen consumption by fat cells improves metabolic defects pp. 47-48

Nolwenn Joffin and Philipp E. Scherer

Satellite pinpoints ammonia sources globally pp. 49-50

Mark A. Sutton and Clare M. Howard

Location matters for insulin-producing cells pp. 50-51

Francesca M. Spagnoli

Change in future climate due to Antarctic meltwater pp. 53-58

Ben Bronselaer, Michael Winton, Stephen M. Griffies, William J. Hurlin, Keith B. Rodgers, Olga V. Sergienko, Ronald J. Stouffer and Joellen L. Russell

Abiotic synthesis of amino acids in the recesses of the oceanic lithosphere pp. 59-63

Bénédicte Ménez, Céline Pisapia, Muriel Andreani, Frédéric Jamme, Quentin P. Vanbellingen, Alain Brunelle, Laurent Richard, Paul Dumas and Matthieu Réfrégiers

Amphioxus functional genomics and the origins of vertebrate gene regulation pp. 64-70

Ferdinand Marlétaz, Panos N. Firbas, Ignacio Maeso, Juan J. Tena, Ozren Bogdanovic, Malcolm Perry, Christopher D. R. Wyatt, Elisa Calle-Mustienes, Stephanie Bertrand, Demian Burguera, Rafael D. Acemel, Simon J. Heeringen, Silvia Naranjo, Carlos Herrera-Ubeda, Ksenia Skvortsova, Sandra Jimenez-Gancedo, Daniel Aldea, Yamile Marquez, Lorena Buono, Iryna Kozmikova, Jon Permanyer, Alexandra Louis, Beatriz Albuixech-Crespo, Yann Petillon, Anthony Leon, Lucie Subirana, Piotr J. Balwierz, Paul Edward Duckett, Ensieh Farahani, Jean-Marc Aury, Sophie Mangenot, Patrick Wincker, Ricard Albalat, Èlia Benito-Gutiérrez, Cristian Cañestro, Filipe Castro, Salvatore D’Aniello, David E. K. Ferrier, Shengfeng Huang, Vincent Laudet, Gabriel A. B. Marais, Pierre Pontarotti, Michael Schubert, Hervé Seitz, Ildiko Somorjai, Tokiharu Takahashi, Olivier Mirabeau, Anlong Xu, Jr-Kai Yu, Piero Carninci, Juan Ramon Martinez-Morales, Hugues Roest Crollius, Zbynek Kozmik, Matthew T. Weirauch, Jordi Garcia-Fernàndez, Ryan Lister, Boris Lenhard, Peter W. H. Holland, Hector Escriva, Jose Luis Gómez-Skarmeta and Manuel Irimia

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation pp. 71-76

Jueqi Chen and Zhijian J. Chen

Type 9 secretion system structures reveal a new protein transport mechanism pp. 77-82

Frédéric Lauber, Justin C. Deme, Susan M. Lea and Ben C. Berks

Atomic clock performance enabling geodesy below the centimetre level pp. 87-90

W. F. McGrew, X. Zhang, R. J. Fasano, S. A. Schäffer, K. Beloy, D. Nicolodi, R. C. Brown, N. Hinkley, G. Milani, M. Schioppo, T. H. Yoon and A. D. Ludlow

Extreme-ultraviolet refractive optics pp. 91-94

L. Drescher, O. Kornilov, T. Witting, G. Reitsma, N. Monserud, A. Rouzée, J. Mikosch, M. J. J. Vrakking and B. Schütte

Transformation between meron and skyrmion topological spin textures in a chiral magnet pp. 95-98

X. Z. Yu, W. Koshibae, Y. Tokunaga, K. Shibata, Y. Taguchi, N. Nagaosa and Y. Tokura

Industrial and agricultural ammonia point sources exposed pp. 99-103

Martin Van Damme, Lieven Clarisse, Simon Whitburn, Juliette Hadji-Lazaro, Daniel Hurtmans, Cathy Clerbaux and Pierre-François Coheur

Nonlinear rise in Greenland runoff in response to post-industrial Arctic warming pp. 104-108

Luke D. Trusel, Sarah B. Das, Matthew B. Osman, Matthew J. Evans, Ben E. Smith, Xavier Fettweis, Joseph R. McConnell, Brice P. Y. Noël and Michiel R. Broeke

The hippocampus is crucial for forming non-hippocampal long-term memory during sleep pp. 109-113

Anuck Sawangjit, Carlos N. Oyanedel, Niels Niethard, Carolina Salazar, Jan Born and Marion Inostroza

Mechanosignalling via integrins directs fate decisions of pancreatic progenitors pp. 114-118

Anant Mamidi, Christy Prawiro, Philip A. Seymour, Kristian Honnens Lichtenberg, Abigail Jackson, Palle Serup and Henrik Semb

VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche pp. 119-124

Dantong Li, Wenzhi Xue, Mei Li, Mei Dong, Jianwei Wang, Xianda Wang, Xiyue Li, Kai Chen, Wenjuan Zhang, Shuang Wu, Yingqi Zhang, Lei Gao, Yujie Chen, Jianfeng Chen, Bo O. Zhou, Yi Zhou, Xuebiao Yao, Lin Li, Dianqing Wu and Weijun Pan

TIC236 links the outer and inner membrane translocons of the chloroplast pp. 125-129

Yih-Lin Chen, Lih-Jen Chen, Chiung-Chih Chu, Po-Kai Huang, Jie-Ru Wen and Hsou-min Li

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells pp. 130-135

Xiangbo Meng, Xiwei Liu, Xingdong Guo, Shutan Jiang, Tingting Chen, Zhiqiang Hu, Haifeng Liu, Yibing Bai, Manman Xue, Ronggui Hu, Shao-cong Sun, Xiaolong Liu, Penghui Zhou, Xiaowu Huang, Lai Wei, Wei Yang and Chenqi Xu

Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1 pp. 136-140

Yingfeng Li, Zhuqiang Zhang, Jiayu Chen, Wenqiang Liu, Weiyi Lai, Baodong Liu, Xiang Li, Liping Liu, Shaohua Xu, Qiang Dong, Mingzhu Wang, Xiaoya Duan, Jiajun Tan, Yong Zheng, Pumin Zhang, Guoping Fan, Jiemin Wong, Guo-Liang Xu, Zhigao Wang, Hailin Wang, Shaorong Gao and Bing Zhu

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation pp. 141-145

Sara J. Dubbury, Paul L. Boutz and Phillip A. Sharp

Transparent tissues bring cells into focus for microscopy pp. 147-149

Michael Eisenstein

Meet the supervisors who helped to shape four scientists’ careers pp. 151-152

Emily Sohn

A beginner’s guide to space travel and seafood pp. 154-154

Steven Fischer