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2021, volume 596, articles 7873

Sickle-cell disease pp. S1-S1

Herb Brody

Gene therapies close in on a cure for sickle-cell disease pp. S2-S4

Michael Eisenstein

Collect more data from Africa to improve gene therapy pp. S5-S5

Ambroise Wonkam

Screening saves lives, so why don’t governments fund it? pp. S6-S7

Linda Nordling

The sickle-cell drug boon pp. S8-S9

Benjamin Plackett

Unusual width of the superconducting transition in a hydride pp. E9-E10

J. E. Hirsch and F. Marsiglio

Why severe sickle-cell pain has been neglected pp. S10-S12

Bianca Nogrady

Author Correction: Molecular logic of cellular diversification in the mouse cerebral cortex pp. E11-E11

Daniela J. Di Bella, Ehsan Habibi, Robert R. Stickels, Gabriele Scalia, Juliana Brown, Payman Yadollahpour, Sung Min Yang, Catherine Abbate, Tommaso Biancalani, Evan Z. Macosko, Fei Chen, Aviv Regev and Paola Arlotta

Author Correction: Quantum-enhanced nonlinear microscopy pp. E12-E12

Catxere A. Casacio, Lars S. Madsen, Alex Terrasson, Muhammad Waleed, Kai Barnscheidt, Boris Hage, Michael A. Taylor and Warwick P. Bowen

Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer pp. E13-E13

Chao Mao, Xiaoguang Liu, Yilei Zhang, Guang Lei, Yuelong Yan, Hyemin Lee, Pranavi Koppula, Shiqi Wu, Li Zhuang, Bingliang Fang, Masha V. Poyurovsky, Kellen Olszewski and Boyi Gan

No adult left behind: bridge the health-care gap for sickle-cell disease pp. S13-S15

Julian Nowogrodzki

Publisher Correction: Observation of first and second sound in a BKT superfluid pp. E14-E14

Panagiotis Christodoulou, Maciej Gałka, Nishant Dogra, Raphael Lopes, Julian Schmitt and Zoran Hadzibabic

Publisher Correction: A highly magnetized and rapidly rotating white dwarf as small as the Moon pp. E15-E15

Ilaria Caiazzo, Kevin B. Burdge, James Fuller, Jeremy Heyl, S. R. Kulkarni, Thomas A. Prince, Harvey B. Richer, Josiah Schwab, Igor Andreoni, Eric C. Bellm, Andrew Drake, Dmitry A. Duev, Matthew J. Graham, George Helou, Ashish A. Mahabal, Frank J. Masci, Roger Smith and Maayane T. Soumagnac

Why the Middle East is a sickle-cell hotspot pp. S16-S16

Benjamin Plackett

Too many scientists still say Caucasian pp. 463-463

Alice B. Popejoy

African languages to get more bespoke scientific terms pp. 469-470

Sarah Wild

Decades-old SARS virus infection triggers potent response to COVID vaccines pp. 471-472

Smriti Mallapaty

The mutation that helps Delta spread like wildfire pp. 472-473

Ewen Callaway

Brazilian road proposal threatens famed biodiversity hotspot pp. 473-474

Meghie Rodrigues

Iran hopes to defeat COVID with home-grown crop of vaccines pp. 475-475

Smriti Mallapaty

Can artificially altered clouds save the Great Barrier Reef? pp. 476-478

Jeff Tollefson

COVID vaccines and blood clots: what researchers know so far pp. 479-481

Heidi Ledford

Origins of SARS-CoV-2: window is closing for key scientific studies pp. 482-485

Marion Koopmans, Peter Daszak, Vladimir G. Dedkov, Dominic E. Dwyer, Elmoubasher Farag, Thea K. Fischer, David T. S. Hayman, Fabian Leendertz, Ken Maeda, Hung Nguyen-Viet and John Watson

Home laboratory: interactive science from the kitchen pp. 486-486

Poorti Kathpalia, Arpita Konar and Beena Pillai

Five principles for climate-resilient cities pp. 486-486

Christian Albert, Samuel Rufat and Christian Kuhlicke

First authors: is co-equal genuinely equal? pp. 486-486

Jonathan Kipnis

Could Europe become the first climate-neutral continent? pp. 486-486

Nebojsa Nakicenovic and Peter D. Lund

Protein-structure prediction revolutionized pp. 487-488

Mohammed AlQuraishi

African tropical montane forests store more carbon than was thought pp. 488-490

Nicolas Barbier

Single proton cooled by distant ions pp. 490-491

Manas Mukherjee

A persistent look at how tumours evade therapy pp. 491-493

Karen Gomez and Raul Rabadan

A bridge across the democracy–expertise divide pp. 493-494

Mark E. Warren

After the pandemic: perspectives on the future trajectory of COVID-19 pp. 495-504

Amalio Telenti, Ann Arvin, Lawrence Corey, Davide Corti, Michael S. Diamond, Adolfo García-Sastre, Robert F. Garry, Edward C. Holmes, Phillip S. Pang and Herbert W. Virgin

Chromatic periodic activity down to 120 megahertz in a fast radio burst pp. 505-508

Inés Pastor-Marazuela, Liam Connor, Joeri Leeuwen, Yogesh Maan, Sander Veen, Anna Bilous, Leon Oostrum, Emily Petroff, Samayra Straal, Dany Vohl, Jisk Attema, Oliver M. Boersma, Eric Kooistra, Daniel Schuur, Alessio Sclocco, Roy Smits, Elizabeth A. K. Adams, Björn Adebahr, W. J. G. Blok, Arthur H. W. M. Coolen, Sieds Damstra, Helga Dénes, Kelley M. Hess, Thijs Hulst, Boudewijn Hut, V. Marianna Ivashina, Alexander Kutkin, G. Marcel Loose, Danielle M. Lucero, Ágnes Mika, Vanessa A. Moss, Henk Mulder, Menno J. Norden, Tom Oosterloo, Emanuela Orrú, Mark Ruiter and Stefan J. Wijnholds

Universal pair polaritons in a strongly interacting Fermi gas pp. 509-513

Hideki Konishi, Kevin Roux, Victor Helson and Jean-Philippe Brantut

Sympathetic cooling of a trapped proton mediated by an LC circuit pp. 514-518

M. Bohman, V. Grunhofer, C. Smorra, M. Wiesinger, C. Will, M. J. Borchert, J. A. Devlin, S. Erlewein, M. Fleck, S. Gavranovic, J. Harrington, B. Latacz, A. Mooser, D. Popper, E. Wursten, K. Blaum, Y. Matsuda, C. Ospelkaus, W. Quint, J. Walz and S. Ulmer

Single-crystal, large-area, fold-free monolayer graphene pp. 519-524

Meihui Wang, Ming Huang, Da Luo, Yunqing Li, Myeonggi Choe, Won Kyung Seong, Minhyeok Kim, Sunghwan Jin, Mengran Wang, Shahana Chatterjee, Youngwoo Kwon, Zonghoon Lee and Rodney S. Ruoff

Rechargeable Na/Cl2 and Li/Cl2 batteries pp. 525-530

Guanzhou Zhu, Xin Tian, Hung-Chun Tai, Yuan-Yao Li, Jiachen Li, Hao Sun, Peng Liang, Michael Angell, Cheng-Liang Huang, Ching-Shun Ku, Wei-Hsuan Hung, Shi-Kai Jiang, Yongtao Meng, Hui Chen, Meng-Chang Lin, Bing-Joe Hwang and Hongjie Dai

Direct observation of ultrafast hydrogen bond strengthening in liquid water pp. 531-535

Jie Yang, Riccardo Dettori, J. Pedro F. Nunes, Nanna H. List, Elisa Biasin, Martin Centurion, Zhijiang Chen, Amy A. Cordones, Daniel P. Deponte, Tony F. Heinz, Michael E. Kozina, Kathryn Ledbetter, Ming-Fu Lin, Aaron M. Lindenberg, Mianzhen Mo, Anders Nilsson, Xiaozhe Shen, Thomas J. A. Wolf, Davide Donadio, Kelly J. Gaffney, Todd J. Martinez and Xijie Wang

High aboveground carbon stock of African tropical montane forests pp. 536-542

Aida Cuni-Sanchez, Martin J. P. Sullivan, Philip J. Platts, Simon L. Lewis, Rob Marchant, Gérard Imani, Wannes Hubau, Iveren Abiem, Hari Adhikari, Tomas Albrecht, Jan Altman, Christian Amani, Abreham B. Aneseyee, Valerio Avitabile, Lindsay Banin, Rodrigue Batumike, Marijn Bauters, Hans Beeckman, Serge K. Begne, Amy C. Bennett, Robert Bitariho, Pascal Boeckx, Jan Bogaert, Achim Bräuning, Franklin Bulonvu, Neil D. Burgess, Kim Calders, Colin Chapman, Hazel Chapman, James Comiskey, Thales Haulleville, Mathieu Decuyper, Ben DeVries, Jiri Dolezal, Vincent Droissart, Corneille Ewango, Senbeta Feyera, Aster Gebrekirstos, Roy Gereau, Martin Gilpin, Dismas Hakizimana, Jefferson Hall, Alan Hamilton, Olivier Hardy, Terese Hart, Janne Heiskanen, Andreas Hemp, Martin Herold, Ulrike Hiltner, David Horak, Marie-Noel Kamdem, Charles Kayijamahe, David Kenfack, Mwangi J. Kinyanjui, Julia Klein, Janvier Lisingo, Jon Lovett, Mark Lung, Jean-Remy Makana, Yadvinder Malhi, Andrew Marshall, Emanuel H. Martin, Edward T. A. Mitchard, Alexandra Morel, John T. Mukendi, Tom Muller, Felix Nchu, Brigitte Nyirambangutse, Joseph Okello, Kelvin S.-H. Peh, Petri Pellikka, Oliver L. Phillips, Andrew Plumptre, Lan Qie, Francesco Rovero, Moses N. Sainge, Christine B. Schmitt, Ondrej Sedlacek, Alain S. K. Ngute, Douglas Sheil, Demisse Sheleme, Tibebu Y. Simegn, Murielle Simo-Droissart, Bonaventure Sonké, Teshome Soromessa, Terry Sunderland, Miroslav Svoboda, Hermann Taedoumg, James Taplin, David Taylor, Sean C. Thomas, Jonathan Timberlake, Darlington Tuagben, Peter Umunay, Eustrate Uzabaho, Hans Verbeeck, Jason Vleminckx, Göran Wallin, Charlotte Wheeler, Simon Willcock, John T. Woods and Etienne Zibera

Genome of a middle Holocene hunter-gatherer from Wallacea pp. 543-547

Selina Carlhoff, Akin Duli, Kathrin Nägele, Muhammad Nur, Laurits Skov, Iwan Sumantri, Adhi Agus Oktaviana, Budianto Hakim, Basran Burhan, Fardi Ali Syahdar, David P. McGahan, David Bulbeck, Yinika L. Perston, Kim Newman, Andi Muhammad Saiful, Marlon Ririmasse, Stephen Chia, Hasanuddin, Dwia Aries Tina Pulubuhu, Suryatman, Supriadi, Choongwon Jeong, Benjamin M. Peter, Kay Prüfer, Adam Powell, Johannes Krause, Cosimo Posth and Adam Brumm

Fair algorithms for selecting citizens’ assemblies pp. 548-552

Bailey Flanigan, Paul Gölz, Anupam Gupta, Brett Hennig and Ariel D. Procaccia

Oxytocin neurons enable social transmission of maternal behaviour pp. 553-557

Ioana Carcea, Naomi López Caraballo, Bianca J. Marlin, Rumi Ooyama, Justin S. Riceberg, Joyce M. Mendoza Navarro, Maya Opendak, Veronica E. Diaz, Luisa Schuster, Maria I. Alvarado Torres, Harper Lethin, Daniel Ramos, Jessica Minder, Sebastian L. Mendoza, Chloe J. Bair-Marshall, Grace H. Samadjopoulos, Shizu Hidema, Annegret Falkner, Dayu Lin, Adam Mar, Youssef Z. Wadghiri, Katsuhiko Nishimori, Takefumi Kikusui, Kazutaka Mogi, Regina M. Sullivan and Robert C. Froemke

Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis pp. 558-564

Ranen Aviner, Kathy H. Li, Judith Frydman and Raul Andino

Antibody epitopes in vaccine-induced immune thrombotic thrombocytopaenia pp. 565-569

Angela Huynh, John G. Kelton, Donald M. Arnold, Mercy Daka and Ishac Nazy

Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C pp. 570-575

Ting-Ting Chu, Xintao Tu, Kun Yang, Jianjun Wu, Joyce J. Repa and Nan Yan

Cycling cancer persister cells arise from lineages with distinct programs pp. 576-582

Yaara Oren, Michael Tsabar, Michael S. Cuoco, Liat Amir-Zilberstein, Heidie F. Cabanos, Jan-Christian Hütter, Bomiao Hu, Pratiksha I. Thakore, Marcin Tabaka, Charles P. Fulco, William Colgan, Brandon M. Cuevas, Sara A. Hurvitz, Dennis J. Slamon, Amy Deik, Kerry A. Pierce, Clary Clish, Aaron N. Hata, Elma Zaganjor, Galit Lahav, Katerina Politi, Joan S. Brugge and Aviv Regev

Highly accurate protein structure prediction with AlphaFold pp. 583-589

John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A. A. Kohl, Andrew J. Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W. Senior, Koray Kavukcuoglu, Pushmeet Kohli and Demis Hassabis

Highly accurate protein structure prediction for the human proteome pp. 590-596

Kathryn Tunyasuvunakool, Jonas Adler, Zachary Wu, Tim Green, Michal Zielinski, Augustin Žídek, Alex Bridgland, Andrew Cowie, Clemens Meyer, Agata Laydon, Sameer Velankar, Gerard J. Kleywegt, Alex Bateman, Richard Evans, Alexander Pritzel, Michael Figurnov, Olaf Ronneberger, Russ Bates, Simon A. A. Kohl, Anna Potapenko, Andrew J. Ballard, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Ellen Clancy, David Reiman, Stig Petersen, Andrew W. Senior, Koray Kavukcuoglu, Ewan Birney, Pushmeet Kohli, John Jumper and Demis Hassabis

Molecular basis for DarT ADP-ribosylation of a DNA base pp. 597-602

Marion Schuller, Rachel E. Butler, Antonio Ariza, Callum Tromans-Coia, Gytis Jankevicius, Tim D. W. Claridge, Sharon L. Kendall, Shan Goh, Graham R. Stewart and Ivan Ahel

Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution pp. 603-607

Zhaoming Su, Kaiming Zhang, Kalli Kappel, Shanshan Li, Michael Z. Palo, Grigore D. Pintilie, Ramya Rangan, Bingnan Luo, Yuquan Wei, Rhiju Das and Wah Chiu

Three questions to address rigour and reproducibility concerns in your grant proposal pp. 609-610

Jennifer L. Wilson and Crystal M. Botham

Innovative tools take aim at antibiotic-resistant microbes pp. 611-613

Jyoti Madhusoodanan

Making sense of quantum-level chaos pp. 616-616

Amber Dance

2021, volume 596, articles 7872

Author Correction: Climate-driven flyway changes and memory-based long-distance migration pp. E4-E4

Zhongru Gu, Shengkai Pan, Zhenzhen Lin, Li Hu, Xiaoyang Dai, Jiang Chang, Yuanchao Xue, Han Su, Juan Long, Mengru Sun, Sergey Ganusevich, Vasiliy Sokolov, Aleksandr Sokolov, Ivan Pokrovsky, Fen Ji, Michael W. Bruford, Andrew Dixon and Xiangjiang Zhan

Author Correction: Blastocyst-like structures generated from human pluripotent stem cells pp. E5-E5

Leqian Yu, Yulei Wei, Jialei Duan, Daniel A. Schmitz, Masahiro Sakurai, Lei Wang, Kunhua Wang, Shuhua Zhao, Gary C. Hon and Jun Wu

Author Correction: Quantum distance and anomalous Landau levels of flat bands pp. E6-E6

Jun-Won Rhim, Kyoo Kim and Bohm-Jung Yang

Author Correction: Summertime increases in upper-ocean stratification and mixed-layer depth pp. E7-E7

Jean-Baptiste Sallée, Violaine Pellichero, Camille Akhoudas, Etienne Pauthenet, Lucie Vignes, Sunke Schmidtko, Alberto Naveira Garabato, Peter Sutherland and Mikael Kuusela

Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19 pp. E8-E8

Alexis J. Combes, Tristan Courau, Nicholas F. Kuhn, Kenneth H. Hu, Arja Ray, William S. Chen, Nayvin W. Chew, Simon J. Cleary, Divyashree Kushnoor, Gabriella C. Reeder, Alan Shen, Jessica Tsui, Kamir J. Hiam-Galvez, Priscila Muñoz-Sandoval, Wandi S. Zhu, David S. Lee, Yang Sun, Ran You, Mélia Magnen, Lauren Rodriguez, K. W. Im, Nina K. Serwas, Aleksandra Leligdowicz, Colin R. Zamecnik, Rita P. Loudermilk, Michael R. Wilson, Chun J. Ye, Gabriela K. Fragiadakis, Mark R. Looney, Vincent Chan, Alyssa Ward, Sidney Carrillo, Michael Matthay, David J. Erle, Prescott G. Woodruff, Charles Langelier, Kirsten Kangelaris, Carolyn M. Hendrickson, Carolyn Calfee, Arjun Arkal Rao and Matthew F. Krummel

Great Barrier Reef: accept ‘in danger’ status, there’s more to gain than lose pp. 319-319

Tiffany H. Morrison

Delta threatens rural regions that dodged earlier COVID waves pp. 325-326

Smriti Mallapaty

How do vaccinated people spread Delta? What the science says pp. 327-328

Nidhi Subbaraman

‘Tortured phrases’ give away fabricated research papers pp. 328-329

Holly Else

Mammoth’s epic travels preserved in tusk pp. 329-329

Ariana Remmel

Exotic four-quark particle spotted at Large Hadron Collider pp. 330-330

Davide Castelvecchi

Chelsea Clinton urges global sharing of COVID vaccine technology pp. 331-331

Amy Maxmen

Has COVID taught us anything about pandemic preparedness? pp. 332-335

Amy Maxmen

Electric cars and batteries: how will the world produce enough? pp. 336-339

Davide Castelvecchi

Can start-ups fast-track fusion energy? pp. 341-342

Melanie Windridge

Amazing ants, brain maps, and mammals before the dinosaurs: Books in brief pp. 342-342

Andrew Robinson

Track disability in COVID-19 statistics pp. 343-343

Fei Qi

Bespoke open databases would be cheaper and easier to analyse pp. 343-343

Nikolaus Obwegeser, Henrik M. Rønnow and Tomoko Yokoi

Richly resourced researchers: work with developing-world scientists pp. 343-343

Brady Lund and Amrollah Shamsi

Use photos of Black doctors and patients to heal not hurt pp. 343-343

Paula Littlejohn

Genomic analysis identifies variants that can predict the timing of menopause pp. 345-346

Krina T. Zondervan

‘Polluter pays’ policy could speed up emission reductions and removal of atmospheric CO2 pp. 346-347

David A. Stainforth

Supersolids go two-dimensional pp. 348-349

Bruno Laburthe-Tolra

Deranged chromatin drives uterine fibroid tumours pp. 349-351

Zehra Ordulu

A cocktail of pesticides, parasites and hunger leaves bees down and out pp. 351-352

Adam J. Vanbergen

Lenghu on the Tibetan Plateau as an astronomical observing site pp. 353-356

Licai Deng, Fan Yang, Xiaodian Chen, Fei He, Qili Liu, Bo Zhang, Chunguang Zhang, Kun Wang, Nian Liu, Anbing Ren, Zhiquan Luo, Zhengzhou Yan, Jianfeng Tian and Jun Pan

Two-dimensional supersolidity in a dipolar quantum gas pp. 357-361

Matthew A. Norcia, Claudia Politi, Lauritz Klaus, Elena Poli, Maximilian Sohmen, Manfred J. Mark, Russell N. Bisset, Luis Santos and Francesca Ferlaino

Ghost hyperbolic surface polaritons in bulk anisotropic crystals pp. 362-366

Weiliang Ma, Guangwei Hu, Debo Hu, Runkun Chen, Tian Sun, Xinliang Zhang, Qing Dai, Ying Zeng, Andrea Alù, Cheng-Wei Qiu and Peining Li

How to design an icosahedral quasicrystal through directional bonding pp. 367-371

Eva G. Noya, Chak Kui Wong, Pablo Llombart and Jonathan P. K. Doye

Mobility gradients yield rubbery surfaces on top of polymer glasses pp. 372-376

Zhiwei Hao, Asieh Ghanekarade, Ningtao Zhu, Katelyn Randazzo, Daisuke Kawaguchi, Keiji Tanaka, Xinping Wang, David S. Simmons, Rodney D. Priestley and Biao Zuo

Operationalizing the net-negative carbon economy pp. 377-383

Johannes Bednar, Michael Obersteiner, Artem Baklanov, Marcus Thomson, Fabian Wagner, Oliver Geden, Myles Allen and Jim W. Hall

The Montreal Protocol protects the terrestrial carbon sink pp. 384-388

Paul J. Young, Anna B. Harper, Chris Huntingford, Nigel D. Paul, Olaf Morgenstern, Paul A. Newman, Luke D. Oman, Sasha Madronich and Rolando R. Garcia

Agrochemicals interact synergistically to increase bee mortality pp. 389-392

Harry Siviter, Emily J. Bailes, Callum D. Martin, Thomas R. Oliver, Julia Koricheva, Ellouise Leadbeater and Mark J. F. Brown

Genetic insights into biological mechanisms governing human ovarian ageing pp. 393-397

Katherine S. Ruth, Felix R. Day, Jazib Hussain, Ana Martínez-Marchal, Catherine E. Aiken, Ajuna Azad, Deborah J. Thompson, Lucie Knoblochova, Hironori Abe, Jane L. Tarry-Adkins, Javier Martin Gonzalez, Pierre Fontanillas, Annique Claringbould, Olivier B. Bakker, Patrick Sulem, Robin G. Walters, Chikashi Terao, Sandra Turon, Momoko Horikoshi, Kuang Lin, N. Charlotte Onland-Moret, Aditya Sankar, Emil Peter Thrane Hertz, Pascal N. Timshel, Vallari Shukla, Rehannah Borup, Kristina W. Olsen, Paula Aguilera, Mònica Ferrer-Roda, Yan Huang, Stasa Stankovic, Paul R. H. J. Timmers, Thomas U. Ahearn, Behrooz Z. Alizadeh, Elnaz Naderi, Irene L. Andrulis, Alice M. Arnold, Kristan J. Aronson, Annelie Augustinsson, Stefania Bandinelli, Caterina M. Barbieri, Robin N. Beaumont, Heiko Becher, Matthias W. Beckmann, Stefania Benonisdottir, Sven Bergmann, Murielle Bochud, Eric Boerwinkle, Stig E. Bojesen, Manjeet K. Bolla, Dorret I. Boomsma, Nicholas Bowker, Jennifer A. Brody, Linda Broer, Julie E. Buring, Archie Campbell, Harry Campbell, Jose E. Castelao, Eulalia Catamo, Stephen J. Chanock, Georgia Chenevix-Trench, Marina Ciullo, Tanguy Corre, Fergus J. Couch, Angela Cox, Laura Crisponi, Simon S. Cross, Francesco Cucca, Kamila Czene, George Davey Smith, Eco J. C. N. Geus, Renée Mutsert, Immaculata Vivo, Ellen W. Demerath, Joe Dennis, Alison M. Dunning, Miriam Dwek, Mikael Eriksson, Tõnu Esko, Peter A. Fasching, Jessica D. Faul, Luigi Ferrucci, Nora Franceschini, Timothy M. Frayling, Manuela Gago-Dominguez, Massimo Mezzavilla, Montserrat García-Closas, Christian Gieger, Graham G. Giles, Harald Grallert, Daniel F. Gudbjartsson, Vilmundur Gudnason, Pascal Guénel, Christopher A. Haiman, Niclas Håkansson, Per Hall, Caroline Hayward, Chunyan He, Wei He, Gerardo Heiss, Miya K. Høffding, John L. Hopper, Jouke J. Hottenga, Frank Hu, David Hunter, Mohammad A. Ikram, Rebecca D. Jackson, Micaella D. R. Joaquim, Esther M. John, Peter K. Joshi, David Karasik, Sharon L. R. Kardia, Christiana Kartsonaki, Robert Karlsson, Cari M. Kitahara, Ivana Kolcic, Charles Kooperberg, Peter Kraft, Allison W. Kurian, Zoltan Kutalik, Martina Bianca, Genevieve LaChance, Claudia Langenberg, Lenore J. Launer, Joop S. E. Laven, Deborah A. Lawlor, Loic Marchand, Jingmei Li, Annika Lindblom, Sara Lindstrom, Tricia Lindstrom, Martha Linet, YongMei Liu, Simin Liu, Jian’an Luan, Reedik Mägi, Patrik K. E. Magnusson, Massimo Mangino, Arto Mannermaa, Brumat Marco, Jonathan Marten, Nicholas G. Martin, Hamdi Mbarek, Barbara McKnight, Sarah E. Medland, Christa Meisinger, Thomas Meitinger, Cristina Menni, Andres Metspalu, Lili Milani, Roger L. Milne, Grant W. Montgomery, Dennis O. Mook-Kanamori, Antonella Mulas, Anna M. Mulligan, Alison Murray, Mike A. Nalls, Anne Newman, Raymond Noordam, Teresa Nutile, Dale R. Nyholt, Andrew F. Olshan, Håkan Olsson, Jodie N. Painter, Alpa V. Patel, Nancy L. Pedersen, Natalia Perjakova, Annette Peters, Ulrike Peters, Paul D. P. Pharoah, Ozren Polasek, Eleonora Porcu, Bruce M. Psaty, Iffat Rahman, Gad Rennert, Hedy S. Rennert, Paul M. Ridker, Susan M. Ring, Antonietta Robino, Lynda M. Rose, Frits R. Rosendaal, Jacques Rossouw, Igor Rudan, Rico Rueedi, Daniela Ruggiero, Cinzia F. Sala, Emmanouil Saloustros, Dale P. Sandler, Serena Sanna, Elinor J. Sawyer, Chloé Sarnowski, David Schlessinger, Marjanka K. Schmidt, Minouk J. Schoemaker, Katharina E. Schraut, Christopher Scott, Saleh Shekari, Amruta Shrikhande, Albert V. Smith, Blair H. Smith, Jennifer A. Smith, Rossella Sorice, Melissa C. Southey, Tim D. Spector, John J. Spinelli, Meir Stampfer, Doris Stöckl, Joyce B. J. Meurs, Konstantin Strauch, Unnur Styrkarsdottir, Anthony J. Swerdlow, Toshiko Tanaka, Lauren R. Teras, Alexander Teumer, Unnur Þorsteinsdottir, Nicholas J. Timpson, Daniela Toniolo, Michela Traglia, Melissa A. Troester, Thérèse Truong, Jessica Tyrrell, André G. Uitterlinden, Sheila Ulivi, Celine M. Vachon, Veronique Vitart, Uwe Völker, Peter Vollenweider, Henry Völzke, Qin Wang, Nicholas J. Wareham, Clarice R. Weinberg, David R. Weir, Amber N. Wilcox, Ko Willems Dijk, Gonneke Willemsen, James F. Wilson, Bruce H. R. Wolffenbuttel, Alicja Wolk, Andrew R. Wood, Wei Zhao, Marek Zygmunt, Zhengming Chen, Liming Li, Lude Franke, Stephen Burgess, Patrick Deelen, Tune H. Pers, Marie Louise Grøndahl, Claus Yding Andersen, Anna Pujol, Andres J. Lopez-Contreras, Jeremy A. Daniel, Kari Stefansson, Jenny Chang-Claude, Yvonne T. van der Schouw, Kathryn L. Lunetta, Daniel I. Chasman, Douglas F. Easton, Jenny A. Visser, Susan E. Ozanne, Satoshi H. Namekawa, Petr Solc, Joanne M. Murabito, Ken K. Ong, Eva R. Hoffmann, Anna Murray, Ignasi Roig and John R. B. Perry

Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma pp. 398-403

Davide G. Berta, Heli Kuisma, Niko Välimäki, Maritta Räisänen, Maija Jäntti, Annukka Pasanen, Auli Karhu, Jaana Kaukomaa, Aurora Taira, Tatiana Cajuso, Sanna Nieminen, Rosa-Maria Penttinen, Saija Ahonen, Rainer Lehtonen, Miika Mehine, Pia Vahteristo, Jyrki Jalkanen, Biswajyoti Sahu, Janne Ravantti, Netta Mäkinen, Kristiina Rajamäki, Kimmo Palin, Jussi Taipale, Oskari Heikinheimo, Ralf Bützow, Eevi Kaasinen and Lauri A. Aaltonen

Locally ordered representation of 3D space in the entorhinal cortex pp. 404-409

Gily Ginosar, Johnatan Aljadeff, Yoram Burak, Haim Sompolinsky, Liora Las and Nachum Ulanovsky

Systems vaccinology of the BNT162b2 mRNA vaccine in humans pp. 410-416

Prabhu S. Arunachalam, Madeleine K. D. Scott, Thomas Hagan, Chunfeng Li, Yupeng Feng, Florian Wimmers, Lilit Grigoryan, Meera Trisal, Venkata Viswanadh Edara, Lilin Lai, Sarah Esther Chang, Allan Feng, Shaurya Dhingra, Mihir Shah, Alexandra S. Lee, Sharon Chinthrajah, Sayantani B. Sindher, Vamsee Mallajosyula, Fei Gao, Natalia Sigal, Sangeeta Kowli, Sheena Gupta, Kathryn Pellegrini, Gregory Tharp, Sofia Maysel-Auslender, Sydney Hamilton, Hadj Aoued, Kevin Hrusovsky, Mark Roskey, Steven E. Bosinger, Holden T. Maecker, Scott D. Boyd, Mark M. Davis, Paul J. Utz, Mehul S. Suthar, Purvesh Khatri, Kari C. Nadeau and Bali Pulendran

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2 pp. 417-422

Dami A. Collier, Isabella A. T. M. Ferreira, Prasanti Kotagiri, Rawlings P. Datir, Eleanor Y. Lim, Emma Touizer, Bo Meng, Adam Abdullahi, Anne Elmer, Nathalie Kingston, Barbara Graves, Emma Gresley, Daniela Caputo, Laura Bergamaschi, Kenneth G. C. Smith, John R. Bradley, Lourdes Ceron-Gutierrez, Paulina Cortes-Acevedo, Gabriela Barcenas-Morales, Michelle A. Linterman, Laura E. McCoy, Chris Davis, Emma Thomson, Paul A. Lyons, Eoin McKinney, Rainer Doffinger, Mark Wills and Ravindra K. Gupta

Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques pp. 423-427

Jingyou Yu, Lisa H. Tostanoski, Noe B. Mercado, Katherine McMahan, Jinyan Liu, Catherine Jacob-Dolan, Abishek Chandrashekar, Caroline Atyeo, David R. Martinez, Tochi Anioke, Esther A. Bondzie, Aiquan Chang, Sarah Gardner, Victoria M. Giffin, David L. Hope, Felix Nampanya, Joseph Nkolola, Shivani Patel, Owen Sanborn, Daniel Sellers, Huahua Wan, Tammy Hayes, Katherine Bauer, Laurent Pessaint, Daniel Valentin, Zack Flinchbaugh, Renita Brown, Anthony Cook, Deandre Bueno-Wilkerson, Elyse Teow, Hanne Andersen, Mark G. Lewis, Amanda J. Martinot, Ralph S. Baric, Galit Alter, Frank Wegmann, Roland Zahn, Hanneke Schuitemaker and Dan H. Barouch

In silico saturation mutagenesis of cancer genes pp. 428-432

Ferran Muiños, Francisco Martínez-Jiménez, Oriol Pich, Abel Gonzalez-Perez and Nuria Lopez-Bigas

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination pp. 433-437

Jordan R. Becker, Gillian Clifford, Clara Bonnet, Anja Groth, Marcus D. Wilson and J. Ross Chapman

Mechanisms of BRCA1–BARD1 nucleosome recognition and ubiquitylation pp. 438-443

Qi Hu, Maria Victoria Botuyan, Debiao Zhao, Gaofeng Cui, Elie Mer and Georges Mer

Structure and mechanism of blood–brain-barrier lipid transporter MFSD2A pp. 444-448

Chase A. P. Wood, Jinru Zhang, Deniz Aydin, Yan Xu, Benjamin J. Andreone, Urs H. Langen, Ron O. Dror, Chenghua Gu and Liang Feng

The hashtags that brought Black scientists together pp. 449-452

Virginia Gewin

Exploring ‘the most spooky, weird kind of science’ pp. 454-454

Josie Glausiusz

2021, volume 596, articles 7871

Phantom epistasis between unlinked loci pp. E1-E3

Gibran Hemani, Joseph E. Powell, Huanwei Wang, Konstantin Shakhbazov, Harm-Jan Westra, Tonu Esko, Anjali K. Henders, Allan F. McRae, Nicholas G. Martin, Andres Metspalu, Lude Franke, Grant W. Montgomery, Michael E. Goddard, Greg Gibson, Jian Yang and Peter M. Visscher

Talking to science deniers and sceptics is not hopeless pp. 165-165

Lee McIntyre

IPCC climate report: Earth is warmer than it’s been in 125,000 years pp. 171-172

Jeff Tollefson

Flawed ivermectin preprint highlights challenges of COVID drug studies pp. 173-174

Sara Reardon

After Trump, US researchers urge Biden to block political meddling in science pp. 174-175

Nidhi Subbaraman

Surprise dip in UK COVID cases baffles researchers pp. 175-176

Philip Ball

More women than ever are starting careers in science pp. 177-177

Katharine Sanderson

COVID vaccine boosters: the most important questions pp. 178-180

Ewen Callaway

Think outside the brain box pp. 181-182

Alison Abbott

Pain in the brain, climate racism, and quantum cusp: Books in brief pp. 182-182

Andrew Robinson

Steven Weinberg (1933–2021) pp. 183-183

Frank Wilczek

Use HIV’s lessons to help children orphaned by COVID-19 pp. 185-188

Rachel Kidman

Call to update US re-entry rules for international researchers pp. 189-189

Alice Braga, Valerio Francioni, Valeria Barra, Carmen Falcone and Gabrielle String

What costs half a year’s pay for African scholars? Open access pp. 189-189

Addisu Mekonnen, Colleen Downs, Edu O. Effiom, Onja Razafindratsima, Nils Chr. Stenseth and Colin A. Chapman

After malaria: which parasitic disease will China eliminate next? pp. 189-189

Men-Bao Qian, Shi-Zhu Li and Xiao-Nong Zhou

Iran: drought must top new government’s agenda pp. 189-189

Jamshid Parchizadeh and Jerrold L. Belant

Protein pile-up plays havoc in ageing nematode worms pp. 191-192

Bart P. Braeckman

How the amino acid leucine activates the key cell-growth regulator mTOR pp. 192-194

Tibor Vellai

A microscopy technique that images single reaction events in total darkness pp. 194-195

Frédéric Kanoufi and Neso Sojic

Chain-mail fabric stiffens under confining pressure pp. 196-197

Laurent Orgéas

Deep continental roots and cratons pp. 199-210

D. Graham Pearson, James M. Scott, Jingao Liu, Andrew Schaeffer, Lawrence Hongliang Wang, Jeroen Hunen, Kristoffer Szilas, Thomas Chacko and Peter B. Kelemen

Exploring tissue architecture using spatial transcriptomics pp. 211-220

Anjali Rao, Dalia Barkley, Gustavo S. França and Itai Yanai

Demonstration of reduced neoclassical energy transport in Wendelstein 7-X pp. 221-226

C. D. Beidler, H. M. Smith, A. Alonso, T. Andreeva, J. Baldzuhn, M. N. A. Beurskens, M. Borchardt, S. A. Bozhenkov, K. J. Brunner, H. Damm, M. Drevlak, O. P. Ford, G. Fuchert, J. Geiger, P. Helander, U. Hergenhahn, M. Hirsch, U. Höfel, Ye. O. Kazakov, R. Kleiber, M. Krychowiak, S. Kwak, A. Langenberg, H. P. Laqua, U. Neuner, N. A. Pablant, E. Pasch, A. Pavone, T. S. Pedersen, K. Rahbarnia, J. Schilling, E. R. Scott, T. Stange, J. Svensson, H. Thomsen, Y. Turkin, F. Warmer, R. C. Wolf and D. Zhang

Evidence for an atomic chiral superfluid with topological excitations pp. 227-231

Xiao-Qiong Wang, Guang-Quan Luo, Jin-Yu Liu, W. Vincent Liu, Andreas Hemmerich and Zhi-Fang Xu

Actively variable-spectrum optoelectronics with black phosphorus pp. 232-237

Hyungjin Kim, Shiekh Zia Uddin, Lien Der-Hsien, Matthew Yeh, Nima Sefidmooye Azar, Sivacarendran Balendhran, Taehun Kim, Niharika Gupta, Yoonsoo Rho, Costas P. Grigoropoulos, Kenneth B. Crozier and Ali Javey

Structured fabrics with tunable mechanical properties pp. 238-243

Yifan Wang, Liuchi Li, Douglas Hofmann, José E. Andrade and Chiara Daraio

Direct imaging of single-molecule electrochemical reactions in solution pp. 244-249

Jinrun Dong, Yuxian Lu, Yang Xu, Fanfan Chen, Jinmei Yang, Yuang Chen and Jiandong Feng

Photoinduced copper-catalysed asymmetric amidation via ligand cooperativity pp. 250-256

Caiyou Chen, Jonas C. Peters and Gregory C. Fu

Connectomes across development reveal principles of brain maturation pp. 257-261

Daniel Witvliet, Ben Mulcahy, James K. Mitchell, Yaron Meirovitch, Daniel R. Berger, Yuelong Wu, Yufang Liu, Wan Xian Koh, Rajeev Parvathala, Douglas Holmyard, Richard L. Schalek, Nir Shavit, Andrew D. Chisholm, Jeff W. Lichtman, Aravinthan D. T. Samuel and Mei Zhen

Microbes exploit death-induced nutrient release by gut epithelial cells pp. 262-267

Christopher J. Anderson, Christopher B. Medina, Brady J. Barron, Laura Karvelyte, Tania Løve Aaes, Irina Lambertz, Justin S. A. Perry, Parul Mehrotra, Amanda Gonçalves, Kelly Lemeire, Gillian Blancke, Vanessa Andries, Farzaneh Ghazavi, Arne Martens, Geert van Loo, Lars Vereecke, Peter Vandenabeele and Kodi S. Ravichandran

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans pp. 268-272

Galit Alter, Jingyou Yu, Jinyan Liu, Abishek Chandrashekar, Erica N. Borducchi, Lisa H. Tostanoski, Katherine McMahan, Catherine Jacob-Dolan, David R. Martinez, Aiquan Chang, Tochi Anioke, Michelle Lifton, Joseph Nkolola, Kathryn E. Stephenson, Caroline Atyeo, Sally Shin, Paul Fields, Ian Kaplan, Harlan Robins, Fatima Amanat, Florian Krammer, Ralph S. Baric, Mathieu Gars, Jerald Sadoff, Anne Marit Groot, Dirk Heerwegh, Frank Struyf, Macaya Douoguih, Johan Hoof, Hanneke Schuitemaker and Dan H. Barouch

BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants pp. 273-275

Jianying Liu, Yang Liu, Hongjie Xia, Jing Zou, Scott C. Weaver, Kena A. Swanson, Hui Cai, Mark Cutler, David Cooper, Alexander Muik, Kathrin U. Jansen, Ugur Sahin, Xuping Xie, Philip R. Dormitzer and Pei-Yong Shi

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization pp. 276-280

Delphine Planas, David Veyer, Artem Baidaliuk, Isabelle Staropoli, Florence Guivel-Benhassine, Maaran Michael Rajah, Cyril Planchais, Françoise Porrot, Nicolas Robillard, Julien Puech, Matthieu Prot, Floriane Gallais, Pierre Gantner, Aurélie Velay, Julien Guen, Najiby Kassis-Chikhani, Dhiaeddine Edriss, Laurent Belec, Aymeric Seve, Laura Courtellemont, Hélène Péré, Laurent Hocqueloux, Samira Fafi-Kremer, Thierry Prazuck, Hugo Mouquet, Timothée Bruel, Etienne Simon-Lorière, Felix A. Rey and Olivier Schwartz

SAR1B senses leucine levels to regulate mTORC1 signalling pp. 281-284

Jie Chen, Yuhui Ou, Rong Luo, Jie Wang, Dong Wang, Jialiang Guan, Yi Li, Peixue Xia, Peng R. Chen and Ying Liu

Rewiring of the ubiquitinated proteome determines ageing in C. elegans pp. 285-290

Seda Koyuncu, Rute Loureiro, Hyun Ju Lee, Prerana Wagle, Marcus Krueger and David Vilchez

Regulated control of gene therapies by drug-induced splicing pp. 291-295

Alex Mas Monteys, Amiel A. Hundley, Paul T. Ranum, Luis Tecedor, Amy Muehlmatt, Euyn Lim, Dmitriy Lukashev, Rajeev Sivasankaran and Beverly L. Davidson

Structural insights into how Prp5 proofreads the pre-mRNA branch site pp. 296-300

Zhenwei Zhang, Norbert Rigo, Olexandr Dybkov, Jean-Baptiste Fourmann, Cindy L. Will, Vinay Kumar, Henning Urlaub, Holger Stark and Reinhard Lührmann

Structural basis of ketamine action on human NMDA receptors pp. 301-305

Youyi Zhang, Fei Ye, Tongtong Zhang, Shiyun Lv, Liping Zhou, Daohai Du, He Lin, Fei Guo, Cheng Luo and Shujia Zhu

Retraction Note: Detection and replication of epistasis influencing transcription in humans pp. 306-306

Gibran Hemani, Konstantin Shakhbazov, Harm-Jan Westra, Tonu Esko, Anjali K. Henders, Allan F. McRae, Jian Yang, Greg Gibson, Nicholas G. Martin, Andres Metspalu, Lude Franke, Grant W. Montgomery, Peter M. Visscher and Joseph E. Powell

UK academics seethe over universities’ cost-cutting moves pp. 307-308

Natasha Gilbert

Power plants: making electricity from flowers and fruits pp. 310-310

Linda Nordling

2021, volume 596, articles 7870

Cash payments in Africa could boost vaccine uptake pp. 9-9

Rabah Arezki

NASA investigates renaming James Webb telescope after anti-LGBT+ claims pp. 15-16

Alexandra Witze

COVID vaccines slash viral spread – but Delta is an unknown pp. 17-18

Smriti Mallapaty

Water transformed into shiny, golden metal pp. 18-18

Davide Castelvecchi

Sponge-like fossil could be Earth’s earliest known animal pp. 19-19

Max Kozlov

China’s space station is preparing to host 1,000 scientific experiments pp. 20-21

Smriti Mallapaty

The world’s species are playing musical chairs: how will it end? pp. 22-25

Gayathri Vaidyanathan

Why sports concussions are worse for women pp. 26-28

Katharine Sanderson

The COVID vaccine makers tell all pp. 29-30

Heidi Ledford

Cooperation’s pros and cons, construction decarbonized, and into the wild: Books in brief pp. 30-30

Andrew Robinson

Test quantum mechanics in space — invest US$1 billion pp. 32-34

Alessio Belenchia, Matteo Carlesso, Sandro Donadi, Giulio Gasbarri, Hendrik Ulbricht, Angelo Bassi and Mauro Paternostro

Genomics of African American remains — limits must not compound inequity pp. 35-35

Fatimah Jackson, Carter Clinton and Joseph Graves

Declare how you are limiting your environmental impact pp. 35-35

Paul Grogan, Kate M. Buckeridge and Anders Priemé

India’s cyclones: hasten mitigation measures pp. 35-35

Joyita Roy Chowdhury, Yashobanta Parida and Prakash Kumar Sahoo

The fraction of the global population at risk of floods is growing pp. 37-38

Brenden Jongman

Private immune protection at the border of the central nervous system pp. 38-40

Britta Engelhardt

Bouncing droplets mimic spin systems pp. 40-41

Nicolas Vandewalle

Two giants of cell division in an oppressive embrace pp. 41-42

Silke Hauf

The role of retrotransposable elements in ageing and age-associated diseases pp. 43-53

Vera Gorbunova, Andrei Seluanov, Paolo Mita, Wilson McKerrow, David Fenyö, Jef D. Boeke, Sara B. Linker, Fred H. Gage, Jill A. Kreiling, Anna P. Petrashen, Trenton A. Woodham, Jackson R. Taylor, Stephen L. Helfand and John M. Sedivy

Global upper-atmospheric heating on Jupiter by the polar aurorae pp. 54-57

J. O’Donoghue, L. Moore, T. Bhakyapaibul, H. Melin, T. Stallard, J. E. P. Connerney and C. Tao

Emergent order in hydrodynamic spin lattices pp. 58-62

Pedro J. Sáenz, Giuseppe Pucci, Sam E. Turton, Alexis Goujon, Rodolfo R. Rosales, Jörn Dunkel and John W. M. Bush

Quantized nonlinear Thouless pumping pp. 63-67

Marius Jürgensen, Sebabrata Mukherjee and Mikael C. Rechtsman

Pseudogap in a crystalline insulator doped by disordered metals pp. 68-73

Sae Hee Ryu, Minjae Huh, Do Yun Park, Chris Jozwiak, Eli Rotenberg, Aaron Bostwick and Keun Su Kim

Aziridine synthesis by coupling amines and alkenes via an electrogenerated dication pp. 74-79

Dylan E. Holst, Diana J. Wang, Min Ji Kim, Ilia A. Guzei and Zachary K. Wickens

Satellite imaging reveals increased proportion of population exposed to floods pp. 80-86

B. Tellman, J. A. Sullivan, C. Kuhn, A. J. Kettner, C. S. Doyle, G. R. Brakenridge, T. A. Erickson and D. A. Slayback

Possible poriferan body fossils in early Neoproterozoic microbial reefs pp. 87-91

Elizabeth C. Turner

Molecular architecture of the developing mouse brain pp. 92-96

Gioele La Manno, Kimberly Siletti, Alessandro Furlan, Daniel Gyllborg, Elin Vinsland, Alejandro Mossi Albiach, Christoffer Mattsson Langseth, Irina Khven, Alex R. Lederer, Lisa M. Dratva, Anna Johnsson, Mats Nilsson, Peter Lönnerberg and Sten Linnarsson

Gut cytokines modulate olfaction through metabolic reprogramming of glia pp. 97-102

Xiaoyu Tracy Cai, Hongjie Li, Martin Borch Jensen, Elie Maksoud, Jovencio Borneo, Yuxin Liang, Stephen R. Quake, Liqun Luo, Pejmun Haghighi and Heinrich Jasper

In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains pp. 103-108

Rita E. Chen, Emma S. Winkler, James Brett Case, Ishmael D. Aziati, Traci L. Bricker, Astha Joshi, Tamarand L. Darling, Baoling Ying, John M. Errico, Swathi Shrihari, Laura A. VanBlargan, Xuping Xie, Pavlo Gilchuk, Seth J. Zost, Lindsay Droit, Zhuoming Liu, Spencer Stumpf, David Wang, Scott A. Handley, W. Blaine Stine, Pei-Yong Shi, Meredith E. Davis-Gardner, Mehul S. Suthar, Miguel Garcia Knight, Raul Andino, Charles Y. Chiu, Ali H. Ellebedy, Daved H. Fremont, Sean P. J. Whelan, James E. Crowe, Lisa Purcell, Davide Corti, Adrianus C. M. Boon and Michael S. Diamond

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses pp. 109-113

Jackson S. Turner, Jane A. O’Halloran, Elizaveta Kalaidina, Wooseob Kim, Aaron J. Schmitz, Julian Q. Zhou, Tingting Lei, Mahima Thapa, Rita E. Chen, James Brett Case, Fatima Amanat, Adriana M. Rauseo, Alem Haile, Xuping Xie, Michael K. Klebert, Teresa Suessen, William D. Middleton, Pei-Yong Shi, Florian Krammer, Sharlene A. Teefey, Michael S. Diamond, Rachel M. Presti and Ali H. Ellebedy

Adaptive immunity induces mutualism between commensal eukaryotes pp. 114-118

Kyla S. Ost, Teresa R. O’Meara, W. Zac Stephens, Tyson Chiaro, Haoyang Zhou, Jourdan Penman, Rickesha Bell, Jason R. Catanzaro, Deguang Song, Shakti Singh, Daniel H. Call, Elizabeth Hwang-Wong, Kimberly E. Hanson, John F. Valentine, Kenneth A. Christensen, Ryan M. O’Connell, Brendan Cormack, Ashraf S. Ibrahim, Noah W. Palm, Suzanne M. Noble and June L. Round

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma pp. 119-125

Giacomo Oliveira, Kari Stromhaug, Susan Klaeger, Tomasz Kula, Dennie T. Frederick, Phuong M. Le, Juliet Forman, Teddy Huang, Shuqiang Li, Wandi Zhang, Qikai Xu, Nicoletta Cieri, Karl R. Clauser, Sachet A. Shukla, Donna Neuberg, Sune Justesen, Gavin MacBeath, Steven A. Carr, Edward F. Fritsch, Nir Hacohen, Moshe Sade-Feldman, Kenneth J. Livak, Genevieve M. Boland, Patrick A. Ott, Derin B. Keskin and Catherine J. Wu

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers pp. 126-132

Justina X. Caushi, Jiajia Zhang, Zhicheng Ji, Ajay Vaghasia, Boyang Zhang, Emily Han-Chung Hsiue, Brian J. Mog, Wenpin Hou, Sune Justesen, Richard Blosser, Ada Tam, Valsamo Anagnostou, Tricia R. Cottrell, Haidan Guo, Hok Yee Chan, Dipika Singh, Sampriti Thapa, Arbor G. Dykema, Poromendro Burman, Begum Choudhury, Luis Aparicio, Laurene S. Cheung, Mara Lanis, Zineb Belcaid, Margueritta El Asmar, Peter B. Illei, Rulin Wang, Jennifer Meyers, Kornel Schuebel, Anuj Gupta, Alyza Skaist, Sarah Wheelan, Jarushka Naidoo, Kristen A. Marrone, Malcolm Brock, Jinny Ha, Errol L. Bush, Bernard J. Park, Matthew Bott, David R. Jones, Joshua E. Reuss, Victor E. Velculescu, Jamie E. Chaft, Kenneth W. Kinzler, Shibin Zhou, Bert Vogelstein, Janis M. Taube, Matthew D. Hellmann, Julie R. Brahmer, Taha Merghoub, Patrick M. Forde, Srinivasan Yegnasubramanian, Hongkai Ji, Drew M. Pardoll and Kellie N. Smith

BANP opens chromatin and activates CpG-island-regulated genes pp. 133-137

Ralph S. Grand, Lukas Burger, Cathrin Gräwe, Alicia K. Michael, Luke Isbel, Daniel Hess, Leslie Hoerner, Vytautas Iesmantavicius, Sevi Durdu, Marco Pregnolato, Arnaud R. Krebs, Sébastien A. Smallwood, Nicolas Thomä, Michiel Vermeulen and Dirk Schübeler

Structural basis of human separase regulation by securin and CDK1–cyclin B1 pp. 138-142

Jun Yu, Pierre Raia, Chloe M. Ghent, Tobias Raisch, Yashar Sadian, Simone Cavadini, Pramod M. Sabale, David Barford, Stefan Raunser, David O. Morgan and Andreas Boland

Structure of human Cav2.2 channel blocked by the painkiller ziconotide pp. 143-147

Shuai Gao, Xia Yao and Nieng Yan

Pandemic upheaval offers a huge natural experiment pp. 149-151

Julia Rosen

The hunt for red fluorescent proteins pp. 152-153

Amber Dance

A race against time to feed the world pp. 156-156

Linda Nordling