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2025, volume 647, articles 8091

Author Correction: Reciprocal signalling by Notch–Collagen V–CALCR retains muscle stem cells in their niche pp. E4-E4

Meryem B. Baghdadi, David Castel, Léo Machado, So-ichiro Fukada, David E. Birk, Frederic Relaix, Shahragim Tajbakhsh and Philippos Mourikis

Author Correction: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2 pp. E5-E5

Manolis Pasparakis, Gilles Courtois, Martin Hafner, Marc Schmidt-Supprian, Arianna Nenci, Atiye Toksoy, Monika Krampert, Matthias Goebeler, Reinhard Gillitzer, Alain Israel, Thomas Krieg, Klaus Rajewsky and Ingo Haase

Author Correction: The emergence of transcriptional identity in somatosensory neurons pp. E6-E6

Nikhil Sharma, Kali Flaherty, Karina Lezgiyeva, Daniel E. Wagner, Allon M. Klein and David D. Ginty

Author Correction: The oldest known lepidosaur and origins of lepidosaur feeding adaptations pp. E7-E7

Daniel Marke, David I. Whiteside, Thitiwoot Sethapanichsakul, Robert A. Coram, Vincent Fernandez, Alexander Liptak, Elis Newham and Michael J. Benton

Author Correction: Learning the natural history of human disease with generative transformers pp. E8-E8

Artem Shmatko, Alexander Wolfgang Jung, Kumar Gaurav, Søren Brunak, Laust Hvas Mortensen, Ewan Birney, Tom Fitzgerald and Moritz Gerstung

Publisher Correction: Radiation-induced amphiregulin drives tumour metastasis pp. E9-E9

András Piffkó, Kaiting Yang, Arpit Panda, Janna Heide, Krystyna Tesak, Chuangyu Wen, Katarzyna Zawieracz, Liangliang Wang, Emile Z. Naccasha, Jason Bugno, Yanbin Fu, Dapeng Chen, Leonhard Donle, Ernst Lengyel, Douglas G. Tilley, Matthias Mack, Ronald S. Rock, Steven J. Chmura, Everett E. Vokes, Chuan He, Sean P. Pitroda, Hua Laura Liang and Ralph R. Weichselbaum

How to stop the revolving door of German academia pp. S27-S29

Diana Kwon

Why the world must wake up to China’s science leadership pp. 823-823

Kerry Brown

Don’t scrap climate COPs, reform them pp. 824-824

Kilaparti Ramakrishna

Psychedelics and immortality: Nature went to a health summit starring RFK and JD Vance pp. 827-828

Max Kozlov

How obesity drugs quiet ‘food noise’ in the brain pp. 828-829

Mariana Lenharo

How ancient humans bred and traded the first domestic dogs pp. 829-830

Ewen Callaway

First new type of malaria treatment in decades shows promise against drug resistance pp. 830-830

Mariana Lenharo

Global greenhouse-gas emissions are still rising: when will they peak? pp. 831-832

Jeff Tollefson

CRISPR vs cholesterol: can gene editing prevent heart disease? pp. 832-833

Heidi Ledford

Women seem to retract fewer papers than men — but why? pp. 833-834

Jenna Ahart

‘Tiny’ AI model beats massive LLMs at logic test pp. 834-834

Elizabeth Gibney

ADHD diagnoses are growing. What’s going on? pp. 836-840

Helen Pearson

How good old-fashioned AI could spark the field's next revolution pp. 842-844

Nicola Jones

What is the future of intelligence? The answer could lie in the story of its evolution pp. 846-850

Blaise Agüera y Arcas

Putting nature on the balance sheet: how to account for the ecological costs of our actions pp. 850-852

Jacob Hochard

The Internet is broken and the inventor of the World Wide Web wants to fix it pp. 852-853

Chris Stokel-Walker

George Smoot obituary: Charismatic cosmologist who revealed ripples in the Big Bang’s afterglow pp. 854-854

Douglas Scott, Joseph Silk and Tom Broadhurst

International environmental treaties cannot be reformed through rational design pp. 855-855

Vito De Lucia and Jan Solski

Chile must preserve international science in Antarctica pp. 855-855

Cristóbal Galbán Malagón, Marcelo Leppe, Gustavo Chiang and Paulina Bahamonde

Universities must help students faced with the death of a supervisor pp. 855-855

Laura Zárraga-Vargas

Lack of funding is pushing research in Romania to extinction pp. 855-855

Lucian Pintilie

Is there lightning on Mars? pp. 857-858

Daniel Mitchard

First known fossil hand of the hominin Paranthropus boisei pp. 858-859

Tracy L. Kivell and Samar M. Syeda

Thirty years of Bose–Einstein condensation pp. 860-861

Zoran Hadzibabic and Ulrich Schneider

Gene implicated in the heart defects associated with Down’s syndrome pp. 861-863

Beverly A. Rothermel

Bacteria use a decoy defence molecule to set a trap for viruses pp. 863-864

Malcolm F. White

Detection of triboelectric discharges during dust events on Mars pp. 865-869

Baptiste Chide, Ralph D. Lorenz, Franck Montmessin, Sylvestre Maurice, Yann Parot, Ricardo Hueso, German Martinez, Alvaro Vicente-Retortillo, Xavier Jacob, Mark Lemmon, Bruno Dubois, Pierre-Yves Meslin, Claire Newman, Tanguy Bertrand, Grégoire Deprez, Daniel Toledo, Agustin Sánchez-Lavega, Agnès Cousin and Roger C. Wiens

Operating two exchange-only qubits in parallel pp. 870-875

Mateusz T. Mądzik, Florian Luthi, Gian Giacomo Guerreschi, Fahd A. Mohiyaddin, Felix Borjans, Jason D. Chadwick, Matthew J. Curry, Joshua Ziegler, Sarah Atanasov, Peter L. Bavdaz, Elliot J. Connors, J. Corrigan, H. Ekmel Ercan, Robert Flory, Hubert C. George, Benjamin Harpt, Eric Henry, Mohammad M. Islam, Nader Khammassi, Daniel Keith, Lester F. Lampert, Todor M. Mladenov, Randy W. Morris, Aditi Nethwewala, Samuel Neyens, René Otten, Linda P. Osuna Ibarra, Bishnu Patra, Ravi Pillarisetty, Shavindra Premaratne, Mick Ramsey, Andrew Risinger, John D. Rooney, Rostyslav Savytskyy, Thomas F. Watson, Otto K. Zietz, Anne Y. Matsuura, Stefano Pellerano, Nathaniel C. Bishop, Jeanette Roberts and James S. Clarke

Multi-qubit nanoscale sensing with entanglement as a resource pp. 876-882

Jared Rovny, Shimon Kolkowitz and Nathalie P. de Leon

Entanglement-enhanced nanoscale single-spin sensing pp. 883-888

Xu Zhou, Mengqi Wang, Xiangyu Ye, Haoyu Sun, Yuhang Guo, Shuo Han, Zihua Chai, Wentao Ji, Kangwei Xia, Fazhan Shi, Ya Wang and Jiangfeng Du

Slipknot-gauged mechanical transmission and robotic operation pp. 889-896

Yaoting Xue, Jiasheng Cao, Tao Feng, Kaihang Zhang, Siyang Li, Jiahao Hu, Haotian Guo, Jinming Zhang, Yaoxian Song, Zhuofan Wang, Lei Wang, Qishan Huang, Haofei Zhou, Fanghao Zhou, Jiliang Shen, Yaowei Fan, Zhe Wang, Xinge Li, Jie-Wei Wong, Zhiwei Chen, Dongrui Ruan, Zhikun Miao, Bin Zhang, Enjie Zhou, Letian Gan, Xuanqi Wang, Ertai Cao, Tong Chen, Weifeng Zou, Junhui Zhang, Haojian Lu, Qinghai Zhang, Song Liu, Huixu Dong, Shiying Xiong, Shuyou Peng, Tuck-Whye Wong, Yuanjie Chen, Tiefeng Li, Mingyu Chen, Xuxu Yang, Wei Yang and Xiujun Cai

Controlling pyramidal nitrogen chirality by asymmetric organocatalysis pp. 897-905

San Wu, Pengquan Chen, Meng Duan, Peng-Ying Jiang, Qingyang Zhou, Shao-Hua Xiang, K. N. Houk and Bin Tan

Photocatalytic oxygen-atom transmutation of oxetanes pp. 906-912

Ying-Qi Zhang, Shuo-Han Li, Xinglong Zhang and Ming Joo Koh

Deaminative cross-coupling of amines by boryl radical β-scission pp. 913-920

Zhenhua Zhang, Giovanni Lonardi, Thomas Sephton, Yusuf C. Guersoy, Chiara Stavagna, Giovanni V. A. Lenardon, Massimo Bietti and Daniele Leonori

The contribution of rock strength to soil production pp. 921-927

Emily C. Geyman, David A. Paige and Michael P. Lamb

Global warming amplifies wildfire health burden and reshapes inequality pp. 928-934

Junri Zhao, Bo Zheng, Philippe Ciais, Yang Chen, Thomas Gasser, Josep G. Canadell, Longyi Zhang and Qiang Zhang

Wildfire smoke exposure and mortality burden in the USA under climate change pp. 935-943

Minghao Qiu, Jessica Li, Carlos F. Gould, Renzhi Jing, Makoto Kelp, Marissa L. Childs, Jeff Wen, Yuanyu Xie, Meiyun Lin, Mathew V. Kiang, Sam Heft-Neal, Noah S. Diffenbaugh and Marshall Burke

New fossils reveal the hand of Paranthropus boisei pp. 944-951

Carrie S. Mongle, Caley M. Orr, Matthew W. Tocheri, Thomas Cody Prang, Frederick E. Grine, Craig Feibel, Biren A. Patel, Olivia Laureijs, Tara E. Hobbs, Stephanie Maiolino, James Rossie, Winfred Mbogo, Anton Du Plessis, John Lonyericho, William Woto Huka, Hilary Sale, Abdi Umuro, Peter Yirgudo, Ibrae Dalacha, Martin Kirinya, Ezekiel Linga, Richard Loki, Apolo Longaye, Malmalo Longaye, Emmanuel Lonyericho, Iyole Loyapan, Nyiber Nakudo, Cyprian Nyete, Meave G. Leakey and Louise N. Leakey

The formation and propagation of human Robertsonian chromosomes pp. 952-961

Leonardo Gomes de Lima, Andrea Guarracino, Sergey Koren, Tamara Potapova, Sean McKinney, Arang Rhie, Steven J. Solar, Chris Seidel, Brandon L. Fagen, Brian P. Walenz, Gerard G. Bouffard, Shelise Y. Brooks, Michael Peterson, Kate Hall, Juyun Crawford, Alice C. Young, Brandon D. Pickett, Erik Garrison, Adam M. Phillippy and Jennifer L. Gerton

Flexible perceptual encoding by discrete gamma events pp. 962-969

Quentin Perrenoud, Antonio H. de O. Fonseca, Austin Airhart, James Bonanno, Rong Mao and Jessica A. Cardin

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis pp. 970-978

Tanner Michaelis, Cecilia S. Lindestam Arlehamn, Emil Johansson, April Frazier, James D. Berry, Merit Cudkowicz, Namita A. Goyal, Christina Fournier, Allison Snyder, Justin Y. Kwan, Jody Crook, Elizabeth J. Phillips, Simon A. Mallal, John Ravits, Karen S. Marder, John Sidney, David Sulzer and Alessandro Sette

Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21 pp. 979-987

Sanjeev S. Ranade, Feiya Li, Sean Whalen, Angelo Pelonero, Lin Ye, Yu Huang, Abigail Brand, Tomohiro Nishino, Rahul Mital, Ryan M. Boileau, Frances Koback, Arun Padmanabhan, Victoria Yu, Bastien Cimarosti, Diana Presas-Ramos, Alexander F. Merriman, Langley Grace Wallace, Annie Nguyen, Nikolaos Poulis, Mauro W. Costa, Casey A. Gifford, Katherine S. Pollard and Deepak Srivastava

The Panoptes system uses decoy cyclic nucleotides to defend against phage pp. 988-996

Ashley E. Sullivan, Ali Nabhani, Daniel S. Izrailevsky, Kate Schinkel, Charlotte R. K. Hoffman, Laurel K. Robbins, Toni A. Nagy, Melissa L. Duncan, Hannah E. Ledvina, Annette H. Erbse, Emily M. Kibby, Uday Tak, David M. Dinh, Eirene Marie Q. Ednacot, Christy M. Nguyen, A. Maxwell Burroughs, L. Aravind, Aaron T. Whiteley and Benjamin R. Morehouse

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling pp. 997-1004

Erin E. Doherty, Benjamin A. Adler, Peter H. Yoon, Kendall Hsieh, Kenneth Loi, Emily G. Armbruster, Arushi Lahiri, Cydni S. Bolling, Xander E. Wilcox, Amogha Akkati, Anthony T. Iavarone, Joe Pogliano and Jennifer A. Doudna

A vaccine central in A(H5) influenza antigenic space confers broad immunity pp. 1005-1013

Adinda Kok, Samuel H. Wilks, Sina Tureli, Sarah L. James, Theo M. Bestebroer, David F. Burke, Mathis Funk, Stefan van der Vliet, Monique I. Spronken, Willemijn F. Rijnink, David J. Pattinson, Dennis de Meulder, Miruna E. Rosu, Pascal Lexmond, Judith M. A. van den Brand, Sander Herfst, Derek J. Smith, Ron A. M. Fouchier and Mathilde Richard

Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death pp. 1014-1024

Pavel N. Zakharov, Chanchal S. Chowdhury, Orion J. Peterson, Brady Barron, Anthony N. Vomund, Laurent Gorvel, Emil R. Unanue, Eynav Klechevsky, Xiaoxiao Wan and Kodi S. Ravichandran

Proteotoxic stress response drives T cell exhaustion and immune evasion pp. 1025-1035

Yi Wang, Anjun Ma, No-Joon Song, Ariana E. Shannon, Yaa S. Amankwah, Xingyu Chen, Weidong Wu, Ziyu Wang, Abbey A. Saadey, Amir Yousif, Gautam Ghosh, Jay K. Mandula, Maria Velegraki, Tong Xiao, Haitao Wen, Stanley Ching-Cheng Huang, Ruoning Wang, Christian M. Beusch, Abdelhameed S. Dawood, David E. Gordon, Mohamed S. Abdel-Hakeem, Hazem E. Ghoneim, Gang Xin, Brian C. Searle and Zihai Li

Efficient and accurate search in petabase-scale sequence repositories pp. 1036-1044

Mikhail Karasikov, Harun Mustafa, Daniel Danciu, Oleksandr Kulkov, Marc Zimmermann, Christopher Barber, Gunnar Rätsch and André Kahles

Hijacking a bacterial ABC transporter for genetic code expansion pp. 1045-1053

Tarun Iype, Maximilian Fottner, Paul Böhm, Carlos Piedrafita, Yannis Möller, Michael Groll and Kathrin Lang

Cas9 senses CRISPR RNA abundance to regulate CRISPR spacer acquisition pp. 1054-1062

Xufei Zhou, Rucheng Diao, Xin Li, Christine A. Ziegler, Max J. Gramelspacher, Lydia Freddolino, Zhonggang Hou and Yan Zhang

Delta-type glutamate receptors are ligand-gated ion channels pp. 1063-1071

Haobo Wang, Fairine Ahmed, Jeffrey Khau, Anish Kumar Mondal and Edward C. Twomey

My funding applications are taking up too much time. How can I stay focused on my research? pp. 1073-1074

Xiaoying You

Shadow scholars: inside Kenya’s multibillion-dollar fake-essay industry pp. 1074-1075

Anna McKie

Chasing crayfish and the leeches that live on them pp. 1078-1078

Stav Dimitropoulos

2025, volume 647, articles 8090

Science on shaky ground: Canadian research shifts in the wake of US cuts pp. S23-S25

Lesley Evans Ogden

Bill Gates’s climate comments are a dangerous distraction pp. 561-561

Michael E. Mann

DNA pioneer James Watson has died ― colleagues wrestle with his legacy pp. 563-564

Heidi Ledford, Mariana Lenharo, Brendan Maher and Traci Watson

Chinese researchers reveal unexplored section of mysterious Arctic Ocean ridge pp. 564-565

Alexandra Witze

Pressure to publish is rising as research time shrinks, finds survey of scientists pp. 565-566

Chris Simms

China’s new scientist visa is a ‘serious bid’ for the world’s top talent pp. 566-567

Xiaoying You

‘Godfather of AI’ becomes first person to hit one million citations pp. 567-568

Davide Castelvecchi

‘Google Maps’ for Roman roads reveals vast extent of ancient network pp. 568-569

Katie Kavanagh

International PhD student numbers in US hold steady — for now pp. 569-570

Dan Garisto

Want a younger brain? Learn another language pp. 570-570

Katie Kavanagh

Google DeepMind won a Nobel prize for AI: can it produce the next big breakthrough? pp. 572-574

Elizabeth Gibney

Mind-reading devices can now predict preconscious thoughts: is it time to worry? pp. 575-577

Liam Drew

How COVAX raced to protect the world from COVID-19 pp. 578-580

William P. Hausdorff

AI has a democracy problem — here’s why pp. 580-582

Virginia Eubanks

Fossilized technology: Books in brief pp. 582-582

Andrew Robinson

James Watson obituary: co-discoverer of DNA’s double helix who reshaped modern biology pp. 583-583

Jan Witkowski

Why space exploration needs science leadership now — before it’s too late pp. 585-588

Gioia Rau

Beyond growth — why we need to agree on an alternative to GDP now pp. 589-591

Robert Costanza, Joseph Eastoe, Rutger Hoekstra, Ida Kubiszewski and Daniel W. O’Neill

Nations at COP30 must cancel fossil-fuel concessions to keep the Paris agreement in reach pp. 592-592

Martí Orta-Martínez, Gorka Muñoa, Marcel Llavero-Pasquina and Guillem Rius-Taberner

Leaders at COP30 should promote solar and wind power over mega-dams pp. 592-592

Hong Yang, Xiang Gao, Jianhua Wu and Julian R. Thompson

Fishing around offshore wind farms could boost both conservation and green energy pp. 592-592

Joachim Claudet, Emma V. Sheehan and Ryan R. E. Stanley

Panels of peers are needed to gauge AI’s trustworthiness — experts are not enough pp. 592-592

Cong Cheng, Jian Dai, Lulu Yan and Chengliang Wang

Treatment made that is effective against a wide range of snake venoms pp. 593-594

Irene S. Khalek and Joseph G. Jardine

Lanthanides go electric: promising light emitters used in LEDs pp. 594-596

P. James Schuck

Climate change is reshaping fish communities in the United States pp. 596-598

Ian P. Vaughan

Mix-and-match fossils tell the tale of snake and lizard evolution pp. 598-600

Hussam Zaher

Sex differences in depression revealed by large genetics study pp. 600-601

Na Cai

Radio burst from a stellar coronal mass ejection pp. 603-607

J. R. Callingham, C. Tasse, R. Keers, R. D. Kavanagh, H. K. Vedantham, P. Zarka, S. Bellotti, P. I. Cristofari, S. Bloot, D. C. Konijn, M. J. Hardcastle, L. Lamy, E. K. Pass, B. J. S. Pope, H. Reid, H. J. A. Röttgering, T. W. Shimwell and P. Zucca

A universal speed limit for spreading of coherence pp. 608-612

Gevorg Martirosyan, Martin Gazo, Jiří Etrych, Simon M. Fischer, Sebastian J. Morris, Christopher J. Ho, Christoph Eigen and Zoran Hadzibabic

Topological nodal i-wave superconductivity in PtBi2 pp. 613-618

Susmita Changdar, Oleksandr Suvorov, Andrii Kuibarov, Setti Thirupathaiah, Grigory Shipunov, Saicharan Aswartham, Sabine Wurmehl, Iryna Kovalchuk, Klaus Koepernik, Carsten Timm, Bernd Büchner, Ion Cosma Fulga, Sergey Borisenko and Jeroen van den Brink

Photoinduced twist and untwist of moiré superlattices pp. 619-624

Cameron J. R. Duncan, Amalya C. Johnson, Indrajit Maity, Angel Rubio, Matthew Gordon, Adam C. Bartnik, Michael Kaemingk, William H. Li, Matthew B. Andorf, Chad A. Pennington, Ivan V. Bazarov, Mark W. Tate, David A. Muller, Julia Thom-Levy, Sol. M. Gruner, Aaron M. Lindenberg, Jared M. Maxson and Fang Liu

Triplets electrically turn on insulating lanthanide-doped nanoparticles pp. 625-631

Zhongzheng Yu, Yunzhou Deng, Junzhi Ye, Lars van Turnhout, Tianjun Liu, Alasdair Tew, Rakesh Arul, Simon Dowland, Yuqi Sun, Xinjuan Li, Linjie Dai, Yang Lu, Caterina Ducati, Jeremy J. Baumberg, Richard H. Friend, Robert L. Z. Hoye and Akshay Rao

Electro-generated excitons for tunable lanthanide electroluminescence pp. 632-638

Jing Tan, Peng Zhang, Xiaoqing Song, Chunmiao Han, Feng Wang, Jing Zhang, Chunbo Duan, Zhilong Zhang, Sanyang Han, Hui Xu and Xiaogang Liu

Enzyme specificity prediction using cross-attention graph neural networks pp. 639-647

Haiyang Cui, Yufeng Su, Tanner J. Dean, Tianhao Yu, Zhengyi Zhang, Jian Peng, Diwakar Shukla and Huimin Zhao

Synthesis of enantioenriched atropisomers by biocatalytic deracemization pp. 648-655

Casey B. Roos, S. Luke Schulert, Lara E. Zetzsche, Spencer E. McMinn, Angela E. Cheong, Eunjae Shim, Eugene E. Kwan and Alison R. H. Narayan

Diverging fish biodiversity trends in cold and warm rivers and streams pp. 656-662

Samantha L. Rumschlag, Brian Gallagher, Ryan Hill, Ralf B. Schäfer, Travis S. Schmidt, Taylor Woods, Darin Kopp, Michael Dumelle, Jason R. Rohr, Frederik De Laender, Joel Hoffman, Jonathan Behrens, Ryan Lepak, Devin K. Jones and Michael B. Mahon

The oldest known lepidosaur and origins of lepidosaur feeding adaptations pp. 663-672

Daniel Marke, David I. Whiteside, Thitiwoot Sethapanichsakul, Robert A. Coram, Vincent Fernandez, Alexander Liptak, Elis Newham and Michael J. Benton

Mosaic anatomy in an early fossil squamate pp. 673-679

Roger B. J. Benson, Stig A. Walsh, Elizabeth F. Griffiths, Zoe T. Kulik, Jennifer Botha, Vincent Fernandez, Jason J. Head and Susan E. Evans

A haplotype-based evolutionary history of barley domestication pp. 680-688

Yu Guo, Murukarthick Jayakodi, Axel Himmelbach, Erez Ben-Yosef, Uri Davidovich, Michal David, Anat Hartmann-Shenkman, Mordechai Kislev, Tzion Fahima, Verena J. Schuenemann, Ella Reiter, Johannes Krause, Brian J. Steffenson, Nils Stein, Ehud Weiss and Martin Mascher

A parabrachial hub for need-state control of enduring pain pp. 689-697

Nitsan Goldstein, Amadeus Maes, Heather N. Allen, Tyler S. Nelson, Kayla A. Kruger, Morgan Kindel, Albert T. M. Yeung, Nicholas K. Smith, Jamie R. E. Carty, Lavinia Boccia, Niklas Blank, Emily Lo, Rachael E. Villari, Ella Cho, Erin L. Marble, Michelle Awh, Yasmina Dumiaty, Melissa J. Chee, Rajesh Khanna, Christoph A. Thaiss, Bradley K. Taylor, Ann Kennedy and J. Nicholas Betley

Isolation, engineering and ecology of temperate phages from the human gut pp. 698-705

Sofia Dahlman, Laura Avellaneda-Franco, Emily L. Rutten, Emily L. Gulliver, Sean Solari, Michelle Chonwerawong, Ciaren Kett, Dinesh Subedi, Remy B. Young, Nathan Campbell, Jodee A. Gould, Jasmine D. Bell, Callum A. H. Docherty, Christopher J. R. Turkington, Neda Nezam-Abadi, Juris A. Grasis, Dena Lyras, Robert A. Edwards, Samuel C. Forster and Jeremy J. Barr

Dietary cysteine enhances intestinal stemness via CD8+ T cell-derived IL-22 pp. 706-715

Fangtao Chi, Qiming Zhang, Jessica E. S. Shay, Shixun Han, Johanna Ten Hoeve, Yin Yuan, Zhenning Yang, Heaji Shin, Samuel Block, Sumeet Solanki, Yatrik M. Shah, Matthew G. Vander Heiden, Judith Agudo and Ömer H. Yilmaz

Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites pp. 716-725

Shirin Ahmadi, Nick J. Burlet, Melisa Benard-Valle, Alid Guadarrama-Martínez, Samuel Kerwin, Iara A. Cardoso, Amy E. Marriott, Rebecca J. Edge, Edouard Crittenden, Edgar Neri-Castro, Monica L. Fernandez-Quintero, Giang T. T. Nguyen, Carol O’Brien, Yessica Wouters, Konstantinos Kalogeropoulos, Suthimon Thumtecho, Tasja Wainani Ebersole, Camilla Holst Dahl, Emily U. Glegg-Sørensen, Tom Jansen, Kim Boddum, Evangelia Manousaki, Esperanza Rivera- de-Torre, Andrew B. Ward, J. Preben Morth, Alejandro Alagón, Stephen P. Mackessy, Stuart Ainsworth, Stefanie K. Menzies, Nicholas R. Casewell, Timothy P. Jenkins, Anne Ljungars and Andreas H. Laustsen

Ribonucleotide incorporation into mitochondrial DNA drives inflammation pp. 726-734

Amir Bahat, Dusanka Milenkovic, Eileen Cors, Mabel Barnett, Sadig Niftullayev, Athanasios Katsalifis, Marc Schwill, Petra Kirschner, Thomas MacVicar, Patrick Giavalisco, Louise Jenninger, Anders R. Clausen, Vincent Paupe, Julien Prudent, Nils-Göran Larsson, Manuel Rogg, Christoph Schell, Isabella Muylaert, Erik Larsson, Hendrik Nolte, Maria Falkenberg and Thomas Langer

STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD pp. 735-746

Konstantinos Kelepouras, Julia Saggau, Debora Bonasera, Christine Kiefer, Federica Locci, Hassan Rakhsh-Khorshid, Louisa Grauvogel, Ana Beatriz Varanda, Martin Peifer, Elena Loricchio, Antonella Montinaro, Marijana Croon, Aleksandra Trifunovic, Giusi Prencipe, Antonella Insalaco, Fabrizio De Benedetti, Henning Walczak and Gianmaria Liccardi

Myeloperoxidase transforms chromatin into neutrophil extracellular traps pp. 747-756

Garth Lawrence Burn, Tobias Raisch, Sebastian Tacke, Moritz Winkler, Daniel Prumbaum, Stephanie Thee, Niclas Gimber, Stefan Raunser and Arturo Zychlinsky

Tracking clonal evolution during treatment in ovarian cancer using cell-free DNA pp. 757-765

Marc J. Williams, Ignacio Vázquez-García, Grittney Tam, Michelle Wu, Nancy Varice, Eliyahu Havasov, Hongyu Shi, Duaa H. Al-Rawi, Gryte Satas, Hannah J. Lees, Jake June-Koo Lee, Matthew A. Myers, Matthew Zatzman, Nicole Rusk, Emily Ali, Ronak H. Shah, Michael F. Berger, Neeman Mohibullah, Yulia Lakhman, Dennis S. Chi, Nadeem R. Abu-Rustum, Carol Aghajanian, Andrew McPherson, Dmitriy Zamarin, Brian Loomis, Britta Weigelt, Claire F. Friedman and Sohrab P. Shah

Holliday junction–ZMM protein feedback enables meiotic crossover assurance pp. 766-775

Adrian Henggeler, Lucija Orlić, Daniel Velikov and Joao Matos

Protecting double Holliday junctions ensures crossing over during meiosis pp. 776-785

Shangming Tang, Sara Hariri, Regina Bohn, John E. McCarthy, Jennifer Koo, Mohammad Pourhosseinzadeh, Emerald Nguyen, Natalie Liu, Christopher Ma, Hanyu Lu, Monica Lee and Neil Hunter

A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization pp. 786-797

Yuanyong Huang, Yimei Sun, Hongyun Qi, Quanlong Jiang, Jialun Li, Mingzhi Chang, Xinyan Li, Lei Shu, Xiaoya Duan, Yiqin Wang, Kailun Fang, Hailei Mao, Mengmeng Han, Yuan Weng, Qiao Zhang, Zhaosu Chen, Wei Wei, Gaojie Song, Qiansen Zhang, Jiwen Li, Jing-Dong J. Han, Charlie Degui Chen and Jiemin Wong

Collective homeostasis of condensation-prone proteins via their mRNAs pp. 798-808

Rupert Faraway, Neve Costello Heaven, Holly Digby, Klara Kuret Hodnik, Jure Rebselj, Oscar G. Wilkins, Anob M. Chakrabarti, Ira A. Iosub, Neža Vadnjal, Rhys Dore, Lea Knez, Stefan L. Ameres, Clemens Plaschka and Jernej Ule

On the move: why PhD students study abroad in 2025 pp. 809-811

Linda Nordling

The apple of my eye: How I’ve created a plant-health tracker for farmers in Tanzania pp. 814-814

Tavares Cebola

2025, volume 647, articles 8089

The future of ageing: science aims to deliver another leap in lifespan pp. S1-S1

Simon Baker

Could humans live to 150? Why some researchers think we’re on the cusp of a major longevity breakthrough pp. S2-S5

James Mitchell Crow

Is ageing a disease? The debate that could reshape medicine pp. S8-S11

Rachel Nuwer

Three rising stars in ageing research pp. S14-S15

Sandy Ong and Felicity Nelson

For real climate action, empower women pp. 291-291

Elma Kay

‘Almost utopian’: how protecting the environment is boosting the economy in Brazil pp. 292-292

Carolina Grottera

‘Biotech Barbie’ says the time has come to consider CRISPR babies. Do scientists agree? pp. 295-297

Heidi Ledford

‘Mind-captioning’ AI decodes brain activity to turn thoughts into text pp. 297-297

Max Kozlov

Personalized gene editing helped one baby: can it be rolled out widely? pp. 298-299

Heidi Ledford

COVID-19 is spreading again — how serious is it and what are the symptoms? pp. 299-300

Katie Kavanagh

Biggest black-hole outburst ever seen records death throes of a star pp. 300-300

Jenna Ahart

Chinese scientists increasingly lead joint projects with the UK, US and Europe pp. 301-302

Mohana Basu

Why India’s controversial ‘cloud seeding’ trial failed to make it rain pp. 302-302

Mohana Basu

How much protein do you really need? What the science says pp. 304-305

Mariana Lenharo

The computers that run on human brain cells pp. 306-308

David Adam

Don’t despair, collective action can address climate change pp. 309-310

Michael Jakob

Hamilton Smith obituary: molecular biologist who co-discovered precise molecular scissors for cutting DNA pp. 311-311

J. Craig Venter

Africa finally has its own drug-regulation agency — and it could transform the continent’s health pp. 313-316

Mwila Mulubwa, Leon Mutesa and Kelly Chibale

To reform universities, first tackle global rankings pp. 317-319

Elizabeth Gadd

Rebuilding Ukraine — one university’s bold vision pp. 319-320

Aisling Irwin

COP meetings must evolve to turn climate promises into action pp. 321-321

Carlos Garcia-Soto

Academic freedom is key to the future of universities pp. 321-321

Isaac Zablah, Yolly Molina and Marcio Madrid

Partnerships between academia and industry must serve the public good pp. 321-321

Alexis Walker

Kenya’s black rhino revival is a story of hope for conservationists pp. 321-321

Cedric Khayale, Erustus Kanga and Rajan Amin

The search for mutations that sperm acquire as men age pp. 323-324

Caroline Watson

Ultrathin films of a 2D polymer provide airtight seal pp. 324-326

Xiansong Shi and Dan Zhao

Ultra-sensitive DNA sequencing maps mutations that precede cancer pp. 326-328

Jian Carrot-Zhang

Be rational: chimp decision-making is guided by the strongest evidence pp. 327-327

Mary Abraham

Jazzy jaw joints: evolutionary fine-tuning reveals unexpected bone connections in ancient predecessors of mammals pp. 328-329

Elsa Panciroli

GREGoR: accelerating genomics for rare diseases pp. 331-342

Moez Dawood, Ben Heavner, Marsha M. Wheeler, Rachel A. Ungar, Jonathan LoTempio, Laurens Wiel, Seth Berger, Jonathan A. Bernstein, Jessica X. Chong, Emmanuèle C. Délot, Evan E. Eichler, James R. Lupski, Ali Shojaie, Michael E. Talkowski, Alex H. Wagner, Chia-Lin Wei, Christopher Wellington, Matthew T. Wheeler, Claudia M. B. Carvalho, Richard A. Gibbs, Casey A. Gifford, Susanne May, Danny E. Miller, Heidi L. Rehm, Kaitlin E. Samocha, Fritz J. Sedlazeck, Eric Vilain, Anne O’Donnell-Luria, Jennifer E. Posey, Lisa H. Chadwick, Michael J. Bamshad and Stephen B. Montgomery

Millisecond lifetimes and coherence times in 2D transmon qubits pp. 343-348

Matthew P. Bland, Faranak Bahrami, Jeronimo G. C. Martinez, Paal H. Prestegaard, Basil M. Smitham, Atharv Joshi, Elizabeth Hedrick, Shashwat Kumar, Ambrose Yang, Alexander C. Pakpour-Tabrizi, Apoorv Jindal, Ray D. Chang, Guangming Cheng, Nan Yao, Robert J. Cava, Nathalie P. de Leon and Andrew A. Houck

Aligning machine and human visual representations across abstraction levels pp. 349-355

Lukas Muttenthaler, Klaus Greff, Frieda Born, Bernhard Spitzer, Simon Kornblith, Michael C. Mozer, Klaus-Robert Müller, Thomas Unterthiner and Andrew K. Lampinen

Electromagnetic interference shielding using metal and MXene thin films pp. 356-363

Geosan Kang, Guhyeon Kwon, Jiwoon Jeon, Jisung Kwon, Myung-Ki Kim, Junpyo Hong, Albert S. Lee, Seongi Lee, Binhyung Lee, Yujin Kim, Moonkyu Lee, Sungjae Choi, Inhye Jeong, Chaeyoung Kang, Da-Ae Kim, Hyunmin Park, Young-Chang Joo and Hanwool Yeon

Atomically resolved edges and defects in lead halide perovskites pp. 364-368

Biao Yuan, Zeyu Wang, Shuchen Zhang, Christoph Hofer, Chuang Gao, Tamazouzt Chennit, Hongsheng Shi, Xiaoyan Wu, Yu Han, Letian Dou, Yi Yu and Timothy J. Pennycook

Silicon solar cells with hybrid back contacts pp. 369-374

Genshun Wang, Mingzhe Yu, Hua Wu, Yunpeng Li, Lei Xie, Junzhe Wei, Xiaoyu Deng, Shenghou Zhou, Tuan Yuan, Fei Luo, Yunlai Yuan, Zhipeng Huang, Xiyan Tang, Qing Tang, Shi Yin, Haoran Qiu, Yong Liu, Miao Yang, Chang Sun, Lu Wu, Hao Lin, Hanbo Tang, Qiming Liu, Hao Liu, Jiansheng Chen, Xiaoning Ru, Feng Ye, Minghao Qu, Jianbo Wang, Junxiong Lu, Bo He, Lan Chen, Chaowei Xue, Pingqi Gao, Deyan He, Liang Fang, Xixiang Xu and Zhenguo Li

Vector-stimuli-responsive magnetorheological fibrous materials pp. 375-382

Junhong Pu, Haiqiong Li, Jin Liu, Ke Li and Xiaoming Tao

A molecularly impermeable polymer from two-dimensional polyaramids pp. 383-389

Cody L. Ritt, Michelle Quien, Zitang Wei, Hagen Gress, Mohan T. Dronadula, Kaan Altmisdort, Huong Giang T. Nguyen, Christopher D. Zangmeister, Yu-Ming Tu, Sanjay S. Garimella, Shahab Amirabadi, Michael Gadaloff, Weiguo Hu, Narayana R. Aluru, Kamil L. Ekinci, J. Scott Bunch and Michael S. Strano

A multimodal robotic platform for multi-element electrocatalyst discovery pp. 390-396

Zhen Zhang, Zhichu Ren, Chia-Wei Hsu, Weibin Chen, Zhang-Wei Hong, Chi-Feng Lee, Aubrey Penn, Hongbin Xu, Daniel J. Zheng, Shuhan Miao, Yimeng Huang, Yifan Gao, Weiyin Chen, Hugh Smith, Yaoshen Niu, Yunsheng Tian, Ying-Rui Lu, Yu-Cheng Shao, Sipei Li, Hsiao-Tsu Wang, Iwnetim I. Abate, Pulkit Agrawal, Yang Shao-Horn and Ju Li

Global satellite survey reveals uncertainty in landfill methane emissions pp. 397-402

Matthieu Dogniaux, Joannes D. Maasakkers, Marianne Girard, Dylan Jervis, Jason McKeever, Berend J. Schuit, Shubham Sharma, Ana Lopez-Noreña, Daniel J. Varon and Ilse Aben

Convergent evolution of diverse jaw joints in mammaliamorphs pp. 403-410

Fangyuan Mao, Shan Jiang, Jun Liu, Jicheng Ren, Yong Ye, Yu Liu, Xin Shen, Tao Wang, Guofu Wang, Ping Wang, Juan Chen and Jin Meng

Somatic mutation and selection at population scale pp. 411-420

Andrew R. J. Lawson, Federico Abascal, Pantelis A. Nicola, Stefanie V. Lensing, Amy L. Roberts, Georgios Kalantzis, Adrian Baez-Ortega, Natalia Brzozowska, Julia S. El-Sayed Moustafa, Dovile Vaitkute, Belma Jakupovic, Ayrun Nessa, Samuel Wadge, Marc F. Österdahl, Anna L. Paterson, Doris M. Rassl, Raul E. Alcantara, Laura O’Neill, Sara Widaa, Siobhan Austin-Guest, Matthew D. C. Neville, Moritz J. Przybilla, Wei Cheng, Maria Morra, Lucy Sykes, Matthew Mayho, Nicole Müller-Sienerth, Nicholas Williams, Diana Alexander, Luke M. R. Harvey, Thomas Clarke, Alex Byrne, Jamie R. Blundell, Matthew D. Young, Krishnaa T. A. Mahbubani, Kourosh Saeb-Parsy, Hilary C. Martin, Michael R. Stratton, Peter J. Campbell, Raheleh Rahbari, Kerrin S. Small and Iñigo Martincorena

Sperm sequencing reveals extensive positive selection in the male germline pp. 421-428

Matthew D. C. Neville, Andrew R. J. Lawson, Rashesh Sanghvi, Federico Abascal, My H. Pham, Alex Cagan, Pantelis A. Nicola, Tetyana Bayzetinova, Adrian Baez-Ortega, Kirsty Roberts, Stefanie V. Lensing, Sara Widaa, Raul E. Alcantara, María Paz García, Sam Wadge, Michael R. Stratton, Peter J. Campbell, Kerrin Small, Iñigo Martincorena, Matthew E. Hurles and Raheleh Rahbari

Hotspots of human mutation point to clonal expansions in spermatogonia pp. 429-435

Vladimir Seplyarskiy, Mikhail A. Moldovan, Evan Koch, Prathitha Kar, Matthew D. C. Neville, Raheleh Rahbari and Shamil Sunyaev

Sex and smoking bias in the selection of somatic mutations in human bladder pp. 436-444

Ferriol Calvet, Raquel Blanco Martinez-Illescas, Ferran Muiños, Maria Tretiakova, Elena S. Latorre-Esteves, Jeanne Fredrickson, Maria Andrianova, Stefano Pellegrini, Axel Rosendahl Huber, Joan Enric Ramis-Zaldivar, Shuyi Charlotte An, Elana Thieme, Brendan F. Kohrn, Miguel L. Grau, Abel Gonzalez-Perez, Nuria Lopez-Bigas and Rosa Ana Risques

Selective presynaptic inhibition of leg proprioception in behaving Drosophila pp. 445-453

Chris J. Dallmann, Yichen Luo, Sweta Agrawal, Akira Mamiya, Grant M. Chou, Andrew Cook, Anne Sustar, Bingni W. Brunton and John C. Tuthill

Arousal as a universal embedding for spatiotemporal brain dynamics pp. 454-461

Ryan V. Raut, Zachary P. Rosenthal, Xiaodan Wang, Hanyang Miao, Zhanqi Zhang, Jin-Moo Lee, Marcus E. Raichle, Adam Q. Bauer, Steven L. Brunton, Bingni W. Brunton and J. Nathan Kutz

ABCA7 variants impact phosphatidylcholine and mitochondria in neurons pp. 462-471

Djuna Maydell, Shannon E. Wright, Ping-Chieh Pao, Colin Staab, Oisín King, Andrea Spitaleri, Julia Maeve Bonner, Liwang Liu, Chung Jong Yu, Ching-Chi Chiu, Daniel Leible, Aine Ni Scannail, Mingpei Li, Carles A. Boix, Hansruedi Mathys, Guillaume Leclerc, Gloria Suella Menchaca, Gwyneth Welch, Agnese Graziosi, Noelle Leary, George Samaan, Manolis Kellis and Li-Huei Tsai

Assessing phylogenetic confidence at pandemic scales pp. 472-478

Nicola De Maio, Nhan Ly-Trong, Samuel Martin, Bui Quang Minh and Nick Goldman

A new paradigm for outer membrane protein biogenesis in the Bacteroidota pp. 479-487

Xiaolong Liu, Luis Orenday Tapia, Justin C. Deme, Susan M. Lea and Ben C. Berks

SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade pp. 488-497

Adam J. Grippin, Christiano Marconi, Sage Copling, Nan Li, Chen Braun, Cole Woody, Elliana Young, Priti Gupta, Min Wang, Annette Wu, Seong Dong Jeong, Dhruvkumar Soni, Frances Weidert, Chao Xie, Eden Goldenberg, Andrew Kim, Chong Zhao, Anna DeVries, Paul Castillo, Rishabh Lohray, Michael K. Rooney, Benjamin R. Schrank, Yifan Wang, Yifan Ma, Enoch Chang, Ramez Kouzy, Kyle Dyson, Jordan Jafarnia, Nina Nariman, Gregory Gladish, Jacob New, Ada Argueta, Diana Amaya, Nagheme Thomas, Andria Doty, Joe Chen, Nikhil Copling, Gabriel Alatrash, Julie Simon, Alicia Bea Davies, William Dennis, Richard Liang, Jeff Lewis, Xiong Wei, Waree Rinsurongkawong, Ara A. Vaporciyan, Andrew Johns, Jack Lee, Ji-Hyun Lee, Ryan Sun, Padmanee Sharma, Hai Tran, Jianjun Zhang, Don L. Gibbons, Jennifer Wargo, Betty Y. S. Kim, John V. Heymach, Hector R. Mendez-Gomez, Wen Jiang, Elias J. Sayour and Steven H. Lin

Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus pp. 498-505

Qintao Wang, Honghao Zhu, Xiangwei Sun, Changming Zhang, Shuangyue Ma, Ying Jin, Jinjian Fu, Chenlu Liu, Jiahui Peng, Ruoran Wang, Lin Liu, Yi Zeng, Cheng Gong, Qing Zhou, Xiaomin Yu and Zhihong Liu

Amplifying antigen-induced cellular responses with proximity labelling pp. 506-516

Shuojun Li, Yinghui Men, Zihan Wang, Yingcheng Wu, Hao Sun, Mingyang Yin, Xinrui Fan, Guiyun Deng, Zhicheng Yang, Tiange Yang, Yudian Xiao, Hu Zhou, Guangchuan Wang, Jia Fan, Chenqi Xu, Qiang Gao and Shuo Han

Mechanical confinement governs phenotypic plasticity in melanoma pp. 517-527

Miranda V. Hunter, Eshita Joshi, Sydney Bowker, Emily Montal, Yilun Ma, Young Hun Kim, Zhifan Yang, Laura Tuffery, Zhuoning Li, Eric Rosiek, Alexander Browning, Reuben Moncada, Itai Yanai, Helen Byrne, Mara Monetti, Elisa Stanchina, Pierre-Jacques Hamard, Richard P. Koche and Richard M. White

Design of facilitated dissociation enables timing of cytokine signalling pp. 528-535

Adam J. Broerman, Christoph Pollmann, Yang Zhao, Mauriz A. Lichtenstein, Mark D. Jackson, Maxx H. Tessmer, Won Hee Ryu, Masato Ogishi, Mohamad H. Abedi, Danny D. Sahtoe, Aza Allen, Alex Kang, Joshmyn Cruz, Evans Brackenbrough, Banumathi Sankaran, Asim K. Bera, Daniel M. Zuckerman, Stefan Stoll, K. Christopher Garcia, Florian Praetorius, Jacob Piehler and David Baker

Structural basis for mTORC1 activation on the lysosomal membrane pp. 536-543

Zhicheng Cui, Alessandra Esposito, Gennaro Napolitano, Andrea Ballabio and James H. Hurley

Retraction Note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance pp. 544-544

Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel, Vanessa M. Dang, Jessica Appleton, Michael P. O’Connell, Phil Cheng, Alexander A. Valiga, Rachel Morissette, Nazli B. McDonnell, Luigi Ferrucci, Andrew V. Kossenkov, Katrina Meeth, Hsin-Yao Tang, Xiangfan Yin, William H. Wood, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Dennie T. Frederick, Jennifer A. Wargo, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Katherine M. Aird, Rugang Zhang, Xiaowei Xu, Qin Liu, Edmund Bartlett, Giorgos Karakousis, Zeynep Eroglu, Roger S. Lo, Matthew Chan, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Jeffrey Sosman, Bastian Schilling, Dirk Schadendorf, David W. Speicher, Marcus Bosenberg, Antoni Ribas and Ashani T. Weeraratna

Parenting, illnesses and medical commitments: the private details grant reviewers shouldn’t need to know pp. 545-546

Nathalie Bock

How genetically encoded sensors have lit up neuroscience pp. 547-549

Diana Kwon

Witnessing chamois populations recover pp. 552-552

Ugo Mellone

2025, volume 647, articles 8088

Author Correction: Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus pp. E1-E1

Qintao Wang, Honghao Zhu, Xiangwei Sun, Changming Zhang, Shuangyue Ma, Ying Jin, Jinjian Fu, Chenlu Liu, Jiahui Peng, Ruoran Wang, Lin Liu, Yi Zeng, Cheng Gong, Qing Zhou, Xiaomin Yu and Zhihong Liu

Author Correction: A room temperature rechargeable all-solid-state hydride ion battery pp. E2-E2

Jirong Cui, Ren Zou, Weijin Zhang, Hong Wen, Jingyao Liu, Shangshang Wang, Shukun Liu, Hetong Chen, Wei Liu, Xiaohua Ju, Weiwei Wang, Tao Gan, Jiong Li, Jianping Guo, Teng He, Hujun Cao and Ping Chen

Author Correction: Structures of α-synuclein filaments from multiple system atrophy pp. E3-E3

Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G. Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa, Shigeo Murayama, Mari Yoshida, Masato Hasegawa, Sjors H. W. Scheres and Michel Goedert

Japan’s first female prime minister doesn’t call herself a feminist — but the country needs her to tackle sexism in science pp. 9-9

Misa Shimuta

China seeks self-reliance in science in next five-year plan pp. 11-12

Xiaoying You

Glowing sperm helps to reveal secrets of mosquito sex pp. 12-13

Mariana Lenharo

AI chatbots are sycophants — researchers say it’s harming science pp. 13-14

Miryam Naddaf

This luxury ‘cat poo’ coffee has a unique flavour: what’s behind it? pp. 14-15

Nicola Jones

US PhD admissions shrink as fears over Trump’s cuts take hold pp. 15-16

Alexandra Witze

These iconic corals are nearly extinct due to heatwaves: can they be saved? pp. 16-17

Jeff Tollefson

How Napoleon’s army met its doom: DNA reveals surprise illnesses had a role pp. 17-18

Jenna Ahart

Can IVF save the northern white rhino from extinction? — October’s best science images pp. 18-18

Fred Schwaller and Katie Kavanagh

How to fight climate change without the US: a guide to global action pp. 20-23

Xiaoying You, Mariana Lenharo, Mohana Basu, Davide Castelvecchi and Jeff Tollefson

Can AI be truly creative? pp. 24-26

Jo Marchant

PhD training needs a reboot in an AI world pp. 27-28

Alex Sen Gupta

Sex, drugs and the conscious brain: Francis Crick beyond the double helix pp. 29-31

Georgina Ferry

Ancient graffiti and brain complexities: Books in brief pp. 31-31

Andrew Robinson

Chen-Ning Yang obituary: intuitive physicist whose work was inspired by the beauty of symmetry pp. 32-32

Christine Sutton

How the rush for critical minerals is neglecting human needs pp. 33-36

Daniel M. Franks, Natalie Gardner, Bora Aska, Johanna H. Linus, Shrey Varshney, Paul Rogers, Fitsum Weldegiorgis, Lynda Lawson and Louise Gallagher

Climate change is devastating mining of minerals needed to fight it pp. 36-39

Tom Savige, Mark Quigley and Tim T. Werner

Safeguards for virology must be designed in partnership with the public pp. 40-40

Caesar Alimsinya Atuire and Jonathan Ewbank

Can AI predict and limit online hate? pp. 40-40

Chirantan Chatterjee

China should undertake more risky research to close the Nobel gap pp. 40-40

Alex J. Yang, Sanhong Deng and Richard B. Freeman

When will Africa have a Nobel prize in medicine? pp. 40-40

Nicholas Aderinto

Developmental maps of the brain trace when cell types emerge pp. 41-42

Emily Sylwestrak

‘Memory foam’ skeleton in cells helps them to navigate pp. 42-44

Joseph d’Alessandro and Mélina L. Heuzé

AI uses medical records to accurately predict onset of disease 20 years into the future pp. 44-45

Yonghui Wu

Ultrashort laser pulse amplified by back-and-forth propagation pp. 45-46

Christoph Heyl and Marc Hanna

Ancient viral DNA in the human genome shapes early development pp. 47-48

Sherif Khodeer and Vincent Pasque

Years of hits to the head prime the brain for decline pp. 48-49

Adam Bachstetter and Josh Morganti

The new frontier in understanding human and mammalian brain development pp. 51-59

Tomasz J. Nowakowski, Patricia R. Nano, Katherine S. Matho, Xiaoyin Chen, Emily K. Corrigan, Wubin Ding, Yuan Gao, Matthew Heffel, Jaikishan Jayakumar, Harris S. Kaplan, Fae N. Kronman, Rothem Kovner, Camiel C. A. Mannens, Mengyi Song, Marilyn R. Steyert, Sridevi Venkatesan, Jenelle L. Wallace, Li Wang, Jonathan M. Werner, Di Zhang, Guohua Yuan, Guolong Zuo, Seth A. Ament, Carlo Colantuoni, Catherine Dulac, Rong Fan, Jesse Gillis, Arnold R. Kriegstein, Fenna M. Krienen, Yongsoo Kim, Sten Linnarsson, Partha P. Mitra, Alex A. Pollen, Nenad Sestan, Daniel J. Tward, Cindy T. J. Velthoven, Zizhen Yao, Aparna Bhaduri and Hongkui Zeng

A tweezer array with 6,100 highly coherent atomic qubits pp. 60-67

Hannah J. Manetsch, Gyohei Nomura, Elie Bataille, Xudong Lv, Kon H. Leung and Manuel Endres

Many-body interference in kagome crystals pp. 68-73

Chunyu Guo, Kaize Wang, Ling Zhang, Carsten Putzke, Dong Chen, Maarten R. Delft, Steffen Wiedmann, Fedor F. Balakirev, Ross D. McDonald, Martin Gutierrez-Amigo, Manex Alkorta, Ion Errea, Maia G. Vergniory, Takashi Oka, Roderich Moessner, Mark H. Fischer, Titus Neupert, Claudia Felser and Philip J. W. Moll

Dispersion-engineered multipass optical parametric amplification pp. 74-79

Jan H. Nägele, Tobias Steinle, Johann Thannheimer, Philipp Flad and Harald Giessen

Non-van der Waals superlattices of carbides and carbonitrides pp. 80-85

Qi Zhao, Zhiguo Du, Kunpeng Si, Zian Xu, Ziming Wang, Qi Zhu, Yuxuan Ye, Xinping Wu, Genqing Wang, Guanhui Gao, Yongji Gong, Li Song, Peizhe Tang and Shubin Yang

A ductile solid electrolyte interphase for solid-state batteries pp. 86-92

Jinshuo Mi, Jun Yang, Likun Chen, Wenting Cui, Yuhang Li, Xufei An, Jiabin Ma, Ke Yang, Yaoshu Xie, Jie Biao, Yu Long, Huilin Ge, Bing Han, Ruohong Ke, Guanyou Xiao, Shendong Tan, Danfeng Zhang, Xing Cheng, Tingzheng Hou, Yan-Fei Huang, Ming Liu, Wei Lv, Lin Gan, Yan-Bing He, Quan-Hong Yang and Feiyu Kang

Technological pathways for cost-effective steel decarbonization pp. 93-101

Xinyi Wu, Jing Meng, Xi Liang, Laixiang Sun, D’Maris Coffman, Andreas Kontoleon and Dabo Guan

Ocean warming threatens the viability of 60% of Antarctic ice shelves pp. 102-108

C. Burgard, N. C. Jourdain, C. Mosbeux, J. Caillet, P. Mathiot and C. Kittel

Oxidative potential of atmospheric particles in Europe and exposure scenarios pp. 109-114

Cécile Tassel, Jean-Luc Jaffrezo, Pamela Dominutti, Kaspar R. Daellenbach, Sophie Darfeuil, Rhabira Elazzouzi, Paolo Laj, Anouk Marsal, Takoua Mhadhbi, Vy Ngoc Thuy Dinh, Céline Voiron, Stephan Houdier, Marc Durif, Mélodie Chatain, Florie Francony, Julie Cozic, Guillaume Salque Moreton, Meryll Quilleuc, Véronique Ghersi, Grégory Gille, Boualem Mesbah, Evdokia Stratigou, Manuela Zublena, Henri Diémoz, Andrés Alastuey, Barbara D’Anna, Nicolas Marchand, Sébastien Conil, Valérie Gros, Marloes F. Os, Imre Salma, Nikolaos Mihalopoulos, Griša Močnik, Katja Džepina, Katarzyna Styszko, Christoph Hüglin, Xavier Querol, André S. H. Prévôt, Olivier Favez, Valérie Siroux and Gaëlle Uzu

The importance of past rifting in large igneous province development pp. 115-120

R. Kounoudis, I. D. Bastow, C. J. Ebinger, S. Goes, P. Zhou, M. Musila, C. S. Ogden and A. Ayele

Extreme armour in the world’s oldest ankylosaur pp. 121-126

Susannah C. R. Maidment, Driss Ouarhache, Kawtar Ech-charay, Ahmed Oussou, Khadija Boumir, Abdessalam El Khanchoufi, Alison Park, Luke E. Meade, D. Cary Woodruff, Simon Wills, Mike Smith, Paul M. Barrett and Richard J. Butler

Continuous cell-type diversification in mouse visual cortex development pp. 127-142

Yuan Gao, Cindy T. J. Velthoven, Changkyu Lee, Emma D. Thomas, Rémi Mathieu, Angela P. Ayala, Stuard Barta, Darren Bertagnolli, Jazmin Campos, Trangthanh Cardenas, Daniel Carey, Tamara Casper, Anish Bhaswanth Chakka, Rushil Chakrabarty, Megan Chiang, Lindsey Ching, Michael Clark, Marie J. Desierto, Rebecca Ferrer, Jessica Gloe, Jeff Goldy, Nathan Guilford, Junitta Guzman, Carliana R. Halterman, Samantha D. Hastings, Daniel Hirschstein, Windy Ho, Katelyn James, Zoe Juneau, Naomi Martin, Rachel McCue, Emma Meyerdierks, Amanda C. Mitchell, Josh S. Nagra, Beagan Nguy, Thuc Nghi Nguyen, Paul Olsen, Alana A. Oyama, Nick Pena, Jacob Quon, Qingzhong Ren, Augustin Ruiz, Nadiya V. Shapovalova, Josef Sulc, Amy Torkelson, Alex Tran, Herman Tung, Nasmil Valera Cuevas, Justin Wang, Jeanelle Ariza, Delissa A. M. McMillen, Jack Waters, Michael Kunst, Kara Ronellenfitch, Boaz Levi, Michael J. Hawrylycz, Chelsea Pagan, Nick Dee, Kimberly A. Smith, Bosiljka Tasic, Zizhen Yao and Hongkui Zeng

Transcriptomic and spatial organization of telencephalic GABAergic neurons pp. 143-156

Cindy T. J. Velthoven, Yuan Gao, Michael Kunst, Changkyu Lee, Delissa McMillen, Anish Bhaswanth Chakka, Tamara Casper, Michael Clark, Rushil Chakrabarty, Scott Daniel, Tim Dolbeare, Rebecca Ferrer, Jessica Gloe, Jeff Goldy, Junitta Guzman, Carliana Halterman, Windy Ho, Mike J. Huang, Katelyn James, Rachel McCue, Beagan Nguy, Trangthanh Cardenas, Kara Ronellenfitch, Emma D. Thomas, Amy Torkelson, Chelsea M. Pagan, Lauren Kruse, Nick Dee, Lydia Ng, Jack Waters, Kimberly A. Smith, Bosiljka Tasic, Zizhen Yao and Hongkui Zeng

Sensory input, sex and function shape hypothalamic cell type development pp. 157-168

Harris S. Kaplan, Brandon L. Logeman, Kai Zhang, Tate A. Yawitz, Celine Santiago, Noor Sohail, Mustafa Talay, Changwoo Seo, Serhiy Naumenko, Shannan J. Ho Sui, David D. Ginty, Bing Ren and Catherine Dulac

Molecular and cellular dynamics of the developing human neocortex pp. 169-178

Li Wang, Cheng Wang, Juan A. Moriano, Songcang Chen, Guolong Zuo, Arantxa Cebrián-Silla, Shaobo Zhang, Tanzila Mukhtar, Shaohui Wang, Mengyi Song, Lilian Gomes Oliveira, Qiuli Bi, Jonathan J. Augustin, Xinxin Ge, Mercedes F. Paredes, Eric J. Huang, Arturo Alvarez-Buylla, Xin Duan, Jingjing Li and Arnold R. Kriegstein

Chromatin accessibility during human first-trimester neurodevelopment pp. 179-186

Camiel C. A. Mannens, Lijuan Hu, Peter Lönnerberg, Marijn Schipper, Caleb C. Reagor, Xiaofei Li, Xiaoling He, Roger A. Barker, Erik Sundström, Danielle Posthuma and Sten Linnarsson

Conservation and alteration of mammalian striatal interneurons pp. 187-193

Emily K. Corrigan, Michael DeBerardine, Aunoy Poddar, Miguel Turrero García, Sean de la O, Siting He, Harsha Sen, Mariana Duhne, Shanti Lindberg, Mengyi Song, Matthew T. Schmitz, Karen E. Sears, Ricardo Mallarino, Joshua D. Berke, Corey C. Harwell, Mercedes F. Paredes, Fenna M. Krienen and Alex A. Pollen

Lineage-resolved atlas of the developing human cortex pp. 194-202

Matthew G. Keefe, Marilyn R. Steyert and Tomasz J. Nowakowski

Whole-cortex in situ sequencing reveals input-dependent area identity pp. 203-212

Xiaoyin Chen, Stephan Fischer, Mara C. P. Rue, Aixin Zhang, Didhiti Mukherjee, Patrick O. Kanold, Jesse Gillis and Anthony M. Zador

Spatial dynamics of brain development and neuroinflammation pp. 213-227

Di Zhang, Leslie A. Rubio Rodríguez-Kirby, Yingxin Lin, Wenqi Wang, Mengyi Song, Li Wang, Lijun Wang, Shigeaki Kanatani, Tony Jimenez-Beristain, Yonglong Dang, Mei Zhong, Petra Kukanja, Shuozhen Bao, Shaohui Wang, Xinyi Lisa Chen, Fu Gao, Dejiang Wang, Hang Xu, Cong Ma, Xing Lou, Yang Liu, Jinmiao Chen, Nenad Sestan, Per Uhlén, Arnold Kriegstein, Hongyu Zhao, Gonçalo Castelo-Branco and Rong Fan

Repeated head trauma causes neuron loss and inflammation in young athletes pp. 228-237

Morgane L. M. D. Butler, Nida Pervaiz, Kerry Breen, Samantha Calderazzo, Petra Ypsilantis, Yichen Wang, Julia Cammasola Breda, Sarah Mazzilli, Raymond Nicks, Elizabeth Spurlock, Marco M. Hefti, Kimberly L. Fiock, Bertrand R. Huber, Victor E. Alvarez, Thor D. Stein, Joshua D. Campbell, Ann C. McKee and Jonathan D. Cherry

A human-specific regulatory mechanism revealed in a pre-implantation model pp. 238-247

Raquel Fueyo, Sicong Wang, Olivia J. Crocker, Tomek Swigut, Hiromitsu Nakauchi and Joanna Wysocka

Learning the natural history of human disease with generative transformers pp. 248-256

Artem Shmatko, Alexander Wolfgang Jung, Kumar Gaurav, Søren Brunak, Laust Hvas Mortensen, Ewan Birney, Tom Fitzgerald and Moritz Gerstung

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer pp. 257-267

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