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2026, volume 657, articles 8133

Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution pp. E19-E19

Zhao Feng, Xiangning Li, Yue Luo, Xin Liu, Ben Long, Tao Jiang, Xueyan Jia, Xiaowei Chen, Jie Luo, Xiaokang Chai, Zhen Wang, Miao Ren, Xin Lu, Gang Yao, Mengting Zhao, Yuxin Li, Zhixiang Liu, Hong Ni, Chuhao Dou, Shengda Bao, Shicheng Yang, Zoutao Zhang, Jiandong Zhou, Lingyi Cai, Qi Zhang, Ayizuohere Tudi, Chaozhen Tan, Zhengchao Xu, Siqi Chen, Wenxiang Ding, Wenjuan Shi, Anan Li, Hong-wei Dong, Hui Gong and Qingming Luo

Author Correction: AhR inhibition promotes axon regeneration via a stress–growth switch pp. E20-E20

Dalia Halawani, Yiqun Wang, Jiaxi Li, Daniel Halperin, Haofei Ni, Molly Estill, Aarthi Ramakrishnan, Li Shen, Arthur Sefiani, Cédric G. Geoffroy, Roland H. Friedel and Hongyan Zou

Author Correction: Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia pp. E21-E21

Panagiotis Ntziachristos, Aristotelis Tsirigos, G. Grant Welstead, Thomas Trimarchi, Sofia Bakogianni, Luyao Xu, Evangelia Loizou, Linda Holmfeldt, Alexandros Strikoudis, Bryan King, Jasper Mullenders, Jared Becksfort, Jelena Nedjic, Elisabeth Paietta, Martin S. Tallman, Jacob M. Rowe, Giovanni Tonon, Takashi Satoh, Laurens Kruidenier, Rab Prinjha, Shizuo Akira, Pieter Van Vlierberghe, Adolfo A. Ferrando, Rudolf Jaenisch, Charles G. Mullighan and Iannis Aifantis

Author Correction: The molecular basis of force selectivity by PIEZO2 pp. E22-E22

Eric M. Mulhall, Oleg Yarishkin, Rose Z. Hill, Anna K. Koster and Ardem Patapoutian

What is needed for regenerative medicine to flourish? pp. S51-S51

Alexia Austin

‘Remarkably encouraging’: stem-cell treatments for autoimmune diseases enter new phase pp. S52-S55

Rachel Nuwer

Lack of female researchers and participants in regenerative-medicine research holds everyone back pp. S59-S59

Doris A. Taylor

Losing your way of life to climate change matters — and we need a way to measure it pp. 857-857

Manasi Kumar

The worst El Niño in recorded history is brewing — here’s how governments must prepare pp. 858-858

Zeke Hausfather

Exclusive: New evidence for hidden chambers beyond Tutankhamun’s tomb pp. 861-862

Jo Marchant

Successful early-career scientists rely on network of mentors pp. 863-863

Mohana Basu

The super El Niño is already wreaking havoc: here’s what’s in store pp. 864-865

James Dinneen

Human brain cells transplanted into mice in ‘most extensive’ integration ever pp. 865-866

Max Kozlov

Science philanthropy is rising in Brazil ― upending a long tradition pp. 866-867

Mariana Lenharo

People trust scientists seen to be ‘on their side’, UK study finds pp. 868-868

Chris Simms

All the ways a cell can die — and why the variety matters pp. 870-872

Amber Dance

How to stay smart in the age of AI: the science of critical thinking pp. 873-875

Helen Pearson

Six principles for supporting academic freedom in universities pp. 876-879

Sarah de Rijcke

Combined satellite and news data capture unseen aspects of war pp. 881-882

Hannes Mueller

Plasma-jet movie is astronomy’s summer blockbuster pp. 882-883

Yosuke Mizuno

Conifer trees can prosper half a world away from their usual home pp. 884-885

Steven A. Kannenberg

Vast cellular gene-expression atlas could transform how scientists understand brain ageing and disease pp. 885-887

Jennifer E. Below

Nearly one in seven young, male white voters in the US support white nationalism pp. 887-888

Jennifer Chudy

Antimatter: coming soon to a lab near you? pp. 888-889

Nancy Paul and Davide Gamba

Advancing conflict research and response through satellite-derived data pp. 891-899

Valerie Sticher, Corinne Bara, Jenniina Kotajoki, Lars Bromley, Thierry Crevoisier, Emanuele Dalsasso, Olivier Dietrich, Karsten Donnay, Filip Dorm, Manuel Fiol, Xi Li, Mikael Hiberg Naghizadeh, Corey Scher, Jamon Van Den Hoek, Konrad Schindler, Devis Tuia and Jan Dirk Wegner

Video reconstruction of variable VLBI observations with neural fields pp. 900-905

Marianna Foschi, Brandon Zhao, Antonio Fuentes, Katherine L. Bouman, José L. Gómez and Aviad Levis

Road transport of trapped antiprotons pp. 906-911

M. Leonhardt, J. Morgner, F. Abbass, K. K. Anjum, B. Arndt, R. P. Czampiel, N. Daehnhardt, S. Endoh, T. Imamura, J. I. Jäger, L. Kürschner, B. M. Latacz, P. Micke, D. Natakala, R. Rahner, D. Schweitzer, S. Stahl, F. Völksen, H. Yildiz, K. Blaum, J. A. Devlin, Y. Matsuda, C. Ospelkaus, W. Quint, A. Soter, J. Walz, Y. Yamazaki, S. Ulmer and C. Smorra

Evidence for vacuum-enhanced superconductivity in NbSe2 pp. 912-917

Zheyan Wang, Gabriel Cardoso, Liu Yang, Xun Gong, Chi Zhang, Yufei Zhu, Dongbo Zhang, Nan Pan, Hongbing Cai, Yong P. Chen, Qing-Dong Jiang, Guanghui Cheng, Frank Wilczek and Changgan Zeng

Lead carboxylates passivation for metre-scale perovskite solar modules pp. 918-924

Dongdong Xu, Ke Xiao, Ye Liu, Xin Luo, Jian Xu, Yikang Wei, Yameen Ahmed, Shuncheng Yang, Haonan Liu, Yinke Wang, Shun Huang, Manya Li, Yuhong Zhang, Han Gao, Hongfei Sun, Gongtao Duan, Qiaolei Han, Qiang Liu, Shuo Zhang, Xingjie Lv, Jingfu Jiang, Chao Li, Dongxue Liu, Min Hao, Xincheng Hou, Makhsud I. Saidaminov and Hairen Tan

Foaming photopolymers as a high-resolution biomimetic printing platform pp. 925-934

Detao Qin, Xianghui Liu, Baian Kuang, Yuzhe Zhang, Masateru Ito, Tatsuya Katsuno, Yuan Liu, Jianduo Zhang, Claudia Rosa, Meifang Zhu, Mikihito Takenaka, Hiroshi Imahori, Ganesh N. Pandian, Taiki Yanagishima and Easan Sivaniah

Sequence-encoded hexagonal lattices in multichannel peptide nanofibrils pp. 935-943

Jasmina Gačanin, Francesca Mazzotta, Luis Andre Baptista, Nikolay Stoyanov, Matthias Schmidt, Nico Alleva, Thunchanok Thummaraj, Fanny Bonnicel, Cong Zhou, Lei Gao, Jan Münch, Mischa Bonn, Marcus Fändrich, Ingo Lieberwirth, Robinson Cortes-Huerto, Katharina Landfester and Tanja Weil

Breaking timescales with generative sampling of conformational transitions pp. 944-949

Chenyu Tang, Mayank Prakash Pandey, Cheng Giuseppe Chen, Alberto Megías, François Dehez and Christophe Chipot

Positional isomerization of pyridine through nitrogen transposition pp. 950-956

Wonjun Choi, Hyewon Ju, Jiyong Park and Sungwoo Hong

Phosphine-mediated azine C–H couplings with water and ammonia pp. 957-963

Kyle G. Nottingham, Dane A. Brunner, David Dalmau, Amanda K. Melanese, Juan V. Alegre-Requena, Robert S. Paton and Andrew McNally

Predictors and prevalence of support for white nationalism in the United States pp. 964-972

Patrick J. Egan, James Bisbee and Joshua A. Tucker

Cretaceous zhelestid mammals are zalambdalestoids pp. 973-980

Andres Giallombardo, Eva A. Hoffman, Maureen A. O’Leary, Paúl M. Velazco, Shawn P. Zack and Michael J. Novacek

Long-read sequencing reveals pre-meiotic gene conversion in sperm pp. 981-987

Regev Schweiger, Sangjin Lee, Chenxi Zhou, Tsun-Po Yang, Stacy Li, Rashesh Sanghvi, Matthew Neville, Katie Smith, Kirsty Roberts, Ayrun Nessa, Sam Wadge, Kerrin S. Small, Peter J. Campbell, Kristian Almstrup, Peter H. Sudmant, Raheleh Rahbari and Richard Durbin

Single-cell atlas of transcriptomic vulnerability across brain disorders pp. 988-1002

Donghoon Lee, Mikaela Koutrouli, Nicolas Y. Masse, Gabriel E. Hoffman, Seon Kinrot, Xinyi Wang, Prashant N. M., Milos Pjanic, Tereza Clarence, Fotios Tsetsos, Deepika Mathur, David Burstein, Karen Therrien, Aram Hong, Clara Casey, Zhiping Shao, Marcela Alvia, Stathis Argyriou, Jennifer Monteiro Fortes, Sarah R. Murphy, Pavel Katsel, Pavan K. Auluck, Lisa L. Barnes, Stefano Marenco, David A. Bennett, PsychAD Consortium, Lars Juhl Jensen, Kiran Girdhar, Georgios Voloudakis, Vahram Haroutunian, Jaroslav Bendl, John F. Fullard and Panos Roussos

Lifespan single-cell transcriptomic atlas of the human prefrontal cortex pp. 1003-1015

Hui Yang, Tereza Clarence, Madeline R. Scott, Xinyi Wang, Prashant N. M., Milos Pjanic, Sanan Venkatesh, Aram Hong, Clara Casey, Sarah R. Murphy, Zhiping Shao, Marcela Alvia, Stathis Argyriou, Alexander Kawah Yu, PsychAD Consortium, Nadejda M. Tsankova, Pavan K. Auluck, Stefano Marenco, Vahram Haroutunian, Georgios Voloudakis, Jaroslav Bendl, Colleen A. McClung, Donghoon Lee, John F. Fullard, Gabriel E. Hoffman, Kiran Girdhar and Panos Roussos

Single-nucleus transcriptome-wide association study of human brain disorders pp. 1016-1026

Sanan Venkatesh, Roman Kosoy, Zhenyi Wu, Marios Anyfantakis, Christian Dillard, Prashant N. M., David Burstein, Deepika Mathur, Chris Chatzinakos, Bukola Ajanaku, Fotis Tsetsos, Biao Zeng, Sonali Gupta, Rachel Bercovitch, Aram Hong, Clara Casey, Marcela Alvia, Zhiping Shao, Stathis Argyriou, Karen Therrien, PsychAD Consortium, Tim Bigdeli, Pavan Auluck, David A. Bennett, Stefano Marenco, Vahram Haroutunian, Kiran Girdhar, Jaroslav Bendl, Donghoon Lee, John F. Fullard, Gabriel E. Hoffman, Georgios Voloudakis and Panos Roussos

An ancient mitochondrial program tunes translation to haem availability pp. 1027-1034

Xiang Zhang, Max-Hinderk Schuler, Gonca Çetin, Eva-Maria Eckl, Lara Rheinemann, Julia Mergner, Barbara Steigenberger, Andreas Pichlmair and Lucas T. Jae

Genetic background sets the trajectory of experimental cancer evolution pp. 1035-1044

Sarah J. Aitken, Frances Connor, Christine Feig, Tim F. Rayner, Margus Lukk, Juliet Luft, Stuart Aitken, Claudia Arnedo-Pac, James F. Hayes, Michael D. Nicholson, Ailith Ewing, Vasavi Sundaram, Jan C. Verburg, John Connelly, Craig J. Anderson, Mikaela Behm, Susan Campbell, Maëlle Daunesse, Vera B. Kaiser, Elissavet Kentepozidou, Oriol Pich, Aisling M. Redmond, Javier Santoyo-Lopez, Inés Sentís, Lana Talmane, Liver Cancer Evolution Consortium, Paul Flicek, Núria López-Bigas, Colin A. Semple, Martin S. Taylor and Duncan T. Odom

DCAF11-dependent molecular glue degrader activated by glutathionylation pp. 1045-1052

Hojong Yoon, Franziska Wachter, Katharine A. Barrett, Cyrus Jin, Anna Rodríguez-Pöhnlein, Justine C. Rutter, Ryan J. Lumpkin, Rebecca J. Metivier, Katherine A. Donovan, Kheewoong Baek, Yongying Jiang, Minwoo Lee, Robert W. Kalis, Jianwei Che, Yuan Xiong, Eric S. Fischer and Benjamin L. Ebert

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer pp. 1053-1063

Qingwen Jiang, Manisha S. Raghavan, Aileen M. Rodriguez, Morgan Lallo, Cyrus L. Tam, Saskia Hartner, Britney Forsyth, Ahmed Mahmoud, Fabian Zincke, Huiyong Zhao, Andrew Moorman, Sasha Balkaran, Kathleen Luckett, Jura Pintar, Yevgeniy Romin, Eric Chan, Anthony Santella, Bernadette Mödl, Farheen Shah, Ilyes Baali, Michael G. Kharas, Elisa de Stanchina, Nil Urganci, Jinru Shia, Dana Pe’er, Francisco Sanchez-Vega, Richard Koche, Quaid Morris, Joseph M. Chan and Karuna Ganesh

Miniaturizing and modifying natural proteins with Raygun pp. 1064-1072

Kapil Devkota, Daichi Shonai, Joey Mao, Young Su Ko, Wei Wang, Scott Soderling and Rohit Singh

Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase pp. 1073-1083

Lu Xue, Jiacheng Gui, Hainei Pan, Fan Wu, Shenghua Gao, Wenhua Kuang, Tiancai Chang, Zimu Li, Binqian Zou, Heyu Zhao, Mei Li, Min Zhou, Hongyu Yuan, Lijun Rong, Peng Gong, Jun He, Zengqin Deng, Manli Wang, Peng Zhan, Xinwen Chen and Xiaoli Xiong

RNA synthesis and substrate analogue inhibition in the CCHFV polymerase pp. 1084-1093

Hengxia Jia, Bo Tang, Shunli Liu, Xin Wen, Fan Wu, Xiao Hu, Hu Zhou, Tingting Chong, Lincan Lv, Qiaojie Liu, Guibo Rao, Mingyu Wei, Xuping Jing, Sheng Cao, Fei Deng, Zhihong Hu, Bo Shu, Rui Gong, Jiqin Wu, Manli Wang and Peng Gong

In situ structures of plant photosystem supercomplexes pp. 1094-1103

Jiao Li, Eduard Elias, Kai Zhang, Roberta Croce and Jiapeng Zhu

A guide to emotional intelligence in the lab pp. 1105-1107

Gemma Conroy

AI co-scientists are revolutionizing how research is done pp. 1108-1110

Elie Dolgin

A global safety net for climate-risk intelligence is urgently needed pp. 1112-1112

Safdar Bashir and Muhammad Adil

Biosecurity must protect human functional capacity pp. 1112-1112

Nicolas Paccini

Why insects need their own protected areas pp. 1112-1112

Jiangwei Zhu

2026, volume 657, articles 8132

Author Correction: Plasticity and language in the anaesthetized human hippocampus pp. E15-E16

Kalman A. Katlowitz, Eric R. Cole, Elizabeth A. Mickiewicz, Shraddha Shah, Melissa Franch, Joshua A. Adkinson, James L. Belanger, Raissa K. Mathura, Domokos Meszéna, Matthew McGinley, William Muñoz, Garrett P. Banks, Sydney S. Cash, Chih-Wei Hsu, Angelique C. Paulk, Nicole R. Provenza, Andrew J. Watrous, Ziv Williams, Alica M. Goldman, Vaishnav Krishnan, Atul Maheshwari, Sarah R. Heilbronner, Robert Kim, Nuttida Rungratsameetaweemana, Benjamin Y. Hayden and Sameer A. Sheth

Author Correction: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia pp. E17-E17

Zhengshan Chen, Seyedmehdi Shojaee, Maike Buchner, Huimin Geng, Jae Woong Lee, Lars Klemm, Björn Titz, Thomas G. Graeber, Eugene Park, Ying Xim Tan, Anne Satterthwaite, Elisabeth Paietta, Stephen P. Hunger, Cheryl L. Willman, Ari Melnick, Mignon L. Loh, Jae U. Jung, John E. Coligan, Silvia Bolland, Tak W. Mak, Andre Limnander, Hassan Jumaa, Michael Reth, Arthur Weiss, Clifford A. Lowell and Markus Müschen

Author Correction: Endocannabinoids facilitate reward engagement through retrograde gain control pp. E18-E18

David J. Marcus, Anthony E. English, Gunn Chun, Emmaline F. Seth, Rachel Oommen, Sabrina Hwang, Bailey A. Wells, Sean C. Piantadosi, Azra Suko, Sayaka J. Kenmochi, Anupritaa A. Parasnis, Ethan Ancell, Yulong Li, Larry S. Zweifel, Benjamin B. Land, Nephi Stella and Michael R. Bruchas

Will wearable technologies transform clinical trials? pp. S47-S49

Nic Fleming

Use AI as a sparring partner, not an oracle pp. 575-575

Marc Schmitt

CRISPR crops are coming to Europe — why bolder would be better pp. 576-576

Nico De Storme

OpenAI claims huge maths breakthrough on a famed ‘Millennium Problem’ pp. 579-580

Davide Castelvecchi

Pick up the phone! Phone calls with tutors keep kids learning when schools shut down pp. 580-581

Mohana Basu

Bunsen burners’ reputation for sterilizing workplaces flames out pp. 581-582

Kaia Glickman

Buried underpants and a new definition of kissing win 2026 Ig Nobel prizes pp. 582-583

Chris Simms

China’s fast-track clinical trials are in the spotlight after child deaths pp. 584-585

Xiaoying You

Immune therapy engineered inside the body eases multiple sclerosis pp. 585-585

Rachel Fieldhouse

Who were the Denisovans? Rich trove of fossils and tools paints new picture pp. 586-586

Dyani Lewis

These bizarre, much-coveted microbes are revealing the origins of complex life pp. 587-589

Elizabeth Quill

Underground hydrogen could spur a green-energy revolution — if companies can find it pp. 590-591

James Mitchell Crow

Fraud sealed the fate of controversial zoologist Paul Kammerer — 100 years on, his ideas deserve revisiting pp. 592-594

Max Telford

Ada Yonath obituary: Crystallographer who overcame ‘impossible’ challenge of mapping the ribosome pp. 595-595

Georgina Ferry

The pet trade puts reptiles and amphibians at risk: close legal gaps now pp. 596-598

Neil M. Vora, Susan Lieberman, Sandra Altherr, Juliana Machado Ferreira, Rachel Boratto, Michèle Hamers, John E. Scanlon and Chris Walzer

Cities and countryside are intimately linked — green initiatives must recognize that pp. 599-601

Yansui Liu and Xinxin Huang

Tropical cyclones could be predicted with an extra day’s warning, thanks to an AI model pp. 603-604

Tom Beucler and Milton Gomez

Phone-based tutoring improves learning during school closures pp. 604-606

Felipe Barrera-Osorio

Virus-like particles observed assembling in real time pp. 606-608

Charlotte Uetrecht

How is climate change affecting conifers and their ability to sequester carbon? pp. 607-607

Mary Abraham

‘Superdark’ protein looks like a G-protein-coupled receptor — but shows unconventional behaviour pp. 608-610

Nil Casajuana-Martin and M. Madan Babu

Assessing biological degradation of non-hydrolysable synthetic polymers pp. 611-620

Anton A. Stepnov, Allison Werner, Soo-Jin Yeom, Uwe T. Bornscheuer, Shannon S. Stahl, Gregg T. Beckham and Gustav Vaaje-Kolstad

Overmassive black holes and little red dots naturally form in simulations pp. 621-625

Sunmyon Chon, Shingo Hirano, Tomoaki Ishiyama, Seok-Jun Chang and Volker Springel

Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus pp. 626-631

I. Morawetz, T. Riebner, L. Toscani De Col, F. Schneider, N. Sempelmann, F. Schaden, M. Bartokos, G. A. Kazakov, S. Lahs, K. Beeks, B. Gerstenecker, A. Grüneis, M. Pimon, T. Schumm, V. Lal, G. Zitzer, V. Petrov, J. Tiedau, M. V. Okhapkin and E. Peik

Electrically controllable superconducting memory effect in UTe2 pp. 632-637

Zheyu Wu, Hanyi Chen, Mengmeng Long, Daniel Shaffer, Dmitry V. Chichinadze, Andrej Cabala, Theodore I. Weinberger, Alexander J. Hickey, Jinxu Pu, Dave Graf, Vladimir Sechovský, Michal Vališka, Gang Li, Rui Zhou, F. Malte Grosche and Alexander G. Eaton

Heterogeneous photonic integration of single-crystalline nanomembranes pp. 638-645

Yuan Meng, Wenbo Mao, Zhihao Xu, Di Jia, Mengxin Lin, Jisung Seo, Bora Kim, Xinyuan Zhang, Eugene Park, Seokje Lee, Jekyung Kim, Sangmoon Han, Ji-Yun Moon, Weijie Xu, Qian Zhang, Xiaoqing He, Mingfeng Chen, Sang Hyun Nam, Jianqi Hu, Justin S. Kim, Sejin Lee, Sanggeun Bae, Soo Ho Choi, Tae Hyung Kim, Yunseok Choi, Seung-Il Kim, Kyubeen Kim, Minho Jin, Chen Jiang, Yiheng Zhang, Young-Hoon Kim, Jae-Hyun Lee, Hobeom Kim, Sheng Ran, Xi Wang, Cheng-Wei Qiu, Frances M. Ross, Jeehwan Kim, Minjoo Larry Lee, Hyunseok Kim, Tobias J. Kippenberg, Lan Yang and Sang-Hoon Bae

A thermodynamically favoured molecular computer pp. 646-652

Tristan Stérin, Abeer Eshra, Constantine Glen Evans, Janet Adio and Damien Woods

Molecular-level observation of the self-assembly of a virus-like particle pp. 653-660

Roi Asor, Dan Loewenthal, Diana Melnyk, Tiong Kit Tan and Philipp Kukura

Probing far-from-equilibrium dynamics of electrical double layers pp. 661-667

Xiao-Yu Li, Yu-Chen Cai, Zhao-Dong Meng, Ze-Tong Jia, Yu-Chen Sun, Jin-Yu Ye, Na Tian, Zhi-You Zhou, Jun Huang, Junxiang Chen, Shi-Gang Sun and Tao Wang

Anodic Pd membrane H2 extraction enhances thermochemical dehydrogenation pp. 668-673

Rui Zeng, Julian Ufert, Bryan Y. Tang, Ryan P. Bisbey and Yogesh Surendranath

Atmospheric CH4 plateau sustained by NOx emission rise and southward shift pp. 674-679

Yu Zhu, Lu Shen, Gang Liu, Kelvin H. Bates, Yuxin Cai and Shushi Peng

Operational tropical cyclone forecasting with AI pp. 680-688

Ferran Alet, Tom R. Andersson, Ilan Price, Stratis Markou, Andrew El-Kadi, Dominic Masters, Amy Li, Samier Merchant, Natalie Williams, Gregory Thornton, Ken MacKay, Olivia Graham, Akib Uddin, Ben Gaiarin, Devaja Shah, Elinor Kruse, Wallace Hogsett, David Zelinsky, John Cangialosi, Jonathan Martinez, James Franklin, Mark DeMaria, Kate Musgrave, Caroline L. Bain, Helen Titley, Jacklynn Stott, Remi Lam, Aaron Bell, Paul Komarek, Matthew Willson, Alvaro Sanchez-Gonzalez and Peter Battaglia

Mobile education builds resilience during shocks in five countries pp. 689-696

Noam Angrist, Micheal Ainomugisha, Sai Pramod Bathena, Peter Bergman, Colin Crossley, Claire Cullen, Thato Letsomo, Moitshepi Matsheng, Rene Marlon Panti, Shwetlena Sabarwal and Tim Sullivan

Pines grow faster and are more drought resilient in the Southern Hemisphere pp. 697-702

Alex Fajardo, Antonio Gazol, J. Julio Camarero, Michael J. Gundale, Frida I. Piper, J. Stephen Brewer, Rowan Buxton, Ellen Cieraad, Alejandro Dezzotti, Angel Fernández-Cortés, Florian Goedecke, Ester González de Andrés, Suzaan Kritzinger-Klopper, Annamari Laurén, Juan C. Llancabure, Anne C. S. McIntosh, Tomás Milani, Jaime Moyano, Martín A. Núñez, Marjo Palviainen, Duane Peltzer, Claudia Reyes-Bahamonde, Lina Rinne, Anna Sala, Robert P. Skelton, Cristina Valeriano and Ragan M. Callaway

FNIP1 variants are associated with favourable metabolism in 1 million humans pp. 703-712

George Hindy, Rene C. Adam, Olukayode Sosina, Dwaine Pryce, David Blair, Joseph Herman, Joseph Lee, Peter Dornbos, Ernst Mayerhofer, Arthur Gilly, Charleen Hunt, Benjamin Geraghty, Karl Landheer, Liron Ganel, Antoine Baldassari, Chuanyi Zhang, Ivory Mintah, Daphne Sun, Angel Coppola, Kyle Brown, Tram Nguyen, Xin Xia, Regeneron Genetics Center, DiscovEHR Collaboration Ghs-Rgc, Penn Medicine Biobank, Colorado Center for Personalized Medicine, Mayo Clinic-RGC Project Generation, Mexico City Prospective Study, Malmö Diet and Cancer Study, Indiana University School of Medicine (Indiana-CLDB), ATLAS Collaboration Ucla-Rgc, Mount Sinai Million Health Discoveries Program, UTSW-Dallas Biobank, South Asia Biobank Study, Daniel J. Rader, Olle Melander, Christopher D. Still, Jaime Berumen, Pablo Kuri-Morales, Jesus Alegre-Díaz, Jason M. Torres, Jonathan R. Emberson, Rory Collins, Roberto Tapia-Conyer, Suganthi Balasubramanian, Marcus B. Jones, Michelle G. LeBlanc, Andrew J. Murphy, Christos A. Kyratsous, John D. Overton, Jeffrey G. Reid, Goncalo R. Abecasis, Jonathan Marchini, Cristen Willer, George D. Yancopoulos, Mark W. Sleeman, Jonas Bovijn, Adam Locke, Aris Baras, Niek Verweij, Viktoria Gusarova and Luca A. Lotta

Human brain organoids record the passage of time over multiple years pp. 713-723

Irene Faravelli, Noelia Antón-Bolaños, Anqi Wei, Tyler Faits, Abhishek Sampath Kumar, Sophia Andreadis, Rahel Kastli, Marta Montero Crespo, Mara Steiger, Daniel Leible, Elizabeth Zhang, Bobae An, Yaron Meirovitch, Sayara Silwal, Sung Min Yang, Alexander Kovacsovics, Xian Adiconis, Helene Kretzmer, Joshua Z. Levin, Edward S. Boyden, Jeff Lichtman, Aviv Regev, Alexander Meissner and Paola Arlotta

Stimulation modulates gene-linked cell assemblies in the human brain pp. 724-734

Haley Moore, Mantre Dehnad, Anne Freelin, Bryan Granger, Suganya Subramanian, Tjitse van der Molen, Ashwinikumar Kulkarni, Stefano Berto, Bradley C. Lega and Genevieve Konopka

Diverse bacterial pattern recognition receptors sense the core phage proteome pp. 735-743

Hyunbin Lee, Sofia Luengo-Woods, Jianxiu Zhang, Kira S. Makarova, Yuri I. Wolf, Collin Chiu, Simone A. Evans, Junyi Chen, Haopeng Xiao, Liang Feng, Eugene V. Koonin and Alex Gao

The Virtual Tissues foundation model resolves spatial proteomics across scales pp. 744-754

Johann Wenckstern, Eeshaan Jain, Benedikt von Querfurth, Yexiang Cheng, Kiril Vasilev, Matteo Pariset, Phil F. Cheng, Petros Liakopoulos, Olivier Michielin, Andreas Wicki, Gabriele Gut and Charlotte Bunne

Antigen presentation by CD40+MHC-II+ astrocytes promotes CNS autoimmunity pp. 755-764

Joon-Hyuk Lee, Zhaorong Li, Joselyn S. Soto, Ah-Ram Kim, Tomer Illouz, Carolina M. Polonio, Michael Kilian, Jessica E. Kenison, Anton M. Schüle, Camilo Faust Akl, Hong-Gyun Lee, Brian M. Andersen, Jessica J. Ye, Joseph M. Rone, Gavin Piester, Lena Srun, Jazmin Martinez, Austin Danko, Jinsu Lee, Tae Hyun Heo, Elizabeth N. Chung, Landon K. Oetjen, Pere Duart-Abadia, Nakyung Koo, Norbert Perrimon, Michael A. Wheeler, Baljit S. Khakh, Stephanie E. J. Zandee, Alexandre Prat and Francisco J. Quintana

A tumour-derived organoid biobank maps cancer gene dependencies pp. 765-774

C. Herranz-Ors, S. G. Bhosle, A. E. Beck, J. G. R. Gilbert, G. Picco, J. Espejo Valle-Inclan, F. Muyas, S. Valentini, A. E. Andres, R. Ansari, S. Barthorpe, G. Battarbee, C. M. Beaver, S. Brocklesby, J. Cantwell, C. A. Collins, J. Davis, H. G. Dimitrova, J. Doran, E. Efendi, K. Evans, M. Fekry, T. A. Fowler, M. Garcia-Casado, J. A. T. Griffiths, C. Hall, R. Hamer, C. Hardy, Z. Hewitson, E. Hitch, L. Holland, D. A. Jackson, N. Joshi, A. Kavasakali, L. Letchford, H. B. Lightfoot, H. Lingala, I. Mali, K. May, T. Mironenko, J. Morris, C. Pacini, S. Price, G. Robert-Tissot, H. A. Rogers, J. V. Smith, K. Smith, E. Souster, W. J. Spence, F. Thomas, S. F. Vieira, S. Walker, G. Alfonsin, H. Bermingham, H. Coles, D. P. Ennis, A. Freeman, G. Giannone, N. Grehan, E. A. Griffiths, J. Hall, S. L. Lee, E. Y. L. Leung, C. Loreno, C. Millington, A. Mirnezami, B. Nutzinger, K. Orzechowska, C. M. A. Pinna, A. M. Redmond, K. Roberts, S. Roy, D. A. Sanders, P. Taniere, M. Vias, K. Wanigasooriya, Consortium Occams, M. R. Stratton, L. M. Staudt, U. McDermott, J. D. Brenton, I. A. McNeish, A. Biankin, O. J. Sansom, I. Cortes-Ciriano, T. J. Underwood, R. C. Fitzgerald, A. D. Beggs, H. E. Francies and M. J. Garnett

A compendium of next-generation patient-derived models for diverse cancers pp. 775-788

Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A. Misek, Heeju Noh, Luca Zanella, Yuen-Yi Tseng, Hayley E. Francies, Dennis Plenker, Cindy W. Kyi, Julyann Perez-Mayoral, Megan J. Stine, Eva Tonsing-Carter, Rachana Agarwal, Jean Claude Zenklusen, James M. Clinton, Jennifer M. Shelton, Timothy R. Chu, William F. Hooper, Xavi Loinaz, Paula Keskula, Jordan Tagle, Peyton C. Kuhlers, Bahar Tercan, Sylvia F. Boj, Alessandro Vasciaveo, Lorenzo Tomassoni, James M. Crawford, Shawna Walsh, Claire Sinai, Sonam Bhatia, Priya Sridevi, Hardik Patel, Maria Antonietta Cerone, The HCMI Network, Kyle Ellrott, Calvin J. Kuo, Olivier Elemento, Semir Beyaz, Vincenzo Corbo, David L. Spector, Rameen Beroukhim, Martin L. Ferguson, Andrew D. Cherniack, Peter W. Laird, Nicolas Robine, Andrew McPherson, Katherine A. Hoadley, Mathew J. Garnett, David A. Tuveson, Andrea Califano, Paul T. Spellman, Keith L. Ligon, Daniela S. Gerhard, Louis M. Staudt and Jesse S. Boehm

A dependency map enhanced with next-generation 3D cancer models pp. 789-799

James V. Neiswender, Samuel Maffa, Lisa Brenan, Dina ElHarouni, Yejie Yun, Isabella Boyle, Kirsty Wienand, Haider Inam, Tate Bertea, Ashley Anderson, Megan Wong, Matias Enriquez, Evan Lenz, Beatriz Villafranca, Nora Shanks, Mary Hager, Nia Lloyd, Hannah Shadmany, Sarah J. Wie, Harry Liang, Konnor Yunghans, Xiaomeng Zhang, Lauren Golden, Hannah Harris, Serena Day, Philip Montgomery, Samantha Stokes, Ross M. Giglio, Cynthia Hajal, James R. Whittle, Guadalupe Garcia, Caitlin E. Mills, Mehdi Touat, Kristine Pelton, Hongyu Li, Prem Sai Prabhakar, Sonja Herter, Zoe Hoffmann Kamrat, Dan Gui, Julien Dilly, Chen Khuan Wong, Jimmy A. Guo, Sangita Pal, Yossef Baidi, Ryan Johnston, Daniel D. Brown, Sonam Bhatia, Peter S. Winter, Srivatsan Raghavan, Rameen Beroukhim, Eva Colas, David L. Spector, Adam J. Bass, Peter K. Sorger, Yu Chen, Sarah J. Hill, Steffi Oesterreich, Adrian V. Lee, Himisha Beltran, Jesse S. Boehm, Yuen-Yi Tseng, David E. Root, William C. Hahn, Andrew J. Aguirre, Catarina D. Campbell, Keith L. Ligon, Joshua M. Dempster, Tsukasa Shibue and Francisca Vazquez

Aneuploidy selects for the acquisition of driver genes in breast cancer pp. 800-810

Khalid N. Al-Zahrani, Ellen R. Langille, Jocelyn Nurtanto, Andreea Obersterescu, Katie Teng, Christopher Lowden, Julien Dessapt, Cynthia H. Chiu, Lauren V. Caldwell, David P. Cook, Miguel A. Pérez-Castro, Jacob M. Berman, Ricky Tsai, Alexander T. Bahcheli, Geraldine Mbamalu, Shifei Wu, Masahiro Narimatsu, Adele G. Lopes, Iosifina Fotiadou, Kin Chan, Linkang Zhang, K. W. Annie Bang, Michael J. Parsons, Larissa Mourao, E. Idil Temel, Liddy McCulla, Palavalasa Sravya, Li Zhang, Peter Sajjakulnukit, Costas A. Lyssiotis, Alexander D. Borowsky, Colinda L. G. J. Scheele, Daniel R. Wahl, Hartland W. Jackson, Katherine S. Stewart, Elaine Fuchs, Sean E. Egan, Miguel Angel Pujana, Jüri Reimand, Jeffrey L. Wrana and Daniel Schramek

Prior therapy defines mutation profiles in childhood cancer at relapse pp. 811-820

Mehdi Layeghifard, Marcos Díaz-Gay, Erik N. Bergstrom, Mathepan J. Mahendralingam, Nicholas Light, Sasha Blay, Joshua O. Nash, Nathaniel D. Anderson, Jessica N. Au, Scott Davidson, Pedro L. Ballester, Timmy Wen, Syed Kashif Daud, Lisa-Monique Edward, S. M. Ashiqul Islam, Azhar Khandekar, Burçak Otlu, Ledia Brunga, Rawan Hammad, Shimaa Nassif, Nirav H. Thacker, Tara Feltham, Noemi A. Fuentes-Bolanos, Marie Wong-Erasmus, Max F. Levine, Katherine E. Miller, Neerav N. Shukla, Michael D. Kinnaman, Dominik Glodzik, Carol Portwine, Sabrina Millson, Alexandra P. Zorzi, Mariam Mikhail, Conrad V. Fernandez, Laura Wheaton, Gunes Gundem, Andrew L. Kung, Uri Tabori, Chelsea Mayoh, Elli Papaemmanuil, Mark J. Cowley, David Malkin, Anita Villani, Ludmil B. Alexandrov and Adam Shlien

Structural basis of the RNA-editing cascade in trypanosome mitochondria pp. 821-832

Yun-Tao Liu, Andres F. Vacas, Jonathan Jih, Xiaojing Zhao, Clinton Yu, Jane K. J. Lee, Takuma Suematsu, Md Solayman, Hong Wang, Xiaorong Wang, Lan Huang, Liye Zhang, Inna Aphasizheva, Z. Hong Zhou and Ruslan Aphasizhev

TM184C is a GPCR-like regulator of intercellular exchange and autophagy pp. 833-843

Kyutae D. Lee, Samuel Taylor, Jennifer Arcuri, Shraddha Chandthakuri, Jacinda Pujols, Bruno Colon, Qiang Wang, Chenzhou Wu, Zhipeng Meng, Sebastian J. Thompson-Ceccato, Jonathan Mitchell, Defne Bayik, Alexandra Carbone, Vladlen Slepak, Tatiana I. Slepak, Scott M. Welford, Michael E. Ivan, Dazhi Wang, Blake O. Goldberg, Warner Baringer, Elvis Maradzike and Daniel G. Isom

Retraction Note: Warming accelerates global drought severity pp. 844-844

Solomon H. Gebrechorkos, Justin Sheffield, Sergio M. Vicente-Serrano, Chris Funk, Diego G. Miralles, Jian Peng, Ellen Dyer, Joshua Talib, Hylke E. Beck, Michael B. Singer and Simon J. Dadson

A call to celebrate your achievements — from dissertations to tenure pp. 845-846

Amanda Heidt

A wake-up call: diversify global research funding pp. 848-848

Huixue Zhang and Shiyu Wang

Make AI traceable before it shapes global climate assessments pp. 848-848

Carlos Garcia-Soto

Why the NIH must resist the metrics trap pp. 848-848

Kirsten K. Davison

Why Nepal floods resulted in a disaster even after satellites spotted danger pp. 848-848

Rajeev Bhattarai

2026, volume 657, articles 8131

A good drug is useless if it misses its target pp. S1-S1

Richard Hodson

These six advances could change how drugs are delivered pp. S2-S3

Nic Fleming

Drug-delivering particles aim to breach the blood–brain barrier pp. S4-S7

Simon Makin

Addendum: Sea level much higher than assumed in most coastal hazard assessments pp. E8-E14

Katharina Seeger and Philip S. J. Minderhoud

Nasal vaccines could stop pandemics before they begin pp. S8-S9

Anthony King

Special delivery: bacterial couriers are smuggling drugs into cancers pp. S10-S12

Liam Drew

Medicines do no good if people don’t take them pp. S13-S13

Laura Vargas-Parada

Drug delivery gets subcellular pp. S14-S15

Katherine Bourzac

Dose once, treat forever: drugs are being engineered to last much longer pp. S16-S18

Ben Deighton

NASA’s Roman telescope holds promise far beyond mapping the invisible Universe pp. 321-321

Priyamvada Natarajan

‘Mother of Hubble’: how Nancy Grace Roman ushered in a new era of astronomy pp. 322-322

Robert W. Smith

Lift-off! NASA launches Roman Space Telescope to tackle dark-energy mysteries pp. 325-326

Davide Castelvecchi

‘Robot Olympics’ reveal humanoids’ rapid progress — and flaws pp. 327-328

Kaia Glickman

Satellite images before Nepal disaster showed warning signs pp. 328-329

Mohana Basu

Landmark pancreatic cancer drug shows potential against lung cancer too pp. 329-329

Heidi Ledford

Is this the first glimpse of dark matter? Data point excites physicists pp. 330-331

Davide Castelvecchi

Mutating every DNA letter of a genome shows surprising effects — and the limits of AI pp. 331-331

Ewen Callaway

Say hello to the next generation of lobsters — August’s best science images pp. 332-332

Dhruv Shenai

A data leak shut a top research biobank: lessons from the recovery pp. 334-336

Diana Kwon

The Einstein test: what happens when AI tries to rediscover relativity? pp. 338-340

Philip Ball

Isaac Newton’s remarkable year — and the plagiarism accusations that followed pp. 341-343

Andrew Robinson

Mysteries of the deep and AI friendship: Books in brief pp. 343-343

Andrew Robinson

Heisuke Hironaka obituary: mathematician who smoothed out geometry’s complexities pp. 344-344

Allyn Jackson

Why we need an International Panel on Inequality pp. 345-348

Joseph E. Stiglitz, Adriana E. Abdenur, Winnie Byanyima, Jayati Ghosh, Imraan Valodia and Wanga Zembe-Mkabile

How countries can grow without impoverishing future generations pp. 348-350

Eoin McLaughlin

Evolutionary mystery revealed by structures of a key enzyme in the synthesis of glycolipids pp. 351-352

Yaxin Dai and Chia-Hsueh Lee

Vaporization trick enables ‘tandem’ solar cells to be made at lower temperatures pp. 352-353

Ulrich W. Paetzold and Paul Fassl

Weight-loss drug slows ageing in female mice pp. 354-355

Maria Emilia Fernandez and Rafael de Cabo

Computational ‘gym’ trains AI models to control turbulence pp. 355-356

Clara M. Velte

The secret life of a cell-cycle gatekeeper of breast cancer pp. 357-358

Cristina Guarducci and Luca Malorni

Discovery of a star sensitive to the spin of Sagittarius A* pp. 359-363

K. Abd El Dayem, R. Abuter, N. Aimar, P. Amaro-Seoane, A. Berdeu, J.-P. Berger, G. Bourdarot, W. Brandner, A. Burkert, D. Caldéron, C. Correia, J. Cuadra, R. Davies, D. Defrère, L. Delit, A. Drescher, F. Eisenhauer, L. Esteras Otal, M. Fabricius, H. Feuchtgruber, S. Flesch, N. M. Förster Schreiber, A. Foschi, Q. Fournier, P. Garcia, R. Garcia Lopez, A. Generozov, R. Genzel, S. Gillessen, F. Gonté, X. Haubois, S. F. Hönig, M. Houllé, S. Joharle, A. Kaufer, J. Kammerer, P. Kervella, J. Kolb, L. Kreidberg, L. Labadie, S. Lacour, O. Lai, R. Laugier, J.-B. Le Bouquin, J. Leftley, R. Li, B. Lopez, D. Lutz, F. Mang, A. Mérand, F. Millour, M. Montargès, N. Morujão, H. Nowacki, M. Nowak, S. Oberti, J. Osorno, T. Ott, T. Paumard, C. Paladini, S. Pappert, H. B. Perets, K. Perraut, G. Perrin, R. Petrov, P. O. Petrucci, T. Piran, N. Pourré, S. Rabien, D. C. Ribeiro, S. Robbe-Dubois, M. Sadun Bordoni, J. Sanchez-Bermudez, D. Santos, R. Sari, J. Sauter, S. Scheithauer, J. Scigliuto, J. Shangguan, T. T. Shimizu, F. Soulez, J. Stadler, C. Straubmeier, E. Sturm, M. Subroweit, C. Sykes, L. J. Tacconi, P. Thévenet, I. Urso, F. Vincent, J. Woillez, G. Zins and Collaboration Gravity+

Infrared absorption spectroscopy of a single polyatomic molecular ion pp. 364-368

Zhenlin Wu, Tim Duka, Mariano Isaza-Monsalve, Miriam Kautzky, Vojtěch Švarc, Andrea Turci, René Nardi, Marcin Gronowski, Michał Tomza, Brandon J. Furey and Philipp Schindler

The HydroGym reinforcement learning platform for fluid dynamics pp. 369-376

Christian Lagemann, Sajeda Mokbel, Miro Gondrum, Mario Rüttgers, Yuning Wang, Pol Suárez, Ludger Paehler, Deniz A. Bezgin, Aaron B. Buhendwa, Jared L. Callaham, Samuel Ahnert, Nicholas Zolman, Xiao Shao, Jean-Christophe Loiseau, Nikolaus A. Adams, Matthias Meinke, Wolfgang Schröder, Kai Lagemann, Esther Lagemann, Ricardo Vinuesa and Steven L. Brunton

Degree-of-polarization modulation for high-dimensional optical computing pp. 377-384

Alessandro Petrini, Claudio Conti and Davide Pierangeli

Thermally evaporated perovskite/silicon tandems via formamidinium eutectic pp. 385-392

Chao Luo, Rui He, Ran Luo, Jingcong Hu, Yuduan Wang, Yu Shi, Yi Mo, Cheng Yan, Yuxin Yao, Zihao Zhu, Chenxia Kan, Xinyi Du, Ling Kai Lee, Qilin Zhou, Nengxu Li, Xiuxiu Niu, Fengtao Pei, Ming Lin, Xi Wang, Jinxi Chen, Zhenrong Jia, Tao Wang, Zijing Dong, Xiao Guo, Xin Meng, Xinyu Zhang, Yuhui Jiang, Peng Gao, Keli Wang, Yabin Ma, Zhen Guan, Jing Wei, Sai Bai, Yu Chen, Wan-Jian Yin, Qing Zhao, Zhigang Xie, Xueling Zhang, Yifeng Chen, Jifan Gao and Yi Hou

Spontaneously charged water drops induce corrosion pp. 393-399

Zhongyuan Ni, Xiaomei Li, Aaron D. Ratschow, Lin Jian, Xiaoteng Zhou, Pravash Bista, Diego Cortes, Gunnar Glasser, Haojian Luo, Shuai Chen, Jiyao Yu, Yongkang Wang, Katrin Amann-Winkel, Kaloian Koynov, Rüdiger Berger and Hans-Jürgen Butt

Entangled dual-site migration through boracycle rearrangement pp. 400-408

Zheng Zhu, Peiqi Zhang, Bin Gao, Kit San Ly, Hongyi Tao, Yiyi Fu, Zhenyang Lin and Yangjian Quan

A global atmospheric methane record from a tropical ice core pp. 409-413

Kara A. Lamantia, Lonnie G. Thompson, Mary E. Davis, Ben Riddell-Young, Ivo Strawson, Emilie Beaudon, Ellen Mosley-Thompson, Newton Nguyen and Edward J. Brook

New-deal mortgage programmes benefited white borrowers disproportionately pp. 414-419

Katherine A. Thomas, Thomas B. Storrs, Wenfei Xu and Jacob W. Faber

Over 20,000 precolonial earthworks in the Southwest Amazonia pp. 420-425

Martti Pärssinen, Risto Kalliola, Alceu Ranzi, Eetu Puttonen, Rhuan Carlos Lopes, Pirjo Kristiina Virtanen, Francisco Apurinã, Kalle Ruokolainen, Juha Hyyppä, Antero Kukko, Mariana Campos, Fabio de Novaes, Markku Oinonen, Antonia D. Barbosa, Sanna Saunaluoma and Evandro Ferreira

The planktonic microbiome of the Great Barrier Reef pp. 426-435

Steven Robbins, Marko Terzin, Katherine Dougan, Julian Zaugg, Sara C. Bell, Patrick W. Laffy, J. Pamela Engelberts, Kim-Anh Lê Cao, Renee K. Gruber, Nicole S. Webster, David G. Bourne, Philip Hugenholtz and Yun Kit Yeoh

Uncovering the mechanism of female restitution in sugarcane hybrids pp. 436-442

Sihui Zhu, Haibao Tang, Tyler Jones, Nathan Fumia, Jing Zhou, Lingmin Cai, Wen Wang, Yanhong Zhou, Haoming Mao, Liping Zuo, Yutong Zheng, Yixing Zhang, Zhaoqian Ji, Huanhuan Tao, Jianling Pan, Yating Xu, Huiru Chen, Chifumi Nagai and Ray Ming

A vector-based strategy for olfactory navigation in Drosophila pp. 443-454

Andrew F. Siliciano, Sun Minni, Chad Morton, Charles K. Dowell, Noelle B. Eghbali, Silas E. Busch, Juliana Y. Rhee, L. F. Abbott and Vanessa Ruta

Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours pp. 455-468

Sara G. Pelaz, Katsukuni Mitsui, Natalia Kolosowska, Haley Fritch, Chiranjivi Neupane, Vanessa H. Casha, Marta Alonso-Gardón, Vijaya Pandey, Lizheng Wang, Riki Kawaguchi, James A. Wohlschlegel, Jiami Guo, Steven A. McCarroll, Sabina Berretta and Baljit S. Khakh

Late-life semaglutide treatment slows ageing and extends lifespan in female mice pp. 469-476

Yufan Feng, Marine Barthez, Yifei Wang, Yibing Chen, Huixian Qiu, Chih-Ling Wang, Kartoosh Heydari, Melaine Delcroix, Lene Juel Rasmussen, Vilhelm A. Bohr and Danica Chen

Glucose-responsive probiotics for glycaemic modulation in mice and monkeys pp. 477-486

Ningzi Guan, Deqiang Kong, Xianyun Gao, Lingxue Niu, Yang Zhou, Guiling Yu, Tian Gao, Mengyao Liu, Wenbo Ma, Yiyu Jin, Jianli Yin, Shangang Zhao and Haifeng Ye

The past and future impact of climate change on childhood malaria in Africa pp. 487-494

Colin J. Carlson, Tamma Carleton, Romaric C. Odoulami, Cullen D. Molitor and Christopher H. Trisos

GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma pp. 495-504

Qi Zhang, Qihan Fu, Yinan Shen, Wanyue Cao, Gaowei Jin, Yize Zhang, Jiangchao Wu, Cao Chen, Hongkan Wang, Xingyuan Xu, Ke Sun, Xing Xue, Attilio Bondanza, Daisy Cao, Nina Chu, Nick Durham, Mark Cobbold, Benedetto Farsaci, Maria Letizia Giardino Torchia, Yixin Hao, Yi Hong, Jiaqi Huang, Michael Humphries, Qijie Jian, Gordon Moody, John Stone, Lingyan Sun, Eric Tu, Fei Wang, Fuzhe Wang, Ye Yang, Yihong Yao, Andy Zou, Xueli Bai and Tingbo Liang

Diet–microbiome synergy underlies obesity-associated immunotherapy efficacy pp. 505-516

Lysanne Desharnais, Anikka Swaby, Meriem Messaoudene, Samuel Doré, Miranda W. Yu, Benoit Fiset, Valérie Breton, Mayra Ponce, Yongjia Hu, Liam Wilson, Mark Sorin, Ye Wang, Ken Dewar, Michael Pollak, Arielle Elkrief, Bertrand Routy, Logan A. Walsh and Daniela F. Quail

Rb-driven transcription limits its tumour-suppressive effects in breast cancer pp. 517-524

April C. Watt, Antonio Ahn, Catherine Blyth, Julia R. Dixon-Douglas, Krutika Ambani, Rhiannon Coulson, Michael Taylor, Keefe T. Chan, Catherine Dietrich, Brendan E. Russ, Susanne Ramm, Christabella A. Mahendra, Kun-Hui Lu, Nichelle Pires, Jesus Garcia-Sannicolas, Olivia Voulgaris, Sheena Nunag, Ching-Seng Ang, Mark A. Dawson, Elgene Lim, Monica Arnedos, Sarat Chandarlapaty, Fabrice André and Shom Goel

AI-redesigned starting points and outcomes enhance protein evolution pp. 525-538

Nicholas A. Krasnow, Joy A. Xu, Emily Zhang, Gandhar K. Mahadeshwar, Y. Allen Tao, Julia McCreary, Colin F. Hemez, Logan E. Brown, Wei Jiang and David R. Liu

Subnuclear genome compartmentalization controls bivalent chromatin activity pp. 539-548

Sajad Hamid Ahanger, Evan R. Semenza, Chujing Zhang, Eugene Gil, Mitchel A. Cole, Serena Huei-An Lu, Li Wang, Arnold R. Kriegstein and Daniel A. Lim

Primate-specific regulation of the human glycosphingolipid gatekeeper UGCG pp. 549-558

Canrong Wu, Sanshan Jin, Jiuyin Xu, James Jiqi Wang, Xiaoqi Guo, Yunhai Li, Zhenyu Cao, Mengting Jiang, Qingning Yuan, Wen Hu, Changyao Li, Youwei Xu, Ming-Wei Wang, Yi Jiang and H. Eric Xu

How to make your science business succeed when you’re a female founder pp. 559-561

Rachel Brazil

Probing the proteome at cellular scale pp. 562-564

Michael Eisenstein

Nepal disaster is a wake-up call to take compound climate risks seriously pp. 566-566

Ramit Debnath

Limit bets on clinical-trial outcomes being placed on prediction markets pp. 566-566

Thomas J. Hwang and Sarah M. E. Gabriele

Put patients at the centre of medical AI governance pp. 566-566

Yuan Shen and Linghua Yu

Sideline vested interests to reform China’s research pp. 566-566

Qilin Zhang

2026, volume 657, articles 8130

Author Correction: Structural mechanism of cGAS inhibition by the nucleosome pp. E1-E1

Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä and Andrea Ablasser

Author Correction: Cretaceous bird from Brazil informs the evolution of the avian skull and brain pp. E2-E4

Luis M. Chiappe, Guillermo Navalón, Agustín G. Martinelli, Ismar de Souza Carvalho, Rodrigo Miloni Santucci, Yun-Hsin Wu and Daniel J. Field

Author Correction: Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP pp. E5-E5

Andrea Ablasser, Jonathan L. Schmid-Burgk, Inga Hemmerling, Gabor L. Horvath, Tobias Schmidt, Eicke Latz and Veit Hornung

Author Correction: Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer pp. E6-E6

Giannicola Genovese, Alessandro Carugo, James Tepper, Frederick Scott Robinson, Liren Li, Maria Svelto, Luigi Nezi, Denise Corti, Rosalba Minelli, Piergiorgio Pettazzoni, Tony Gutschner, Chia-Chin Wu, Sahil Seth, Kadir Caner Akdemir, Elisabetta Leo, Samirkumar Amin, Marco Dal Molin, Haoqiang Ying, Lawrence N. Kwong, Simona Colla, Koichi Takahashi, Papia Ghosh, Virginia Giuliani, Florian Muller, Prasenjit Dey, Shan Jiang, Jill Garvey, Chang-Gong Liu, Jianhua Zhang, Timothy P. Heffernan, Carlo Toniatti, Jason B. Fleming, Michael G. Goggins, Laura D. Wood, Alessandro Sgambato, Abbas Agaimy, Anirban Maitra, Charles W. M. Roberts, Huamin Wang, Andrea Viale, Ronald A. DePinho, Giulio F. Draetta and Lynda Chin

Publisher Correction: Targeting cancer-specific mutations with RNA-triggered chromatin shredding pp. E7-E7

Jingkun Zeng, Zhiyuan Cheng, Huadong Chen, Zhaojun Wang, Jared Thompson, Kadin T. Crosby, Hesong Han, Arushi Singhal, Wayne Ngo, Chenglong Xia, Daniel Rosas-Rivera, Zeyuan Zhang, Min Hyung Kang, Ying Mao, Morgan E. Diolaiti, Giselle C. Lee, John F. X. Diffley, Yixuan Song, Longhui Qiu, Nathan M. Krah, Niren Murthy, Ryan N. Jackson, Yang Liu, Alan Ashworth and Jennifer A. Doudna

Women face bans on research underground — here’s how to modernize the system pp. 9-9

Linqi Huang

The Moderna cancer vaccine offers hope — now we must speed up personalized therapies pp. 10-10

Patrick A. Ott

Billion-dollar machine aims to set a fusion-energy record — and study nuclear weapons pp. 13-15

James Dinneen

These trees are making air quality in cities worse pp. 15-16

Mohana Basu

Moderna cancer vaccine stops melanoma returning: what’s next for personalized treatments? pp. 16-17

Rachel Fieldhouse and Mohana Basu

More than 18,000 questionable images found in antibody catalogues of 15 companies pp. 17-18

Dan Garisto

Exclusive: NSF set to issue lowest number of new grants in four decades pp. 18-19

Dan Garisto

Staggering 90% of biomedical papers now show signs of AI help pp. 20-20

Kaia Glickman

Bland new world: is AI making us all think the same? pp. 22-24

Matthew Hutson

When do infections lead to long COVID? Scientists close in on triggers and treatments for post-viral syndromes pp. 26-28

Simon Makin

Order from disorder: do we need a new law of physics? pp. 29-31

Graham Shields

Einstein the musician, AI prophets and more: Books in brief pp. 31-31

Andrew Robinson

Rudolph A. Marcus obituary: theoretical chemist who explained how electrons jump between molecules pp. 33-33

Garnet Kin-Lic Chan and Kenneth H. Marcus

Who is responsible when AI helps to write science? pp. 34-36

Robert Braun

Why are rich people so pessimistic? What the numbers say pp. 36-38

Florence Gaub

Self-driving cars make mistakes, and now users can see why pp. 39-40

Hyochang Kim and Hyunmin Kang

Intraspecific variation in tropical trees can drive resistance to drought pp. 40-42

Brendan Choat and Erick Calderón-Morales

Antimatter ‘tag’ used to detect elusive particle decay pp. 42-44

Matt Kenzie

Scale of snakebites estimated globally pp. 43-43

Mary Abraham

Skin cancer spreads between catfish in a freshwater lake pp. 44-45

Hannah Siddle

Designing physics experiments with artificial intelligence pp. 47-58

Jonathan Klimesch, Sören Arlt, Carlos Ruiz-Gonzalez, Carla Rodríguez, Xuemei Gu, Philipp Haslinger, Pietro Vischia, Christian Haack, Yehonathan Drori, Rana Adhikari, Markus Arndt, Michael Kagan, Lukas Heinrich and Mario Krenn

Molecular mechanisms and pathogenesis of MASH pp. 59-75

Suchira Gallage, Olivier Govaere, Quentin M. Anstee, Gerald I. Shulman, Frank Tacke and Mathias Heikenwalder

Current therapeutic landscape and future treatment perspectives of MASH pp. 76-91

Suchira Gallage, Olivier Govaere, Quentin M. Anstee, Gerald I. Shulman, Frank Tacke and Mathias Heikenwalder

Exploring baryon semileptonic decays through polarization and entanglement pp. 92-97

The BESIII Collaboration

Observation of conformal field theory spectra in a quantum simulator pp. 98-106

Xiangkai Sun, Yuan Le, Stephen Naus, Richard Bing-Shiun Tsai, Lewis R. B. Picard, Sara Murciano, Michael Knap, Jason Alicea and Manuel Endres

Atomic-scale double-slit interferometry with a focused electron probe pp. 107-113

Koudai Tabata, Takehito Seki, Toma Susi, Ryo Ishikawa and Naoya Shibata

Explainable deep learning improves human mental models of self-driving cars pp. 114-120

Eoin M. Kenny, Akshay Dharmavaram, Sang Uk Lee, Tung Phan-Minh, Shreyas Rajesh, Yunqing Hu, Laura Major, Momchil S. Tomov and Julie A. Shah

Phase-homogeneous mixed-halide perovskites for stable tandem photovoltaics pp. 121-126

Pengju Shi, Jiale Zhuang, Dayong Zhang, Chu Li, Stefan Zeiske, Jin Hou, Isaiah W. Gilley, Ilhan Yavuz, Ubaid Kazianga, Congqi Li, Yu Zhang, Kefu Huang, Teerapat Itsoponpan, Xin Jiang, Chiung-Han Chen, Chuying Huang, Yi Yang, Xianfu Zhang, Pronoy Nandi, Samantha A. Reitz, Antonio Facchetti, Keith P. White, Keenan W. Wyatt, Michael F. Toney, Mercouri G. Kanatzidis, Tobin J. Marks, Cheng Liu, Bin Chen and Edward H. Sargent

Luminescent-reaction-enabled super-resolution imaging pp. 127-134

Wenxin Zhu, Chi Zhang, Jiahui Gui, Yibo Yang, Yuxin Wan, Xin Wang, Liying Qu, Ao Guo, Ziqing Zhang, Zhenqian Han, Weisong Zhao and Jiandong Feng

Synthesis of pyrroles from isoxazoles by an O-to-C skeletal edit pp. 135-141

Abigail J. Bracken, Alexandra P. Lawrie, Isabella F. Romita and Mark D. Levin

Pyridoxal photoenzymes for asymmetric radical–radical cross-couplings pp. 142-149

Cole C. Sorensen, Suhao Wang, Yao Ouyang, Saim Waheed, Claire G. Page, Greg Mann, Simon Allmendinger and Todd K. Hyster

Critical zone processes limit alkalinity export from natural basaltic systems pp. 150-155

L. A. Derry, K. Maher and O. A. Chadwick

Food systems transformation would reshape global agriculture pp. 156-163

Matthew Gibson, Marina Sundiang, Daniel Mason-D’Croz, Thais Diniz Oliveira, Felicitas Beier, Lauren Benavidez, Astrid Bos, Maksym Chepeliev, Jonathan Doelman, Shahnila Dunston, Shinichiro Fujimori, Tomoko Hasegawa, Peter Havlik, Jordan Hristov, Jonas Jägermeyr, Marta Kozicka, Marijke Kuiper, Page Kyle, Thijs de Lange, Benjamin Leon Bodirsky, Hermann Lotze-Campen, Hermen Luchtenbelt, David Meng-Chuen Chen, Abhijeet Mishra, Christoph Müller, Gerald Nelson, Amanda Palazzo, Ignacio Perez Dominguez, Alexander Popp, Ronald Sands, Marco Springmann, Elke Stehfest, Timothy B. Sulser, Kiyoshi Takahashi, Gianmaria Tassinari, Ferike Thom, Philip Thornton, Kazuaki Tsuchiya, Willem-Jan van Zeist, Hans van Meijl, Dominique van der Mensbrugghe, Detlef Van Vuuren, Hannah H. E. van Zanten, Isabelle Weindl, Keith Wiebe, Xin Zhao and Mario Herrero

Species intraspecific variation drives tropical forest drought resistance pp. 164-169

Chris M. Smith-Martin, Robert Muscarella, Timothy J. Brodribb and María Uriarte

Exceptional brain and ecological diversity in the earliest snakes pp. 170-178

Tiago R. Simões, Gabriela Sobral, Simone Macrì, Roy Ebel, Thiago S. Fachini, Agustín G. Martinelli, William R. Nava, Giovanna M. X. Paixão, Luis M. Chiappe, Nicolas Di-Poï and Annie S. Hsiou

An encyclopedia of human enhancer–gene regulatory interactions pp. 179-190

Andreas R. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh, Maya U. Sheth, Kushal K. Dey, Evelyn Jagoda, Ramil N. Nurtdinov, Wang Xi, Anthony S. Tan, James Galante, Hank Jones, X. Rosa Ma, David Yao, Dulguun Amgalan, Judhajeet Ray, Chad J. Munger, Joseph Nasser, Žiga Avsec, Benjamin T. James, Muhammad S. Shamim, Neva C. Durand, Suhas S. P. Rao, Ragini Mahajan, Benjamin R. Doughty, Kalina Andreeva, Jacob C. Ulirsch, Kaili Fan, Elizabeth M. Perez, Tri C. Nguyen, David R. Kelley, Hilary K. Finucane, Jill E. Moore, Zhiping Weng, Manolis Kellis, Michael C. Bassik, Berk Ustun, Alkes L. Price, Michael A. Beer, Roderic Guigó, John A. Stamatoyannopoulos, Erez Lieberman Aiden, William J. Greenleaf, Christina S. Leslie, Lars M. Steinmetz, Anshul Kundaje and Jesse M. Engreitz

Cell-type signatures of Alzheimer’s disease shared across population groups pp. 191-201

Tain Luquez, Jonathan Algoo, Rebecca Chiu, Jason A. Mares, Archana Yadav, Matti Lam, Pallavi Gaur, Xiaoying Lai, Dylan I. Lee, Fahad Paryani, Rafe Batchelor, Irla Belli, Jordan Henry, Bat Hoter-Ishay, Courteney Mattison, Lindsey Starr, Tsering Lama, Berke Karaahmet, Wenqing Cao, Philip L. De Jager, Mariko Taga, Lisa L. Barnes, David X. Marquez, David A. Bennett, Ya Zhang and Vilas Menon

A global molecular code for birth order and neuronal identity in Drosophila pp. 202-212

Sebastian Cachero, Myrto Mitletton, Isabella R. Beckett, Elizabeth C. Marin, Laia Serratosa Capdevila, Marina Gkantia, Jelly H. M. Soffers, Haluk Lacin, Gregory S. X. E. Jefferis and Erika Donà

An intrinsic cytoskeletal oscillator establishes neuronal polarity pp. 213-225

Tien-chen Lin, Charlotte H. Coles, Eissa Alfadil, Florian Fäßler, Andreas Husch, Sebastian Dupraz, Thorben Pietralla, Akihiro Narita, Max Schelski, Kevin C. Flynn, Sina Stern, Christoph Möhl, Brett J. Hilton, Franz Vauti, Hans-Henning Arnold, Florian K. M. Schur and Frank Bradke

CRISPR–Cas regulates expression of embedded anti-phage defence systems pp. 226-235

Xian Shu, Rui Wang, Xufei Zhou, Feiyue Cheng, Jiayue Ma, Zhihua Li, Xin Li, Tuozhan Wu, Aici Wu, Qiong Xue, Chao Liu, Huiwei Zhao, Xifeng Cao, Lin Wang, Shouyue Zhang, Yan Zhang and Ming Li

In vivo feasibility study of humanoid robots in surgery pp. 236-244

Zekai Liang, Nikita Thareja, Peihan Zhang, Calvin Joyce, Soofiyan Atar, Florian Richter, Garth Jacobsen, Shanglei Liu, Ryan Broderick and Michael Yip

Brown bullhead catfish melanoma represents a novel transmissible cancer pp. 245-251

Emily E. Curd, Samuel F. M. Hart, James Lubkowitz, Kirsten M. Tracy, Lucas Milazzo, Matthew Bodnar, Tom Jones, Mark J. Henderson, Peter Emerson and Julie A. Dragon

Modular in vivo antibody–ADC click to reverse drug resistance in tumours pp. 252-261

Cristina Simó, Alexander C. Vanover, Ricardo D’Oliveira Albanus, Sandeep Surendra Panikar, Shayla Shmuel, Alex Benton, Jader Giraldo-Guzman, José M. Luna, Yifei Xu, Na-Keysha Berry, Nai Keltee, Jingxia Liu, Farrokh Dehdashti and Patrícia M. R. Pereira

Non-genotoxic transplantation and in vivo selection through epitope editing pp. 262-274

Gabriele Casirati, Andrea Cosentino, Marta Freschi, Jing Zeng, Adele Mucci, Sébastien Levesque, Nola Neri, Enrico Drago, Viola Carzaniga, Francesco Romano, Varun Katta, Azusa Matsubara, Yichao Li, Mohammed S. Mahmoud, Moisés Chávez-Navarro, Christian Brendel, John P. Manis, Shengdar Tsai, Danilo Pellin, Daniel Bauer and Pietro Genovese

An expanded codebook of human transcription factor DNA-binding specificity pp. 275-283

Arttu Jolma, Kaitlin U. Laverty, Ali Fathi, Ally W. H. Yang, Isaac Yellan, Ilya E. Vorontsov, Antoni J. Gralak, Judith F. Kribelbauer-Swietek, Sachi Inukai, Rozita Razavi, Mihai Albu, Alexander Brechalov, Zain M. Patel, Vladimir Nozdrin, Georgy Meshcheryakov, Andrey Buyan, Ivan Kozin, Sergey Abramov, Alexandr Boytsov, The Codebook Consortium, Quaid Morris, Matthew T. Weirauch, Oriol Fornes, Vsevolod J. Makeev, Jan Grau, Ivo Grosse, Philipp Bucher, Bart Deplancke, Ivan V. Kulakovskiy and Timothy R. Hughes

Efficient and precise programmable DNA knock-in without double-strand breaks pp. 284-294

Yanmin Gao, Yu Ma, Kexin Yu, Yintian Liu, Buming Gu, Hao Tang, Wenjie Yan, Shuangshuang Yang, Jingran Su, Xindong Wang, Xin Ma, Xinming Wang, Fang Wang, Qingyang Li, Mengying Liu and Haifeng Wang

Enzymatic glycosylation and amidation reshapes polyene bioactivity pp. 295-303

Saadia N. Mirza, Alberto Carella, Joseph W. Thompson, Deepanjan Panda, Anna R. I. McDonald, Matthew D. Crossley, Wei Li Thong, Katherine J. Robins, Sarah. A. Shepherd, Matthew J. Cliff, Clara Valero, Andrew Thom, Michael Bromley and Jason Micklefield

Researcher, heal thyself: meet the scientists studying their own diseases pp. 305-307

Josie Glausiusz

AI models are being used to track zoonotic diseases. Will they prevent the next pandemic? pp. 308-310

Heather Richardson

When AI does science, who is accountable for mistakes? pp. 312-312

Chiranjib Chakraborty

Europe should adapt, not copy, China’s practical PhD pp. 312-312

Alan Żukowski and Martyna Stępień

China’s regulatory innovation for new biomedical technologies pp. 312-312

Yuan Fang, Siying Guo, Jun Du and Ning Li

The global plastics treaty must account for conflict-driven energy insecurity pp. 312-312

Wei Wu and Farooq Shah