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2015, volume 518, articles 7540

The Microbes Within pp. S2-S2

David Grogan

The Peacekeepers pp. S3-S5

Moises Velasquez-Manoff

Why Microbiome Treatments Could Pay Off Soon pp. S5-S5

Rob Knight

The Gene–Microbe Link pp. S7-S7

Ruth E. Ley

Microbiome Engineering pp. S10-S10

Justin L. Sonnenburg

Thinking from the Gut pp. S12-S14

Charles Schmidt

The Diverse Microbiome of the Hunter-Gatherer pp. S14-S15

Stephanie L. Schnorr

Focus on political Islamic groups to boost science pp. 457-457

Dyna Rochmyaningsih

Scientists are cautious about public outreach pp. 459-459

Chris Woolston

Wanted: 80,000 British babies for massive study pp. 463-464

Helen Pearson

Francis Crick Institute raises alarm about train line pp. 464-465

Daniel Cressey

Game-playing software holds lessons for neuroscience pp. 465-466

Elizabeth Gibney

Researchers seek definition of head-trauma disorder pp. 466-467

Helen Shen

A tale of two dwarf planets pp. 468-469

Alexandra Witze

Planetary science: The Pluto siblings pp. 470-472

Alexandra Witze

Neuroscience in court: The painful truth pp. 474-476

Sara Reardon

Data sharing: Make outbreak research open access pp. 477-479

Nathan L. Yozwiak, Stephen F. Schaffner and Pardis C. Sabeti

Big data: The revolution is digitized pp. 480-481

Charles Seife

Books in brief pp. 481-481

Barbara Kiser

Environmental science: Dryland epiphany pp. 482-482

Andrew Robinson

Gear students up for big medical data pp. 483-483

Ervin Sejdić

Antibodies: The solution is validation pp. 483-483

Roberto D. Polakiewicz

Antibodies: Validate recombinants too pp. 483-483

Leonard P. Freedman

Polluters migrate to China's poor areas pp. 483-483

Xin Miao, Yanhong Tang and Christina W. Y. Wong

Biochar: Bring on the sewage pp. 483-483

Marc Breulmann, Manfred van Afferden and Christoph Fühner

Biochar: Pros must outweigh cons pp. 483-483

Hong Yang, Xianjin Huang and Julian R. Thompson

Robert A. Berner (1935–2015) pp. 484-484

Don Canfield

Learning to see and act pp. 486-487

Bernhard Schölkopf

The benefits of traditional knowledge pp. 487-488

Manuel Pardo- de-Santayana and Manuel J. Macía

Chasing blood pp. 488-490

Sidhartha Goyal and Peter W. Zandstra

A giant in the young Universe pp. 490-491

Bram Venemans

Teleportation for two pp. 491-492

Wolfgang Tittel

RNA modification does a regulatory two-step pp. 492-493

Dominik Theler and Frédéric H.-T. Allain

Whole genomes redefine the mutational landscape of pancreatic cancer pp. 495-501

Nicola Waddell, Marina Pajic, Ann-Marie Patch, David K. Chang, Karin S. Kassahn, Peter Bailey, Amber L. Johns, David Miller, Katia Nones, Kelly Quek, Michael C. J. Quinn, Alan J. Robertson, Muhammad Z. H. Fadlullah, Tim J. C. Bruxner, Angelika N. Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne Manning, Craig Nourse, Ehsan Nourbakhsh, Shivangi Wani, Peter J. Wilson, Emma Markham, Nicole Cloonan, Matthew J. Anderson, J. Lynn Fink, Oliver Holmes, Stephen H. Kazakoff, Conrad Leonard, Felicity Newell, Barsha Poudel, Sarah Song, Darrin Taylor, Nick Waddell, Scott Wood, Qinying Xu, Jianmin Wu, Mark Pinese, Mark J. Cowley, Hong C. Lee, Marc D. Jones, Adnan M. Nagrial, Jeremy Humphris, Lorraine A. Chantrill, Venessa Chin, Angela M. Steinmann, Amanda Mawson, Emily S. Humphrey, Emily K. Colvin, Angela Chou, Christopher J. Scarlett, Andreia V. Pinho, Marc Giry-Laterriere, Ilse Rooman, Jaswinder S. Samra, James G. Kench, Jessica A. Pettitt, Neil D. Merrett, Christopher Toon, Krishna Epari, Nam Q. Nguyen, Andrew Barbour, Nikolajs Zeps, Nigel B. Jamieson, Janet S. Graham, Simone P. Niclou, Rolf Bjerkvig, Robert Grützmann, Daniela Aust, Ralph H. Hruban, Anirban Maitra, Christine A. Iacobuzio-Donahue, Christopher L. Wolfgang, Richard A. Morgan, Rita T. Lawlor, Vincenzo Corbo, Claudio Bassi, Massimo Falconi, Giuseppe Zamboni, Giampaolo Tortora, Margaret A. Tempero, Anthony J. Gill, James R. Eshleman, Christian Pilarsky, Aldo Scarpa, Elizabeth A. Musgrove, John V. Pearson, Andrew V. Biankin and Sean M. Grimmond

Lagging-strand replication shapes the mutational landscape of the genome pp. 502-506

Martin A. M. Reijns, Harriet Kemp, James Ding, Sophie Marion de Procé, Andrew P. Jackson and Martin S. Taylor

Crystal structure of the V(D)J recombinase RAG1–RAG2 pp. 507-511

Min-Sung Kim, Mikalai Lapkouski, Wei Yang and Martin Gellert

An ultraluminous quasar with a twelve-billion-solar-mass black hole at redshift 6.30 pp. 512-515

Xue-Bing Wu, Feige Wang, Xiaohui Fan, Weimin Yi, Wenwen Zuo, Fuyan Bian, Linhua Jiang, Ian D. McGreer, Ran Wang, Jinyi Yang, Qian Yang, David Thompson and Yuri Beletsky

Quantum teleportation of multiple degrees of freedom of a single photon pp. 516-519

Xi-Lin Wang, Xin-Dong Cai, Zu-En Su, Ming-Cheng Chen, Dian Wu, Li Li, Nai-Le Liu, Chao-Yang Lu and Jian-Wei Pan

Dynamically reconfigurable complex emulsions via tunable interfacial tensions pp. 520-524

Lauren D. Zarzar, Vishnu Sresht, Ellen M. Sletten, Julia A. Kalow, Daniel Blankschtein and Timothy M. Swager

An extremely high-altitude plume seen at Mars’ morning terminator pp. 525-528

A. Sánchez-Lavega, A. García Muñoz, E. García-Melendo, S. Pérez-Hoyos, J. M. Gómez-Forrellad, C. Pellier, M. Delcroix, M. A. López-Valverde, F. González-Galindo, W. Jaeschke, D. Parker, J. Phillips and D. Peach

Human-level control through deep reinforcement learning pp. 529-533

Volodymyr Mnih, Koray Kavukcuoglu, David Silver, Andrei A. Rusu, Joel Veness, Marc G. Bellemare, Alex Graves, Martin Riedmiller, Andreas K. Fidjeland, Georg Ostrovski, Stig Petersen, Charles Beattie, Amir Sadik, Ioannis Antonoglou, Helen King, Dharshan Kumaran, Daan Wierstra, Shane Legg and Demis Hassabis

Evolution of the new vertebrate head by co-option of an ancient chordate skeletal tissue pp. 534-537

David Jandzik, Aaron T. Garnett, Tyler A. Square, Maria V. Cattell, Jr-Kai Yu and Daniel M. Medeiros

Experimentally induced innovations lead to persistent culture via conformity in wild birds pp. 538-541

Lucy M. Aplin, Damien R. Farine, Julie Morand-Ferron, Andrew Cockburn, Alex Thornton and Ben C. Sheldon

Fundamental properties of unperturbed haematopoiesis from stem cells in vivo pp. 542-546

Katrin Busch, Kay Klapproth, Melania Barile, Michael Flossdorf, Tim Holland-Letz, Susan M. Schlenner, Michael Reth, Thomas Höfer and Hans-Reimer Rodewald

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors pp. 547-551

Elisa Gomez Perdiguero, Kay Klapproth, Christian Schulz, Katrin Busch, Emanuele Azzoni, Lucile Crozet, Hannah Garner, Celine Trouillet, Marella F. de Bruijn, Frederic Geissmann and Hans-Reimer Rodewald

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia pp. 552-555

Terrence N. Wong, Giridharan Ramsingh, Andrew L. Young, Christopher A. Miller, Waseem Touma, John S. Welch, Tamara L. Lamprecht, Dong Shen, Jasreet Hundal, Robert S. Fulton, Sharon Heath, Jack D. Baty, Jeffery M. Klco, Li Ding, Elaine R. Mardis, Peter Westervelt, John F. DiPersio, Matthew J. Walter, Timothy A. Graubert, Timothy J. Ley, Todd E. Druley, Daniel C. Link and Richard K. Wilson

Enhancer–core-promoter specificity separates developmental and housekeeping gene regulation pp. 556-559

Muhammad A. Zabidi, Cosmas D. Arnold, Katharina Schernhuber, Michaela Pagani, Martina Rath, Olga Frank and Alexander Stark

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions pp. 560-564

Nian Liu, Qing Dai, Guanqun Zheng, Chuan He, Marc Parisien and Tao Pan

Environmental technology: Green light pp. 565-566

Bryn Nelson

BFF's first adventure pp. 568-568

Vernor Vinge

2015, volume 518, articles 7539

Europe needs fresh focus on big-science projects pp. 275-275

Olof Hallonsten

Journal publishes 200-word papers pp. 277-277

Chris Woolston

Saudi Arabia opens top-notch laser lab pp. 281-282

Alison Abbott

Cybercrime fighters target human error pp. 282-283

Erika Check Hayden

Young scientists lead the way on fresh ideas pp. 283-284

Ewen Callaway

Steppe migration rekindles debate on language origin pp. 284-285

Ewen Callaway

Biodefence researchers seek 'Homo chippiens' pp. 285-286

Sara Reardon

Radical energy ideas secure US private funds pp. 286-287

Jeff Tollefson

Sex redefined pp. 288-291

Claire Ainsworth

Museums: The endangered dead pp. 292-294

Christopher Kemp

Corruption: Good governance powers innovation pp. 295-297

Alina Mungiu-Pippidi

Neuroscience: Halving it all pp. 298-299

Douwe Draaisma

Books in brief pp. 299-299

Barbara Kiser

History of science: Unshadowed lens on the past pp. 300-300

Robert P. Crease

Theatre: Atomic tragedian pp. 301-301

Philip Ball

Early antibiotic from a cranberry bog pp. 303-303

Carol L. Moberg

Rescue Eastern Europe's collections pp. 303-303

Boris Kryštufek, Nataliya Abramson and Dražen Kotrošan

Tweak Chinese law to end ivory demand pp. 303-303

Zhao-Min Zhou

'Simple' or 'elegant' criteria are not valid pp. 303-303

Richard Dawid

Czech centre marks Mendel anniversary pp. 303-303

Anna Matalová and Eva Matalová

Vernon B. Mountcastle (1918–2015) pp. 304-304

Kevan Martin

The cortical connection pp. 306-307

Benjamin Scholl and Nicholas J. Priebe

A lithium-rich stellar explosion pp. 307-308

Margarita Hernanz

Finches sequenced pp. 308-308

Magdalena Skipper

Breaking methane pp. 309-310

Amy C. Rosenzweig

The future of coastal ocean upwelling pp. 310-311

Emanuele Di Lorenzo

Presenting the Epigenome Roadmap pp. 313-313

Magdalena Skipper, Alex Eccleston, Noah Gray, Therese Heemels, Nathalie Le Bot, Barbara Marte and Ursula Weiss

Roadmap for regulation pp. 314-316

Casey E. Romanoski, Christopher K. Glass, Hendrik G. Stunnenberg, Laurence Wilson and Genevieve Almouzni

Integrative analysis of 111 reference human epigenomes pp. 317-330

Anshul Kundaje, Wouter Meuleman, Jason Ernst, Misha Bilenky, Angela Yen, Alireza Heravi-Moussavi, Pouya Kheradpour, Zhizhuo Zhang, Jianrong Wang, Michael J. Ziller, Viren Amin, John W. Whitaker, Matthew D. Schultz, Lucas D. Ward, Abhishek Sarkar, Gerald Quon, Richard S. Sandstrom, Matthew L. Eaton, Yi-Chieh Wu, Andreas R. Pfenning, Xinchen Wang, Melina Claussnitzer, Yaping Liu, Cristian Coarfa, R. Alan Harris, Noam Shoresh, Charles B. Epstein, Elizabeta Gjoneska, Danny Leung, Wei Xie, R. David Hawkins, Ryan Lister, Chibo Hong, Philippe Gascard, Andrew J. Mungall, Richard Moore, Eric Chuah, Angela Tam, Theresa K. Canfield, R. Scott Hansen, Rajinder Kaul, Peter J. Sabo, Mukul S. Bansal, Annaick Carles, Jesse R. Dixon, Kai-How Farh, Soheil Feizi, Rosa Karlic, Ah-Ram Kim, Ashwinikumar Kulkarni, Daofeng Li, Rebecca Lowdon, GiNell Elliott, Tim R. Mercer, Shane J. Neph, Vitor Onuchic, Paz Polak, Nisha Rajagopal, Pradipta Ray, Richard C. Sallari, Kyle T. Siebenthall, Nicholas A. Sinnott-Armstrong, Michael Stevens, Robert E. Thurman, Jie Wu, Bo Zhang, Xin Zhou, Arthur E. Beaudet, Laurie A. Boyer, Philip L. De Jager, Peggy J. Farnham, Susan J. Fisher, David Haussler, Steven J. M. Jones, Wei Li, Marco A. Marra, Michael T. McManus, Shamil Sunyaev, James A. Thomson, Thea D. Tlsty, Li-Huei Tsai, Wei Wang, Robert A. Waterland, Michael Q. Zhang, Lisa H. Chadwick, Bradley E. Bernstein, Joseph F. Costello, Joseph R. Ecker, Martin Hirst, Alexander Meissner, Aleksandar Milosavljevic, Bing Ren, John A. Stamatoyannopoulos, Ting Wang and Manolis Kellis

Chromatin architecture reorganization during stem cell differentiation pp. 331-336

Jesse R. Dixon, Inkyung Jung, Siddarth Selvaraj, Yin Shen, Jessica E. Antosiewicz-Bourget, Ah Young Lee, Zhen Ye, Audrey Kim, Nisha Rajagopal, Wei Xie, Yarui Diao, Jing Liang, Huimin Zhao, Victor V. Lobanenkov, Joseph R. Ecker, James A. Thomson and Bing Ren

Genetic and epigenetic fine mapping of causal autoimmune disease variants pp. 337-343

Kyle Kai-How Farh, Alexander Marson, Jiang Zhu, Markus Kleinewietfeld, William J. Housley, Samantha Beik, Noam Shoresh, Holly Whitton, Russell J. H. Ryan, Alexander A. Shishkin, Meital Hatan, Marlene J. Carrasco-Alfonso, Dita Mayer, C. John Luckey, Nikolaos A. Patsopoulos, Philip L. De Jager, Vijay K. Kuchroo, Charles B. Epstein, Mark J. Daly, David A. Hafler and Bradley E. Bernstein

Transcription factor binding dynamics during human ES cell differentiation pp. 344-349

Alexander M. Tsankov, Hongcang Gu, Veronika Akopian, Michael J. Ziller, Julie Donaghey, Ido Amit, Andreas Gnirke and Alexander Meissner

Integrative analysis of haplotype-resolved epigenomes across human tissues pp. 350-354

Danny Leung, Inkyung Jung, Nisha Rajagopal, Anthony Schmitt, Siddarth Selvaraj, Ah Young Lee, Chia-An Yen, Shin Lin, Yiing Lin, Yunjiang Qiu, Wei Xie, Feng Yue, Manoj Hariharan, Pradipta Ray, Samantha Kuan, Lee Edsall, Hongbo Yang, Neil C. Chi, Michael Q. Zhang, Joseph R. Ecker and Bing Ren

Dissecting neural differentiation regulatory networks through epigenetic footprinting pp. 355-359

Michael J. Ziller, Reuven Edri, Yakey Yaffe, Julie Donaghey, Ramona Pop, William Mallard, Robbyn Issner, Casey A. Gifford, Alon Goren, Jeffrey Xing, Hongcang Gu, Davide Cacchiarelli, Alexander M. Tsankov, Charles Epstein, John L. Rinn, Tarjei S. Mikkelsen, Oliver Kohlbacher, Andreas Gnirke, Bradley E. Bernstein, Yechiel Elkabetz and Alexander Meissner

Cell-of-origin chromatin organization shapes the mutational landscape of cancer pp. 360-364

Paz Polak, Rosa Karlić, Amnon Koren, Robert Thurman, Richard Sandstrom, Michael S. Lawrence, Alex Reynolds, Eric Rynes, Kristian Vlahoviček, John A. Stamatoyannopoulos and Shamil R. Sunyaev

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease pp. 365-369

Elizabeta Gjoneska, Andreas R. Pfenning, Hansruedi Mathys, Gerald Quon, Anshul Kundaje, Li-Huei Tsai and Manolis Kellis

Evolution of Darwin’s finches and their beaks revealed by genome sequencing pp. 371-375

Sangeet Lamichhaney, Jonas Berglund, Markus Sällman Almén, Khurram Maqbool, Manfred Grabherr, Alvaro Martinez-Barrio, Marta Promerová, Carl-Johan Rubin, Chao Wang, Neda Zamani, B. Rosemary Grant, Peter R. Grant, Matthew T. Webster and Leif Andersson

Architecture of the RNA polymerase II–Mediator core initiation complex pp. 376-380

C. Plaschka, L. Larivière, L. Wenzeck, M. Seizl, M. Hemann, D. Tegunov, E. V. Petrotchenko, C. H. Borchers, W. Baumeister, F. Herzog, E. Villa and P. Cramer

Explosive lithium production in the classical nova V339 Del (Nova Delphini 2013) pp. 381-384

Akito Tajitsu, Kozo Sadakane, Hiroyuki Naito, Akira Arai and Wako Aoki

Direct observation of bond formation in solution with femtosecond X-ray scattering pp. 385-389

Kyung Hwan Kim, Jong Goo Kim, Shunsuke Nozawa, Tokushi Sato, Key Young Oang, Tae Wu Kim, Hosung Ki, Junbeom Jo, Sungjun Park, Changyong Song, Takahiro Sato, Kanade Ogawa, Tadashi Togashi, Kensuke Tono, Makina Yabashi, Tetsuya Ishikawa, Joonghan Kim, Ryong Ryoo, Jeongho Kim, Hyotcherl Ihee and Shin-ichi Adachi

Intensification and spatial homogenization of coastal upwelling under climate change pp. 390-394

Daiwei Wang, Tarik C. Gouhier, Bruce A. Menge and Auroop R. Ganguly

Seismic evidence of effects of water on melt transport in the Lau back-arc mantle pp. 395-398

S. Shawn Wei, Douglas A. Wiens, Yang Zha, Terry Plank, Spahr C. Webb, Donna K. Blackman, Robert A. Dunn and James A. Conder

Functional organization of excitatory synaptic strength in primary visual cortex pp. 399-403

Lee Cossell, Maria Florencia Iacaruso, Dylan R. Muir, Rachael Houlton, Elie N. Sader, Ho Ko, Sonja B. Hofer and Thomas D. Mrsic-Flogel

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury pp. 404-408

Bradley T. Lang, Jared M. Cregg, Marc A. DePaul, Amanda P. Tran, Kui Xu, Scott M. Dyck, Kathryn M. Madalena, Benjamin P. Brown, Yi-Lan Weng, Shuxin Li, Soheila Karimi-Abdolrezaee, Sarah A. Busch, Yingjie Shen and Jerry Silver

Towards a therapy for Angelman syndrome by targeting a long non-coding RNA pp. 409-412

Linyan Meng, Amanda J. Ward, Seung Chun, C. Frank Bennett, Arthur L. Beaudet and Frank Rigo

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells pp. 413-416

Bryce W. Carey, Lydia W. S. Finley, Justin R. Cross, C. David Allis and Craig B. Thompson

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells pp. 417-421

Sascha Rutz, Nobuhiko Kayagaki, Qui T. Phung, Celine Eidenschenk, Rajkumar Noubade, Xiaoting Wang, Justin Lesch, Rongze Lu, Kim Newton, Oscar W. Huang, Andrea G. Cochran, Mark Vasser, Benjamin P. Fauber, Jason DeVoss, Joshua Webster, Lauri Diehl, Zora Modrusan, Donald S. Kirkpatrick, Jennie R. Lill, Wenjun Ouyang and Vishva M. Dixit

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution pp. 422-426

Peter Eirew, Adi Steif, Jaswinder Khattra, Gavin Ha, Damian Yap, Hossein Farahani, Karen Gelmon, Stephen Chia, Colin Mar, Adrian Wan, Emma Laks, Justina Biele, Karey Shumansky, Jamie Rosner, Andrew McPherson, Cydney Nielsen, Andrew J. L. Roth, Calvin Lefebvre, Ali Bashashati, Camila de Souza, Celia Siu, Radhouane Aniba, Jazmine Brimhall, Arusha Oloumi, Tomo Osako, Alejandra Bruna, Jose L. Sandoval, Teresa Algara, Wendy Greenwood, Kaston Leung, Hongwei Cheng, Hui Xue, Yuzhuo Wang, Dong Lin, Andrew J. Mungall, Richard Moore, Yongjun Zhao, Julie Lorette, Long Nguyen, David Huntsman, Connie J. Eaves, Carl Hansen, Marco A. Marra, Carlos Caldas, Sohrab P. Shah and Samuel Aparicio

Catalysts from synthetic genetic polymers pp. 427-430

Alexander I. Taylor, Vitor B. Pinheiro, Matthew J. Smola, Alexey S. Morgunov, Sew Peak-Chew, Christopher Cozens, Kevin M. Weeks, Piet Herdewijn and Philipp Holliger

Structure of the key species in the enzymatic oxidation of methane to methanol pp. 431-434

Rahul Banerjee, Yegor Proshlyakov, John D. Lipscomb and Denis A. Proshlyakov

Structure of human cytoplasmic dynein-2 primed for its power stroke pp. 435-438

Helgo Schmidt, Ruta Zalyte, Linas Urnavicius and Andrew P. Carter

Measure for measure pp. 439-443

Jim Kling

Workplace safety: Risky encounters pp. 445-446

Chris Woolston

Turning point: Stacey Gabriel pp. 447-447

Virginia Gewin

Good for something pp. 450-450

Deborah Walker

2015, volume 518, articles 7538

And the winner is: not science pp. 139-139

Colin Macilwain

Bigger is not better when it comes to lab size pp. 141-141

Chris Woolston

World hails UK vote on three-person embryos pp. 145-146

Ewen Callaway

NIH plan to give ageing scientists cash draws scepticism pp. 146-147

Boer Deng

Darwin’s iconic finches join genome club pp. 147-147

Geoff Marsh

Measles by the numbers: A race to eradication pp. 148-149

Declan Butler

Impact of UK research revealed in 7,000 case studies pp. 150-151

Richard Van Noorden

Optics: Leading lights pp. 154-157

Elizabeth Gibney

Optics: Super vision pp. 158-160

Zeeya Merali

Physics in finance: Trading at the speed of light pp. 161-163

Mark Buchanan

In retrospect: Book of Optics pp. 164-165

Jim Al-Khalili

Books in brief pp. 165-165

Barbara Kiser

Neuroscience: Drama of consciousness pp. 166-166

Alison Abbott

Greek politics stall research reforms pp. 167-167

Kevin Featherstone

Leave Brazil's Red List alone pp. 167-167

Alexander C. Lees

EU research plan may widen gaps pp. 167-167

Pier Francesco Moretti

Biodiversity: Include freshwater species pp. 167-167

Sebastian Heilpern

Biodiversity: Sharks and rays in peril too pp. 167-167

Peter M. Kyne, Nicholas J. Bax and Nicholas K. Dulvy

Hubert Markl (1938–2015) pp. 168-168

Wilhelm Krull

The oldest cosmic light pp. 170-171

David Spergel and Brian Keating

Death drags down the neighbourhood pp. 171-173

Claudia G. Vasquez and Adam C. Martin

Sibling rivalry begins at birth pp. 173-174

Kaitlin M. Kratter

Familiar ends with alternative endings pp. 174-175

Nam Woo Cho and Roger A. Greenberg

When carbon escaped from the sea pp. 176-177

Katherine A. Allen

Cold shock protects the brain pp. 177-178

Graham Knott

From quantum matter to high-temperature superconductivity in copper oxides pp. 179-186

B. Keimer, S. A. Kivelson, M. R. Norman, S. Uchida and J. Zaanen

New genetic loci link adipose and insulin biology to body fat distribution pp. 187-196

Dmitry Shungin, Thomas W. Winkler, Damien C. Croteau-Chonka, Teresa Ferreira, Adam E. Locke, Reedik Mägi, Rona J. Strawbridge, Tune H. Pers, Krista Fischer, Anne E. Justice, Tsegaselassie Workalemahu, Joseph M. W. Wu, Martin L. Buchkovich, Nancy L. Heard-Costa, Tamara S. Roman, Alexander W. Drong, Ci Song, Stefan Gustafsson, Felix R. Day, Tonu Esko, Tove Fall, Zoltán Kutalik, Jian’an Luan, Joshua C. Randall, André Scherag, Sailaja Vedantam, Andrew R. Wood, Jin Chen, Rudolf Fehrmann, Juha Karjalainen, Bratati Kahali, Ching-Ti Liu, Ellen M. Schmidt, Devin Absher, Najaf Amin, Denise Anderson, Marian Beekman, Jennifer L. Bragg-Gresham, Steven Buyske, Ayse Demirkan, Georg B. Ehret, Mary F. Feitosa, Anuj Goel, Anne U. Jackson, Toby Johnson, Marcus E. Kleber, Kati Kristiansson, Massimo Mangino, Irene Mateo Leach, Carolina Medina-Gomez, Cameron D. Palmer, Dorota Pasko, Sonali Pechlivanis, Marjolein J. Peters, Inga Prokopenko, Alena Stančáková, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Jana V. Van Vliet-Ostaptchouk, Loïc Yengo, Weihua Zhang, Eva Albrecht, Johan Ärnlöv, Gillian M. Arscott, Stefania Bandinelli, Amy Barrett, Claire Bellis, Amanda J. Bennett, Christian Berne, Matthias Blüher, Stefan Böhringer, Fabrice Bonnet, Yvonne Böttcher, Marcel Bruinenberg, Delia B. Carba, Ida H. Caspersen, Robert Clarke, E. Warwick Daw, Joris Deelen, Ewa Deelman, Graciela Delgado, Alex S. F. Doney, Niina Eklund, Michael R. Erdos, Karol Estrada, Elodie Eury, Nele Friedrich, Melissa E. Garcia, Vilmantas Giedraitis, Bruna Gigante, Alan S. Go, Alain Golay, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Jagvir Grewal, Christopher J. Groves, Toomas Haller, Goran Hallmans, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Kauko Heikkilä, Karl-Heinz Herzig, Quinta Helmer, Hans L. Hillege, Oddgeir Holmen, Steven C. Hunt, Aaron Isaacs, Till Ittermann, Alan L. James, Ingegerd Johansson, Thorhildur Juliusdottir, Ioanna-Panagiota Kalafati, Leena Kinnunen, Wolfgang Koenig, Ishminder K. Kooner, Wolfgang Kratzer, Claudia Lamina, Karin Leander, Nanette R. Lee, Peter Lichtner, Lars Lind, Jaana Lindström, Stéphane Lobbens, Mattias Lorentzon, François Mach, Patrik K. E. Magnusson, Anubha Mahajan, Wendy L. McArdle, Cristina Menni, Sigrun Merger, Evelin Mihailov, Lili Milani, Rebecca Mills, Alireza Moayyeri, Keri L. Monda, Simon P. Mooijaart, Thomas W. Mühleisen, Antonella Mulas, Gabriele Müller, Martina Müller-Nurasyid, Ramaiah Nagaraja, Michael A. Nalls, Narisu Narisu, Nicola Glorioso, Ilja M. Nolte, Matthias Olden, Nigel W. Rayner, Frida Renstrom, Janina S. Ried, Neil R. Robertson, Lynda M. Rose, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Bengt Sennblad, Thomas Seufferlein, Colleen M. Sitlani, Albert Vernon Smith, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Amy J. Swift, Ann-Christine Syvänen, Bamidele O. Tayo, Barbara Thorand, Gudmar Thorleifsson, Andreas Tomaschitz, Chiara Troffa, Floor V. A. van Oort, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Roman Wennauer, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Qunyuan Zhang, Jing Hua Zhao, Eoin P. Brennan, Murim Choi, Per Eriksson, Lasse Folkersen, Anders Franco-Cereceda, Ali G. Gharavi, Åsa K. Hedman, Marie-France Hivert, Jinyan Huang, Stavroula Kanoni, Fredrik Karpe, Sarah Keildson, Krzysztof Kiryluk, Liming Liang, Richard P. Lifton, Baoshan Ma, Amy J. McKnight, Ruth McPherson, Andres Metspalu, Josine L. Min, Miriam F. Moffatt, Grant W. Montgomery, Joanne M. Murabito, George Nicholson, Dale R. Nyholt, Christian Olsson, John R. B. Perry, Eva Reinmaa, Rany M. Salem, Niina Sandholm, Eric E. Schadt, Robert A. Scott, Lisette Stolk, Edgar E. Vallejo, Harm-Jan Westra, Krina T. Zondervan, Philippe Amouyel, Dominique Arveiler, Stephan J. L. Bakker, John Beilby, Richard N. Bergman, John Blangero, Morris J. Brown, Michel Burnier, Harry Campbell, Aravinda Chakravarti, Peter S. Chines, Simone Claudi-Boehm, Francis S. Collins, Dana C. Crawford, John Danesh, Ulf de Faire, Eco J. C. de Geus, Marcus Dörr, Raimund Erbel, Johan G. Eriksson, Martin Farrall, Ele Ferrannini, Jean Ferrières, Nita G. Forouhi, Terrence Forrester, Oscar H. Franco, Ron T. Gansevoort, Christian Gieger, Vilmundur Gudnason, Christopher A. Haiman, Tamara B. Harris, Andrew T. Hattersley, Markku Heliövaara, Andrew A. Hicks, Aroon D. Hingorani, Wolfgang Hoffmann, Albert Hofman, Georg Homuth, Steve E. Humphries, Elina Hyppönen, Thomas Illig, Marjo-Riitta Jarvelin, Berit Johansen, Pekka Jousilahti, Antti M. Jula, Jaakko Kaprio, Frank Kee, Sirkka M. Keinanen-Kiukaanniemi, Jaspal S. Kooner, Charles Kooperberg, Peter Kovacs, Aldi T. Kraja, Meena Kumari, Kari Kuulasmaa, Johanna Kuusisto, Timo A. Lakka, Claudia Langenberg, Loic Le Marchand, Terho Lehtimäki, Valeriya Lyssenko, Satu Männistö, André Marette, Tara C. Matise, Colin A. McKenzie, Barbara McKnight, Arthur W. Musk, Stefan Möhlenkamp, Andrew D. Morris, Mari Nelis, Claes Ohlsson, Albertine J. Oldehinkel, Ken K. Ong, Lyle J. Palmer, Brenda W. Penninx, Annette Peters, Peter P. Pramstaller, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Treva K. Rice, Paul M. Ridker, Marylyn D. Ritchie, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Jouko Saramies, Mark A. Sarzynski, Peter E. H. Schwarz, Alan R. Shuldiner, Jan A. Staessen, Valgerdur Steinthorsdottir, Ronald P. Stolk, Konstantin Strauch, Anke Tönjes, Angelo Tremblay, Elena Tremoli, Marie-Claude Vohl, Uwe Völker, Peter Vollenweider, James F. Wilson, Jacqueline C. Witteman, Linda S. Adair, Murielle Bochud, Bernhard O. Boehm, Stefan R. Bornstein, Claude Bouchard, Stéphane Cauchi, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Richard S. Cooper, George Dedoussis, Luigi Ferrucci, Philippe Froguel, Hans-Jörgen Grabe, Anders Hamsten, Jennie Hui, Kristian Hveem, Karl-Heinz Jöckel, Mika Kivimaki, Diana Kuh, Markku Laakso, Yongmei Liu, Winfried März, Patricia B. Munroe, Inger Njølstad, Ben A. Oostra, Colin N. A. Palmer, Nancy L. Pedersen, Markus Perola, Louis Pérusse, Ulrike Peters, Chris Power, Thomas Quertermous, Rainer Rauramaa, Fernando Rivadeneira, Timo E. Saaristo, Danish Saleheen, Juha Sinisalo, P. Eline Slagboom, Harold Snieder, Tim D. Spector, Unnur Thorsteinsdottir, Michael Stumvoll, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Giovanni Veronesi, Mark Walker, Nicholas J. Wareham, Hugh Watkins, H-Erich Wichmann, Goncalo R. Abecasis, Themistocles L. Assimes, Sonja I. Berndt, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Lude Franke, Timothy M. Frayling, Leif C. Groop, David J. Hunter, Robert C. Kaplan, Jeffrey R. O’Connell, Lu Qi, David Schlessinger, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Cristen J. Willer, Peter M. Visscher, Jian Yang, Joel N. Hirschhorn, M. Carola Zillikens, Mark I. McCarthy, Elizabeth K. Speliotes, Kari E. North, Caroline S. Fox, Inês Barroso, Paul W. Franks, Erik Ingelsson, Iris M. Heid, Ruth J. F. Loos, L. Adrienne Cupples, Andrew P. Morris, Cecilia M. Lindgren and Karen L Mohlke

Genetic studies of body mass index yield new insights for obesity biology pp. 197-206

Adam E. Locke, Bratati Kahali, Sonja I. Berndt, Anne E. Justice, Tune H. Pers, Felix R. Day, Corey Powell, Sailaja Vedantam, Martin L. Buchkovich, Jian Yang, Damien C. Croteau-Chonka, Tonu Esko, Tove Fall, Teresa Ferreira, Stefan Gustafsson, Zoltán Kutalik, Jian’an Luan, Reedik Mägi, Joshua C. Randall, Thomas W. Winkler, Andrew R. Wood, Tsegaselassie Workalemahu, Jessica D. Faul, Jennifer A. Smith, Jing Hua Zhao, Wei Zhao, Jin Chen, Rudolf Fehrmann, Åsa K. Hedman, Juha Karjalainen, Ellen M. Schmidt, Devin Absher, Najaf Amin, Denise Anderson, Marian Beekman, Jennifer L. Bolton, Jennifer L. Bragg-Gresham, Steven Buyske, Ayse Demirkan, Guohong Deng, Georg B. Ehret, Bjarke Feenstra, Mary F. Feitosa, Krista Fischer, Anuj Goel, Jian Gong, Anne U. Jackson, Stavroula Kanoni, Marcus E. Kleber, Kati Kristiansson, Unhee Lim, Vaneet Lotay, Massimo Mangino, Irene Mateo Leach, Carolina Medina-Gomez, Sarah E. Medland, Michael A. Nalls, Cameron D. Palmer, Dorota Pasko, Sonali Pechlivanis, Marjolein J. Peters, Inga Prokopenko, Dmitry Shungin, Alena Stančáková, Rona J. Strawbridge, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. van der Laan, Jessica van Setten, Jana V. Van Vliet-Ostaptchouk, Zhaoming Wang, Loïc Yengo, Weihua Zhang, Aaron Isaacs, Eva Albrecht, Johan Ärnlöv, Gillian M. Arscott, Antony P. Attwood, Stefania Bandinelli, Amy Barrett, Isabelita N. Bas, Claire Bellis, Amanda J. Bennett, Christian Berne, Roza Blagieva, Matthias Blüher, Stefan Böhringer, Lori L. Bonnycastle, Yvonne Böttcher, Heather A. Boyd, Marcel Bruinenberg, Ida H. Caspersen, Yii- Der Ida Chen, Robert Clarke, E. Warwick Daw, Anton J. M. de Craen, Graciela Delgado, Maria Dimitriou, Alex S. F. Doney, Niina Eklund, Karol Estrada, Elodie Eury, Lasse Folkersen, Ross M. Fraser, Melissa E. Garcia, Frank Geller, Vilmantas Giedraitis, Bruna Gigante, Alan S. Go, Alain Golay, Alison H. Goodall, Scott D. Gordon, Mathias Gorski, Hans-Jörgen Grabe, Harald Grallert, Tanja B. Grammer, Jürgen Gräßler, Henrik Grönberg, Christopher J. Groves, Gaëlle Gusto, Jeffrey Haessler, Per Hall, Toomas Haller, Goran Hallmans, Catharina A. Hartman, Maija Hassinen, Caroline Hayward, Nancy L. Heard-Costa, Quinta Helmer, Christian Hengstenberg, Oddgeir Holmen, Jouke-Jan Hottenga, Alan L. James, Janina M. Jeff, Åsa Johansson, Jennifer Jolley, Thorhildur Juliusdottir, Leena Kinnunen, Wolfgang Koenig, Markku Koskenvuo, Wolfgang Kratzer, Jaana Laitinen, Claudia Lamina, Karin Leander, Nanette R. Lee, Peter Lichtner, Lars Lind, Jaana Lindström, Ken Sin Lo, Stéphane Lobbens, Roberto Lorbeer, Yingchang Lu, François Mach, Patrik K. E. Magnusson, Anubha Mahajan, Wendy L. McArdle, Stela McLachlan, Cristina Menni, Sigrun Merger, Evelin Mihailov, Lili Milani, Alireza Moayyeri, Keri L. Monda, Mario A. Morken, Antonella Mulas, Gabriele Müller, Martina Müller-Nurasyid, Arthur W. Musk, Ramaiah Nagaraja, Markus M. Nöthen, Ilja M. Nolte, Stefan Pilz, Nigel W. Rayner, Frida Renstrom, Rainer Rettig, Janina S. Ried, Stephan Ripke, Neil R. Robertson, Lynda M. Rose, Serena Sanna, Hubert Scharnagl, Salome Scholtens, Fredrick R. Schumacher, William R. Scott, Thomas Seufferlein, Jianxin Shi, Albert Vernon Smith, Joanna Smolonska, Alice V. Stanton, Valgerdur Steinthorsdottir, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Morris A. Swertz, Amy J. Swift, Ann-Christine Syvänen, Sian-Tsung Tan, Bamidele O. Tayo, Barbara Thorand, Gudmar Thorleifsson, Jonathan P. Tyrer, Hae-Won Uh, Liesbeth Vandenput, Frank C. Verhulst, Sita H. Vermeulen, Niek Verweij, Judith M. Vonk, Lindsay L. Waite, Helen R. Warren, Dawn Waterworth, Michael N. Weedon, Lynne R. Wilkens, Christina Willenborg, Tom Wilsgaard, Mary K. Wojczynski, Andrew Wong, Alan F. Wright, Qunyuan Zhang, Eoin P. Brennan, Murim Choi, Zari Dastani, Alexander W. Drong, Per Eriksson, Anders Franco-Cereceda, Jesper R. Gådin, Ali G. Gharavi, Michael E. Goddard, Robert E. Handsaker, Jinyan Huang, Fredrik Karpe, Sekar Kathiresan, Sarah Keildson, Krzysztof Kiryluk, Michiaki Kubo, Jong-Young Lee, Liming Liang, Richard P. Lifton, Baoshan Ma, Steven A. McCarroll, Amy J. McKnight, Josine L. Min, Miriam F. Moffatt, Grant W. Montgomery, Joanne M. Murabito, George Nicholson, Dale R. Nyholt, Yukinori Okada, John R. B. Perry, Rajkumar Dorajoo, Eva Reinmaa, Rany M. Salem, Niina Sandholm, Robert A. Scott, Lisette Stolk, Atsushi Takahashi, Toshihiro Tanaka, Ferdinand M. van’t Hooft, Anna A. E. Vinkhuyzen, Harm-Jan Westra, Wei Zheng, Krina T. Zondervan, Andrew C. Heath, Dominique Arveiler, Stephan J. L. Bakker, John Beilby, Richard N. Bergman, John Blangero, Pascal Bovet, Harry Campbell, Mark J. Caulfield, Giancarlo Cesana, Aravinda Chakravarti, Daniel I. Chasman, Peter S. Chines, Francis S. Collins, Dana C. Crawford, L. Adrienne Cupples, Daniele Cusi, John Danesh, Ulf de Faire, Hester M. den Ruijter, Anna F. Dominiczak, Raimund Erbel, Jeanette Erdmann, Johan G. Eriksson, Martin Farrall, Stephan B. Felix, Ele Ferrannini, Jean Ferrières, Ian Ford, Nita G. Forouhi, Terrence Forrester, Oscar H. Franco, Ron T. Gansevoort, Pablo V. Gejman, Christian Gieger, Omri Gottesman, Vilmundur Gudnason, Ulf Gyllensten, Alistair S. Hall, Tamara B. Harris, Andrew T. Hattersley, Andrew A. Hicks, Lucia A. Hindorff, Aroon D. Hingorani, Albert Hofman, Georg Homuth, G. Kees Hovingh, Steve E. Humphries, Steven C. Hunt, Elina Hyppönen, Thomas Illig, Kevin B. Jacobs, Marjo-Riitta Jarvelin, Karl-Heinz Jöckel, Berit Johansen, Pekka Jousilahti, J. Wouter Jukema, Antti M. Jula, Jaakko Kaprio, John J. P. Kastelein, Sirkka M. Keinanen-Kiukaanniemi, Lambertus A. Kiemeney, Paul Knekt, Jaspal S. Kooner, Charles Kooperberg, Peter Kovacs, Aldi T. Kraja, Meena Kumari, Johanna Kuusisto, Timo A. Lakka, Claudia Langenberg, Loic Le Marchand, Terho Lehtimäki, Valeriya Lyssenko, Satu Männistö, André Marette, Tara C. Matise, Colin A. McKenzie, Barbara McKnight, Frans L. Moll, Andrew D. Morris, Andrew P. Morris, Jeffrey C. Murray, Mari Nelis, Claes Ohlsson, Albertine J. Oldehinkel, Ken K. Ong, Pamela A. F. Madden, Gerard Pasterkamp, John F. Peden, Annette Peters, Dirkje S. Postma, Peter P. Pramstaller, Jackie F. Price, Lu Qi, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Treva K. Rice, Paul M. Ridker, John D. Rioux, Marylyn D. Ritchie, Igor Rudan, Veikko Salomaa, Nilesh J. Samani, Jouko Saramies, Mark A. Sarzynski, Heribert Schunkert, Peter E. H. Schwarz, Peter Sever, Alan R. Shuldiner, Juha Sinisalo, Ronald P. Stolk, Konstantin Strauch, Anke Tönjes, David-Alexandre Trégouët, Angelo Tremblay, Elena Tremoli, Jarmo Virtamo, Marie-Claude Vohl, Uwe Völker, Gérard Waeber, Gonneke Willemsen, Jacqueline C. Witteman, M. Carola Zillikens, Linda S. Adair, Philippe Amouyel, Folkert W. Asselbergs, Themistocles L. Assimes, Murielle Bochud, Bernhard O. Boehm, Eric Boerwinkle, Stefan R. Bornstein, Erwin P. Bottinger, Claude Bouchard, Stéphane Cauchi, John C. Chambers, Stephen J. Chanock, Richard S. Cooper, Paul I. W. de Bakker, George Dedoussis, Luigi Ferrucci, Paul W. Franks, Philippe Froguel, Leif C. Groop, Christopher A. Haiman, Anders Hamsten, Jennie Hui, David J. Hunter, Kristian Hveem, Robert C. Kaplan, Mika Kivimaki, Diana Kuh, Markku Laakso, Yongmei Liu, Nicholas G. Martin, Winfried März, Mads Melbye, Andres Metspalu, Susanne Moebus, Patricia B. Munroe, Inger Njølstad, Ben A. Oostra, Colin N. A. Palmer, Nancy L. Pedersen, Markus Perola, Louis Pérusse, Ulrike Peters, Chris Power, Thomas Quertermous, Rainer Rauramaa, Fernando Rivadeneira, Timo E. Saaristo, Danish Saleheen, Naveed Sattar, Eric E. Schadt, David Schlessinger, P. Eline Slagboom, Harold Snieder, Tim D. Spector, Unnur Thorsteinsdottir, Michael Stumvoll, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Pim van der Harst, Mark Walker, Henri Wallaschofski, Nicholas J. Wareham, Hugh Watkins, David R. Weir, H-Erich Wichmann, James F. Wilson, Pieter Zanen, Ingrid B. Borecki, Panos Deloukas, Caroline S. Fox, Iris M. Heid, Jeffrey R. O’Connell, David P. Strachan, Kari Stefansson, Cornelia M. van Duijn, Gonçalo R. Abecasis, Lude Franke, Timothy M. Frayling, Mark I. McCarthy, Peter M. Visscher, André Scherag, Cristen J. Willer, Michael Boehnke, Karen L. Mohlke, Cecilia M. Lindgren, Jacques S. Beckmann, Inês Barroso, Kari E. North, Erik Ingelsson, Joel N. Hirschhorn, Ruth J. F. Loos and Elizabeth K. Speliotes

Shearing-induced asymmetry in entorhinal grid cells pp. 207-212

Tor Stensola, Hanne Stensola, May-Britt Moser and Edvard I. Moser

The formation of a quadruple star system with wide separation pp. 213-215

Jaime E. Pineda, Stella S. R. Offner, Richard J. Parker, Héctor G. Arce, Alyssa A. Goodman, Paola Caselli, Gary A. Fuller, Tyler L. Bourke and Stuartt A. Corder

Comet 67P/Churyumov-Gerasimenko sheds dust coat accumulated over the past four years pp. 216-218

Rita Schulz, Martin Hilchenbach, Yves Langevin, Jochen Kissel, Johan Silen, Christelle Briois, Cecile Engrand, Klaus Hornung, Donia Baklouti, Anaïs Bardyn, Hervé Cottin, Henning Fischer, Nicolas Fray, Marie Godard, Harry Lehto, Léna Le Roy, Sihane Merouane, François-Régis Orthous-Daunay, John Paquette, Jouni Rynö, Sandra Siljeström, Oliver Stenzel, Laurent Thirkell, Kurt Varmuza and Boris Zaprudin

Boron isotope evidence for oceanic carbon dioxide leakage during the last deglaciation pp. 219-222

M. A. Martínez-Botí, G. Marino, G. L. Foster, P. Ziveri, M. J. Henehan, J. W. B. Rae, P. G. Mortyn and D. Vance

Recharge of a subglacial lake by surface meltwater in northeast Greenland pp. 223-227

Michael J. Willis, Bradley G. Herried, Michael G. Bevis and Robin E. Bell

Homo erectus at Trinil on Java used shells for tool production and engraving pp. 228-231

Josephine C. A. Joordens, Francesco d’Errico, Frank P. Wesselingh, Stephen Munro, John de Vos, Jakob Wallinga, Christina Ankjærgaard, Tony Reimann, Jan R. Wijbrans, Klaudia F. Kuiper, Herman J. Mücher, Hélène Coqueugniot, Vincent Prié, Ineke Joosten, Bertil van Os, Anne S. Schulp, Michel Panuel, Victoria van der Haas, Wim Lustenhouwer, John J. G. Reijmer and Wil Roebroeks

Grid cell symmetry is shaped by environmental geometry pp. 232-235

Julija Krupic, Marius Bauza, Stephen Burton, Caswell Barry and John O’Keefe

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration pp. 236-239

Diego Peretti, Amandine Bastide, Helois Radford, Nicholas Verity, Colin Molloy, Maria Guerra Martin, Julie A. Moreno, Joern R. Steinert, Tim Smith, David Dinsdale, Anne E. Willis and Giovanna R. Mallucci

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor pp. 240-244

Dejan Juric, Pau Castel, Malachi Griffith, Obi L. Griffith, Helen H. Won, Haley Ellis, Saya H. Ebbesen, Benjamin J. Ainscough, Avinash Ramu, Gopa Iyer, Ronak H. Shah, Tiffany Huynh, Mari Mino-Kenudson, Dennis Sgroi, Steven Isakoff, Ashraf Thabet, Leila Elamine, David B. Solit, Scott W. Lowe, Cornelia Quadt, Malte Peters, Adnan Derti, Robert Schegel, Alan Huang, Elaine R. Mardis, Michael F. Berger, José Baselga and Maurizio Scaltriti

Apico-basal forces exerted by apoptotic cells drive epithelium folding pp. 245-248

Bruno Monier, Melanie Gettings, Guillaume Gay, Thomas Mangeat, Sonia Schott, Ana Guarner and Magali Suzanne

RNA helicase DDX21 coordinates transcription and ribosomal RNA processing pp. 249-253

Eliezer Calo, Ryan A. Flynn, Lance Martin, Robert C. Spitale, Howard Y. Chang and Joanna Wysocka

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination pp. 254-257

Pedro A. Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M. Miller, Eros Lazzerini-Denchi and Agnel Sfeir

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair pp. 258-262

Raphael Ceccaldi, Jessica C. Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I. R. Petalcorin, Kevin W. O’Connor, Panagiotis A. Konstantinopoulos, Stephen J. Elledge, Simon J. Boulton, Timur Yusufzai and Alan D. D’Andrea

Social media: A network boost pp. 263-265

Monya Baker

The last one pp. 268-268

Iulia Georgescu

2015, volume 518, articles 7537

Major biodiversity initiative needs support pp. 7-7

Ehsan Masood

Mathematical model helps scientists decide where to submit their papers pp. 9-9

Chris Woolston

Obama budget seeks big boost for science pp. 13-15

Boer Deng, Richard Monastersky, Lauren Morello, Sara Reardon and Jeff Tollefson

Gravitational-wave hunt enters next phase pp. 16-17

Elizabeth Gibney

Graphene’s cousin silicene makes transistor debut pp. 17-18

Mark Peplow

Saudi university backs slow road to modernization pp. 18-19

Declan Butler

Autonomous vehicles: No drivers required pp. 20-23

M. Mitchell Waldrop

Neuroscience: The brain, interrupted pp. 24-26

Alison Abbott

Reproducibility: Standardize antibodies used in research pp. 27-29

Andrew Bradbury and Andreas Plückthun

Policy: Start research on climate engineering pp. 29-31

Jane C. S. Long, Frank Loy and M. Granger Morgan

Nuclear physics: New light on a cold war conundrum pp. 32-33

Sharon Weinberger

Books in brief pp. 33-33

Barbara Kiser

More than 70 ways to show resilience pp. 35-35

Len Fisher

Labs leak staff under French law pp. 35-35

Juan Iovanna

Replace 'pathogens' with 'perceptogens' pp. 35-35

Danny Altmann and Rosemary Boyton

Learning from Typhoon Haiyan pp. 35-35

Raul Lejano, Joyce Melcar Tan and Meriwether Wilson

Build neuroscience capacity in Africa pp. 35-35

Fanuel Muindi and Joseph Keller

Mary F. Lyon (1925–2014) pp. 36-36

Sohaila Rastan

How to minimalize antibodies pp. 38-39

Christoph Rader

The slippery base of a tectonic plate pp. 39-40

Catherine A. Rychert

Organelles under light control pp. 41-42

Franck Perez

Three-dimensional printed electronics pp. 42-43

Jennifer A. Lewis and Bok Y. Ahn

Deep and complex ways to survive bleaching pp. 43-44

John M. Pandolfi

Elusive source of sulfur unravelled pp. 45-46

Charles E. Melançon

Climate sensitivity in a warmer world pp. 46-47

David W. Lea

Plio-Pleistocene climate sensitivity evaluated using high-resolution CO2 records pp. 49-54

M. A. Martínez-Botí, G. L. Foster, T. B. Chalk, E. J. Rohling, P. F. Sexton, D. J. Lunt, R. D. Pancost, M. P. S. Badger and D. N. Schmidt

Biocontainment of genetically modified organisms by synthetic protein design pp. 55-60

Daniel J. Mandell, Marc J. Lajoie, Michael T. Mee, Ryo Takeuchi, Gleb Kuznetsov, Julie E. Norville, Christopher J. Gregg, Barry L. Stoddard and George M. Church

Mechanistic insights into the recycling machine of the SNARE complex pp. 61-67

Minglei Zhao, Shenping Wu, Qiangjun Zhou, Sandro Vivona, Daniel J. Cipriano, Yifan Cheng and Axel T. Brunger

Transport domain unlocking sets the uptake rate of an aspartate transporter pp. 68-73

Nurunisa Akyuz, Elka R. Georgieva, Zhou Zhou, Sebastian Stolzenberg, Michel A. Cuendet, George Khelashvili, Roger B. Altman, Daniel S. Terry, Jack H. Freed, Harel Weinstein, Olga Boudker and Scott C. Blanchard

A possible close supermassive black-hole binary in a quasar with optical periodicity pp. 74-76

Matthew J. Graham, S. G. Djorgovski, Daniel Stern, Eilat Glikman, Andrew J. Drake, Ashish A. Mahabal, Ciro Donalek, Steve Larson and Eric Christensen

Brittle intermetallic compound makes ultrastrong low-density steel with large ductility pp. 77-79

Sang-Heon Kim, Hansoo Kim and Nack J. Kim

Silylation of C–H bonds in aromatic heterocycles by an Earth-abundant metal catalyst pp. 80-84

Anton A. Toutov, Wen-Bo Liu, Kerry N. Betz, Alexey Fedorov, Brian M. Stoltz and Robert H. Grubbs

A seismic reflection image for the base of a tectonic plate pp. 85-88

T. A. Stern, S. A. Henrys, D. Okaya, J. N. Louie, M. K. Savage, S. Lamb, H. Sato, R. Sutherland and T. Iwasaki

Recoded organisms engineered to depend on synthetic amino acids pp. 89-93

Alexis J. Rovner, Adrian D. Haimovich, Spencer R. Katz, Zhe Li, Michael W. Grome, Brandon M. Gassaway, Miriam Amiram, Jaymin R. Patel, Ryan R. Gallagher, Jesse Rinehart and Farren J. Isaacs

Predicting climate-driven regime shifts versus rebound potential in coral reefs pp. 94-97

Nicholas A. J. Graham, Simon Jennings, M. Aaron MacNeil, David Mouillot and Shaun K. Wilson

Transferred interbacterial antagonism genes augment eukaryotic innate immune function pp. 98-101

Seemay Chou, Matthew D. Daugherty, S. Brook Peterson, Jacob Biboy, Youyun Yang, Brandon L. Jutras, Lillian K. Fritz-Laylin, Michael A. Ferrin, Brittany N. Harding, Christine Jacobs-Wagner, X. Frank Yang, Waldemar Vollmer, Harmit S. Malik and Joseph D. Mougous

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction pp. 102-106

Ron Do, Nathan O. Stitziel, Hong-Hee Won, Anders Berg Jørgensen, Stefano Duga, Pier Angelica Merlini, Adam Kiezun, Martin Farrall, Anuj Goel, Or Zuk, Illaria Guella, Rosanna Asselta, Leslie A. Lange, Gina M. Peloso, Paul L. Auer, Domenico Girelli, Nicola Martinelli, Deborah N. Farlow, Mark A. DePristo, Robert Roberts, Alexander F. R. Stewart, Danish Saleheen, John Danesh, Stephen E. Epstein, Suthesh Sivapalaratnam, G. Kees Hovingh, John J. Kastelein, Nilesh J. Samani, Heribert Schunkert, Jeanette Erdmann, Svati H. Shah, William E. Kraus, Robert Davies, Majid Nikpay, Christopher T. Johansen, Jian Wang, Robert A. Hegele, Eliana Hechter, Winfried Marz, Marcus E. Kleber, Jie Huang, Andrew D. Johnson, Mingyao Li, Greg L. Burke, Myron Gross, Yongmei Liu, Themistocles L. Assimes, Gerardo Heiss, Ethan M. Lange, Aaron R. Folsom, Herman A. Taylor, Oliviero Olivieri, Anders Hamsten, Robert Clarke, Dermot F. Reilly, Wu Yin, Manuel A. Rivas, Peter Donnelly, Jacques E. Rossouw, Bruce M. Psaty, David M. Herrington, James G. Wilson, Stephen S. Rich, Michael J. Bamshad, Russell P. Tracy, L. Adrienne Cupples, Daniel J. Rader, Muredach P. Reilly, John A. Spertus, Sharon Cresci, Jaana Hartiala, W. H. Wilson Tang, Stanley L. Hazen, Hooman Allayee, Alex P. Reiner, Christopher S. Carlson, Charles Kooperberg, Rebecca D. Jackson, Eric Boerwinkle, Eric S. Lander, Stephen M. Schwartz, David S. Siscovick, Ruth McPherson, Anne Tybjaerg-Hansen, Goncalo R. Abecasis, Hugh Watkins, Deborah A. Nickerson, Diego Ardissino, Shamil R. Sunyaev, Christopher J. O'Donnell, David Altshuler, Stacey Gabriel and Sekar Kathiresan

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Christopher J. Cheng, Raman Bahal, Imran A. Babar, Zachary Pincus, Francisco Barrera, Connie Liu, Alexander Svoronos, Demetrios T. Braddock, Peter M. Glazer, Donald M. Engelman, W. Mark Saltzman and Frank J. Slack

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Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase pp. 120-124

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Turning point: William S. Horton pp. 129-129

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How to configure your quantum disambiguator pp. 132-132

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