A 17-gene stemness score for rapid determination of risk in acute leukaemia

Stanley W. K. Ng, Amanda Mitchell, James A. Kennedy, Weihsu C. Chen, Jessica McLeod, Narmin Ibrahimova, Andrea Arruda, Andreea Popescu, Vikas Gupta, Aaron D. Schimmer, Andre C. Schuh, Karen W. Yee, Lars Bullinger, Tobias Herold, Dennis Görlich, Thomas Büchner, Wolfgang Hiddemann, Wolfgang E. Berdel, Bernhard Wörmann, Meyling Cheok, Claude Preudhomme, Hervé Dombret, Klaus Metzeler, Christian Buske, Bob Löwenberg, Peter J. M. Valk, Peter W. Zandstra, Mark D. Minden, John E. Dick and Jean C. Y. Wang ()
Additional contact information
Stanley W. K. Ng: Institute of Biomaterials and Biomedical Engineering, University of Toronto
Amanda Mitchell: Princess Margaret Cancer Centre, University Health Network
James A. Kennedy: Princess Margaret Cancer Centre, University Health Network
Weihsu C. Chen: Princess Margaret Cancer Centre, University Health Network
Jessica McLeod: Princess Margaret Cancer Centre, University Health Network
Narmin Ibrahimova: Princess Margaret Cancer Centre, University Health Network
Andrea Arruda: Princess Margaret Cancer Centre, University Health Network
Andreea Popescu: Princess Margaret Cancer Centre, University Health Network
Vikas Gupta: Princess Margaret Cancer Centre, University Health Network
Aaron D. Schimmer: Princess Margaret Cancer Centre, University Health Network
Andre C. Schuh: Princess Margaret Cancer Centre, University Health Network
Karen W. Yee: Princess Margaret Cancer Centre, University Health Network
Lars Bullinger: University Hospital of Ulm
Tobias Herold: University of Munich
Dennis Görlich: Institute of Biostatistics and Clinical Research, University of Münster
Thomas Büchner: Hematology and Oncology, University of Münster
Wolfgang Hiddemann: University of Munich
Wolfgang E. Berdel: Hematology and Oncology, University of Münster
Bernhard Wörmann: Oncology and Tumor Immunology, Charité University Medicine, Campus Virchow
Meyling Cheok: Jean-Pierre AUBERT Research Center UMR-S 1172, Institute for Cancer Research Lille
Claude Preudhomme: University Hospital of Lille, Center of Pathology, Laboratory of Hematology
Hervé Dombret: Saint-Louis Hospital, University of Paris Diderot
Klaus Metzeler: University of Munich
Christian Buske: Comprehensive Cancer Center Ulm, Institute of Experimental Cancer Research, University Hospital of Ulm
Bob Löwenberg: Erasmus University Medical Centre
Peter J. M. Valk: Erasmus University Medical Centre
Peter W. Zandstra: Institute of Biomaterials and Biomedical Engineering, University of Toronto
Mark D. Minden: Princess Margaret Cancer Centre, University Health Network
John E. Dick: Princess Margaret Cancer Centre, University Health Network
Jean C. Y. Wang: Princess Margaret Cancer Centre, University Health Network

Nature, 2016, vol. 540, issue 7633, 433-437

Abstract: A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy response and survival, facilitating initial treatment stratification.

Date: 2016
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DOI: 10.1038/nature20598

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