Genomic evolution and chemoresistance in germ-cell tumours

Amaro Taylor-Weiner, Travis Zack, Elizabeth O’Donnell, Jennifer L. Guerriero, Brandon Bernard, Anita Reddy, G. Celine Han, Saud AlDubayan, Ali Amin-Mansour, Steven E. Schumacher, Kevin Litchfield, Clare Turnbull, Stacey Gabriel, Rameen Beroukhim, Gad Getz, Scott L. Carter, Michelle S. Hirsch, Anthony Letai, Christopher Sweeney and Eliezer M Van Allen ()
Additional contact information
Amaro Taylor-Weiner: Harvard University
Travis Zack: Harvard University
Elizabeth O’Donnell: Dana-Farber Cancer Institute
Jennifer L. Guerriero: Dana-Farber Cancer Institute
Brandon Bernard: Dana-Farber Cancer Institute
Anita Reddy: Harvard Medical School
G. Celine Han: Cancer Program, Broad Institute of MIT and Harvard
Saud AlDubayan: Boston Children’s Hospital
Ali Amin-Mansour: Cancer Program, Broad Institute of MIT and Harvard
Steven E. Schumacher: Cancer Program, Broad Institute of MIT and Harvard
Kevin Litchfield: The Institute of Cancer Research
Clare Turnbull: The Institute of Cancer Research
Stacey Gabriel: Cancer Program, Broad Institute of MIT and Harvard
Rameen Beroukhim: Cancer Program, Broad Institute of MIT and Harvard
Gad Getz: Cancer Program, Broad Institute of MIT and Harvard
Scott L. Carter: Cancer Program, Broad Institute of MIT and Harvard
Michelle S. Hirsch: Brigham and Women’s Hospital
Anthony Letai: Dana-Farber Cancer Institute
Christopher Sweeney: Dana-Farber Cancer Institute
Eliezer M Van Allen: Cancer Program, Broad Institute of MIT and Harvard

Nature, 2016, vol. 540, issue 7631, 114-118

Abstract: Genomic analyses show that primary germ-cell tumours are highly enriched for chromosomal reciprocal loss of heterozygosity, mutations in KRAS and have high mitochondrial priming, providing insight into chemosensitivity and the evolution of chemoresistance in this disease.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature20596 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:540:y:2016:i:7631:d:10.1038_nature20596

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature20596

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().