NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

Rajendra Karki, Si Ming Man, R. K. Subbarao Malireddi, Sannula Kesavardhana, Qifan Zhu, Amanda R. Burton, Bhesh Raj Sharma, Xiaopeng Qi, Stephane Pelletier, Peter Vogel, Philip Rosenstiel and Thirumala-Devi Kanneganti ()
Additional contact information
Rajendra Karki: St. Jude Children’s Research Hospital
Si Ming Man: St. Jude Children’s Research Hospital
R. K. Subbarao Malireddi: St. Jude Children’s Research Hospital
Sannula Kesavardhana: St. Jude Children’s Research Hospital
Qifan Zhu: St. Jude Children’s Research Hospital
Amanda R. Burton: St. Jude Children’s Research Hospital
Bhesh Raj Sharma: St. Jude Children’s Research Hospital
Xiaopeng Qi: St. Jude Children’s Research Hospital
Stephane Pelletier: St. Jude Children’s Research Hospital
Peter Vogel: Animal Resources Center and the Veterinary Pathology Core, St. Jude Children’s Research Hospital
Philip Rosenstiel: Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel
Thirumala-Devi Kanneganti: St. Jude Children’s Research Hospital

Nature, 2016, vol. 540, issue 7634, 583-587

Abstract: Mice deficient in the protein NLRC3 are highly prone to colitis and tumour development in the colon as NLRC3 suppresses the activation of mTOR signalling pathways that help drive tumorigenesis.

Date: 2016
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DOI: 10.1038/nature20597

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