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2021, volume 600, articles 7890

Collect feedback to improve your event experience pp. S83-S85

Andy Tay

Reconsidering the role of alcohol in the scientific workplace pp. S86-S88

Nikki Forrester

How to tell a compelling story in scientific presentations pp. S88-S89

Bruce Kirchoff

Build a registry of results that students can replicate pp. 571-571

Yusuf A. Hannun

How severe are Omicron infections? pp. 577-578

Heidi Ledford

Evidence of racism found at prestigious London university pp. 578-579

Linda Nordling

Omicron blindspots: why it’s hard to track coronavirus variants pp. 579-579

Amy Maxmen

How COVID vaccines shaped 2021 in eight powerful charts pp. 580-583

Smriti Mallapaty, Ewen Callaway, Max Kozlov, Heidi Ledford, John Pickrell and Richard Van Noorden

The best science images of 2021 pp. 584-589

Emma Stoye

Nature’s 10: ten people who helped shape science in 2021 pp. 591-604

Ewen Callaway, Holly Else, Diana Kwon, Heidi Ledford, Smriti Mallapaty, Amy Maxmen, Linda Nordling, Quirin Schiermeier, Jeff Tollefson and Richard Van Noorden

Ned Seeman (1945–2021) pp. 605-605

Philip Ball

Early-career researchers help Wellcome funding panel pp. 606-606

Rachel V. Guest, Laura Benjamin and Daniel R. Morales

Upgrade the science and technology policy system the US already has pp. 606-606

Valerie J. Karplus and M. Granger Morgan

Secret of Hellenic Foundation’s success? Its staff pp. 606-606

Nektarios K. Nasikas

Half measures in One Health fail people and the environment pp. 606-606

Andrew Peters and Carlos das Neves

Alternatives to standard quantum theory ruled out pp. 607-608

William K. Wootters

Stomach cancer gets a triple punch of therapy pp. 608-609

Myriam Chalabi

Low-power light modifies electron microscopy pp. 610-611

Martin Kozák

Gut clues to weight gain after quitting smoking pp. 611-612

Matthew P. Spindler, Jeremiah J. Faith, Junshi Wang and Paul J. Kenny

Clever substitutions reveal magnetism in zigzag graphene nanoribbons pp. 613-614

Aran Garcia-Lekue and Daniel Sánchez-Portal

What surveys really say pp. 614-615

Frauke Kreuter

Very-high-frequency oscillations in the main peak of a magnetar giant flare pp. 621-624

A. J. Castro-Tirado, N. Østgaard, E. Göǧüş, C. Sánchez-Gil, J. Pascual-Granado, V. Reglero, A. Mezentsev, M. Gabler, M. Marisaldi, T. Neubert, C. Budtz-Jørgensen, A. Lindanger, D. Sarria, I. Kuvvetli, P. Cerdá-Durán, J. Navarro-González, J. A. Font, B.-B. Zhang, N. Lund, C. A. Oxborrow, S. Brandt, M. D. Caballero-García, I. M. Carrasco-García, A. Castellón, M. A. Castro Tirado, F. Christiansen, C. J. Eyles, E. Fernández-García, G. Genov, S. Guziy, Y.-D. Hu, A. Nicuesa Guelbenzu, S. B. Pandey, Z.-K. Peng, C. Pérez del Pulgar, A. J. Reina Terol, E. Rodríguez, R. Sánchez-Ramírez, T. Sun, K. Ullaland and S. Yang

Quantum theory based on real numbers can be experimentally falsified pp. 625-629

Marc-Olivier Renou, David Trillo, Mirjam Weilenmann, Thinh P. Le, Armin Tavakoli, Nicolas Gisin, Antonio Acín and Miguel Navascués

Programmable interactions and emergent geometry in an array of atom clouds pp. 630-635

Avikar Periwal, Eric S. Cooper, Philipp Kunkel, Julian F. Wienand, Emily J. Davis and Monika Schleier-Smith

Resonance from antiferromagnetic spin fluctuations for superconductivity in UTe2 pp. 636-640

Chunruo Duan, R. E. Baumbach, Andrey Podlesnyak, Yuhang Deng, Camilla Moir, Alexander J. Breindel, M. Brian Maple, E. M. Nica, Qimiao Si and Pengcheng Dai

Quantum anomalous Hall effect from intertwined moiré bands pp. 641-646

Tingxin Li, Shengwei Jiang, Bowen Shen, Yang Zhang, Lizhong Li, Zui Tao, Trithep Devakul, Kenji Watanabe, Takashi Taniguchi, Liang Fu, Jie Shan and Kin Fai Mak

Spin splitting of dopant edge state in magnetic zigzag graphene nanoribbons pp. 647-652

Raymond E. Blackwell, Fangzhou Zhao, Erin Brooks, Junmian Zhu, Ilya Piskun, Shenkai Wang, Aidan Delgado, Yea-Lee Lee, Steven G. Louie and Felix R. Fischer

Integrated photonics enables continuous-beam electron phase modulation pp. 653-658

Jan-Wilke Henke, Arslan Sajid Raja, Armin Feist, Guanhao Huang, Germaine Arend, Yujia Yang, F. Jasmin Kappert, Rui Ning Wang, Marcel Möller, Jiahe Pan, Junqiu Liu, Ofer Kfir, Claus Ropers and Tobias J. Kippenberg

Dynamic spatial progression of isolated lithium during battery operations pp. 659-663

Fang Liu, Rong Xu, Yecun Wu, David Thomas Boyle, Ankun Yang, Jinwei Xu, Yangying Zhu, Yusheng Ye, Zhiao Yu, Zewen Zhang, Xin Xiao, Wenxiao Huang, Hansen Wang, Hao Chen and Yi Cui

High-entropy polymer produces a giant electrocaloric effect at low fields pp. 664-669

Xiaoshi Qian, Donglin Han, Lirong Zheng, Jie Chen, Madhusudan Tyagi, Qiang Li, Feihong Du, Shanyu Zheng, Xingyi Huang, Shihai Zhang, Junye Shi, Houbing Huang, Xiaoming Shi, Jiangping Chen, Hancheng Qin, Jerzy Bernholc, Xin Chen, Long-Qing Chen, Liang Hong and Q. M. Zhang

Rapid microbial methanogenesis during CO2 storage in hydrocarbon reservoirs pp. 670-674

R. L. Tyne, P. H. Barry, M. Lawson, D. J. Byrne, O. Warr, H. Xie, D. J. Hillegonds, M. Formolo, Z. M. Summers, B. Skinner, J. M. Eiler and C. J. Ballentine

The power of genetic diversity in genome-wide association studies of lipids pp. 675-679

Sarah E. Graham, Shoa L. Clarke, Kuan-Han H. Wu, Stavroula Kanoni, Greg J. M. Zajac, Shweta Ramdas, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam, Thomas W. Winkler, Adam E. Locke, Eirini Marouli, Mi Yeong Hwang, Sohee Han, Akira Narita, Ananyo Choudhury, Amy R. Bentley, Kenneth Ekoru, Anurag Verma, Bhavi Trivedi, Hilary C. Martin, Karen A. Hunt, Qin Hui, Derek Klarin, Xiang Zhu, Gudmar Thorleifsson, Anna Helgadottir, Daniel F. Gudbjartsson, Hilma Holm, Isleifur Olafsson, Masato Akiyama, Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M. Brumpton, Humaira Rasheed, Sanni E. Ruotsalainen, Aki S. Havulinna, Yogasudha Veturi, QiPing Feng, Elisabeth A. Rosenthal, Todd Lingren, Jennifer Allen Pacheco, Sarah A. Pendergrass, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E. Miller, Archie Campbell, Kuang Lin, Iona Y. Millwood, George Hindy, Asif Rasheed, Jessica D. Faul, Wei Zhao, David R. Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Anubha Mahajan, Michael R. Brown, Weihua Zhang, Ketian Yu, Ellen M. Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian’an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez, Achilleas Pitsillides, Jouke Jan Hottenga, Gonneke Willemsen, Andrew R. Wood, Yingji Ji, Zishan Gao, Simon Haworth, Ruth E. Mitchell, Jin Fang Chai, Mette Aadahl, Jie Yao, Ani Manichaikul, Helen R. Warren, Julia Ramirez, Jette Bork-Jensen, Line L. Kårhus, Anuj Goel, Maria Sabater-Lleal, Raymond Noordam, Carlo Sidore, Edoardo Fiorillo, Aaron F. McDaid, Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet, Naveed Sattar, Line T. Møllehave, Betina H. Thuesen, Matthias Munz, Lingyao Zeng, Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Claudia Lamina, Lukas Forer, Markus Scholz, Tessel E. Galesloot, Jonathan P. Bradfield, E. Warwick Daw, Joseph M. Zmuda, Jonathan S. Mitchell, Christian Fuchsberger, Henry Christensen, Jennifer A. Brody, Mary F. Feitosa, Mary K. Wojczynski, Michael Preuss, Massimo Mangino, Paraskevi Christofidou, Niek Verweij, Jan W. Benjamins, Jorgen Engmann, Rachel L. Kember, Roderick C. Slieker, Ken Sin Lo, Nuno R. Zilhao, Phuong Le, Marcus E. Kleber, Graciela E. Delgado, Shaofeng Huo, Daisuke D. Ikeda, Hiroyuki Iha, Jian Yang, Jun Liu, Hampton L. Leonard, Jonathan Marten, Börge Schmidt, Marina Arendt, Laura J. Smyth, Marisa Cañadas-Garre, Chaolong Wang, Masahiro Nakatochi, Andrew Wong, Nina Hutri-Kähönen, Xueling Sim, Rui Xia, Alicia Huerta-Chagoya, Juan Carlos Fernandez-Lopez, Valeriya Lyssenko, Meraj Ahmed, Anne U. Jackson, Noha A. Yousri, Marguerite R. Irvin, Christopher Oldmeadow, Han-Na Kim, Seungho Ryu, Paul R. H. J. Timmers, Liubov Arbeeva, Rajkumar Dorajoo, Leslie A. Lange, Xiaoran Chai, Gauri Prasad, Laura Lorés-Motta, Marc Pauper, Jirong Long, Xiaohui Li, Elizabeth Theusch, Fumihiko Takeuchi, Cassandra N. Spracklen, Anu Loukola, Sailalitha Bollepalli, Sophie C. Warner, Ya Xing Wang, Wen B. Wei, Teresa Nutile, Daniela Ruggiero, Yun Ju Sung, Yi-Jen Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang, Katherine A. Kentistou, Mathias Gorski, Marco Brumat, Karina Meidtner, Lawrence F. Bielak, Jennifer A. Smith, Prashantha Hebbar, Aliki-Eleni Farmaki, Edith Hofer, Maoxuan Lin, Chao Xue, Jifeng Zhang, Maria Pina Concas, Simona Vaccargiu, Peter J. Most, Niina Pitkänen, Brian E. Cade, Jiwon Lee, Sander W. Laan, Kumaraswamy Naidu Chitrala, Stefan Weiss, Martina E. Zimmermann, Jong Young Lee, Hyeok Sun Choi, Maria Nethander, Sandra Freitag-Wolf, Lorraine Southam, Nigel W. Rayner, Carol A. Wang, Shih-Yi Lin, Jun-Sing Wang, Christian Couture, Leo-Pekka Lyytikäinen, Kjell Nikus, Gabriel Cuellar-Partida, Henrik Vestergaard, Bertha Hildalgo, Olga Giannakopoulou, Qiuyin Cai, Morgan O. Obura, Jessica Setten, Xiaoyin Li, Karen Schwander, Natalie Terzikhan, Jae Hun Shin, Rebecca D. Jackson, Alexander P. Reiner, Lisa Warsinger Martin, Zhengming Chen, Liming Li, Heather M. Highland, Kristin L. Young, Takahisa Kawaguchi, Joachim Thiery, Joshua C. Bis, Girish N. Nadkarni, Lenore J. Launer, Huaixing Li, Mike A. Nalls, Olli T. Raitakari, Sahoko Ichihara, Sarah H. Wild, Christopher P. Nelson, Harry Campbell, Susanne Jäger, Toru Nabika, Fahd Al-Mulla, Harri Niinikoski, Peter S. Braund, Ivana Kolcic, Peter Kovacs, Tota Giardoglou, Tomohiro Katsuya, Konain Fatima Bhatti, Dominique Kleijn, Gert J. Borst, Eung Kweon Kim, Hieab H. H. Adams, M. Arfan Ikram, Xiaofeng Zhu, Folkert W. Asselbergs, Adriaan O. Kraaijeveld, Joline W. J. Beulens, Xiao-Ou Shu, Loukianos S. Rallidis, Oluf Pedersen, Torben Hansen, Paul Mitchell, Alex W. Hewitt, Mika Kähönen, Louis Pérusse, Claude Bouchard, Anke Tönjes, Yii- Der Ida Chen, Craig E. Pennell, Trevor A. Mori, Wolfgang Lieb, Andre Franke, Claes Ohlsson, Dan Mellström, Yoon Shin Cho, Hyejin Lee, Jian-Min Yuan, Woon-Puay Koh, Sang Youl Rhee, Jeong-Taek Woo, Iris M. Heid, Klaus J. Stark, Henry Völzke, Georg Homuth, Michele K. Evans, Alan B. Zonderman, Ozren Polasek, Gerard Pasterkamp, Imo E. Hoefer, Susan Redline, Katja Pahkala, Albertine J. Oldehinkel, Harold Snieder, Ginevra Biino, Reinhold Schmidt, Helena Schmidt, Y. Eugene Chen, Stefania Bandinelli, George Dedoussis, Thangavel Alphonse Thanaraj, Sharon L. R. Kardia, Norihiro Kato, Matthias B. Schulze, Giorgia Girotto, Bettina Jung, Carsten A. Böger, Peter K. Joshi, David A. Bennett, Philip L. Jager, Xiangfeng Lu, Vasiliki Mamakou, Morris Brown, Mark J. Caulfield, Patricia B. Munroe, Xiuqing Guo, Marina Ciullo, Jost B. Jonas, Nilesh J. Samani, Jaakko Kaprio, Päivi Pajukanta, Linda S. Adair, Sonny Augustin Bechayda, H. Janaka Silva, Ananda R. Wickremasinghe, Ronald M. Krauss, Jer-Yuarn Wu, Wei Zheng, Anneke I. Hollander, Dwaipayan Bharadwaj, Adolfo Correa, James G. Wilson, Lars Lind, Chew-Kiat Heng, Amanda E. Nelson, Yvonne M. Golightly, James F. Wilson, Brenda Penninx, Hyung-Lae Kim, John Attia, Rodney J. Scott, D. C. Rao, Donna K. Arnett, Steven C. Hunt, Mark Walker, Heikki A. Koistinen, Giriraj R. Chandak, Chittaranjan S. Yajnik, Josep M. Mercader, Teresa Tusié-Luna, Carlos A. Aguilar-Salinas, Clicerio Gonzalez Villalpando, Lorena Orozco, Myriam Fornage, E. Shyong Tai, Rob M. Dam, Terho Lehtimäki, Nish Chaturvedi, Mitsuhiro Yokota, Jianjun Liu, Dermot F. Reilly, Amy Jayne McKnight, Frank Kee, Karl-Heinz Jöckel, Mark I. McCarthy, Colin N. A. Palmer, Veronique Vitart, Caroline Hayward, Eleanor Simonsick, Cornelia M. Duijn, Fan Lu, Jia Qu, Haretsugu Hishigaki, Xu Lin, Winfried März, Esteban J. Parra, Miguel Cruz, Vilmundur Gudnason, Jean-Claude Tardif, Guillaume Lettre, Leen M. ’t Hart, Petra J. M. Elders, Scott M. Damrauer, Meena Kumari, Mika Kivimaki, Pim Harst, Tim D. Spector, Ruth J. F. Loos, Michael A. Province, Bruce M. Psaty, Ivan Brandslund, Peter P. Pramstaller, Kaare Christensen, Samuli Ripatti, Elisabeth Widén, Hakon Hakonarson, Struan F. A. Grant, Lambertus A. L. M. Kiemeney, Jacqueline Graaf, Markus Loeffler, Florian Kronenberg, Dongfeng Gu, Jeanette Erdmann, Heribert Schunkert, Paul W. Franks, Allan Linneberg, J. Wouter Jukema, Amit V. Khera, Minna Männikkö, Marjo-Riitta Jarvelin, Zoltan Kutalik, Francesco Cucca, Dennis O. Mook-Kanamori, Ko Willems Dijk, Hugh Watkins, David P. Strachan, Niels Grarup, Peter Sever, Neil Poulter, Jerome I. Rotter, Thomas M. Dantoft, Fredrik Karpe, Matt J. Neville, Nicholas J. Timpson, Ching-Yu Cheng, Tien-Yin Wong, Chiea Chuen Khor, Charumathi Sabanayagam, Annette Peters, Christian Gieger, Andrew T. Hattersley, Nancy L. Pedersen, Patrik K. E. Magnusson, Dorret I. Boomsma, Eco J. C. Geus, L. Adrienne Cupples, Joyce B. J. Meurs, Mohsen Ghanbari, Penny Gordon-Larsen, Wei Huang, Young Jin Kim, Yasuharu Tabara, Nicholas J. Wareham, Claudia Langenberg, Eleftheria Zeggini, Johanna Kuusisto, Markku Laakso, Erik Ingelsson, Goncalo Abecasis, John C. Chambers, Jaspal S. Kooner, Paul S. Vries, Alanna C. Morrison, Kari E. North, Martha Daviglus, Peter Kraft, Nicholas G. Martin, John B. Whitfield, Shahid Abbas, Danish Saleheen, Robin G. Walters, Michael V. Holmes, Corri Black, Blair H. Smith, Anne E. Justice, Aris Baras, Julie E. Buring, Paul M. Ridker, Daniel I. Chasman, Charles Kooperberg, Wei-Qi Wei, Gail P. Jarvik, Bahram Namjou, M. Geoffrey Hayes, Marylyn D. Ritchie, Pekka Jousilahti, Veikko Salomaa, Kristian Hveem, Bjørn Olav Åsvold, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada, Yoshinori Murakami, Unnur Thorsteinsdottir, Kari Stefansson, Yuk-Lam Ho, Julie A. Lynch, Daniel J. Rader, Philip S. Tsao, Kyong-Mi Chang, Kelly Cho, Christopher J. O’Donnell, John M. Gaziano, Peter Wilson, Charles N. Rotimi, Scott Hazelhurst, Michèle Ramsay, Richard C. Trembath, David A. Heel, Gen Tamiya, Masayuki Yamamoto, Bong-Jo Kim, Karen L. Mohlke, Timothy M. Frayling, Joel N. Hirschhorn, Sekar Kathiresan, Michael Boehnke, Pradeep Natarajan, Gina M. Peloso, Christopher D. Brown, Andrew P. Morris, Themistocles L. Assimes, Panos Deloukas, Yan V. Sun and Cristen J. Willer

Cortical responses to touch reflect subcortical integration of LTMR signals pp. 680-685

Alan J. Emanuel, Brendan P. Lehnert, Stefano Panzeri, Christopher D. Harvey and David D. Ginty

Mechanical actions of dendritic-spine enlargement on presynaptic exocytosis pp. 686-689

Hasan Ucar, Satoshi Watanabe, Jun Noguchi, Yuichi Morimoto, Yusuke Iino, Sho Yagishita, Noriko Takahashi and Haruo Kasai

Collective durotaxis along a self-generated stiffness gradient in vivo pp. 690-694

Adam Shellard and Roberto Mayor

Unrepresentative big surveys significantly overestimated US vaccine uptake pp. 695-700

Valerie C. Bradley, Shiro Kuriwaki, Michael Isakov, Dino Sejdinovic, Xiao-Li Meng and Seth Flaxman

Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination pp. 701-706

Bruno Pozzetto, Vincent Legros, Sophia Djebali, Véronique Barateau, Nicolas Guibert, Marine Villard, Loïc Peyrot, Omran Allatif, Jean-Baptiste Fassier, Amélie Massardier-Pilonchéry, Karen Brengel-Pesce, Melyssa Yaugel-Novoa, Solène Denolly, Bertrand Boson, Thomas Bourlet, Antonin Bal, Martine Valette, Thibault Andrieu, Bruno Lina, François-Loïc Cosset, Stéphane Paul, Thierry Defrance, Jacqueline Marvel, Thierry Walzer and Sophie Trouillet-Assant

Antigen-presenting innate lymphoid cells orchestrate neuroinflammation pp. 707-712

John B. Grigg, Arthi Shanmugavadivu, Tommy Regen, Christopher N. Parkhurst, Anees Ahmed, Ann M. Joseph, Michael Mazzucco, Konrad Gronke, Andreas Diefenbach, Gerard Eberl, Timothy Vartanian, Ari Waisman and Gregory F. Sonnenberg

Gut microbiota modulates weight gain in mice after discontinued smoke exposure pp. 713-719

Leviel Fluhr, Uria Mor, Aleksandra A. Kolodziejczyk, Mally Dori-Bachash, Avner Leshem, Shlomik Itav, Yotam Cohen, Jotham Suez, Niv Zmora, Claudia Moresi, Shahar Molina, Niv Ayalon, Rafael Valdés-Mas, Shanni Hornstein, Hodaya Karbi, Denise Kviatcovsky, Adi Livne, Aurelie Bukimer, Shimrit Eliyahu-Miller, Alona Metz, Alexander Brandis, Tevie Mehlman, Yael Kuperman, Michael Tsoory, Noa Stettner, Alon Harmelin, Hagit Shapiro and Eran Elinav

A hormone complex of FABP4 and nucleoside kinases regulates islet function pp. 720-726

Kacey J. Prentice, Jani Saksi, Lauren T. Robertson, Grace Y. Lee, Karen E. Inouye, Kosei Eguchi, Alexandra Lee, Ozgur Cakici, Emily Otterbeck, Paulina Cedillo, Peter Achenbach, Anette-Gabriele Ziegler, Ediz S. Calay, Feyza Engin and Gökhan S. Hotamisligil

The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer pp. 727-730

Yelena Y. Janjigian, Akihito Kawazoe, Patricio Yañez, Ning Li, Sara Lonardi, Oleksii Kolesnik, Olga Barajas, Yuxian Bai, Lin Shen, Yong Tang, Lucjan S. Wyrwicz, Jianming Xu, Kohei Shitara, Shukui Qin, Eric Cutsem, Josep Tabernero, Lie Li, Sukrut Shah, Pooja Bhagia and Hyun Cheol Chung

ecDNA hubs drive cooperative intermolecular oncogene expression pp. 731-736

King L. Hung, Kathryn E. Yost, Liangqi Xie, Quanming Shi, Konstantin Helmsauer, Jens Luebeck, Robert Schöpflin, Joshua T. Lange, Rocío Chamorro González, Natasha E. Weiser, Celine Chen, Maria E. Valieva, Ivy Tsz-Lo Wong, Sihan Wu, Siavash R. Dehkordi, Connor V. Duffy, Katerina Kraft, Jun Tang, Julia A. Belk, John C. Rose, M. Ryan Corces, Jeffrey M. Granja, Rui Li, Utkrisht Rajkumar, Jordan Friedlein, Anindya Bagchi, Ansuman T. Satpathy, Robert Tjian, Stefan Mundlos, Vineet Bafna, Anton G. Henssen, Paul S. Mischel, Zhe Liu and Howard Y. Chang

Sex-specific chromatin remodelling safeguards transcription in germ cells pp. 737-742

Tien-Chi Huang, Yi-Fang Wang, Eric Vazquez-Ferrer, Ina Theofel, Cristina E. Requena, Courtney W. Hanna, Gavin Kelsey and Petra Hajkova

A conserved mechanism for regulating replisome disassembly in eukaryotes pp. 743-747

Michael Jenkyn-Bedford, Morgan L. Jones, Yasemin Baris, Karim P. M. Labib, Giuseppe Cannone, Joseph T. P. Yeeles and Tom D. Deegan

Activation of homologous recombination in G1 preserves centromeric integrity pp. 748-753

Duygu Yilmaz, Audrey Furst, Karen Meaburn, Aleksandra Lezaja, Yanlin Wen, Matthias Altmeyer, Bernardo Reina-San-Martin and Evi Soutoglou

β-NAD as a building block in natural product biosynthesis pp. 754-758

Lena Barra, Takayoshi Awakawa, Kohei Shirai, Zhijuan Hu, Ghader Bashiri and Ikuro Abe

Structures of the σ2 receptor enable docking for bioactive ligand discovery pp. 759-764

Assaf Alon, Jiankun Lyu, Joao M. Braz, Tia A. Tummino, Veronica Craik, Matthew J. O’Meara, Chase M. Webb, Dmytro S. Radchenko, Yurii S. Moroz, Xi-Ping Huang, Yongfeng Liu, Bryan L. Roth, John J. Irwin, Allan I. Basbaum, Brian K. Shoichet and Andrew C. Kruse

The scientific workplace in 2021 pp. 765-766

Chris Woolston

Embryo-like models shed fresh light on early human development pp. 767-769

Sandeep Ravindran

A partridge in hand on the Spanish steppe pp. 772-772

Jack Leeming

2021, volume 600, articles 7889

On the liquid–liquid phase transition of dense hydrogen pp. E12-E14

Valentin V. Karasiev, Joshua Hinz, S. X. Hu and S. B. Trickey

Reply to: On the liquid–liquid phase transition of dense hydrogen pp. E15-E16

Bingqing Cheng, Guglielmo Mazzola, Chris J. Pickard and Michele Ceriotti

Author Correction: Estimating a social cost of carbon for global energy consumption pp. E17-E17

Ashwin Rode, Tamma Carleton, Michael Delgado, Michael Greenstone, Trevor Houser, Solomon Hsiang, Andrew Hultgren, Amir Jina, Robert Kopp, Kelly E. McCusker, Ishan Nath, James Rising and Jiacan Yuan

Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring pp. E18-E18

Yu Shi, Weina Gao, Nikki K. Lytle, Peiwu Huang, Xiao Yuan, Amanda M. Dann, Maya Ridinger-Saison, Kathleen E. DelGiorno, Corina E. Antal, Gaoyang Liang, Annette R. Atkins, Galina Erikson, Huaiyu Sun, Jill Meisenhelder, Elena Terenziani, Gyunghwi Woo, Linjing Fang, Thom P. Santisakultarm, Uri Manor, Ruilian Xu, Carlos R. Becerra, Erkut Borazanci, Daniel D. Hoff, Paul M. Grandgenett, Michael A. Hollingsworth, Mathias Leblanc, Sarah E. Umetsu, Eric A. Collisson, Miriam Scadeng, Andrew M. Lowy, Timothy R. Donahue, Tannishtha Reya, Michael Downes, Ronald M. Evans, Geoffrey M. Wahl, Tony Pawson, Ruijun Tian and Tony Hunter

Publisher Correction: Single-photon nonlinearity at room temperature pp. E19-E19

Anton V. Zasedatelev, Anton V. Baranikov, Denis Sannikov, Darius Urbonas, Fabio Scafirimuto, Vladislav Yu. Shishkov, Evgeny S. Andrianov, Yurii E. Lozovik, Ullrich Scherf, Thilo Stöferle, Rainer F. Mahrt and Pavlos G. Lagoudakis

Ovarian cancer pp. S35-S35

Richard Hodson

What’s next for PARP inhibitors? pp. S36-S38

Simon Makin

Why Black women with ovarian cancer require greater focus pp. S39-S39

Sophia George

Ovarian cancer and the microbiome: a complex relationship pp. S40-S41

Julianna Photopoulos

The origins of ovarian cancer pp. S42-S44

Sarah DeWeerdt

Innovative therapies to tackle platinum-resistant ovarian cancer pp. S45-S47

Amanda B. Keener

Clarifying the burden of ovarian cancer pp. S48-S49

Andrada Fiscutean

The promise and pitfalls of gene testing for cancer risk pp. S50-S52

Jyoti Madhusoodanan

How to make ovarian cancer screening work for patients pp. S53-S53

Conor Purcell

India — stop looking down on international collaborations pp. 361-361

Arun Kumar Shukla

Omicron likely to weaken COVID vaccine protection pp. 367-368

Ewen Callaway

Half of top cancer studies fail high-profile reproducibility effort pp. 368-369

Asher Mullard

What Sci-Hub’s latest court battle means for research pp. 370-371

Holly Else

DeepMind AI tackles one of chemistry’s most valuable techniques pp. 371-371

Davide Castelvecchi

Science misinformation alarms Francis Collins as he leaves top NIH job pp. 372-373

Nidhi Subbaraman

How the mixed-race mestizo myth warped science in Latin America pp. 374-378

Emiliano Rodríguez Mega

The race to make vaccines for a dangerous respiratory virus pp. 379-380

Kendall Powell

The loss of the world’s frozen places pp. 381-382

Alexandra Witze

Decision makers need constantly updated evidence synthesis pp. 383-385

Julian Elliott, Rebecca Lawrence, Jan C. Minx, Olufemi T. Oladapo, Philippe Ravaud, Britta Tendal Jeppesen, James Thomas, Tari Turner, Per Olav Vandvik and Jeremy M. Grimshaw

To beat Omicron, Delta and bird flu, Europe must pull together pp. 386-386

Amélie Desvars-Larrive

Chile: elect a president to strengthen climate action, not weaken it pp. 386-386

Maisa Rojas, Juan Carlos Muñoz, Rodrigo Palma-Behnke, Pablo A. Marquet, Alejandra Stehr and Humberto González

Prepare PhD holders for different career tracks pp. 386-386

Theo van den Broek, Berent Prakken and Frank Miedema

Remembering a pioneer in biotechnology pp. 386-386

Tzvi Aviv, Frank Sicheri, Alan Bernstein and Robert A. Weinberg

Context is key for learning motor skills pp. 387-388

Anne G. E. Collins and Samuel D. McDougle

Hominin footprints at Laetoli reveal a walk on the wild side pp. 388-390

Stephanie M. Melillo

Human genetic variants identified that affect COVID susceptibility and severity pp. 390-391

Samira Asgari and Lionel A. Pousaz

Benefits of megastudies for testing behavioural interventions pp. 392-393

Heather Royer

Biogeochemical extremes and compound events in the ocean pp. 395-407

Nicolas Gruber, Philip W. Boyd, Thomas L. Frölicher and Meike Vogt

The emergence, genomic diversity and global spread of SARS-CoV-2 pp. 408-418

Juan Li, Shengjie Lai, George F. Gao and Weifeng Shi

Sublimation-driven convection in Sputnik Planitia on Pluto pp. 419-423

Adrien Morison, Stéphane Labrosse and Gaël Choblet

Direct limits for scalar field dark matter from a gravitational-wave detector pp. 424-428

Sander M. Vermeulen, Philip Relton, Hartmut Grote, Vivien Raymond, Christoph Affeldt, Fabio Bergamin, Aparna Bisht, Marc Brinkmann, Karsten Danzmann, Suresh Doravari, Volker Kringel, James Lough, Harald Lück, Moritz Mehmet, Nikhil Mukund, Séverin Nadji, Emil Schreiber, Borja Sorazu, Kenneth A. Strain, Henning Vahlbruch, Michael Weinert, Benno Willke and Holger Wittel

Observation of Feshbach resonances between a single ion and ultracold atoms pp. 429-433

Pascal Weckesser, Fabian Thielemann, Dariusz Wiater, Agata Wojciechowska, Leon Karpa, Krzysztof Jachymski, Michał Tomza, Thomas Walker and Tobias Schaetz

Detecting spins by their fluorescence with a microwave photon counter pp. 434-438

Emanuele Albertinale, Léo Balembois, Eric Billaud, Vishal Ranjan, Daniel Flanigan, Thomas Schenkel, Daniel Estève, Denis Vion, Patrice Bertet and Emmanuel Flurin

Fractional Chern insulators in magic-angle twisted bilayer graphene pp. 439-443

Yonglong Xie, Andrew T. Pierce, Jeong Min Park, Daniel E. Parker, Eslam Khalaf, Patrick Ledwith, Yuan Cao, Seung Hwan Lee, Shaowen Chen, Patrick R. Forrester, Kenji Watanabe, Takashi Taniguchi, Ashvin Vishwanath, Pablo Jarillo-Herrero and Amir Yacoby

Tritiation of aryl thianthrenium salts with a molecular palladium catalyst pp. 444-449

Da Zhao, Roland Petzold, Jiyao Yan, Dieter Muri and Tobias Ritter

A large West Antarctic Ice Sheet explains early Neogene sea-level amplitude pp. 450-455

J. W. Marschalek, L. Zurli, F. Talarico, T. Flierdt, P. Vermeesch, A. Carter, F. Beny, V. Bout-Roumazeilles, F. Sangiorgi, S. R. Hemming, L. F. Pérez, F. Colleoni, J. G. Prebble, T. E. Peer, M. Perotti, A. E. Shevenell, I. Browne, D. K. Kulhanek, R. Levy, D. Harwood, N. B. Sullivan, S. R. Meyers, E. M. Griffith, C.-D. Hillenbrand, E. Gasson, M. J. Siegert, B. Keisling, K. J. Licht, G. Kuhn, J. P. Dodd, C. Boshuis, L. Santis and R. M. McKay

Uncovering global-scale risks from commercial chemicals in air pp. 456-461

Qifan Liu, Li Li, Xianming Zhang, Amandeep Saini, Wenlong Li, Hayley Hung, Chunyan Hao, Kun Li, Patrick Lee, Jeremy J. B. Wentzell, Chunyan Huo, Shao-Meng Li, Tom Harner and John Liggio

Deep-mantle krypton reveals Earth’s early accretion of carbonaceous matter pp. 462-467

Sandrine Péron, Sujoy Mukhopadhyay, Mark D. Kurz and David W. Graham

Footprint evidence of early hominin locomotor diversity at Laetoli, Tanzania pp. 468-471

Ellison J. McNutt, Kevin G. Hatala, Catherine Miller, James Adams, Jesse Casana, Andrew S. Deane, Nathaniel J. Dominy, Kallisti Fabian, Luke D. Fannin, Stephen Gaughan, Simone V. Gill, Josephat Gurtu, Ellie Gustafson, Austin C. Hill, Camille Johnson, Said Kallindo, Benjamin Kilham, Phoebe Kilham, Elizabeth Kim, Cynthia Liutkus-Pierce, Blaine Maley, Anjali Prabhat, John Reader, Shirley Rubin, Nathan E. Thompson, Rebeca Thornburg, Erin Marie Williams-Hatala, Brian Zimmer, Charles M. Musiba and Jeremy M. DeSilva

Megastudies improve the impact of applied behavioural science pp. 478-483

Katherine Milkman, Dena Gromet, Hung Ho, Joseph S. Kay, Timothy W. Lee, Pepi Pandiloski, Yeji Park, Aneesh Rai, Max Bazerman, John Beshears, Lauri Bonacorsi, Colin Camerer, Edward Chang, Gretchen Chapman, Robert Cialdini, Hengchen Dai, Lauren Eskreis-Winkler, Ayelet Fishbach, James J. Gross, Samantha Horn, Alexa Hubbard, Steven J. Jones, Dean Karlan, Tim Kautz, Erika Kirgios, Joowon Klusowski, Ariella Kristal, Rahul Ladhania, George Loewenstein, Jens Ludwig, Barbara Mellers, Sendhil Mullainathan, Silvia Saccardo, Jann Spiess, Gaurav Suri, Joachim H. Talloen, Jamie Taxer, Yaacov Trope, Lyle Ungar, Kevin G. Volpp, Ashley Whillans, Jonathan Zinman and Angela L. Duckworth

Cognitive control persistently enhances hippocampal information processing pp. 484-488

Ain Chung, Claudia Jou, Alejandro Grau-Perales, Eliott R. J. Levy, Dino Dvorak, Nida Hussain and André A. Fenton

Contextual inference underlies the learning of sensorimotor repertoires pp. 489-493

James B. Heald, Máté Lengyel and Daniel M. Wolpert

Exercise plasma boosts memory and dampens brain inflammation via clusterin pp. 494-499

Zurine Miguel, Nathalie Khoury, Michael J. Betley, Benoit Lehallier, Drew Willoughby, Niclas Olsson, Andrew C. Yang, Oliver Hahn, Nannan Lu, Ryan T. Vest, Liana N. Bonanno, Lakshmi Yerra, Lichao Zhang, Nay Lui Saw, J. Kaci Fairchild, Davis Lee, Hui Zhang, Patrick L. McAlpine, Kévin Contrepois, Mehrdad Shamloo, Joshua E. Elias, Thomas A. Rando and Tony Wyss-Coray

Combinatorial, additive and dose-dependent drug–microbiome associations pp. 500-505

Sofia K. Forslund, Rima Chakaroun, Maria Zimmermann-Kogadeeva, Lajos Markó, Judith Aron-Wisnewsky, Trine Nielsen, Lucas Moitinho-Silva, Thomas S. B. Schmidt, Gwen Falony, Sara Vieira-Silva, Solia Adriouch, Renato J. Alves, Karen Assmann, Jean-Philippe Bastard, Till Birkner, Robert Caesar, Julien Chilloux, Luis Pedro Coelho, Leopold Fezeu, Nathalie Galleron, Gerard Helft, Richard Isnard, Boyang Ji, Michael Kuhn, Emmanuelle Le Chatelier, Antonis Myridakis, Lisa Olsson, Nicolas Pons, Edi Prifti, Benoit Quinquis, Hugo Roume, Joe-Elie Salem, Nataliya Sokolovska, Valentina Tremaroli, Mireia Valles-Colomer, Christian Lewinter, Nadja B. Søndertoft, Helle Krogh Pedersen, Tue H. Hansen, Jens Peter Gøtze, Lars Køber, Henrik Vestergaard, Torben Hansen, Jean-Daniel Zucker, Serge Hercberg, Jean-Michel Oppert, Ivica Letunic, Jens Nielsen, Fredrik Bäckhed, S. Dusko Ehrlich, Marc-Emmanuel Dumas, Jeroen Raes, Oluf Pedersen, Karine Clément, Michael Stumvoll and Peer Bork

Genomic reconstruction of the SARS-CoV-2 epidemic in England pp. 506-511

Harald S. Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola Maio, Thuy Nguyen, Richard Goater, Frank Schwach, Ian Harrison, Joel Hellewell, Cristina V. Ariani, Sonia Gonçalves, David K. Jackson, Ian Johnston, Alexander W. Jung, Callum Saint, John Sillitoe, Maria Suciu, Nick Goldman, Jasmina Panovska-Griffiths, Ewan Birney, Erik Volz, Sebastian Funk, Dominic Kwiatkowski, Meera Chand, Inigo Martincorena, Jeffrey C. Barrett and Moritz Gerstung

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape pp. 512-516

Fabian Schmidt, Yiska Weisblum, Magdalena Rutkowska, Daniel Poston, Justin DaSilva, Fengwen Zhang, Eva Bednarski, Alice Cho, Dennis J. Schaefer-Babajew, Christian Gaebler, Marina Caskey, Michel C. Nussenzweig, Theodora Hatziioannou and Paul D. Bieniasz

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination pp. 517-522

Alice Cho, Frauke Muecksch, Dennis Schaefer-Babajew, Zijun Wang, Shlomo Finkin, Christian Gaebler, Victor Ramos, Melissa Cipolla, Pilar Mendoza, Marianna Agudelo, Eva Bednarski, Justin DaSilva, Irina Shimeliovich, Juan Dizon, Mridushi Daga, Katrina G. Millard, Martina Turroja, Fabian Schmidt, Fengwen Zhang, Tarek Ben Tanfous, Mila Jankovic, Thiago Y. Oliveria, Anna Gazumyan, Marina Caskey, Paul D. Bieniasz, Theodora Hatziioannou and Michel C. Nussenzweig

Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity pp. 523-529

Carolina Lucas, Chantal B. F. Vogels, Inci Yildirim, Jessica E. Rothman, Peiwen Lu, Valter Monteiro, Jeff R. Gehlhausen, Melissa Campbell, Julio Silva, Alexandra Tabachnikova, Mario A. Peña-Hernandez, M. Catherine Muenker, Mallery I. Breban, Joseph R. Fauver, Subhasis Mohanty, Jiefang Huang, Albert C. Shaw, Albert I. Ko, Saad B. Omer, Nathan D. Grubaugh and Akiko Iwasaki

Hybrid immunity improves B cells and antibodies against SARS-CoV-2 variants pp. 530-535

Emanuele Andreano, Ida Paciello, Giulia Piccini, Noemi Manganaro, Piero Pileri, Inesa Hyseni, Margherita Leonardi, Elisa Pantano, Valentina Abbiento, Linda Benincasa, Ginevra Giglioli, Concetta De Santi, Massimiliano Fabbiani, Ilaria Rancan, Mario Tumbarello, Francesca Montagnani, Claudia Sala, Emanuele Montomoli and Rino Rappuoli

A multi-scale map of cell structure fusing protein images and interactions pp. 536-542

Yue Qin, Edward L. Huttlin, Casper F. Winsnes, Maya L. Gosztyla, Ludivine Wacheul, Marcus R. Kelly, Steven M. Blue, Fan Zheng, Michael Chen, Leah V. Schaffer, Katherine Licon, Anna Bäckström, Laura Pontano Vaites, John J. Lee, Wei Ouyang, Sophie N. Liu, Tian Zhang, Erica Silva, Jisoo Park, Adriana Pitea, Jason F. Kreisberg, Steven P. Gygi, Jianzhu Ma, J. Wade Harper, Gene W. Yeo, Denis L. J. Lafontaine, Emma Lundberg and Trey Ideker

Accuracy mechanism of eukaryotic ribosome translocation pp. 543-546

Muminjon Djumagulov, Natalia Demeshkina, Lasse Jenner, Alexey Rozov, Marat Yusupov and Gulnara Yusupova

De novo protein design by deep network hallucination pp. 547-552

Ivan Anishchenko, Samuel J. Pellock, Tamuka M. Chidyausiku, Theresa A. Ramelot, Sergey Ovchinnikov, Jingzhou Hao, Khushboo Bafna, Christoffer Norn, Alex Kang, Asim K. Bera, Frank DiMaio, Lauren Carter, Cameron M. Chow, Gaetano T. Montelione and David Baker

The conformational cycle of prestin underlies outer-hair cell electromotility pp. 553-558

Navid Bavi, Michael David Clark, Gustavo F. Contreras, Rong Shen, Bharat G. Reddy, Wieslawa Milewski and Eduardo Perozo

Trapped in a hotel room: my scientific life in the pandemic pp. 559-560

Jen Lewendon

Something in the air: gathering dust that’s crossed an ocean pp. 562-562

Amber Dance

2021, volume 600, articles 7888

Universities under 50 chart a clear roadmap for the future pp. S5-S5

Catherine Armitage

Young universities forge new paths to success pp. S6-S7

James Mitchell Crow

Customized recruitment attracts top talent pp. S14-S15

Benjamin Plackett

Industry demand drives innovation pp. S16-S17

Leigh Dayton

Universities under 50 carve their niche pp. S30-S31

Flynn Murphy and Anthea Lacchia

Understand the real reasons reproducibility reform fails pp. 191-191

Nicole C. Nelson

How bad is Omicron? What scientists know so far pp. 197-199

Ewen Callaway and Heidi Ledford

Omicron-variant border bans ignore the evidence, say scientists pp. 199-199

Smriti Mallapaty

What the Moderna–NIH COVID vaccine patent fight means for research pp. 200-201

Heidi Ledford

DeepMind’s AI helps untangle the mathematics of knots pp. 202-202

Davide Castelvecchi

China’s Mars rover has amassed reams of novel geological data pp. 203-203

Smriti Mallapaty

Beyond Omicron: what’s next for COVID’s viral evolution pp. 204-207

Ewen Callaway

The $11-billion Webb telescope aims to probe the early Universe pp. 208-212

Alexandra Witze

Has Eric Kandel rested on his laurels? No pp. 213-214

Alison Abbott

Climate adaptation, and the next great extinction: Books in brief pp. 214-214

Andrew Robinson

Build solar-energy systems to last — save billions pp. 215-217

Dirk Jordan, Teresa Barnes, Nancy Haegel and Ingrid Repins

Brazil is in water crisis — it needs a drought plan pp. 218-220

Augusto Getirana, Renata Libonati and Marcio Cataldi

Portugal: female science leaders could speed up change pp. 221-221

Paulo Cartaxana

Call to join the decentralized science movement pp. 221-221

Sarah Hamburg

Are female science leaders judged more harshly than men? Study it pp. 221-221

Martina Schraudner and Elizabeth Pollitzer

A peek into the black box of human embryology pp. 223-224

Alexander Goedel and Fredrik Lanner

Constraints on estimating the CO2 fertilization effect emerge pp. 224-225

Chris Huntingford and Rebecca J. Oliver

Clues that natural killer cells help to control COVID pp. 226-227

Emilie Narni-Mancinelli and Eric Vivier

Giant planet imaged orbiting two massive stars pp. 227-228

Kaitlin Kratter

Cerebellar neurons that curb food consumption pp. 229-230

Richard Simerly and Ralph DiLeone

A wide-orbit giant planet in the high-mass b Centauri binary system pp. 231-234

Markus Janson, Raffaele Gratton, Laetitia Rodet, Arthur Vigan, Mickaël Bonnefoy, Philippe Delorme, Eric E. Mamajek, Sabine Reffert, Lukas Stock, Gabriel-Dominique Marleau, Maud Langlois, Gaël Chauvin, Silvano Desidera, Simon Ringqvist, Lucio Mayer, Gayathri Viswanath, Vito Squicciarini, Michael R. Meyer, Matthias Samland, Simon Petrus, Ravit Helled, Matthew A. Kenworthy, Sascha P. Quanz, Beth Biller, Thomas Henning, Dino Mesa, Natalia Engler and Joseph C. Carson

Giant modulation of optical nonlinearity by Floquet engineering pp. 235-239

Jun-Yi Shan, M. Ye, H. Chu, Sungmin Lee, Je-Geun Park, L. Balents and D. Hsieh

Evidence for unconventional superconductivity in twisted bilayer graphene pp. 240-245

Myungchul Oh, Kevin P. Nuckolls, Dillon Wong, Ryan L. Lee, Xiaomeng Liu, Kenji Watanabe, Takashi Taniguchi and Ali Yazdani

High-frequency and intrinsically stretchable polymer diodes pp. 246-252

Naoji Matsuhisa, Simiao Niu, Stephen J. K. O’Neill, Jiheong Kang, Yuto Ochiai, Toru Katsumata, Hung-Chin Wu, Minoru Ashizawa, Ging-Ji Nathan Wang, Donglai Zhong, Xuelin Wang, Xiwen Gong, Rui Ning, Huaxin Gong, Insang You, Yu Zheng, Zhitao Zhang, Jeffrey B.-H. Tok, Xiaodong Chen and Zhenan Bao

 RETRACTED ARTICLE: A constraint on historic growth in global photosynthesis due to increasing CO2 pp. 253-258

T. F. Keenan, X. Luo, M. G. Kauwe, B. E. Medlyn, I. C. Prentice, B. D. Stocker, N. G. Smith, C. Terrer, H. Wang, Y. Zhang and S. Zhou

Bizarre tail weaponry in a transitional ankylosaur from subantarctic Chile pp. 259-263

Sergio Soto-Acuña, Alexander O. Vargas, Jonatan Kaluza, Marcelo A. Leppe, Joao F. Botelho, José Palma-Liberona, Carolina Simon-Gutstein, Roy A. Fernández, Héctor Ortiz, Verónica Milla, Bárbara Aravena, Leslie M. E. Manríquez, Jhonatan Alarcón-Muñoz, Juan Pablo Pino, Cristine Trevisan, Héctor Mansilla, Luis Felipe Hinojosa, Vicente Muñoz-Walther and David Rubilar-Rogers

Quantifying social organization and political polarization in online platforms pp. 264-268

Isaac Waller and Ashton Anderson

Reverse-translational identification of a cerebellar satiation network pp. 269-273

Aloysius Y. T. Low, Nitsan Goldstein, Jessica R. Gaunt, Kuei-Pin Huang, Norliyana Zainolabidin, Alaric K. K. Yip, Jamie R. E. Carty, Ju Y. Choi, Alekso M. Miller, Helen S. T. Ho, Clara Lenherr, Nicholas Baltar, Eiman Azim, October M. Sessions, Toh Hean Ch’ng, Amanda S. Bruce, Laura E. Martin, Mark A. Halko, Roscoe O. Brady, Laura M. Holsen, Amber L. Alhadeff, Albert I. Chen and J. Nicholas Betley

Allometric rules for mammalian cortical layer 5 neuron biophysics pp. 274-278

Lou Beaulieu-Laroche, Norma J. Brown, Marissa Hansen, Enrique H. S. Toloza, Jitendra Sharma, Ziv M. Williams, Matthew P. Frosch, Garth Rees Cosgrove, Sydney S. Cash and Mark T. Harnett

Multiview confocal super-resolution microscopy pp. 279-284

Yicong Wu, Xiaofei Han, Yijun Su, Melissa Glidewell, Jonathan S. Daniels, Jiamin Liu, Titas Sengupta, Ivan Rey-Suarez, Robert Fischer, Akshay Patel, Christian Combs, Junhui Sun, Xufeng Wu, Ryan Christensen, Corey Smith, Lingyu Bao, Yilun Sun, Leighton H. Duncan, Jiji Chen, Yves Pommier, Yun-Bo Shi, Elizabeth Murphy, Sougata Roy, Arpita Upadhyaya, Daniel Colón-Ramos, Patrick La Riviere and Hari Shroff

Single-cell transcriptomic characterization of a gastrulating human embryo pp. 285-289

Richard C. V. Tyser, Elmir Mahammadov, Shota Nakanoh, Ludovic Vallier, Antonio Scialdone and Shankar Srinivas

Observation of universal ageing dynamics in antibiotic persistence pp. 290-294

Yoav Kaplan, Shaked Reich, Elyaqim Oster, Shani Maoz, Irit Levin-Reisman, Irine Ronin, Orit Gefen, Oded Agam and Nathalie Q. Balaban

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells pp. 295-301

Mario Witkowski, Caroline Tizian, Marta Ferreira-Gomes, Daniela Niemeyer, Terry C. Jones, Frederik Heinrich, Stefan Frischbutter, Stefan Angermair, Thordis Hohnstein, Irene Mattiola, Philipp Nawrath, Sophie McEwen, Silvia Zocche, Edoardo Viviano, Gitta Anne Heinz, Marcus Maurer, Uwe Kölsch, Robert Lorenz Chua, Tom Aschman, Christian Meisel, Josefine Radke, Birgit Sawitzki, Jobst Roehmel, Kristina Allers, Verena Moos, Thomas Schneider, Leif Hanitsch, Marcus A. Mall, Christian Conrad, Helena Radbruch, Claudia U. Duerr, Joseph A. Trapani, Emanuela Marcenaro, Tilmann Kallinich, Victor M. Corman, Florian Kurth, Leif Erik Sander, Christian Drosten, Sascha Treskatsch, Pawel Durek, Andrey Kruglov, Andreas Radbruch, Mir-Farzin Mashreghi and Andreas Diefenbach

Host immunomodulatory lipids created by symbionts from dietary amino acids pp. 302-307

Sungwhan F. Oh, T. Praveena, Heebum Song, Ji-Sun Yoo, Da-Jung Jung, Deniz Erturk-Hasdemir, Yoon Soo Hwang, ChangWon C. Lee, Jérôme Nours, Hyunsoo Kim, Jesang Lee, Richard S. Blumberg, Jamie Rossjohn, Seung Bum Park and Dennis L. Kasper

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity pp. 308-313

Lingyun Long, Jun Wei, Seon Ah Lim, Jana L. Raynor, Hao Shi, Jon P. Connelly, Hong Wang, Cliff Guy, Boer Xie, Nicole M. Chapman, Guotong Fu, Yanyan Wang, Hongling Huang, Wei Su, Jordy Saravia, Isabel Risch, Yong-Dong Wang, Yuxin Li, Mingming Niu, Yogesh Dhungana, Anil Kc, Peipei Zhou, Peter Vogel, Jiyang Yu, Shondra M. Pruett-Miller, Junmin Peng and Hongbo Chi

IL-27 signalling promotes adipocyte thermogenesis and energy expenditure pp. 314-318

Qian Wang, Dehai Li, Guangchao Cao, Qiping Shi, Jing Zhu, Mingyue Zhang, Hao Cheng, Qiong Wen, Hao Xu, Leqing Zhu, Hua Zhang, Rachel J. Perry, Olga Spadaro, Yunfan Yang, Shengqi He, Yong Chen, Baocheng Wang, Guangqiang Li, Zonghua Liu, Caixian Yang, Xiaoli Wu, Libing Zhou, Qinghua Zhou, Zhenyu Ju, Hongyun Lu, Yongjie Xin, Xiaoyong Yang, Cunchuan Wang, Yong Liu, Gerald I. Shulman, Vishwa Deep Dixit, Ligong Lu, Hengwen Yang, Richard A. Flavell and Zhinan Yin

The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer pp. 319-323

Hiroki Izumi, Shingo Matsumoto, Jie Liu, Kosuke Tanaka, Shunta Mori, Kumiko Hayashi, Shogo Kumagai, Yuji Shibata, Takuma Hayashida, Kana Watanabe, Tatsuro Fukuhara, Takaya Ikeda, Kiyotaka Yoh, Terufumi Kato, Kazumi Nishino, Atsushi Nakamura, Ichiro Nakachi, Shoichi Kuyama, Naoki Furuya, Jun Sakakibara-Konishi, Isamu Okamoto, Kageaki Taima, Noriyuki Ebi, Haruko Daga, Akira Yamasaki, Masahiro Kodani, Hibiki Udagawa, Keisuke Kirita, Yoshitaka Zenke, Kaname Nosaki, Eri Sugiyama, Tetsuya Sakai, Tokiko Nakai, Genichiro Ishii, Seiji Niho, Atsushi Ohtsu, Susumu S. Kobayashi and Koichi Goto

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation pp. 324-328

Yuqing Feng, Conglei Li, Jessica A. Stewart, Philip Barbulescu, Noé Seija Desivo, Alejandro Álvarez-Quilón, Rossanna C. Pezo, Madusha L. W. Perera, Katherine Chan, Amy Hin Yan Tong, Rukshana Mohamad-Ramshan, Maribel Berru, Diana Nakib, Gavin Li, Gholam Ali Kardar, James R. Carlyle, Jason Moffat, Daniel Durocher, Javier M. Noia, Ashok S. Bhagwat and Alberto Martin

Fam72a enforces error-prone DNA repair during antibody diversification pp. 329-333

Mélanie Rogier, Jacques Moritz, Isabelle Robert, Chloé Lescale, Vincent Heyer, Arthur Abello, Ophélie Martin, Katia Capitani, Morgane Thomas, Anne-Sophie Thomas-Claudepierre, Brice Laffleur, Florence Jouan, Eric Pinaud, Karin Tarte, Michel Cogné, Silvestro G. Conticello, Evi Soutoglou, Ludovic Deriano and Bernardo Reina-San-Martin

Structural insights into Ubr1-mediated N-degron polyubiquitination pp. 334-338

Man Pan, Qingyun Zheng, Tian Wang, Lujun Liang, Junxiong Mao, Chong Zuo, Ruichao Ding, Huasong Ai, Yuan Xie, Dong Si, Yuanyuan Yu, Lei Liu and Minglei Zhao

Structures of the HER2–HER3–NRG1β complex reveal a dynamic dimer interface pp. 339-343

Devan Diwanji, Raphael Trenker, Tarjani M. Thaker, Feng Wang, David A. Agard, Kliment A. Verba and Natalia Jura

Adopting as academics: what we learnt pp. 345-346

Tony Ly and Nathan W. Bailey

Python power-up: new image tool visualizes complex data pp. 347-348

Jeffrey M. Perkel

How remouldable computer hardware is speeding up science pp. 348-349

Jeffrey M. Perkel

Handling snakes for science pp. 352-352

Virginia Gewin

2021, volume 600, articles 7887

Non-trivial role of internal climate feedback on interglacial temperature evolution pp. E1-E3

Xu Zhang and Fahu Chen

The quest to treat dry age-related macular degeneration pp. S1-S1

Michael Eisenstein

A visual guide to repairing the retina pp. S2-S3

Michael Eisenstein

Reply to: Non-trivial role of internal climate feedback on interglacial temperature evolution pp. E4-E6

Samantha Bova, Yair Rosenthal, Zhengyu Liu, Mi Yan, Anthony J. Broccoli, Shital P. Godad and Cheng Zeng

Author Correction: Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy pp. E7-E7

Ana Luísa Correia, Joao C. Guimaraes, Priska Auf der Maur, Duvini De Silva, Marcel P. Trefny, Ryoko Okamoto, Sandro Bruno, Alexander Schmidt, Kirsten Mertz, Katrin Volkmann, Luigi Terracciano, Alfred Zippelius, Marcus Vetter, Christian Kurzeder, Walter Paul Weber and Mohamed Bentires-Alj

Author Correction: Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins pp. E8-E10

Kangpeng Xiao, Junqiong Zhai, Yaoyu Feng, Niu Zhou, Xu Zhang, Jie-Jian Zou, Na Li, Yaqiong Guo, Xiaobing Li, Xuejuan Shen, Zhipeng Zhang, Fanfan Shu, Wanyi Huang, Yu Li, Ziding Zhang, Rui-Ai Chen, Ya-Jiang Wu, Shi-Ming Peng, Mian Huang, Wei-Jun Xie, Qin-Hui Cai, Fang-Hui Hou, Wu Chen, Lihua Xiao and Yongyi Shen

Victories against AIDS have lessons for COVID-19 pp. 9-9

Anthony Fauci

Author Correction: RecA finds homologous DNA by reduced dimensionality search pp. E11-E11

Jakub Wiktor, Arvid H. Gynnå, Prune Leroy, Jimmy Larsson, Giovanna Coceano, Ilaria Testa and Johan Elf

Cuba’s bet on home-grown COVID vaccines is paying off pp. 15-16

Sara Reardon

NASA spacecraft will slam into asteroid in first planetary-defence test pp. 17-18

Alexandra Witze

Outcry as men win outsize share of Australian medical-research funding pp. 18-18

Holly Else

China creates vast research infrastructure to support ambitious climate goals pp. 19-20

Smriti Mallapaty

Scientists question Max Planck Society’s treatment of women leaders pp. 20-20

Alison Abbott

Heavily mutated Omicron variant puts scientists on alert pp. 21-21

Ewen Callaway

What humanity should eat to stay healthy and save the planet pp. 22-25

Gayathri Vaidyanathan

When scientists gave 1,000 vulnerable people hepatitis over 30 years pp. 27-28

Heidi Ledford

Defining Alzheimer’s, and the climate costs of AI: Books in brief pp. 28-28

Andrew Robinson

The United States needs a department of technology and science policy pp. 30-32

Harold Varmus and Elias Zerhouni

Africa: tackle HIV and COVID-19 together pp. 33-36

Nokukhanya Msomi, Richard Lessells, Koleka Mlisana and Tulio de Oliveira

Animal experiments: EU is pushing to find substitutes fast pp. 37-37

Stefan Hippenstiel, Christa Thöne-Reineke and Jens Kurreck

Climate researchers: consider standing for office — I did pp. 37-37

John Dearing

Collaborate equitably in ancient DNA research and beyond pp. 37-37

Mehmet Somel, N. Ezgi Altınışık, Füsun Özer and María C. Ávila-Arcos

Ancient-DNA researchers write their own rules pp. 37-37

Krystal S. Tsosie, Alyssa C. Bader, Keolu Fox, Deborah A. Bolnick, Nanibaa’ A. Garrison and Rick W. A. Smith

Robotic sample return reveals lunar secrets pp. 39-40

Richard W. Carlson

A reconstruction of early cryptic COVID spread pp. 40-41

Simon Cauchemez and Paolo Bosetti

A seagrass harbours a nitrogen-fixing bacterial partner pp. 42-43

Douglas G. Capone

Choreographing water molecules to speed up hydrogen production pp. 43-44

Matthias M. Waegele

Artificial intelligence aids intuition in mathematical discovery pp. 44-45

Christian Stump

Helpline data used to monitor population distress in a pandemic pp. 46-47

Cindy H. Liu and Alexander C. Tsai

A dry lunar mantle reservoir for young mare basalts of Chang’e-5 pp. 49-53

Sen Hu, Huicun He, Jianglong Ji, Yangting Lin, Hejiu Hui, Mahesh Anand, Romain Tartèse, Yihong Yan, Jialong Hao, Ruiying Li, Lixin Gu, Qian Guo, Huaiyu He and Ziyuan Ouyang

Two-billion-year-old volcanism on the Moon from Chang’e-5 basalts pp. 54-58

Qiu-Li Li, Qin Zhou, Yu Liu, Zhiyong Xiao, Yangting Lin, Jin-Hua Li, Hong-Xia Ma, Guo-Qiang Tang, Shun Guo, Xu Tang, Jiang-Yan Yuan, Jiao Li, Fu-Yuan Wu, Ziyuan Ouyang, Chunlai Li and Xian-Hua Li

Non-KREEP origin for Chang’e-5 basalts in the Procellarum KREEP Terrane pp. 59-63

Heng-Ci Tian, Hao Wang, Yi Chen, Wei Yang, Qin Zhou, Chi Zhang, Hong-Lei Lin, Chao Huang, Shi-Tou Wu, Li-Hui Jia, Lei Xu, Di Zhang, Xiao-Guang Li, Rui Chang, Yue-Heng Yang, Lie-Wen Xie, Dan-Ping Zhang, Guang-Liang Zhang, Sai-Hong Yang and Fu-Yuan Wu

Sound emission and annihilations in a programmable quantum vortex collider pp. 64-69

W. J. Kwon, G. Del Pace, K. Xhani, L. Galantucci, A. Muzi Falconi, M. Inguscio, F. Scazza and G. Roati

Advancing mathematics by guiding human intuition with AI pp. 70-74

Alex Davies, Petar Veličković, Lars Buesing, Sam Blackwell, Daniel Zheng, Nenad Tomašev, Richard Tanburn, Peter Battaglia, Charles Blundell, András Juhász, Marc Lackenby, Geordie Williamson, Demis Hassabis and Pushmeet Kohli

Optomechanical dissipative solitons pp. 75-80

Jing Zhang, Bo Peng, Seunghwi Kim, Faraz Monifi, Xuefeng Jiang, Yihang Li, Peng Yu, Lianqing Liu, Yu-xi Liu, Andrea Alù and Lan Yang

In situ Raman spectroscopy reveals the structure and dissociation of interfacial water pp. 81-85

Yao-Hui Wang, Shisheng Zheng, Wei-Min Yang, Ru-Yu Zhou, Quan-Feng He, Petar Radjenovic, Jin-Chao Dong, Shunning Li, Jiaxin Zheng, Zhi-Lin Yang, Gary Attard, Feng Pan, Zhong-Qun Tian and Jian-Feng Li

Late Quaternary dynamics of Arctic biota from ancient environmental genomics pp. 86-92

Yucheng Wang, Mikkel Winther Pedersen, Inger Greve Alsos, Bianca Sanctis, Fernando Racimo, Ana Prohaska, Eric Coissac, Hannah Lois Owens, Marie Kristine Føreid Merkel, Antonio Fernandez-Guerra, Alexandra Rouillard, Youri Lammers, Adriana Alberti, France Denoeud, Daniel Money, Anthony H. Ruter, Hugh McColl, Nicolaj Krog Larsen, Anna A. Cherezova, Mary E. Edwards, Grigory B. Fedorov, James Haile, Ludovic Orlando, Lasse Vinner, Thorfinn Sand Korneliussen, David W. Beilman, Anders A. Bjørk, Jialu Cao, Christoph Dockter, Julie Esdale, Galina Gusarova, Kristian K. Kjeldsen, Jan Mangerud, Jeffrey T. Rasic, Birgitte Skadhauge, John Inge Svendsen, Alexei Tikhonov, Patrick Wincker, Yingchun Xing, Yubin Zhang, Duane G. Froese, Carsten Rahbek, David Nogues Bravo, Philip B. Holden, Neil R. Edwards, Richard Durbin, David J. Meltzer, Kurt H. Kjær, Per Möller and Eske Willerslev

Temporal transitions in the post-mitotic nervous system of Caenorhabditis elegans pp. 93-99

HaoSheng Sun and Oliver Hobert

Thalamic circuits for independent control of prefrontal signal and noise pp. 100-104

Arghya Mukherjee, Norman H. Lam, Ralf D. Wimmer and Michael M. Halassa

Terrestrial-type nitrogen-fixing symbiosis between seagrass and a marine bacterium pp. 105-109

Wiebke Mohr, Nadine Lehnen, Soeren Ahmerkamp, Hannah K. Marchant, Jon S. Graf, Bernhard Tschitschko, Pelin Yilmaz, Sten Littmann, Harald Gruber-Vodicka, Nikolaus Leisch, Miriam Weber, Christian Lott, Carsten J. Schubert, Jana Milucka and Marcel M. M. Kuypers

The human microbiome encodes resistance to the antidiabetic drug acarbose pp. 110-115

Jared Balaich, Michael Estrella, Guojun Wu, Philip D. Jeffrey, Abhishek Biswas, Liping Zhao, Alexei Korennykh and Mohamed S. Donia

Antiviral activity of bacterial TIR domains via immune signalling molecules pp. 116-120

Gal Ofir, Ehud Herbst, Maya Baroz, Daniel Cohen, Adi Millman, Shany Doron, Nitzan Tal, Daniel B. A. Malheiro, Sergey Malitsky, Gil Amitai and Rotem Sorek

Mental health concerns during the COVID-19 pandemic as revealed by helpline calls pp. 121-126

Marius Brülhart, Valentin Klotzbücher, Rafael Lalive and Stephanie K. Reich

Cryptic transmission of SARS-CoV-2 and the first COVID-19 wave pp. 127-132

Jessica T. Davis, Matteo Chinazzi, Nicola Perra, Kunpeng Mu, Ana Pastore y Piontti, Marco Ajelli, Natalie E. Dean, Corrado Gioannini, Maria Litvinova, Stefano Merler, Luca Rossi, Kaiyuan Sun, Xinyue Xiong, Ira M. Longini, M. Elizabeth Halloran, Cécile Viboud and Alessandro Vespignani

Independent infections of porcine deltacoronavirus among Haitian children pp. 133-137

John A. Lednicky, Massimiliano S. Tagliamonte, Sarah K. White, Maha A. Elbadry, Md. Mahbubul Alam, Caroline J. Stephenson, Tania S. Bonny, Julia C. Loeb, Taina Telisma, Sonese Chavannes, David A. Ostrov, Carla Mavian, Valery Madsen Beau De Rochars, Marco Salemi and J. Glenn Morris

Self-guarding of MORC3 enables virulence factor-triggered immunity pp. 138-142

Moritz M. Gaidt, Alyssa Morrow, Marian R. Fairgrieve, Jonathan P. Karr, Nir Yosef and Russell E. Vance

Structural basis of cytokine-mediated activation of ALK family receptors pp. 143-147

Steven Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J. Fernando Bazan, Akihide Yoshimi and Savvas N. Savvides

Structural basis for ligand reception by anaplastic lymphoma kinase pp. 148-152

Tongqing Li, Steven E. Stayrook, Yuko Tsutsui, Jianan Zhang, Yueyue Wang, Hengyi Li, Andrew Proffitt, Stefan G. Krimmer, Mansoor Ahmed, Olivia Belliveau, Ian X. Walker, Krishna C. Mudumbi, Yoshihisa Suzuki, Irit Lax, Diego Alvarado, Mark A. Lemmon, Joseph Schlessinger and Daryl E. Klein

Mechanism for the activation of the anaplastic lymphoma kinase receptor pp. 153-157

Andrey V. Reshetnyak, Paolo Rossi, Alexander G. Myasnikov, Munia Sowaileh, Jyotidarsini Mohanty, Amanda Nourse, Darcie J. Miller, Irit Lax, Joseph Schlessinger and Charalampos G. Kalodimos

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response pp. 158-163

Lee Mulderrig, Juan I. Garaycoechea, Zewen K. Tuong, Christopher L. Millington, Felix A. Dingler, John R. Ferdinand, Liam Gaul, John A. Tadross, Mark J. Arends, Stephen O’Rahilly, Gerry P. Crossan, Menna R. Clatworthy and Ketan J. Patel

Structure, function and pharmacology of human itch receptor complexes pp. 164-169

Fan Yang, Lulu Guo, Yu Li, Guopeng Wang, Jia Wang, Chao Zhang, Guo-Xing Fang, Xu Chen, Lei Liu, Xu Yan, Qun Liu, Changxiu Qu, Yunfei Xu, Peng Xiao, Zhongliang Zhu, Zijian Li, Jiuyao Zhou, Xiao Yu, Ning Gao and Jin-Peng Sun

Structure, function and pharmacology of human itch GPCRs pp. 170-175

Can Cao, Hye Jin Kang, Isha Singh, He Chen, Chengwei Zhang, Wenlei Ye, Byron W. Hayes, Jing Liu, Ryan H. Gumpper, Brian J. Bender, Samuel T. Slocum, Brian E. Krumm, Katherine Lansu, John D. McCorvy, Wesley K. Kroeze, Justin G. English, Jeffrey F. DiBerto, Reid H. J. Olsen, Xi-Ping Huang, Shicheng Zhang, Yongfeng Liu, Kuglae Kim, Joel Karpiak, Lily Y. Jan, Soman N. Abraham, Jian Jin, Brian K. Shoichet, Jonathan F. Fay and Bryan L. Roth

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‘For a brown invertebrate’: rescuing native UK oysters pp. 182-182

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