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2020, volume 588, articles 7839

The effect of interventions on COVID-19 pp. E26-E28

Kristian Soltesz, Fredrik Gustafsson, Toomas Timpka, Joakim Jaldén, Carl Jidling, Albin Heimerson, Thomas B. Schön, Armin Spreco, Joakim Ekberg, Örjan Dahlström, Fredrik Bagge Carlson, Anna Jöud and Bo Bernhardsson

Reply to: The effect of interventions on COVID-19 pp. E29-E32

Seth Flaxman, Swapnil Mishra, James Scott, Neil Ferguson, Axel Gandy and Samir Bhatt

Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression pp. E33-E33

Irene Caffa, Vanessa Spagnolo, Claudio Vernieri, Francesca Valdemarin, Pamela Becherini, Min Wei, Sebastian Brandhorst, Chiara Zucal, Else Driehuis, Lorenzo Ferrando, Francesco Piacente, Alberto Tagliafico, Michele Cilli, Luca Mastracci, Valerio G. Vellone, Silvano Piazza, Anna Laura Cremonini, Raffaella Gradaschi, Carolina Mantero, Mario Passalacqua, Alberto Ballestrero, Gabriele Zoppoli, Michele Cea, Annalisa Arrighi, Patrizio Odetti, Fiammetta Monacelli, Giulia Salvadori, Salvatore Cortellino, Hans Clevers, Filippo Braud, Samir G. Sukkar, Alessandro Provenzani, Valter D. Longo and Alessio Nencioni

Author Correction: Coupling of hippocampal theta and ripples with pontogeniculooccipital waves pp. E34-E34

Juan F. Ramirez-Villegas, Michel Besserve, Yusuke Murayama, Henry C. Evrard, Axel Oeltermann and Nikos K. Logothetis

Author Correction: Virological assessment of hospitalized patients with COVID-2019 pp. E35-E35

Roman Wölfel, Victor M. Corman, Wolfgang Guggemos, Michael Seilmaier, Sabine Zange, Marcel A. Müller, Daniela Niemeyer, Terry C. Jones, Patrick Vollmar, Camilla Rothe, Michael Hoelscher, Tobias Bleicker, Sebastian Brünink, Julia Schneider, Rosina Ehmann, Katrin Zwirglmaier, Christian Drosten and Clemens Wendtner

Author Correction: Enteric neurons increase maternal food intake during reproduction pp. E36-E36

Dafni Hadjieconomou, George King, Pedro Gaspar, Alessandro Mineo, Laura Blackie, Tomotsune Ameku, Chris Studd, Alex Mendoza, Fengqiu Diao, Benjamin H. White, André E. X. Brown, Pierre-Yves Plaçais, Thomas Préat and Irene Miguel-Aliaga

Publisher Correction: Self-assembled poly-catenanes from supramolecular toroidal building blocks pp. E37-E37

Sougata Datta, Yasuki Kato, Seiya Higashiharaguchi, Keisuke Aratsu, Atsushi Isobe, Takuho Saito, Deepak D. Prabhu, Yuichi Kitamoto, Martin J. Hollamby, Andrew J. Smith, Robert Dalgliesh, Najet Mahmoudi, Luca Pesce, Claudio Perego, Giovanni M. Pavan and Shiki Yagai

Arecibo Observatory: another great lost in 2020 pp. 539-539

Abel Méndez

Can Joe Biden rebuild the ravaged US Environmental Protection Agency? pp. 545-546

Jeff Tollefson

Is a racially-biased algorithm delaying health care for one million Black people? pp. 546-547

Jyoti Madhusoodanan

Arab nations first to approve Chinese COVID vaccine — despite lack of public data pp. 548-548

David Cyranoski

Coronavirus and public holidays: what the data say pp. 549-549

Giorgia Guglielmi

COVID and 2020: An extraordinary year for science pp. 550-552

Ewen Callaway, Heidi Ledford, Giuliana Viglione, Traci Watson and Alexandra Witze

How a torrent of COVID science changed research publishing — in seven charts pp. 553-553

Holly Else

2020 beyond COVID: the other science events that shaped the year pp. 554-555

Davide Castelvecchi, Jeff Tollefson, Emma Stoye and Alexandra Witze

The best science images of 2020 pp. 556-561

Nisha Gaind

Nature’s 10: ten people who helped shape science in 2020 pp. 563-576

David Cyranoski, Elie Dolgin, Nisha Gaind, Shannon Hall, Heidi Ledford, Dyani Lewis, Smriti Mallapaty, Emiliano Rodríguez Mega and Nidhi Subbaraman

What are COVID archivists keeping for tomorrow’s historians? pp. 578-580

Laura Spinney

The pandemic bookshelf grows pp. 580-582

Tilli Tansey

The WHO’s chief scientist on a year of loss and learning pp. 583-585

Soumya Swaminathan

Science advisers around the world on 2020 pp. 586-588

Gordon Awandare, Emmanuel André, Eugenia Corrales-Aguilar, Chien-jen Chen, Mohammed A. Mostajo-Radji, Ligita Jancoriene and Mona Nemer

River conservation by an Indigenous community pp. 589-590

Edward H. Allison and Violet Cho

Bacterial species singled out from a diverse crowd pp. 591-592

Jen Nguyen and Carolina Tropini

Targeted wetland restoration could greatly reduce nitrogen pollution pp. 592-593

Jacques C. Finlay

High-resolution 3D printing in seconds pp. 594-595

Cameron Darkes-Burkey and Robert F. Shepherd

Superconducting qubit to optical photon transduction pp. 599-603

Mohammad Mirhosseini, Alp Sipahigil, Mahmoud Kalaee and Oskar Painter

Mastering Atari, Go, chess and shogi by planning with a learned model pp. 604-609

Julian Schrittwieser, Ioannis Antonoglou, Thomas Hubert, Karen Simonyan, Laurent Sifre, Simon Schmitt, Arthur Guez, Edward Lockhart, Demis Hassabis, Thore Graepel, Timothy Lillicrap and David Silver

Strongly correlated Chern insulators in magic-angle twisted bilayer graphene pp. 610-615

Kevin P. Nuckolls, Myungchul Oh, Dillon Wong, Biao Lian, Kenji Watanabe, Takashi Taniguchi, B. Andrei Bernevig and Ali Yazdani

Plasmonic topological quasiparticle on the nanometre and femtosecond scales pp. 616-619

Yanan Dai, Zhikang Zhou, Atreyie Ghosh, Roger S. K. Mong, Atsushi Kubo, Chen-Bin Huang and Hrvoje Petek

Xolography for linear volumetric 3D printing pp. 620-624

Martin Regehly, Yves Garmshausen, Marcus Reuter, Niklas F. König, Eric Israel, Damien P. Kelly, Chun-Yu Chou, Klaas Koch, Baraa Asfari and Stefan Hecht

Maximizing US nitrate removal through wetland protection and restoration pp. 625-630

F. Y. Cheng, K. J. Van Meter, D. K. Byrnes and N. B. Basu

A network of grassroots reserves protects tropical river fish diversity pp. 631-635

Aaron A. Koning, K. Martin Perales, Etienne Fluet-Chouinard and Peter B. McIntyre

Impacts of speciation and extinction measured by an evolutionary decay clock pp. 636-641

Jennifer F. Hoyal Cuthill, Nicholas Guttenberg and Graham E. Budd

Transcriptome and translatome co-evolution in mammals pp. 642-647

Zhong-Yi Wang, Evgeny Leushkin, Angélica Liechti, Svetlana Ovchinnikova, Katharina Mößinger, Thoomke Brüning, Coralie Rummel, Frank Grützner, Margarida Cardoso-Moreira, Peggy Janich, David Gatfield, Boubou Diagouraga, Bernard Massy, Mark E. Gill, Antoine H. F. M. Peters, Simon Anders and Henrik Kaessmann

Spatial connectivity matches direction selectivity in visual cortex pp. 648-652

L. Federico Rossi, Kenneth D. Harris and Matteo Carandini

The neuropeptide Pth2 dynamically senses others via mechanosensation pp. 653-657

Lukas Anneser, Ivan C. Alcantara, Anja Gemmer, Kristina Mirkes, Soojin Ryu and Erin M. Schuman

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1 pp. 658-663

Yuefeng Jiang, Tingting Liu, Chia-Hsueh Lee, Qing Chang, Jing Yang and Zhe Zhang

Creation of bladder assembloids mimicking tissue regeneration and cancer pp. 664-669

Eunjee Kim, Seoyoung Choi, Byunghee Kang, JungHo Kong, Yubin Kim, Woong Hee Yoon, Hwa-Rim Lee, SungEun Kim, Hyo-Min Kim, HyeSun Lee, Chorong Yang, You Jeong Lee, Minyong Kang, Tae-Young Roh, Sungjune Jung, Sanguk Kim, Ja Hyeon Ku and Kunyoo Shin

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids pp. 670-675

Ameen A. Salahudeen, Shannon S. Choi, Arjun Rustagi, Junjie Zhu, Vincent Unen, Sean M. O, Ryan A. Flynn, Mar Margalef-Català, António J. M. Santos, Jihang Ju, Arpit Batish, Tatsuya Usui, Grace X. Y. Zheng, Caitlin E. Edwards, Lisa E. Wagar, Vincent Luca, Benedict Anchang, Monica Nagendran, Khanh Nguyen, Daniel J. Hart, Jessica M. Terry, Phillip Belgrader, Solongo B. Ziraldo, Tarjei S. Mikkelsen, Pehr B. Harbury, Jeffrey S. Glenn, K. Christopher Garcia, Mark M. Davis, Ralph S. Baric, Chiara Sabatti, Manuel R. Amieva, Catherine A. Blish, Tushar J. Desai and Calvin J. Kuo

Highly multiplexed spatial mapping of microbial communities pp. 676-681

Hao Shi, Qiaojuan Shi, Benjamin Grodner, Joan Sesing Lenz, Warren R. Zipfel, Ilana Lauren Brito and Iwijn De Vlaminck

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies pp. 682-687

Christopher O. Barnes, Claudia A. Jette, Morgan E. Abernathy, Kim-Marie A. Dam, Shannon R. Esswein, Harry B. Gristick, Andrey G. Malyutin, Naima G. Sharaf, Kathryn E. Huey-Tubman, Yu E. Lee, Davide F. Robbiani, Michel C. Nussenzweig, Anthony P. West and Pamela J. Bjorkman

Galactosaminogalactan activates the inflammasome to provide host protection pp. 688-692

Benoit Briard, Thierry Fontaine, Parimal Samir, David E. Place, Laetitia Muszkieta, R. K. Subbarao Malireddi, Rajendra Karki, Shelbi Christgen, Perrine Bomme, Peter Vogel, Rémi Beau, Emilia Mellado, Oumaima Ibrahim-Granet, Bernard Henrissat, Ravi C. Kalathur, Cam Robinson, Jean-Paul Latgé and Thirumala-Devi Kanneganti

Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer pp. 693-698

Xinjian Liu, Xuhui Bao, Mengjie Hu, Hanman Chang, Meng Jiao, Jin Cheng, Liyi Xie, Qian Huang, Fang Li and Chuan-Yuan Li

MFSD12 mediates the import of cysteine into melanosomes and lysosomes pp. 699-704

Charles H. Adelmann, Anna K. Traunbauer, Brandon Chen, Kendall J. Condon, Sze Ham Chan, Tenzin Kunchok, Caroline A. Lewis and David M. Sabatini

Lymphoangiocrine signals promote cardiac growth and repair pp. 705-711

Xiaolei Liu, Ester Cruz, Xiaowu Gu, Laszlo Balint, Michael Oxendine-Burns, Tamara Terrones, Wanshu Ma, Hui-Hsuan Kuo, Connor Lantz, Trisha Bansal, Edward Thorp, Paul Burridge, Zoltán Jakus, Joachim Herz, Ondine Cleaver, Miguel Torres and Guillermo Oliver

Small-molecule inhibitors of human mitochondrial DNA transcription pp. 712-716

Nina A. Bonekamp, Bradley Peter, Hauke S. Hillen, Andrea Felser, Tim Bergbrede, Axel Choidas, Moritz Horn, Anke Unger, Raffaella Lucrezia, Ilian Atanassov, Xinping Li, Uwe Koch, Sascha Menninger, Joanna Boros, Peter Habenberger, Patrick Giavalisco, Patrick Cramer, Martin S. Denzel, Peter Nussbaumer, Bert Klebl, Maria Falkenberg, Claes M. Gustafsson and Nils-Göran Larsson

Ways to look after yourself and others in 2021 pp. 717-718

Virginia Gewin

I want to generate opportunities for Black scientists pp. 720-720

Virginia Gewin

2020, volume 588, articles 7838

Beta human papillomaviruses and skin cancer pp. E20-E21

Paul F. Lambert, Karl Münger, Frank Rösl, Daniel Hasche and Massimo Tommasino

Reply to: Beta human papillomaviruses and skin cancer pp. E22-E23

John D. Strickley, Jonathan L. Messerschmidt, Alfred Bennett Jenson, Joongho Joh and Shadmehr Demehri

Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses pp. E24-E24

Maria Marti-Solano, Stephanie E. Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Abigail Pearce, Tezz Quon, Amanda E. Mackenzie, Xusheng Wang, Junmin Peng, Andrew B. Tobin, Graham Ladds, Graeme Milligan, David E. Gloriam, Manojkumar A. Puthenveedu and M. Madan Babu

Author Correction: Observed controls on resilience of groundwater to climate variability in sub-Saharan Africa pp. E25-E25

Mark O. Cuthbert, Richard G. Taylor, Guillaume Favreau, Martin C. Todd, Mohammad Shamsudduha, Karen G. Villholth, Alan M. MacDonald, Bridget R. Scanlon, D. O. Valerie Kotchoni, Jean-Michel Vouillamoz, Fabrice M. A. Lawson, Philippe Armand Adjomayi, Japhet Kashaigili, David Seddon, James P. R. Sorensen, Girma Yimer Ebrahim, Michael Owor, Philip M. Nyenje, Yahaya Nazoumou, Ibrahim Goni, Boukari Issoufou Ousmane, Tenant Sibanda, Matthew J. Ascott, David M. J. Macdonald, William Agyekum, Youssouf Koussoubé, Heike Wanke, Hyungjun Kim, Yoshihide Wada, Min-Hui Lo, Taikan Oki and Neno Kukuric

Reproductive health pp. S161-S161

Herb Brody

Strengthening society with contraception pp. S162-S164

Emily Sohn

Religion is not a barrier to family planning pp. S165-S165

Shareen Joshi

Better birth control pp. S166-S167

Elizabeth Svoboda

Why is long-lasting birth control struggling to catch on? pp. S168-S169

Bianca Nogrady

Stopping sperm at the source pp. S170-S171

Michael Eisenstein

The drug that could save the lives of many women pp. S172-S173

Alla Katsnelson

How much should having a baby cost? pp. S174-S176

Sarah DeWeerdt

Equal opportunities begin with contraception pp. S177-S177

Martha Bailey

Research round-up: reproductive health pp. S178-S179

Claire Ainsworth

The skin microbiome pp. S209-S209

Michael Eisenstein

The skin microbiome and its relationship with the human body explained pp. S210-S211

Michael Eisenstein

Farewell to Europe’s Horizon 2020 pp. 371-371

Alison Abbott

US authorization of first COVID vaccine marks new phase in safety monitoring pp. 377-378

Heidi Ledford

Oxford COVID-vaccine paper highlights lingering unknowns about results pp. 378-379

Heidi Ledford

Physicists in China challenge Google’s ‘quantum advantage’ pp. 380-380

Philip Ball

Scientists fear that ‘covidization’ is distorting research pp. 381-382

David Adam

How kids’ immune systems can evade COVID pp. 382-382

Bianca Nogrady

CRISPR gene therapy shows promise against blood diseases pp. 383-383

Heidi Ledford

Why many countries failed at COVID contact-tracing — but some got it right pp. 384-387

Dyani Lewis

How COVID-19 is changing the cold and flu season pp. 388-390

Nicola Jones

Women of the Nobel factory share their stories pp. 392-393

Georgina Ferry

European rivers are fragmented by many more barriers than had been recorded pp. 395-396

Christiane Zarfl and Bernhard Lehner

Quantum engineering for optical clocks pp. 397-398

Christian Lisdat and Carsten Klempt

Engineered antibodies to combat viral threats pp. 398-399

Xiaojie Yu and Mark S. Cragg

Closest relatives found for pterosaurs, the first flying vertebrates pp. 400-401

Kevin Padian

Spin transport in a tunable Heisenberg model realized with ultracold atoms pp. 403-407

Paul Niklas Jepsen, Jesse Amato-Grill, Ivana Dimitrova, Wen Wei Ho, Eugene Demler and Wolfgang Ketterle

Half-minute-scale atomic coherence and high relative stability in a tweezer clock pp. 408-413

Aaron W. Young, William J. Eckner, William R. Milner, Dhruv Kedar, Matthew A. Norcia, Eric Oelker, Nathan Schine, Jun Ye and Adam M. Kaufman

Entanglement on an optical atomic-clock transition pp. 414-418

Edwin Pedrozo-Peñafiel, Simone Colombo, Chi Shu, Albert F. Adiyatullin, Zeyang Li, Enrique Mendez, Boris Braverman, Akio Kawasaki, Daisuke Akamatsu, Yanhong Xiao and Vladan Vuletić

Tuning the Chern number in quantum anomalous Hall insulators pp. 419-423

Yi-Fan Zhao, Ruoxi Zhang, Ruobing Mei, Ling-Jie Zhou, Hemian Yi, Ya-Qi Zhang, Jiabin Yu, Run Xiao, Ke Wang, Nitin Samarth, Moses H. W. Chan, Chao-Xing Liu and Cui-Zu Chang

Topological superconductivity in a van der Waals heterostructure pp. 424-428

Shawulienu Kezilebieke, Md Nurul Huda, Viliam Vaňo, Markus Aapro, Somesh C. Ganguli, Orlando J. Silveira, Szczepan Głodzik, Adam S. Foster, Teemu Ojanen and Peter Liljeroth

Self-assembly of a layered two-dimensional molecularly woven fabric pp. 429-435

David P. August, Robert A. W. Dryfe, Sarah J. Haigh, Paige R. C. Kent, David A. Leigh, Jean-François Lemonnier, Zheling Li, Christopher A. Muryn, Leoni I. Palmer, Yiwei Song, George F. S. Whitehead and Robert J. Young

More than one million barriers fragment Europe’s rivers pp. 436-441

Barbara Belletti, Carlos Garcia de Leaniz, Joshua Jones, Simone Bizzi, Luca Börger, Gilles Segura, Andrea Castelletti, Wouter van de Bund, Kim Aarestrup, James Barry, Kamila Belka, Arjan Berkhuysen, Kim Birnie-Gauvin, Martina Bussettini, Mauro Carolli, Sofia Consuegra, Eduardo Dopico, Tim Feierfeil, Sara Fernández, Pao Fernandez Garrido, Eva Garcia-Vazquez, Sara Garrido, Guillermo Giannico, Peter Gough, Niels Jepsen, Peter E. Jones, Paul Kemp, Jim Kerr, James King, Małgorzata Łapińska, Gloria Lázaro, Martyn C. Lucas, Lucio Marcello, Patrick Martin, Phillip McGinnity, Jesse O’Hanley, Rosa Olivo del Amo, Piotr Parasiewicz, Martin Pusch, Gonzalo Rincon, Cesar Rodriguez, Joshua Royte, Claus Till Schneider, Jeroen S. Tummers, Sergio Vallesi, Andrew Vowles, Eric Verspoor, Herman Wanningen, Karl M. Wantzen, Laura Wildman and Maciej Zalewski

Global human-made mass exceeds all living biomass pp. 442-444

Emily Elhacham, Liad Ben-Uri, Jonathan Grozovski, Yinon M. Bar-On and Ron Milo

Enigmatic dinosaur precursors bridge the gap to the origin of Pterosauria pp. 445-449

Martín D. Ezcurra, Sterling J. Nesbitt, Mario Bronzati, Fabio Marco Dalla Vecchia, Federico L. Agnolin, Roger B. J. Benson, Federico Brissón Egli, Sergio F. Cabreira, Serjoscha W. Evers, Adriel R. Gentil, Randall B. Irmis, Agustín G. Martinelli, Fernando E. Novas, Lúcio Roberto da Silva, Nathan D. Smith, Michelle R. Stocker, Alan H. Turner and Max C. Langer

Values encoded in orbitofrontal cortex are causally related to economic choices pp. 450-453

Sébastien Ballesta, Weikang Shi, Katherine E. Conen and Camillo Padoa-Schioppa

Assembly of synaptic active zones requires phase separation of scaffold molecules pp. 454-458

Nathan A. McDonald, Richard D. Fetter and Kang Shen

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency pp. 459-465

Jiasheng Zhang, Dmitry Velmeshev, Kei Hashimoto, Yu-Hsin Huang, Jeffrey W. Hofmann, Xiaoyu Shi, Jiapei Chen, Andrew M. Leidal, Julian G. Dishart, Michelle K. Cahill, Kevin W. Kelley, Shane A. Liddelow, William W. Seeley, Bruce L. Miller, Tobias C. Walther, Robert V. Farese, J. Paul Taylor, Erik M. Ullian, Bo Huang, Jayanta Debnath, Torsten Wittmann, Arnold R. Kriegstein and Eric J. Huang

Cells of the adult human heart pp. 466-472

Monika Litviňuková, Carlos Talavera-López, Henrike Maatz, Daniel Reichart, Catherine L. Worth, Eric L. Lindberg, Masatoshi Kanda, Krzysztof Polanski, Matthias Heinig, Michael Lee, Emily R. Nadelmann, Kenny Roberts, Liz Tuck, Eirini S. Fasouli, Daniel M. DeLaughter, Barbara McDonough, Hiroko Wakimoto, Joshua M. Gorham, Sara Samari, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Giannino Patone, Joseph J. Boyle, Hongbo Zhang, Hao Zhang, Anissa Viveiros, Gavin Y. Oudit, Omer Ali Bayraktar, J. G. Seidman, Christine E. Seidman, Michela Noseda, Norbert Hubner and Sarah A. Teichmann

The functional proteome landscape of Escherichia coli pp. 473-478

André Mateus, Johannes Hevler, Jacob Bobonis, Nils Kurzawa, Malay Shah, Karin Mitosch, Camille V. Goemans, Dominic Helm, Frank Stein, Athanasios Typas and Mikhail M. Savitski

Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis pp. 479-484

Xiao-Yi Lu, Xiong-Jie Shi, Ao Hu, Ju-Qiong Wang, Yi Ding, Wei Jiang, Ming Sun, Xiaolu Zhao, Jie Luo, Wei Qi and Bao-Liang Song

Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection pp. 485-490

Stylianos Bournazos, Davide Corti, Herbert W. Virgin and Jeffrey V. Ravetch

IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells pp. 491-497

Jaewoong Lee, Mark E. Robinson, Ning Ma, Dewan Artadji, Mohamed A. Ahmed, Gang Xiao, Teresa Sadras, Gauri Deb, Janet Winchester, Kadriye Nehir Cosgun, Huimin Geng, Lai N. Chan, Kohei Kume, Teemu P. Miettinen, Ye Zhang, Matthew A. Nix, Lars Klemm, Chun Wei Chen, Jianjun Chen, Vishal Khairnar, Arun P. Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Jae U. Jung, David M. Weinstock, Scott R. Manalis, Michael S. Diamond, Nagarajan Vaidehi and Markus Müschen

Structures and distributions of SARS-CoV-2 spike proteins on intact virions pp. 498-502

Zunlong Ke, Joaquin Oton, Kun Qu, Mirko Cortese, Vojtech Zila, Lesley McKeane, Takanori Nakane, Jasenko Zivanov, Christopher J. Neufeldt, Berati Cerikan, John M. Lu, Julia Peukes, Xiaoli Xiong, Hans-Georg Kräusslich, Sjors H. W. Scheres, Ralf Bartenschlager and John A. G. Briggs

A hydrophobic ratchet entrenches molecular complexes pp. 503-508

Georg K. A. Hochberg, Yang Liu, Erik G. Marklund, Brian P. H. Metzger, Arthur Laganowsky and Joseph W. Thornton

Structural basis for the action of the drug trametinib at KSR-bound MEK pp. 509-514

Zaigham M. Khan, Alexander M. Real, William M. Marsiglia, Arthur Chow, Mary E. Duffy, Jayasudhan R. Yerabolu, Alex P. Scopton and Arvin C. Dar

Structure of the shutdown state of myosin-2 pp. 515-520

Charlotte A. Scarff, Glenn Carrington, David Casas-Mao, Joseph M. Chalovich, Peter J. Knight, Neil A. Ranson and Michelle Peckham

Cryo-EM structure of the inhibited (10S) form of myosin II pp. 521-525

Shixin Yang, Prince Tiwari, Kyoung Hwan Lee, Osamu Sato, Mitsuo Ikebe, Raúl Padrón and Roger Craig

2020: the year of hard-won lessons pp. 527-528

Virginia Gewin

The zoologist tracking an island’s rebirth pp. 530-530

Virginia Gewin

2020, volume 588, articles 7837

Crop asynchrony stabilizes food production pp. E7-E12

Lukas Egli, Matthias Schröter, Christoph Scherber, Teja Tscharntke and Ralf Seppelt

Reply to: Crop asynchrony stabilizes food production pp. E13-E13

Delphine Renard and David Tilman

Author Correction: Area-based conservation in the twenty-first century pp. E14-E14

Sean L. Maxwell, Victor Cazalis, Nigel Dudley, Michael Hoffmann, Ana S. L. Rodrigues, Sue Stolton, Piero Visconti, Stephen Woodley, Naomi Kingston, Edward Lewis, Martine Maron, Bernardo B. N. Strassburg, Amelia Wenger, Harry D. Jonas, Oscar Venter and James E. M. Watson

Author Correction: Elephant shark genome provides unique insights into gnathostome evolution pp. E15-E15

Byrappa Venkatesh, Alison P. Lee, Vydianathan Ravi, Ashish K. Maurya, Michelle M. Lian, Jeremy B. Swann, Yuko Ohta, Martin F. Flajnik, Yoichi Sutoh, Masanori Kasahara, Shawn Hoon, Vamshidhar Gangu, Scott W. Roy, Manuel Irimia, Vladimir Korzh, Igor Kondrychyn, Zhi Wei Lim, Boon-Hui Tay, Sumanty Tohari, Kiat Whye Kong, Shufen Ho, Belen Lorente-Galdos, Javier Quilez, Tomas Marques-Bonet, Brian J. Raney, Philip W. Ingham, Alice Tay, LaDeana W. Hillier, Patrick Minx, Thomas Boehm, Richard K. Wilson, Sydney Brenner and Wesley C. Warren

Author Correction: Determination of RNA structural diversity and its role in HIV-1 RNA splicing pp. E16-E16

Phillip J. Tomezsko, Vincent D. A. Corbin, Paromita Gupta, Harish Swaminathan, Margalit Glasgow, Sitara Persad, Matthew D. Edwards, Lachlan Mcintosh, Anthony T. Papenfuss, Ann Emery, Ronald Swanstrom, Trinity Zang, Tammy C. T. Lan, Paul Bieniasz, Daniel R. Kuritzkes, Athe Tsibris and Silvi Rouskin

Author Correction: Innovations present in the primate interneuron repertoire pp. E17-E17

Fenna M. Krienen, Melissa Goldman, Qiangge Zhang, Ricardo C. H. Rosario, Marta Florio, Robert Machold, Arpiar Saunders, Kirsten Levandowski, Heather Zaniewski, Benjamin Schuman, Carolyn Wu, Alyssa Lutservitz, Christopher D. Mullally, Nora Reed, Elizabeth Bien, Laura Bortolin, Marian Fernandez-Otero, Jessica D. Lin, Alec Wysoker, James Nemesh, David Kulp, Monika Burns, Victor Tkachev, Richard Smith, Christopher A. Walsh, Jordane Dimidschstein, Bernardo Rudy, Leslie S. Kean, Sabina Berretta, Gord Fishell, Guoping Feng and Steven A. McCarroll

Publisher Correction: Room-temperature superconductivity in a carbonaceous sulfur hydride pp. E18-E18

Elliot Snider, Nathan Dasenbrock-Gammon, Raymond McBride, Mathew Debessai, Hiranya Vindana, Kevin Vencatasamy, Keith V. Lawler, Ashkan Salamat and Ranga P. Dias

Publisher Correction: Large Chinese land carbon sink estimated from atmospheric carbon dioxide data pp. E19-E19

Jing Wang, Liang Feng, Paul I. Palmer, Yi Liu, Shuangxi Fang, Hartmut Bösch, Christopher W. O’Dell, Xiaoping Tang, Dongxu Yang, Lixin Liu and ChaoZong Xia

Sustainable nutrition pp. S53-S53

Catherine Armitage

Healthy people, healthy planet: the search for a sustainable global diet pp. S54-S56

Chris Woolston

Cooperate to prevent food-system failure pp. S57-S57

Jessica Fanzo

Natural solutions for agricultural productivity pp. S58-S59

Michael Eisenstein

Can aquaculture overcome its sustainability challenges? pp. S60-S62

Sarah DeWeerdt

Could a better diet improve mental health? pp. S63-S63

Clare Watson

Will cell-based meat ever be a dinner staple? pp. S64-S67

Elie Dolgin

Research round-up: sustainable nutrition pp. S68-S69

Dyani Lewis

Changing diets at scale pp. S70-S72

Benjamin Plackett

Artificial-intelligence research escalates amid calls for caution pp. S101-S101

Bec Crew

The race to the top among the world’s leaders in artificial intelligence pp. S102-S104

Neil Savage

Six researchers who are shaping the future of artificial intelligence pp. S114-S117

Gemma Conroy, Hepeng Jia, Benjamin Plackett and Andy Tay

AI will change the world, so it’s time to change AI pp. S118-S118

Tess Posner and Li Fei-Fei

Four AI technologies that could transform the way we live and work pp. S126-S128

Bill Condie and Leigh Dayton

Samsung’s head researcher wants human–AI interactions to be a multisensory experience pp. S129-S129

Leigh Dayton

Sliced, diced and digested: AI-generated science ready in minutes pp. S136-S137

Chris Woolston and Jeffrey M. Perkel

Auto articles: an experiment in AI-generated content pp. S138-S141

Catherine Armitage and Markus Kaindl

Top tips for cell biologists eyeing a move to industry careers pp. S157-S160

Nikki Forrester

Institutions can retool to make research more rigorous pp. 197-197

Ulrich Dirnagl

‘It will change everything’: DeepMind’s AI makes gigantic leap in solving protein structures pp. 203-204

Ewen Callaway

The UK has approved a COVID vaccine — here’s what scientists now want to know pp. 205-206

Heidi Ledford, David Cyranoski and Richard Van Noorden

Can Joe Biden make good on his revolutionary climate agenda? pp. 206-207

Jeff Tollefson

Meet the scientists investigating the origins of the COVID pandemic pp. 208-208

Smriti Mallapaty

The researcher fighting to embed analysis of sex and gender into science pp. 209-209

Elizabeth Gibney

Reversal of biological clock restores vision in old mice pp. 209-209

Heidi Ledford

How the first life on Earth survived its biggest threat — water pp. 210-213

Michael Marshall

Documentary follows implosion of billion-euro brain project pp. 215-216

Alison Abbott

How borders make us ill, decolonizing museums, and the wolves of Yellowstone: Books in brief pp. 216-216

Andrew Robinson and Sara Abdulla

Rescue Brazil’s burning Pantanal wetlands pp. 217-219

Renata Libonati, Carlos C. DaCamara, Leonardo F. Peres, Lino A. Sander de Carvalho and Letícia C. Garcia

Another diversity problem — scientists’ politics pp. 220-220

Andrew Isaac Meso

Land use predicts pandemic disparities pp. 220-220

Cesunica Ivey

What counts as climate finance? Define urgently pp. 220-220

Romain Weikmans, J. Timmons Roberts and Stacy-ann Robinson

Combine resilience and efficiency in post-COVID societies pp. 220-220

Benjamin D. Trump, Igor Linkov and William Hynes

The changing face of birds from the age of the dinosaurs pp. 221-222

Daniel J. Field

Proton collisions probe the final frontier of the standard model of particle physics pp. 222-223

Manuel Lorenz

Cracking the cell access code for the deadly virus VEEV pp. 223-224

James Zengel and Jan E. Carette

Trade-offs for equitable climate policy assessed pp. 225-226

Wei Peng

Detection of large-scale X-ray bubbles in the Milky Way halo pp. 227-231

P. Predehl, R. A. Sunyaev, W. Becker, H. Brunner, R. Burenin, A. Bykov, A. Cherepashchuk, N. Chugai, E. Churazov, V. Doroshenko, N. Eismont, M. Freyberg, M. Gilfanov, F. Haberl, I. Khabibullin, R. Krivonos, C. Maitra, P. Medvedev, A. Merloni, K. Nandra, Vladimir Nazarov, M. Pavlinsky, G. Ponti, J. S. Sanders, M. Sasaki, S. Sazonov, A. W. Strong and J. Wilms

Dipolar evaporation of reactive molecules to below the Fermi temperature pp. 239-243

Giacomo Valtolina, Kyle Matsuda, William G. Tobias, Jun-Ru Li, Luigi De Marco and Jun Ye

Operation of an optical atomic clock with a Brillouin laser subsystem pp. 244-249

William Loh, Jules Stuart, David Reens, Colin D. Bruzewicz, Danielle Braje, John Chiaverini, Paul W. Juodawlkis, Jeremy M. Sage and Robert McConnell

Capillary condensation under atomic-scale confinement pp. 250-253

Qian Yang, P. Z. Sun, L. Fumagalli, Y. V. Stebunov, S. J. Haigh, Z. W. Zhou, I. V. Grigorieva, F. C. Wang and A. K. Geim

Catalytic asymmetric addition of an amine N–H bond across internal alkenes pp. 254-260

Yumeng Xi, Senjie Ma and John F. Hartwig

Quantification of an efficiency–sovereignty trade-off in climate policy pp. 261-266

Nico Bauer, Christoph Bertram, Anselm Schultes, David Klein, Gunnar Luderer, Elmar Kriegler, Alexander Popp and Ottmar Edenhofer

Clustered versus catastrophic global vertebrate declines pp. 267-271

Brian Leung, Anna L. Hargreaves, Dan A. Greenberg, Brian McGill, Maria Dornelas and Robin Freeman

Late Cretaceous bird from Madagascar reveals unique development of beaks pp. 272-276

Patrick M. O’Connor, Alan H. Turner, Joseph R. Groenke, Ryan N. Felice, Raymond R. Rogers, David W. Krause and Lydia J. Rahantarisoa

Multiple wheat genomes reveal global variation in modern breeding pp. 277-283

Sean Walkowiak, Liangliang Gao, Cecile Monat, Georg Haberer, Mulualem T. Kassa, Jemima Brinton, Ricardo H. Ramirez-Gonzalez, Markus C. Kolodziej, Emily Delorean, Dinushika Thambugala, Valentyna Klymiuk, Brook Byrns, Heidrun Gundlach, Venkat Bandi, Jorge Nunez Siri, Kirby Nilsen, Catharine Aquino, Axel Himmelbach, Dario Copetti, Tomohiro Ban, Luca Venturini, Michael Bevan, Bernardo Clavijo, Dal-Hoe Koo, Jennifer Ens, Krystalee Wiebe, Amidou N’Diaye, Allen K. Fritz, Carl Gutwin, Anne Fiebig, Christine Fosker, Bin Xiao Fu, Gonzalo Garcia Accinelli, Keith A. Gardner, Nick Fradgley, Juan Gutierrez-Gonzalez, Gwyneth Halstead-Nussloch, Masaomi Hatakeyama, Chu Shin Koh, Jasline Deek, Alejandro C. Costamagna, Pierre Fobert, Darren Heavens, Hiroyuki Kanamori, Kanako Kawaura, Fuminori Kobayashi, Ksenia Krasileva, Tony Kuo, Neil McKenzie, Kazuki Murata, Yusuke Nabeka, Timothy Paape, Sudharsan Padmarasu, Lawrence Percival-Alwyn, Sateesh Kagale, Uwe Scholz, Jun Sese, Philomin Juliana, Ravi Singh, Rie Shimizu-Inatsugi, David Swarbreck, James Cockram, Hikmet Budak, Toshiaki Tameshige, Tsuyoshi Tanaka, Hiroyuki Tsuji, Jonathan Wright, Jianzhong Wu, Burkhard Steuernagel, Ian Small, Sylvie Cloutier, Gabriel Keeble-Gagnère, Gary Muehlbauer, Josquin Tibbets, Shuhei Nasuda, Joanna Melonek, Pierre J. Hucl, Andrew G. Sharpe, Matthew Clark, Erik Legg, Arvind Bharti, Peter Langridge, Anthony Hall, Cristobal Uauy, Martin Mascher, Simon G. Krattinger, Hirokazu Handa, Kentaro K. Shimizu, Assaf Distelfeld, Ken Chalmers, Beat Keller, Klaus F. X. Mayer, Jesse Poland, Nils Stein, Curt A. McCartney, Manuel Spannagl, Thomas Wicker and Curtis J. Pozniak

The barley pan-genome reveals the hidden legacy of mutation breeding pp. 284-289

Murukarthick Jayakodi, Sudharsan Padmarasu, Georg Haberer, Venkata Suresh Bonthala, Heidrun Gundlach, Cécile Monat, Thomas Lux, Nadia Kamal, Daniel Lang, Axel Himmelbach, Jennifer Ens, Xiao-Qi Zhang, Tefera T. Angessa, Gaofeng Zhou, Cong Tan, Camilla Hill, Penghao Wang, Miriam Schreiber, Lori B. Boston, Christopher Plott, Jerry Jenkins, Yu Guo, Anne Fiebig, Hikmet Budak, Dongdong Xu, Jing Zhang, Chunchao Wang, Jane Grimwood, Jeremy Schmutz, Ganggang Guo, Guoping Zhang, Keiichi Mochida, Takashi Hirayama, Kazuhiro Sato, Kenneth J. Chalmers, Peter Langridge, Robbie Waugh, Curtis J. Pozniak, Uwe Scholz, Klaus F. X. Mayer, Manuel Spannagl, Chengdao Li, Martin Mascher and Nils Stein

PIEZO2 in sensory neurons and urothelial cells coordinates urination pp. 290-295

Kara L. Marshall, Dimah Saade, Nima Ghitani, Adam M. Coombs, Marcin Szczot, Jason Keller, Tracy Ogata, Ihab Daou, Lisa T. Stowers, Carsten G. Bönnemann, Alexander T. Chesler and Ardem Patapoutian

Chemico-genetic discovery of astrocytic control of inhibition in vivo pp. 296-302

Tetsuya Takano, John T. Wallace, Katherine T. Baldwin, Alicia M. Purkey, Akiyoshi Uezu, Jamie L. Courtland, Erik J. Soderblom, Tomomi Shimogori, Patricia F. Maness, Cagla Eroglu and Scott H. Soderling

The gut microbiota is associated with immune cell dynamics in humans pp. 303-307

Jonas Schluter, Jonathan U. Peled, Bradford P. Taylor, Kate A. Markey, Melody Smith, Ying Taur, Rene Niehus, Anna Staffas, Anqi Dai, Emily Fontana, Luigi A. Amoretti, Roberta J. Wright, Sejal Morjaria, Maly Fenelus, Melissa S. Pessin, Nelson J. Chao, Meagan Lew, Lauren Bohannon, Amy Bush, Anthony D. Sung, Tobias M. Hohl, Miguel-Angel Perales, Marcel R. M. Brink and Joao B. Xavier

LDLRAD3 is a receptor for Venezuelan equine encephalitis virus pp. 308-314

Hongming Ma, Arthur S. Kim, Natasha M. Kafai, James T. Earnest, Aadit P. Shah, James Brett Case, Katherine Basore, Theron C. Gilliland, Chengqun Sun, Christopher A. Nelson, Larissa B. Thackray, William B. Klimstra, Daved H. Fremont and Michael S. Diamond

Sex differences in immune responses that underlie COVID-19 disease outcomes pp. 315-320

Takehiro Takahashi, Mallory K. Ellingson, Patrick Wong, Benjamin Israelow, Carolina Lucas, Jon Klein, Julio Silva, Tianyang Mao, Ji Eun Oh, Maria Tokuyama, Peiwen Lu, Arvind Venkataraman, Annsea Park, Feimei Liu, Amit Meir, Jonathan Sun, Eric Y. Wang, Arnau Casanovas-Massana, Anne L. Wyllie, Chantal B. F. Vogels, Rebecca Earnest, Sarah Lapidus, Isabel M. Ott, Adam J. Moore, Albert Shaw, John B. Fournier, Camila D. Odio, Shelli Farhadian, Charles Cruz, Nathan D. Grubaugh, Wade L. Schulz, Aaron M. Ring, Albert I. Ko, Saad B. Omer and Akiko Iwasaki

Tunable dynamics of B cell selection in gut germinal centres pp. 321-326

Carla R. Nowosad, Luka Mesin, Tiago B. R. Castro, Christopher Wichmann, Gregory P. Donaldson, Tatsuya Araki, Ariën Schiepers, Ainsley A. K. Lockhart, Angelina M. Bilate, Daniel Mucida and Gabriel D. Victora

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion pp. 327-330

Donald J. Benton, Antoni G. Wrobel, Pengqi Xu, Chloë Roustan, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel and Steven J. Gamblin

A metastasis map of human cancer cell lines pp. 331-336

Xin Jin, Zelalem Demere, Karthik Nair, Ahmed Ali, Gino B. Ferraro, Ted Natoli, Amy Deik, Lia Petronio, Andrew A. Tang, Cong Zhu, Li Wang, Danny Rosenberg, Vamsi Mangena, Jennifer Roth, Kwanghun Chung, Rakesh K. Jain, Clary B. Clish, Matthew G. Heiden and Todd R. Golub

A map of cis-regulatory elements and 3D genome structures in zebrafish pp. 337-343

Hongbo Yang, Yu Luan, Tingting Liu, Hyung Joo Lee, Li Fang, Yanli Wang, Xiaotao Wang, Bo Zhang, Qiushi Jin, Khai Chung Ang, Xiaoyun Xing, Juan Wang, Jie Xu, Fan Song, Iyyanki Sriranga, Chachrit Khunsriraksakul, Tarik Salameh, Daofeng Li, Mayank N. K. Choudhary, Jacek Topczewski, Kai Wang, Glenn S. Gerhard, Ross C. Hardison, Ting Wang, Keith C. Cheng and Feng Yue

Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction pp. 344-349

C. K. Deniston, J. Salogiannis, S. Mathea, D. M. Snead, I. Lahiri, M. Matyszewski, O. Donosa, R. Watanabe, J. Böhning, A. K. Shiau, S. Knapp, E. Villa, S. L. Reck-Peterson and A. E. Leschziner

Structures and pH-sensing mechanism of the proton-activated chloride channel pp. 350-354

Zheng Ruan, James Osei-Owusu, Juan Du, Zhaozhu Qiu and Wei Lü

Uncertainty plagues junior researchers from underprivileged backgrounds amid pandemic pp. 355-357

Carrie Arnold and Chris Woolston

Core curriculum: learning to manage a shared microscopy facility pp. 358-360

Sandeep Ravindran

Ocean explorer pp. 362-362

Amber Dance

2020, volume 588, articles 7836

Outlook: Allergies pp. S1-S1

David Payne

Author Correction: Insulin resistance in cavefish as an adaptation to a nutrient-limited environment pp. E1-E1

Misty R. Riddle, Ariel C. Aspiras, Karin Gaudenz, Robert Peuß, Jenny Y. Sung, Brian Martineau, Megan Peavey, Andrew C. Box, Julius A. Tabin, Suzanne McGaugh, Richard Borowsky, Clifford J. Tabin and Nicolas Rohner

Research round-up: Allergies pp. S2-S3

Elizabeth Svoboda

Author Correction: Relatives of rubella virus in diverse mammals pp. E2-E2

Andrew J. Bennett, Adrian C. Paskey, Arnt Ebinger, Florian Pfaff, Grit Priemer, Dirk Höper, Angele Breithaupt, Elisa Heuser, Rainer G. Ulrich, Jens H. Kuhn, Kimberly A. Bishop-Lilly, Martin Beer and Tony L. Goldberg

Publisher Correction: Butterfly effect and a self-modulating El Niño response to global warming pp. E3-E3

Wenju Cai, Benjamin Ng, Tao Geng, Lixin Wu, Agus Santoso and Michael J. McPhaden

Food allergies: the psychological toll pp. S4-S6

Roxanne Khamsi

Publisher Correction: The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity pp. E4-E4

Kathrin Thor, Shushu Jiang, Erwan Michard, Jeoffrey George, Sönke Scherzer, Shouguang Huang, Julian Dindas, Paul Derbyshire, Nuno Leitão, Thomas A. DeFalco, Philipp Köster, Kerri Hunter, Sachie Kimura, Julien Gronnier, Lena Stransfeld, Yasuhiro Kadota, Christoph A. Bücherl, Myriam Charpentier, Michael Wrzaczek, Daniel MacLean, Giles E. D. Oldroyd, Frank L. H. Menke, M. Rob G. Roelfsema, Rainer Hedrich, José Feijó and Cyril Zipfel

Publisher Correction: Exuberant fibroblast activity compromises lung function via ADAMTS4 pp. E5-E5

David F. Boyd, E. Kaitlynn Allen, Adrienne G. Randolph, Xi-zhi J. Guo, Yunceng Weng, Catherine J. Sanders, Resha Bajracharya, Natalie K. Lee, Clifford S. Guy, Peter Vogel, Wenda Guan, Yimin Li, Xiaoqing Liu, Tanya Novak, Margaret M. Newhams, Thomas P. Fabrizio, Nicholas Wohlgemuth, Peter M. Mourani, Thomas N. Wight, Stacey Schultz-Cherry, Stephania A. Cormier, Kathryn Shaw-Saliba, Andrew Pekosz, Richard E. Rothman, Kuan-Fu Chen, Zifeng Yang, Richard J. Webby, Nanshan Zhong, Jeremy Chase Crawford and Paul G. Thomas

Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin pp. E6-E6

Peng Zhou, Xing-Lou Yang, Xian-Guang Wang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Chao-Lin Huang, Hui-Dong Chen, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Lin-Lin Liu, Bing Yan, Fa-Xian Zhan, Yan-Yi Wang, Geng-Fu Xiao and Zheng-Li Shi

The race to deliver the hypoallergenic cat pp. S7-S9

Amber Dance

Norway’s Prime Minister: Ocean science can boost jobs and wellbeing pp. 9-9

Erna Solberg

How blockchain and genetic engineering could make food safer for people with allergies pp. S10-S10

Guy Poppy

Microbial ambassadors against food allergies pp. S11-S13

Michael Eisenstein

The peanut snack that triggered a fresh approach to allergy prevention pp. S14-S16

Sarah DeWeerdt

Coronaviruses closely related to the pandemic virus discovered in Japan and Cambodia pp. 15-16

Smriti Mallapaty

Why Oxford’s positive COVID vaccine results are puzzling scientists pp. 16-18

Ewen Callaway

Cracking the meat-allergy mystery with the tick-bite link pp. S17-S19

Bianca Nogrady

Why emergency COVID-vaccine approvals pose a dilemma for scientists pp. 18-19

David Cyranoski

Nature journals reveal terms of landmark open-access option pp. 19-20

Holly Else

Hints of twisted light offer clues to dark energy’s nature pp. 21-21

Davide Castelvecchi

Could COVID delirium bring on dementia? pp. 22-24

Carrie Arnold

Wood — the vein that runs through human history pp. 26-27

Josie Glausiusz

The demons and devils that haunt scientists’ imaginations pp. 27-28

Ramin Skibba

Arthur Ashkin (1922–2020) pp. 29-29

Steven Chu

Five priorities for a sustainable ocean economy pp. 30-32

Jane Lubchenco, Peter M. Haugan and Mari Elka Pangestu

Autonomous balloons take flight with artificial intelligence pp. 33-34

Scott M. Osprey

Sight restored by turning back the epigenetic clock pp. 34-36

Andrew D. Huberman

Building a chemical blueprint for human blood pp. 36-37

Patrick H. Bradley and Katherine S. Pollard

Standard model of particle physics tested by the fine-structure constant pp. 37-38

Holger Müller

Inference in artificial intelligence with deep optics and photonics pp. 39-47

Gordon Wetzstein, Aydogan Ozcan, Sylvain Gigan, Shanhui Fan, Dirk Englund, Marin Soljačić, Cornelia Denz, David A. B. Miller and Demetri Psaltis

Organized crime in the fisheries sector threatens a sustainable ocean economy pp. 48-56

Emma Witbooi, Kamal-Deen Ali, Mas Achmad Santosa, Gail Hurley, Yunus Husein, Sarika Maharaj, Ifesinachi Okafor-Yarwood, Inés Arroyo Quiroz and Omar Salas

Inside China’s response to COVID pp. S49-S51

Flynn Murphy

Enhanced triple-α reaction reduces proton-rich nucleosynthesis in supernovae pp. 57-60

Shilun Jin, Luke F. Roberts, Sam M. Austin and Hendrik Schatz

Determination of the fine-structure constant with an accuracy of 81 parts per trillion pp. 61-65

Léo Morel, Zhibin Yao, Pierre Cladé and Saïda Guellati-Khélifa

Electrical switching of magnetic order in an orbital Chern insulator pp. 66-70

H. Polshyn, J. Zhu, M. A. Kumar, Y. Zhang, F. Yang, C. L. Tschirhart, M. Serlin, K. Watanabe, T. Taniguchi, A. H. MacDonald and A. F. Young

Unconventional ferroelectricity in moiré heterostructures pp. 71-76

Zhiren Zheng, Qiong Ma, Zhen Bi, Sergio Barrera, Ming-Hao Liu, Nannan Mao, Yang Zhang, Natasha Kiper, Kenji Watanabe, Takashi Taniguchi, Jing Kong, William A. Tisdale, Ray Ashoori, Nuh Gedik, Liang Fu, Su-Yang Xu and Pablo Jarillo-Herrero

Autonomous navigation of stratospheric balloons using reinforcement learning pp. 77-82

Marc G. Bellemare, Salvatore Candido, Pablo Samuel Castro, Jun Gong, Marlos C. Machado, Subhodeep Moitra, Sameera S. Ponda and Ziyu Wang

Computational planning of the synthesis of complex natural products pp. 83-88

Barbara Mikulak-Klucznik, Patrycja Gołębiowska, Alison A. Bayly, Oskar Popik, Tomasz Klucznik, Sara Szymkuć, Ewa P. Gajewska, Piotr Dittwald, Olga Staszewska-Krajewska, Wiktor Beker, Tomasz Badowski, Karl A. Scheidt, Karol Molga, Jacek Mlynarski, Milan Mrksich and Bartosz A. Grzybowski

Thermochemical lithosphere differentiation and the origin of cratonic mantle pp. 89-94

Fabio A. Capitanio, Oliver Nebel and Peter A. Cawood

The future of food from the sea pp. 95-100

Christopher Costello, Ling Cao, Stefan Gelcich, Miguel Á. Cisneros-Mata, Christopher M. Free, Halley E. Froehlich, Christopher D. Golden, Gakushi Ishimura, Jason Maier, Ilan Macadam-Somer, Tracey Mangin, Michael C. Melnychuk, Masanori Miyahara, Carryn L. de Moor, Rosamond Naylor, Linda Nøstbakken, Elena Ojea, Erin O’Reilly, Ana M. Parma, Andrew J. Plantinga, Shakuntala H. Thilsted and Jane Lubchenco

An early Cambrian euarthropod with radiodont-like raptorial appendages pp. 101-105

Han Zeng, Fangchen Zhao, Kecheng Niu, Maoyan Zhu and Diying Huang

Contrasting signatures of genomic divergence during sympatric speciation pp. 106-111

Andreas F. Kautt, Claudius F. Kratochwil, Alexander Nater, Gonzalo Machado-Schiaffino, Melisa Olave, Frederico Henning, Julián Torres-Dowdall, Andreas Härer, C. Darrin Hulsey, Paolo Franchini, Martin Pippel, Eugene W. Myers and Axel Meyer

The cellular basis of distinct thirst modalities pp. 112-117

Allan-Hermann Pool, Tongtong Wang, David A. Stafford, Rebecca K. Chance, Sangjun Lee, John Ngai and Yuki Oka

A measure of smell enables the creation of olfactory metamers pp. 118-123

Aharon Ravia, Kobi Snitz, Danielle Honigstein, Maya Finkel, Rotem Zirler, Ofer Perl, Lavi Secundo, Christophe Laudamiel, David Harel and Noam Sobel

Reprogramming to recover youthful epigenetic information and restore vision pp. 124-129

Yuancheng Lu, Benedikt Brommer, Xiao Tian, Anitha Krishnan, Margarita Meer, Chen Wang, Daniel L. Vera, Qiurui Zeng, Doudou Yu, Michael S. Bonkowski, Jae-Hyun Yang, Songlin Zhou, Emma M. Hoffmann, Margarete M. Karg, Michael B. Schultz, Alice E. Kane, Noah Davidsohn, Ekaterina Korobkina, Karolina Chwalek, Luis A. Rajman, George M. Church, Konrad Hochedlinger, Vadim N. Gladyshev, Steve Horvath, Morgan E. Levine, Meredith S. Gregory-Ksander, Bruce R. Ksander, Zhigang He and David A. Sinclair

Tension heterogeneity directs form and fate to pattern the myocardial wall pp. 130-134

Rashmi Priya, Srinivas Allanki, Alessandra Gentile, Shivani Mansingh, Veronica Uribe, Hans-Martin Maischein and Didier Y. R. Stainier

A reference map of potential determinants for the human serum metabolome pp. 135-140

Noam Bar, Tal Korem, Omer Weissbrod, David Zeevi, Daphna Rothschild, Sigal Leviatan, Noa Kosower, Maya Lotan-Pompan, Adina Weinberger, Caroline I. Roy, Cristina Menni, Alessia Visconti, Mario Falchi, Tim D. Spector, Jerzy Adamski, Paul W. Franks, Oluf Pedersen and Eran Segal

Widespread endogenization of giant viruses shapes genomes of green algae pp. 141-145

Mohammad Moniruzzaman, Alaina R. Weinheimer, Carolina A. Martinez-Gutierrez and Frank O. Aylward

Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis pp. 146-150

Julien Carvelli, Olivier Demaria, Frédéric Vély, Luciana Batista, Nassima Chouaki Benmansour, Joanna Fares, Sabrina Carpentier, Marie-Laure Thibult, Ariane Morel, Romain Remark, Pascale André, Agnès Represa, Christelle Piperoglou, Pierre Yves Cordier, Erwan Le Dault, Christophe Guervilly, Pierre Simeone, Marc Gainnier, Yannis Morel, Mikael Ebbo, Nicolas Schleinitz and Eric Vivier

Inhibition of LTβR signalling activates WNT-induced regeneration in lung pp. 151-156

Thomas M. Conlon, Gerrit John-Schuster, Danijela Heide, Dominik Pfister, Mareike Lehmann, Yan Hu, Zeynep Ertüz, Martin A. Lopez, Meshal Ansari, Maximilian Strunz, Christoph Mayr, Ilias Angelidis, Chiara Ciminieri, Rita Costa, Marlene Sophia Kohlhepp, Adrien Guillot, Gizem Günes, Aicha Jeridi, Maja C. Funk, Giorgi Beroshvili, Sandra Prokosch, Jenny Hetzer, Stijn E. Verleden, Hani Alsafadi, Michael Lindner, Gerald Burgstaller, Lore Becker, Martin Irmler, Michael Dudek, Jakob Janzen, Eric Goffin, Reinoud Gosens, Percy Knolle, Bernard Pirotte, Tobias Stoeger, Johannes Beckers, Darcy Wagner, Indrabahadur Singh, Fabian J. Theis, Martin Hrabé Angelis, Tracy O’Connor, Frank Tacke, Michael Boutros, Emmanuel Dejardin, Oliver Eickelberg, Herbert B. Schiller, Melanie Königshoff, Mathias Heikenwalder and Ali Önder Yildirim

Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms pp. 157-163

Ashok Kumar Jayavelu, Tina M. Schnöder, Florian Perner, Carolin Herzog, Arno Meiler, Gurumoorthy Krishnamoorthy, Nicolas Huber, Juliane Mohr, Bärbel Edelmann-Stephan, Rebecca Austin, Sabine Brandt, Francesca Palandri, Nicolas Schröder, Berend Isermann, Frank Edlich, Amit U. Sinha, Martin Ungelenk, Christian A. Hübner, Robert Zeiser, Susann Rahmig, Claudia Waskow, Iain Coldham, Thomas Ernst, Andreas Hochhaus, Stefanie Jilg, Philipp J. Jost, Ann Mullally, Lars Bullinger, Peter R. Mertens, Steven W. Lane, Matthias Mann and Florian H. Heidel

Small-molecule-induced polymerization triggers degradation of BCL6 pp. 164-168

Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel, Lena Nitsch, Shourya S. Roy Burman, Cristina Genua, Katherine A. Donovan, Adam S. Sperling, Moritz Hunkeler, Jonathan M. Tsai, Rohan Sharma, Andrew Guirguis, Charles Zou, Priya Chudasama, Jessica A. Gasser, Peter G. Miller, Claudia Scholl, Stefan Fröhling, Radosław P. Nowak, Eric S. Fischer and Benjamin L. Ebert

Epigenetic therapy induces transcription of inverted SINEs and ADAR1 dependency pp. 169-173

Parinaz Mehdipour, Sajid A. Marhon, Ilias Ettayebi, Ankur Chakravarthy, Amir Hosseini, Yadong Wang, Fabíola Attié Castro, Helen Loo Yau, Charles Ishak, Sagi Abelson, Catherine A. O’Brien and Daniel D. De Carvalho

SLC25A51 is a mammalian mitochondrial NAD+ transporter pp. 174-179

Timothy S. Luongo, Jared M. Eller, Mu-Jie Lu, Marc Niere, Fabio Raith, Caroline Perry, Marc R. Bornstein, Paul Oliphint, Lin Wang, Melanie R. McReynolds, Marie E. Migaud, Joshua D. Rabinowitz, F. Brad Johnson, Kai Johnsson, Mathias Ziegler, Xiaolu A. Cambronne and Joseph A. Baur

Retraction Note: Living annulative π-extension polymerization for graphene nanoribbon synthesis pp. 180-180

Yuuta Yano, Nobuhiko Mitoma, Kaho Matsushima, Feijiu Wang, Keisuke Matsui, Akira Takakura, Yuhei Miyauchi, Hideto Ito and Kenichiro Itami

Uncertain prospects for postdoctoral researchers pp. 181-184

Chris Woolston

Why scientists are turning to Rust pp. 185-186

Jeffrey M. Perkel

Watching the sentinels pp. 188-188

Amber Dance