A pan-cancer compendium of chromosomal instability

Ruben M. Drews, Barbara Hernando, Maxime Tarabichi, Kerstin Haase, Tom Lesluyes, Philip S. Smith, Lena Morrill Gavarró, Dominique-Laurent Couturier, Lydia Liu, Michael Schneider, James D. Brenton, Peter Van Loo, Geoff Macintyre () and Florian Markowetz ()
Additional contact information
Ruben M. Drews: Cancer Research UK Cambridge Institute
Barbara Hernando: Spanish National Cancer Research Centre (CNIO)
Maxime Tarabichi: The Francis Crick Institute
Kerstin Haase: The Francis Crick Institute
Tom Lesluyes: The Francis Crick Institute
Philip S. Smith: Cancer Research UK Cambridge Institute
Lena Morrill Gavarró: Cancer Research UK Cambridge Institute
Dominique-Laurent Couturier: Cancer Research UK Cambridge Institute
Lydia Liu: The Francis Crick Institute
Michael Schneider: Cancer Research UK Cambridge Institute
James D. Brenton: Cancer Research UK Cambridge Institute
Peter Van Loo: The Francis Crick Institute
Geoff Macintyre: Cancer Research UK Cambridge Institute
Florian Markowetz: Cancer Research UK Cambridge Institute

Nature, 2022, vol. 606, issue 7916, 976-983

Abstract: Abstract Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and rearrangements of DNA1. The broad genomic complexity caused by CIN is a hallmark of cancer2; however, there is no systematic framework to measure different types of CIN and their effect on clinical phenotypes pan-cancer. Here we evaluate the extent, diversity and origin of CIN across 7,880 tumours representing 33 cancer types. We present a compendium of 17 copy number signatures that characterize specific types of CIN, with putative aetiologies supported by multiple independent data sources. The signatures predict drug response and identify new drug targets. Our framework refines the understanding of impaired homologous recombination, which is one of the most therapeutically targetable types of CIN. Our results illuminate a fundamental structure underlying genomic complexity in human cancers and provide a resource to guide future CIN research.

Date: 2022
References: Add references at CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://www.nature.com/articles/s41586-022-04789-9 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:606:y:2022:i:7916:d:10.1038_s41586-022-04789-9

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/s41586-022-04789-9

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().