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2016, volume 540, articles 7634

Inflammatory bowel disease pp. S97-S97

Richard Hodson

Biology: A slow-motion epidemic pp. S98-S99

Michael Eisenstein

Epidemiology: Rising in the East pp. S100-S102

Kelly Rae Chi

Q&A: Joel Weinstock pp. S103-S103

Neil Savage

Genetics: Clues in the code pp. S104-S105

Sarah DeWeerdt

Cell-based therapy: Cells on trial pp. S106-S108

Eric Bender

Microbiota: Reseeding the gut pp. S109-S112

Liam Drew

Q&A: Eva Szigethy pp. S113-S113

Neil Savage

How Woody Guthrie can help us fight for science pp. 485-485

Jacqueline M. Vadjunec

Peaceful European Union starts to fund military research pp. 491-492

Elizabeth Gibney

US Earth scientists plan for uncertain future under Trump pp. 492-493

Jeff Tollefson and Alexandra Witze

Europe's Galileo satellites herald new era for Earth science pp. 493-494

Declan Butler

World Health Organization rethinks its response to disease outbreaks pp. 494-495

Erika Check Hayden

2016 in news: The science events that shaped the year pp. 496-499

Alison Abbott, Declan Butler, Davide Castelvecchi, Daniel Cressey, Elizabeth Gibney, Heidi Ledford, Jane J Lee, Lauren Morello, Sara Reardon, Jeff Tollefson and Alexandra Witze

2016 in pictures: The best science images of the year pp. 500-505

Daniel Cressey

So you want to change the world? pp. 517-519

Nancy Baron

Take the long view pp. 520-521

Ian L. Boyd

Agriculture: Sowing the city pp. 522-523

Laura Lawson

Books in brief pp. 523-523

Barbara Kiser

Study epidemiology of fake news pp. 525-525

Adam Kucharski

Be wary of 'ethical' artificial intelligence pp. 525-525

Michael Stocker

New contender for most lethal animal pp. 525-525

Jeffrey R. Powell

Journals, agree on manuscript format pp. 525-525

Quanmin Guo

Vulture restaurants cheat ecosystems pp. 525-525

Ainara Cortés-Avizanda and Henrique Miguel Pereira

Pathways of parallel progression pp. 528-529

Cyrus M. Ghajar and Mina J. Bissell

Unexplored territory for self-assembly pp. 529-530

Florian Beuerle

A turbulent path to plaque formation pp. 531-532

Vedanta Mehta and Ellie Tzima

Sharks shift their spine into high gear pp. 532-533

Matthew A. Kolmann and Adam P. Summers

Quantum mechanics in a spin pp. 534-535

Leon Balents

Frozen in darkness pp. 534-534

Luca Maltagliati

Redefining the invertebrate RNA virosphere pp. 539-543

Mang Shi, Xian-Dan Lin, Jun-Hua Tian, Liang-Jun Chen, Xiao Chen, Ci-Xiu Li, Xin-Cheng Qin, Jun Li, Jian-Ping Cao, John-Sebastian Eden, Jan Buchmann, Wen Wang, Jianguo Xu, Edward C. Holmes and Yong-Zhen Zhang

Persistent microbiome alterations modulate the rate of post-dieting weight regain pp. 544-551

Christoph A. Thaiss, Shlomik Itav, Daphna Rothschild, Mariska T. Meijer, Maayan Levy, Claudia Moresi, Lenka Dohnalová, Sofia Braverman, Shachar Rozin, Sergey Malitsky, Mally Dori-Bachash, Yael Kuperman, Inbal Biton, Arieh Gertler, Alon Harmelin, Hagit Shapiro, Zamir Halpern, Asaph Aharoni, Eran Segal and Eran Elinav

Early dissemination seeds metastasis in breast cancer pp. 552-558

Hedayatollah Hosseini, Milan M. S. Obradović, Martin Hoffmann, Kathryn L. Harper, Maria Soledad Sosa, Melanie Werner-Klein, Lahiri Kanth Nanduri, Christian Werno, Carolin Ehrl, Matthias Maneck, Nina Patwary, Gundula Haunschild, Miodrag Gužvić, Christian Reimelt, Michael Grauvogl, Norbert Eichner, Florian Weber, Andreas D. Hartkopf, Florin-Andrei Taran, Sara Y. Brucker, Tanja Fehm, Brigitte Rack, Stefan Buchholz, Rainer Spang, Gunter Meister, Julio A. Aguirre-Ghiso and Christoph A. Klein

Evidence for a spinon Fermi surface in a triangular-lattice quantum-spin-liquid candidate pp. 559-562

Yao Shen, Yao-Dong Li, Hongliang Wo, Yuesheng Li, Shoudong Shen, Bingying Pan, Qisi Wang, H. C. Walker, P. Steffens, M. Boehm, Yiqing Hao, D. L. Quintero-Castro, L. W. Harriger, M. D. Frontzek, Lijie Hao, Siqin Meng, Qingming Zhang, Gang Chen and Jun Zhao

Self-assembly of tetravalent Goldberg polyhedra from 144 small components pp. 563-566

Daishi Fujita, Yoshihiro Ueda, Sota Sato, Nobuhiro Mizuno, Takashi Kumasaka and Makoto Fujita

Water balance creates a threshold in soil pH at the global scale pp. 567-569

E. W. Slessarev, Y. Lin, N. L. Bingham, J. E. Johnson, Y. Dai, J. P. Schimel and O. A. Chadwick

Broadening not strengthening of the Agulhas Current since the early 1990s pp. 570-573

Lisa M. Beal and Shane Elipot

Chemical intervention in plant sugar signalling increases yield and resilience pp. 574-578

Cara A. Griffiths, Ram Sagar, Yiqun Geng, Lucia F. Primavesi, Mitul K. Patel, Melissa K. Passarelli, Ian S. Gilmore, Rory T. Steven, Josephine Bunch, Matthew J. Paul and Benjamin G. Davis

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow pp. 579-582

Li Wang, Jiang-Yun Luo, Bochuan Li, Xiao Yu Tian, Li-Jing Chen, Yuhong Huang, Jian Liu, Dan Deng, Chi Wai Lau, Song Wan, Ding Ai, King-Lun Kingston Mak, Ka Kui Tong, Kin Ming Kwan, Nanping Wang, Jeng-Jiann Chiu, Yi Zhu and Yu Huang

NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer pp. 583-587

Rajendra Karki, Si Ming Man, R. K. Subbarao Malireddi, Sannula Kesavardhana, Qifan Zhu, Amanda R. Burton, Bhesh Raj Sharma, Xiaopeng Qi, Stephane Pelletier, Peter Vogel, Philip Rosenstiel and Thirumala-Devi Kanneganti

Mechanism of early dissemination and metastasis in Her2+ mammary cancer pp. 588-592

Kathryn L. Harper, Maria Soledad Sosa, David Entenberg, Hedayatollah Hosseini, Julie F. Cheung, Rita Nobre, Alvaro Avivar-Valderas, Chandandaneep Nagi, Nomeda Girnius, Roger J. Davis, Eduardo F. Farias, John Condeelis, Christoph A. Klein and Julio A. Aguirre-Ghiso

mRNA quality control is bypassed for immediate export of stress-responsive transcripts pp. 593-596

Gesa Zander, Alexandra Hackmann, Lysann Bender, Daniel Becker, Thomas Lingner, Gabriela Salinas and Heike Krebber

Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body pp. 597-601

L. J. Worrall, C. Hong, M. Vuckovic, W. Deng, J. R. C. Bergeron, D. D Majewski, R. K. Huang, T. Spreter, B. B. Finlay, Z. Yu and N. C. J. Strynadka

High-resolution crystal structure of the human CB1 cannabinoid receptor pp. 602-606

Zhenhua Shao, Jie Yin, Karen Chapman, Magdalena Grzemska, Lindsay Clark, Junmei Wang and Daniel M. Rosenbaum

Structure of RNA polymerase I transcribing ribosomal DNA genes pp. 607-610

Simon Neyer, Michael Kunz, Christian Geiss, Merle Hantsche, Victor-Valentin Hodirnau, Anja Seybert, Christoph Engel, Margot P. Scheffer, Patrick Cramer and Achilleas S. Frangakis

Science advocacy: Get involved pp. 611-612

Chris Woolston

Breathe the last bits of air pp. 614-614

Emily McCosh

2016, volume 540, articles 7633

Lifespan effects of mitochondrial mutations pp. E13-E14

Misa Hirose, Paul Schilf, Yask Gupta, Marvin N. Wright, Marvin N. Wright, Olaf Jöhren, Anika E. Wagner, Christian Sina, Andreas Ziegler, Michael Ristow and Saleh M. Ibrahim

Simply studying populism is no longer enough pp. 317-317

Matthijs Rooduijn

Tech giants open virtual worlds to bevy of AI programs pp. 323-324

Davide Castelvecchi

Italian scientists won’t miss departing Prime Minister Matteo Renzi pp. 324-325

Alison Abbott

Controversial impact factor gets a heavyweight rival pp. 325-326

Richard Van Noorden

CRISPR heavyweights battle in US patent court pp. 326-327

Sara Reardon

Does it matter if Donald Trump has a science adviser? pp. 327-328

Alexandra Witze

Algorithms compete to predict recipe for cancer vaccine pp. 328-329

Heidi Ledford

Three minutes with Hans Rosling will change your mind about the world pp. 330-333

Amy Maxmen

Make better, safer biomaterials pp. 335-337

Nicholas A. Peppas and Ali Khademhosseini

Medical research: Mariners' malady pp. 338-338

Tilli Tansey

Sustainability: Earth, the long view pp. 339-339

Emma Marris

Digital education: Pedagogy online pp. 340-340

Mike Sharples

Stop government picking professors pp. 341-341

Luigi Nicolais

Trump: renewables for self-sufficiency pp. 341-341

Seth B. C. Shonkoff

Trump: time to seize environmental gains pp. 341-341

Duan Biggs

Diversity is future for genetic analysis pp. 341-341

Christopher S. Carlson

Sustainable fisheries need reserves pp. 341-341

Mark John Costello

Ralph J. Cicerone (1943–2016) pp. 342-342

Mario Molina and Kenneth Janda

Inside-out receptor inhibition pp. 344-345

Thomas P. Sakmar and Thomas Huber

A radical change in enzyme catalysis pp. 345-346

Uwe T. Bornscheuer

A gene-expression profile for leukaemia pp. 346-348

Gerrit J. Schuurhuis

The dynamics of Earth's surface water pp. 348-349

Dai Yamazaki and Mark A. Trigg

Cause and consequence in aged-muscle decline pp. 349-350

Susan Eliazer and Andrew S. Brack

An eye on retinal recovery pp. 350-351

Michael A. Dyer

Polymers pp. 353-353

Ros Daw, Claire Hansell and Magdalena Helmer

Sustainable polymers from renewable resources pp. 354-362

Yunqing Zhu, Charles Romain and Charlotte K. Williams

Polymers with autonomous life-cycle control pp. 363-370

Jason F. Patrick, Maxwell J. Robb, Nancy R. Sottos, Jeffrey S. Moore and Scott R. White

Printing soft matter in three dimensions pp. 371-378

Ryan L. Truby and Jennifer A. Lewis

The rise of plastic bioelectronics pp. 379-385

Takao Someya, Zhenan Bao and George G. Malliaras

Mimicking biological functionality with polymers for biomedical applications pp. 386-394

Jordan J. Green and Jennifer H. Elisseeff

The seahorse genome and the evolution of its specialized morphology pp. 395-399

Qiang Lin, Shaohua Fan, Yanhong Zhang, Meng Xu, Huixian Zhang, Yulan Yang, Alison P. Lee, Joost M. Woltering, Vydianathan Ravi, Helen M. Gunter, Wei Luo, Zexia Gao, Zhi Wei Lim, Geng Qin, Ralf F. Schneider, Xin Wang, Peiwen Xiong, Gang Li, Kai Wang, Jiumeng Min, Chi Zhang, Ying Qiu, Jie Bai, Weiming He, Chao Bian, Xinhui Zhang, Dai Shan, Hongyue Qu, Ying Sun, Qiang Gao, Liangmin Huang, Qiong Shi, Axel Meyer and Byrappa Venkatesh

Electric-field-stimulated protein mechanics pp. 400-405

Doeke R. Hekstra, K. Ian White, Michael A. Socolich, Robert W. Henning, Vukica Šrajer and Rama Ranganathan

Resolved images of a protostellar outflow driven by an extended disk wind pp. 406-409

Per Bjerkeli, Matthijs H. D. van der Wiel, Daniel Harsono, Jon P. Ramsey and Jes K. Jørgensen

Extensive degeneracy, Coulomb phase and magnetic monopoles in artificial square ice pp. 410-413

Yann Perrin, Benjamin Canals and Nicolas Rougemaille

Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light pp. 414-417

Megan A. Emmanuel, Norman R. Greenberg, Daniel G. Oblinsky and Todd K. Hyster

High-resolution mapping of global surface water and its long-term changes pp. 418-422

Jean-François Pekel, Andrew Cottam, Noel Gorelick and Alan S. Belward

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism pp. 423-427

Neelroop N. Parikshak, Vivek Swarup, T. Grant Belgard, Manuel Irimia, Gokul Ramaswami, Michael J. Gandal, Christopher Hartl, Virpi Leppa, Luis de la Torre Ubieta, Jerry Huang, Jennifer K. Lowe, Benjamin J. Blencowe, Steve Horvath and Daniel H. Geschwind

Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals pp. 428-432

Simon Schwörer, Friedrich Becker, Christian Feller, Ali H. Baig, Ute Köber, Henriette Henze, Johann M. Kraus, Beibei Xin, André Lechel, Daniel B. Lipka, Christy S. Varghese, Manuel Schmidt, Remo Rohs, Ruedi Aebersold, Kay L. Medina, Hans A. Kestler, Francesco Neri, Julia von Maltzahn, Stefan Tümpel and K. Lenhard Rudolph

A 17-gene stemness score for rapid determination of risk in acute leukaemia pp. 433-437

Stanley W. K. Ng, Amanda Mitchell, James A. Kennedy, Weihsu C. Chen, Jessica McLeod, Narmin Ibrahimova, Andrea Arruda, Andreea Popescu, Vikas Gupta, Aaron D. Schimmer, Andre C. Schuh, Karen W. Yee, Lars Bullinger, Tobias Herold, Dennis Görlich, Thomas Büchner, Wolfgang Hiddemann, Wolfgang E. Berdel, Bernhard Wörmann, Meyling Cheok, Claude Preudhomme, Hervé Dombret, Klaus Metzeler, Christian Buske, Bob Löwenberg, Peter J. M. Valk, Peter W. Zandstra, Mark D. Minden, John E. Dick and Jean C. Y. Wang

Zika virus infection damages the testes in mice pp. 438-442

Jennifer Govero, Prabagaran Esakky, Suzanne M. Scheaffer, Estefania Fernandez, Andrea Drury, Derek J. Platt, Matthew J. Gorman, Justin M. Richner, Elizabeth A. Caine, Vanessa Salazar, Kelle H. Moley and Michael S. Diamond

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice pp. 443-447

Gopal Sapparapu, Estefania Fernandez, Nurgun Kose, Bin Cao, Julie M. Fox, Robin G. Bombardi, Haiyan Zhao, Christopher A. Nelson, Aubrey L. Bryan, Trevor Barnes, Edgar Davidson, Indira U. Mysorekar, Daved H. Fremont, Benjamin J. Doranz, Michael S. Diamond and James E. Crowe

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets pp. 448-452

Carla M. S. Ribeiro, Ramin Sarrami-Forooshani, Laurentia C. Setiawan, Esther M. Zijlstra-Willems, John L. van Hamme, Wikky Tigchelaar, Nicole N. van der Wel, Neeltje A. Kootstra, Sonja I. Gringhuis and Teunis B. H. Geijtenbeek

Structure of photosystem II and substrate binding at room temperature pp. 453-457

Iris D. Young, Mohamed Ibrahim, Ruchira Chatterjee, Sheraz Gul, Franklin D. Fuller, Sergey Koroidov, Aaron S. Brewster, Rosalie Tran, Roberto Alonso-Mori, Thomas Kroll, Tara Michels-Clark, Hartawan Laksmono, Raymond G. Sierra, Claudiu A. Stan, Rana Hussein, Miao Zhang, Lacey Douthit, Markus Kubin, Casper de Lichtenberg, Long Vo Pham, Håkan Nilsson, Mun Hon Cheah, Dmitriy Shevela, Claudio Saracini, Mackenzie A. Bean, Ina Seuffert, Dimosthenis Sokaras, Tsu-Chien Weng, Ernest Pastor, Clemens Weninger, Thomas Fransson, Louise Lassalle, Philipp Bräuer, Pierre Aller, Peter T. Docker, Babak Andi, Allen M. Orville, James M. Glownia, Silke Nelson, Marcin Sikorski, Diling Zhu, Mark S. Hunter, Thomas J. Lane, Andy Aquila, Jason E. Koglin, Joseph Robinson, Mengning Liang, Sébastien Boutet, Artem Y. Lyubimov, Monarin Uervirojnangkoorn, Nigel W. Moriarty, Dorothee Liebschner, Pavel V. Afonine, David G. Waterman, Gwyndaf Evans, Philippe Wernet, Holger Dobbek, William I. Weis, Axel T. Brunger, Petrus H. Zwart, Paul D. Adams, Athina Zouni, Johannes Messinger, Uwe Bergmann, Nicholas K. Sauter, Jan Kern, Vittal K. Yachandra and Junko Yano

Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists pp. 458-461

Yi Zheng, Ling Qin, Natalia V. Ortiz Zacarías, Henk de Vries, Gye Won Han, Martin Gustavsson, Marta Dabros, Chunxia Zhao, Robert J. Cherney, Percy Carter, Dean Stamos, Ruben Abagyan, Vadim Cherezov, Raymond C. Stevens, Adriaan P. IJzerman, Laura H. Heitman, Andrew Tebben, Irina Kufareva and Tracy M. Handel

Intracellular allosteric antagonism of the CCR9 receptor pp. 462-465

Christine Oswald, Mathieu Rappas, James Kean, Andrew S. Doré, James C. Errey, Kirstie Bennett, Francesca Deflorian, John A. Christopher, Ali Jazayeri, Jonathan S. Mason, Miles Congreve, Robert M. Cooke and Fiona H. Marshall

Structure and regulation of the chromatin remodeller ISWI pp. 466-469

Lijuan Yan, Li Wang, Yuanyuan Tian, Xian Xia and Zhucheng Chen

Erratum: Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection pp. 470-470

Ran He, Shiyue Hou, Cheng Liu, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Pengcheng Wang, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Kai Deng, Yaokai Chen, Yadong Luo, Jianqing Xu, Hai Qi, Yuzhang Wu and Lilin Ye

Correction: Corrigendum: Synergistic, ultrafast mass storage and removal in artificial mixed conductors pp. 470-470

Chia-Chin Chen, Lijun Fu and Joachim Maier

Erratum: Kamakura replies pp. 470-470

M. Kamakura

Addendum: REST and stress resistance in ageing and Alzheimer’s disease pp. 470-470

Lu T., Liviu Aron, Joseph Zullo, Ying Pan, Haeyoung Kim, Yiwen Chen, Tun-Hsiang Yang, Hyun-Min Kim, Derek Drake, X. Shirley Liu, David A. Bennett, Monica P. Colaiácovo and Bruce A. Yankner

Funding: Word perfect pp. 471-473

Amber Dance

Turning point: Climate guardian pp. 473-473

Virginia Gewin

Reflections on a life story pp. 476-476

M. Darusha Wehm

2016, volume 540, articles 7632

Regenerative medicine pp. S49-S49

Herb Brody

Timeline: Regrowing the body pp. S50-S51

Cassandra Willyard

Neuroscience: New nerves for old pp. S52-S54

Katherine Bourzac

Perspective: Work with, not against, biology pp. S55-S55

Stephen Badylak

Technology: The promise of printing pp. S56-S57

Neil Savage

Animal models: Unlock your inner salamander pp. S58-S59

Sujata Gupta

Diabetes: Encapsulating the problem pp. S60-S62

Elie Dolgin

Regulation: Rewriting the regenerative rulebook pp. S64-S67

Michael Eisenstein

Take the time and effort to correct misinformation pp. 171-171

Phil Williamson

Europe’s first Mars rover gets funding — despite crash of test craft pp. 177-178

Elizabeth Gibney

North America’s oldest mummy returned to US tribe after genome sequencing pp. 178-179

Ewen Callaway

Mexico proposal to ban human-embryo research would stifle science pp. 180-181

Sara Reardon

Battle over US overtime pay rules leaves many postdocs in limbo pp. 181-181

Anna Nowogrodzki

Researchers baffled by nationalist surge pp. 182-183

Jeff Tollefson

Deforestation spikes in Brazilian Amazon pp. 182-182

Jeff Tollefson

What DNA reveals about St Helena’s freed slaves pp. 184-187

Ewen Callaway

Four steps to precision public health pp. 189-191

Scott F. Dowell, David Blazes and Susan Desmond-Hellmann

Involve social scientists in defining the Anthropocene pp. 192-193

Erle Ellis, Mark Maslin, Nicole Boivin and Andrew Bauer

Urgent action on Cerrado extinctions pp. 199-199

Bernardo B. N. Strassburg, Agnieszka Latawiec and Andrew Balmford

Fermi's predictions live on pp. 199-199

Philip Yock

Forge a clearer path for technical careers pp. 199-199

Michael Ball, Rob Hardwick and Kelly Vere

Nobel launchpad is immaterial pp. 199-199

Robert Root-Bernstein

Focus like a lens, not like a laser pp. 199-199

Richard Rhodes

The history of Greenland's ice pp. 202-203

Pierre-Henri Blard, Guillaume Leduc and Neil Glasser

A parasite's parasite saves host's neighbours pp. 204-205

Eugene V. Koonin and Mart Krupovic

Elemental abundances across cosmic time pp. 205-206

Chiaki Kobayashi

Neural synchronization in Alzheimer's disease pp. 207-208

Liviu Aron and Bruce A. Yankner

Forty years of linking orbits to ice ages pp. 208-209

Mark Maslin

Replacing the cell's power plants pp. 210-211

Eric A. Shoubridge

Aspiring to naivety pp. 211-212

Ido Sagi and Nissim Benvenisty

Certified randomness in quantum physics pp. 213-219

Antonio Acín and Lluis Masanes

Safeguarding pollinators and their values to human well-being pp. 220-229

Simon G. Potts, Vera Imperatriz-Fonseca, Hien T. Ngo, Marcelo A. Aizen, Jacobus C. Biesmeijer, Thomas D. Breeze, Lynn V. Dicks, Lucas A. Garibaldi, Rosemary Hill, Josef Settele and Adam J. Vanbergen

Gamma frequency entrainment attenuates amyloid load and modifies microglia pp. 230-235

Hunter F. Iaccarino, Annabelle C. Singer, Anthony J. Martorell, Andrii Rudenko, Fan Gao, Tyler Z. Gillingham, Hansruedi Mathys, Jinsoo Seo, Oleg Kritskiy, Fatema Abdurrob, Chinnakkaruppan Adaikkan, Rebecca G. Canter, Richard Rueda, Emery N. Brown, Edward S. Boyden and Li-Huei Tsai

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate pp. 236-241

Petros A. Tyrakis, Asis Palazon, David Macias, Kian. L. Lee, Anthony. T. Phan, Pedro Veliça, Jia You, Grace S. Chia, Jingwei Sim, Andrew Doedens, Alice Abelanet, Colin E. Evans, John R. Griffiths, Lorenz Poellinger, Ananda W. Goldrath and Randall S. Johnson

m6A modulates neuronal functions and sex determination in Drosophila pp. 242-247

Tina Lence, Junaid Akhtar, Marc Bayer, Katharina Schmid, Laura Spindler, Cheuk Hei Ho, Nastasja Kreim, Miguel A. Andrade-Navarro, Burkhard Poeck, Mark Helm and Jean-Yves Roignant

A massive, quiescent, population II galaxy at a redshift of 2.1 pp. 248-251

Mariska Kriek, Charlie Conroy, Pieter G. van Dokkum, Alice E. Shapley, Jieun Choi, Naveen A. Reddy, Brian Siana, Freeke van de Voort, Alison L. Coil and Bahram Mobasher

Greenland was nearly ice-free for extended periods during the Pleistocene pp. 252-255

Joerg M. Schaefer, Robert C. Finkel, Greg Balco, Richard B. Alley, Marc W. Caffee, Jason P. Briner, Nicolas E. Young, Anthony J. Gow and Roseanne Schwartz

A persistent and dynamic East Greenland Ice Sheet over the past 7.5 million years pp. 256-260

Paul R. Bierman, Jeremy D. Shakun, Lee B. Corbett, Susan R. Zimmerman and Dylan H. Rood

Dynamics of a seafloor-spreading episode at the East Pacific Rise pp. 261-265

Yen Joe Tan, Maya Tolstoy, Felix Waldhauser and William S. D. Wilcock

Land-use intensification causes multitrophic homogenization of grassland communities pp. 266-269

Martin M. Gossner, Thomas M. Lewinsohn, Tiemo Kahl, Fabrice Grassein, Steffen Boch, Daniel Prati, Klaus Birkhofer, Swen C. Renner, Johannes Sikorski, Tesfaye Wubet, Hartmut Arndt, Vanessa Baumgartner, Stefan Blaser, Nico Blüthgen, Carmen Börschig, Francois Buscot, Tim Diekötter, Leonardo Ré Jorge, Kirsten Jung, Alexander C. Keyel, Alexandra-Maria Klein, Sandra Klemmer, Jochen Krauss, Markus Lange, Jörg Müller, Jörg Overmann, Esther Pašalić, Caterina Penone, David J. Perović, Oliver Purschke, Peter Schall, Stephanie A. Socher, Ilja Sonnemann, Marco Tschapka, Teja Tscharntke, Manfred Türke, Paul Christiaan Venter, Christiane N. Weiner, Michael Werner, Volkmar Wolters, Susanne Wurst, Catrin Westphal, Markus Fischer, Wolfgang W. Weisser and Eric Allan

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations pp. 270-275

Eunju Kang, Jun Wu, Nuria Marti Gutierrez, Amy Koski, Rebecca Tippner-Hedges, Karen Agaronyan, Aida Platero-Luengo, Paloma Martinez-Redondo, Hong Ma, Yeonmi Lee, Tomonari Hayama, Crystal Van Dyken, Xinjian Wang, Shiyu Luo, Riffat Ahmed, Ying Li, Dongmei Ji, Refik Kayali, Cengiz Cinnioglu, Susan Olson, Jeffrey Jensen, David Battaglia, David Lee, Diana Wu, Taosheng Huang, Don P. Wolf, Dmitry Temiakov, Juan Carlos Izpisua Belmonte, Paula Amato and Shoukhrat Mitalipov

Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis pp. 276-279

Alisa A. Mueller, Cindy T. van Velthoven, Kathryn D. Fukumoto, Tom H. Cheung and Thomas A. Rando

Microcins mediate competition among Enterobacteriaceae in the inflamed gut pp. 280-283

Martina Sassone-Corsi, Sean-Paul Nuccio, Henry Liu, Dulcemaria Hernandez, Christine T. Vu, Amy A. Takahashi, Robert A. Edwards and Manuela Raffatellu

Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys pp. 284-287

Erica N. Borducchi, Crystal Cabral, Kathryn E. Stephenson, Jinyan Liu, Peter Abbink, David Ng’ang’a, Joseph P. Nkolola, Amanda L. Brinkman, Lauren Peter, Benjamin C. Lee, Jessica Jimenez, David Jetton, Jade Mondesir, Shanell Mojta, Abishek Chandrashekar, Katherine Molloy, Galit Alter, Jeffrey M. Gerold, Alison L. Hill, Mark G. Lewis, Maria G. Pau, Hanneke Schuitemaker, Joseph Hesselgesser, Romas Geleziunas, Jerome H. Kim, Merlin L. Robb, Nelson L. Michael and Dan H. Barouch

Host genome integration and giant virus-induced reactivation of the virophage mavirus pp. 288-291

Matthias G. Fischer and Thomas Hackl

Designed proteins induce the formation of nanocage-containing extracellular vesicles pp. 292-295

Jörg Votteler, Cassandra Ogohara, Sue Yi, Yang Hsia, Una Nattermann, David M. Belnap, Neil P. King and Wesley I. Sundquist

Capturing pairwise and multi-way chromosomal conformations using chromosomal walks pp. 296-300

Pedro Olivares-Chauvet, Zohar Mukamel, Aviezer Lifshitz, Omer Schwartzman, Noa Oded Elkayam, Yaniv Lubling, Gintaras Deikus, Robert P. Sebra and Amos Tanay

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination pp. 301-304

Irmgard U. Haussmann, Zsuzsanna Bodi, Eugenio Sanchez-Moran, Nigel P. Mongan, Nathan Archer, Rupert G. Fray and Matthias Soller

Mentoring awards: Leading by example pp. 305-306

Philip Campbell

Trade talk: Drug referee pp. 306-306

Jack Leeming

between two voices talking pp. 308-308

Laurence Raphael Brothers

2016, volume 540, articles 7631

Consistency in large pharmacogenomic studies pp. E1-E2

Paul Geeleher, Eric R. Gamazon, Cathal Seoighe, Nancy J. Cox and R. Stephanie Huang

Multiple sclerosis pp. S1-S1

Brian Owens

Safikhani et al. reply pp. E2-E4

Zhaleh Safikhani, Nehme El-Hachem, Petr Smirnov, Mark Freeman, Anna Goldenberg, Nicolai J. Birkbak, Andrew H. Beck, Hugo J. W. L. Aerts, John Quackenbush and Benjamin Haibe-Kains

Biology: A degenerative affliction pp. S2-S3

Charles Schmidt

Aetiology: Neighbourhood watch pp. S4-S6

Carolyn Brown

Consistency in drug response profiling pp. E5-E6

John Patrick Mpindi, Bhagwan Yadav, Päivi Östling, Prson Gautam, Disha Malani, Astrid Murumägi, Akira Hirasawa, Sara Kangaspeska, Krister Wennerberg, Olli Kallioniemi and Tero Aittokallio

Safikhani et al. reply pp. E6-E8

Zhaleh Safikhani, Nehme El-Hachem, Petr Smirnov, Mark Freeman, Anna Goldenberg, Nicolai J. Birkbak, Andrew H. Beck, Hugo J. W. L. Aerts, John Quackenbush and Benjamin Haibe-Kains

Therapies: Progressive steps pp. S7-S9

Elie Dolgin

Drug response consistency in CCLE and CGP pp. E9-E10

Mehdi Bouhaddou, Matthew S. DiStefano, Eric A. Riesel, Emilce Carrasco, Hadassa Y. Holzapfel, DeAnalisa C. Jones, Gregory R. Smith, Alan D. Stern, Sulaiman S. Somani, T. Victoria Thompson and Marc R. Birtwistle

Post-truth: a guide for the perplexed pp. 9-9

Kathleen Higgins

Perspective: Who dares, wins pp. S10-S10

Bibi Bielekova

Safikhani et al. reply pp. E11-E12

Zhaleh Safikhani, Nehme El-Hachem, Petr Smirnov, Mark Freeman, Anna Goldenberg, Nicolai J. Birkbak, Andrew H. Beck, Hugo J. W. L. Aerts, John Quackenbush and Benjamin Haibe-Kains

Stem cells: Stemming the tide pp. S11-S12

Asher Mullard

Diet: Changing the recipe pp. S13-S14

Sujata Gupta

UK scientists excited by surprise £2-billion government windfall pp. 16-17

Elizabeth Gibney

Experimental treatments aim to prevent brain damage in babies pp. 17-18

Erika Check Hayden

Speedy Antarctic drills start hunt for Earth’s oldest ice pp. 18-19

Quirin Schiermeier

Weaponized antibodies use new tricks to fight cancer pp. 19-20

Heidi Ledford

Updated: NgAgo gene-editing controversy escalates in peer-reviewed papers pp. 20-21

David Cyranoski

Can old computers bring Palestinians and Israelis together? pp. 22-25

Josie Glausiusz

Four routes to better maritime governance pp. 27-29

Zheng Wan, Jihong Chen, Abdel El Makhloufi, Daniel Sperling and Yang Chen

A new global research agenda for food pp. 30-32

Lawrence Haddad, Corinna Hawkes, Patrick Webb, Sandy Thomas, John Beddington, Jeff Waage and Derek Flynn

Fix food metrics pp. 33-34

Pavan Sukhdev, Peter May and Alexander Müller

Book publishing: University presses adapt pp. 35-37

Roger Schonfeld

Books in brief pp. 37-37

Barbara Kiser

Conservation: thrive on slings and arrows pp. 38-39

David Lindenmayer

'Tree of life' took root 150 years ago pp. 38-38

Uwe Hossfeld and Georgy S. Levit

Conservation: smart advocacy needs data pp. 38-38

Douglas J. McCauley, Francis H. Joyce and Jane Lubchenco

Conservation: big data boost in China pp. 38-38

Ruidong Wu

Cities: factor in their biological impact pp. 39-39

Alexandre Antonelli and Allison Perrigo

Cities: new fringes to act as safety nets pp. 39-39

Pranab Chatterjee, Manish Kakkar and Tamoghna Biswas

Trump: voters show importance of SDGs pp. 39-39

David Griggs

Trump: offset fracking risks pp. 39-39

Madelon Finkel

Trump: polls right, models wrong pp. 39-39

Brandon Steelman

Susan Lee Lindquist (1949–2016) pp. 40-40

James Shorter and Aaron D. Gitler

Pluto's telltale heart pp. 42-43

Amy C. Barr

Double agents for mitochondrial division pp. 43-44

Heidi M. McBride and Adam Frost

Efficient fault tolerance pp. 44-45

Daniel Gottesman

Sort of unexpected pp. 45-46

Martin R. Pool

Projections of the soil-carbon deficit pp. 47-48

Eric A. Davidson

A black hole changes its feeding habits pp. 48-49

Stephanie LaMassa

Wild times pp. 49-50

C. Loren Buck

Stem cells and interspecies chimaeras pp. 51-59

Jun Wu, Henry T. Greely, Rudolf Jaenisch, Hiromitsu Nakauchi, Janet Rossant and Juan Carlos Izpisua Belmonte

Organization and functions of mGlu and GABAB receptor complexes pp. 60-68

Jean-Philippe Pin and Bernhard Bettler

The genomic basis of circadian and circalunar timing adaptations in a midge pp. 69-73

Tobias S. Kaiser, Birgit Poehn, David Szkiba, Marco Preussner, Fritz J. Sedlazeck, Alexander Zrim, Tobias Neumann, Lam-Tung Nguyen, Andrea J. Betancourt, Thomas Hummel, Heiko Vogel, Silke Dorner, Florian Heyd, Arndt von Haeseler and Kristin Tessmar-Raible

Correcting mitochondrial fusion by manipulating mitofusin conformations pp. 74-79

Antonietta Franco, Richard N. Kitsis, Julie A. Fleischer, Evripidis Gavathiotis, Opher S. Kornfeld, Guohua Gong, Nikolaos Biris, Ann Benz, Nir Qvit, Sara K. Donnelly, Yun Chen, Steven Mennerick, Louis Hodgson, Daria Mochly-Rosen and Gerald W. Dorn

The pathway to GTPase activation of elongation factor SelB on the ribosome pp. 80-85

Niels Fischer, Piotr Neumann, Lars V. Bock, Cristina Maracci, Zhe Wang, Alena Paleskava, Andrey L. Konevega, Gunnar F Schröder, Helmut Grubmüller, Ralf Ficner, Marina V. Rodnina and Holger Stark

Observed glacier and volatile distribution on Pluto from atmosphere–topography processes pp. 86-89

Tanguy Bertrand and François Forget

Reorientation and faulting of Pluto due to volatile loading within Sputnik Planitia pp. 90-93

James T. Keane, Isamu Matsuyama, Shunichi Kamata and Jordan K. Steckloff

Reorientation of Sputnik Planitia implies a subsurface ocean on Pluto pp. 94-96

F. Nimmo, D. P. Hamilton, W. B. McKinnon, P. M. Schenk, R. P. Binzel, C. J. Bierson, R. A. Beyer, J. M. Moore, S. A. Stern, H. A. Weaver, C. B. Olkin, L. A. Young and K. E. Smith

The rapid formation of Sputnik Planitia early in Pluto’s history pp. 97-99

Douglas P. Hamilton, S. A. Stern, J. M. Moore and L. A. Young

Ghost imaging with atoms pp. 100-103

R. I. Khakimov, B. M. Henson, D. K. Shin, S. S. Hodgman, R. G. Dall, K. G. H. Baldwin and A. G. Truscott

Quantifying global soil carbon losses in response to warming pp. 104-108

T. W. Crowther, K. E. O. Todd-Brown, C. W. Rowe, W. R. Wieder, J. C. Carey, M. B. Machmuller, B. L. Snoek, S. Fang, G. Zhou, S. D. Allison, J. M. Blair, S. D. Bridgham, A. J. Burton, Y. Carrillo, P. B. Reich, J. S. Clark, A. T. Classen, F. A. Dijkstra, B. Elberling, B. A. Emmett, M. Estiarte, S. D. Frey, J. Guo, J. Harte, L. Jiang, B. R. Johnson, G. Kröel-Dulay, K. S. Larsen, H. Laudon, J. M. Lavallee, Y. Luo, M. Lupascu, L. N. Ma, S. Marhan, A. Michelsen, J. Mohan, S. Niu, E. Pendall, J. Peñuelas, L. Pfeifer-Meister, C. Poll, S. Reinsch, L. L. Reynolds, I. K. Schmidt, S. Sistla, N. W. Sokol, P. H. Templer, K. K. Treseder, J. M. Welker and M. A. Bradford

Unexpected diversity in socially synchronized rhythms of shorebirds pp. 109-113

Martin Bulla, Mihai Valcu, Adriaan M. Dokter, Alexei G. Dondua, András Kosztolányi, Anne L. Rutten, Barbara Helm, Brett K. Sandercock, Bruce Casler, Bruno J. Ens, Caleb S. Spiegel, Chris J. Hassell, Clemens Küpper, Clive Minton, Daniel Burgas, David B. Lank, David C. Payer, Egor Y. Loktionov, Erica Nol, Eunbi Kwon, Fletcher Smith, H. River Gates, Hana Vitnerová, Hanna Prüter, James A. Johnson, James J. H. St Clair, Jean-François Lamarre, Jennie Rausch, Jeroen Reneerkens, Jesse R. Conklin, Joanna Burger, Joe Liebezeit, Joël Bêty, Jonathan T. Coleman, Jordi Figuerola, Jos C. E. W. Hooijmeijer, José A. Alves, Joseph A. M. Smith, Karel Weidinger, Kari Koivula, Ken Gosbell, Klaus-Michael Exo, Larry Niles, Laura Koloski, Laura McKinnon, Libor Praus, Marcel Klaassen, Marie-Andrée Giroux, Martin Sládeček, Megan L. Boldenow, Michael I. Goldstein, Miroslav Šálek, Nathan Senner, Nelli Rönkä, Nicolas Lecomte, Olivier Gilg, Orsolya Vincze, Oscar W. Johnson, Paul A. Smith, Paul F. Woodard, Pavel S. Tomkovich, Phil F. Battley, Rebecca Bentzen, Richard B. Lanctot, Ron Porter, Sarah T. Saalfeld, Scott Freeman, Stephen C. Brown, Stephen Yezerinac, Tamás Székely, Tomás Montalvo, Theunis Piersma, Vanessa Loverti, Veli-Matti Pakanen, Wim Tijsen and Bart Kempenaers

Genomic evolution and chemoresistance in germ-cell tumours pp. 114-118

Amaro Taylor-Weiner, Travis Zack, Elizabeth O’Donnell, Jennifer L. Guerriero, Brandon Bernard, Anita Reddy, G. Celine Han, Saud AlDubayan, Ali Amin-Mansour, Steven E. Schumacher, Kevin Litchfield, Clare Turnbull, Stacey Gabriel, Rameen Beroukhim, Gad Getz, Scott L. Carter, Michelle S. Hirsch, Anthony Letai, Christopher Sweeney and Eliezer M Van Allen

Inhibition of mTOR induces a paused pluripotent state pp. 119-123

Aydan Bulut-Karslioglu, Steffen Biechele, Hu Jin, Trisha A. Macrae, Miroslav Hejna, Marina Gertsenstein, Jun S. Song and Miguel Ramalho-Santos

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation pp. 124-128

Juan Lin, Snehlata Kumari, Chun Kim, Trieu-My Van, Laurens Wachsmuth, Apostolos Polykratis and Manolis Pasparakis

RIPK1 inhibits ZBP1-driven necroptosis during development pp. 129-133

Kim Newton, Katherine E. Wickliffe, Allie Maltzman, Debra L. Dugger, Andreas Strasser, Victoria C. Pham, Jennie R. Lill, Merone Roose-Girma, Søren Warming, Margaret Solon, Hai Ngu, Joshua D. Webster and Vishva M. Dixit

The SND proteins constitute an alternative targeting route to the endoplasmic reticulum pp. 134-138

Naama Aviram, Tslil Ast, Elizabeth A. Costa, Eric C. Arakel, Silvia G. Chuartzman, Calvin H. Jan, Sarah Haßdenteufel, Johanna Dudek, Martin Jung, Stefan Schorr, Richard Zimmermann, Blanche Schwappach, Jonathan S. Weissman and Maya Schuldiner

Multiple dynamin family members collaborate to drive mitochondrial division pp. 139-143

Jason E. Lee, Laura M. Westrate, Haoxi Wu, Cynthia Page and Gia K. Voeltz

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration pp. 144-149

Keiichiro Suzuki, Yuji Tsunekawa, Reyna Hernandez-Benitez, Jun Wu, Jie Zhu, Euiseok J. Kim, Fumiyuki Hatanaka, Mako Yamamoto, Toshikazu Araoka, Zhe Li, Masakazu Kurita, Tomoaki Hishida, Mo Li, Emi Aizawa, Shicheng Guo, Song Chen, April Goebl, Rupa Devi Soligalla, Jing Qu, Tingshuai Jiang, Xin Fu, Maryam Jafari, Concepcion Rodriguez Esteban, W. Travis Berggren, Jeronimo Lajara, Estrella Nuñez-Delicado, Pedro Guillen, Josep M. Campistol, Fumio Matsuzaki, Guang-Hui Liu, Pierre Magistretti, Kun Zhang, Edward M. Callaway, Kang Zhang and Juan Carlos Izpisua Belmonte

Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion pp. 150-150

Cristovão M. Sousa, Douglas E. Biancur, Xiaoxu Wang, Christopher J. Halbrook, Mara H. Sherman, Li Zhang, Daniel Kremer, Rosa F. Hwang, Agnes K. Witkiewicz, Haoqiang Ying, John M. Asara, Ronald M. Evans, Lewis C. Cantley, Costas A. Lyssiotis and Alec C. Kimmelman

Erratum: Pore-forming activity and structural autoinhibition of the gasdermin family pp. 150-150

Jingjin Ding, Kun Wang, Wang Liu, Yang She, Qi Sun, Jianjin Shi, Hanzi Sun, Da-Cheng Wang and Feng Shao

Correction: Corrigendum: Design of a hyperstable 60-subunit protein icosahedron pp. 150-150

Yang Hsia, Jacob B. Bale, Shane Gonen, Dan Shi, William Sheffler, Kimberly K. Fong, Una Nattermann, Chunfu Xu, Po-Ssu Huang, Rashmi Ravichandran, Sue Yi, Trisha N. Davis, Tamir Gonen, Neil P. King and David Baker

Correction: Corrigendum: Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition pp. 150-150

Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Richard Maher, Patrick Henry Maxwell, Julio Saez-Rodriguez and Christian Frezza

Stat-checking software stirs up psychology pp. 151-152

Monya Baker

Metabolomics: Small molecules, single cells pp. 153-155

Marissa Fessenden

Human behaviour: Find your voice pp. 157-159

Julia Rosen

The First Fragmented Church of Entropy pp. 162-162

Steven Fischer