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2013, volume 497, articles 7451

The role of epistasis in protein evolution pp. E1-E2

David M. McCandlish, Etienne Rajon, Premal Shah, Yang Ding and Joshua B. Plotkin

Breen et al. reply pp. E2-E3

Michael S. Breen, Carsten Kemena, Peter K. Vlasov, Cedric Notredame and Fyodor A. Kondrashov

Tell fans definitive calls are an impossible goal pp. 537-537

Nic Fleming

Fallout from hailed cloning paper pp. 543-544

David Cyranoski

Immunotherapy’s cancer remit widens pp. 544-544

Heidi Ledford

Long-lived insects raise prime riddle pp. 545-546

Richard Monastersky

Tepid showing for genomics X prize pp. 546-547

Erika Check Hayden

Japan aims high for growth pp. 548-548

David Cyranoski

Neuroscience: Method man pp. 550-552

Kerri Smith

Galaxy formation: Cosmic dawn pp. 554-556

Ron Cowen

The fourth age of research pp. 557-560

Jonathan Adams

A green light for efficiency pp. 560-561

Kevin J. Gaston

Physics: The mind electric pp. 562-563

W. Patrick McCray

Books in brief pp. 563-563

Barbara Kiser

Q&A: Star-map historian pp. 564-564

Daniel Cressey

Account for the 'dark matter' of biology pp. 565-565

Ajit Varki

Getting the word out on biosphere crisis pp. 565-565

Elizabeth A. Hadly

Boost to translational medicine in Europe pp. 565-565

Giovanni Migliaccio, Frank H. de Man and Anton E. Ussi

Don't oversimplify psychiatric disorders pp. 565-565

Daniel R. Weinberger

Communications need NIH funding pp. 565-565

Judith S. Bond and Bethany Drehman

Time, space and memory pp. 568-569

György Buzsáki

A spruce sequence pp. 569-570

Ronald Sederoff

Evolutionary dichotomy for rocky planets pp. 570-572

Linda T. Elkins-Tanton

It's an analog world pp. 572-573

Herbert M. Sauro and Kyung Kim

Hesitation on hominin history pp. 573-574

William H. Kimbel

A glimpse inside a magnetar pp. 574-576

Robert C. Duncan

Rear view of an enzyme pp. 576-577

Mary Dasso

Drug for an 'undruggable' protein pp. 577-578

Nicole M. Baker and Channing J. Der

The Norway spruce genome sequence and conifer genome evolution pp. 579-584

Björn Nystedt, Nathaniel R. Street, Anna Wetterbom, Andrea Zuccolo, Yao-Cheng Lin, Douglas G. Scofield, Francesco Vezzi, Nicolas Delhomme, Stefania Giacomello, Andrey Alexeyenko, Riccardo Vicedomini, Kristoffer Sahlin, Ellen Sherwood, Malin Elfstrand, Lydia Gramzow, Kristina Holmberg, Jimmie Hällman, Olivier Keech, Lisa Klasson, Maxim Koriabine, Melis Kucukoglu, Max Käller, Johannes Luthman, Fredrik Lysholm, Totte Niittylä, Åke Olson, Nemanja Rilakovic, Carol Ritland, Josep A. Rosselló, Juliana Sena, Thomas Svensson, Carlos Talavera-López, Günter Theißen, Hannele Tuominen, Kevin Vanneste, Zhi-Qiang Wu, Bo Zhang, Philipp Zerbe, Lars Arvestad, Rishikesh Bhalerao, Joerg Bohlmann, Jean Bousquet, Rosario Garcia Gil, Torgeir R. Hvidsten, Pieter de Jong, John MacKay, Michele Morgante, Kermit Ritland, Björn Sundberg, Stacey Lee Thompson, Yves Van de Peer, Björn Andersson, Ove Nilsson, Pär K. Ingvarsson, Joakim Lundeberg and Stefan Jansson

The importance of mixed selectivity in complex cognitive tasks pp. 585-590

Mattia Rigotti, Omri Barak, Melissa R. Warden, Xiao-Jing Wang, Nathaniel D. Daw, Earl K. Miller and Stefano Fusi

An anti-glitch in a magnetar pp. 591-593

R. F. Archibald, V. M. Kaspi, C. -Y. Ng, K. N. Gourgouliatos, D. Tsang, P. Scholz, A. P. Beardmore, N. Gehrels and J. A. Kennea

Cloning of Dirac fermions in graphene superlattices pp. 594-597

L. A. Ponomarenko, R. V. Gorbachev, G. L. Yu, D. C. Elias, R. Jalil, A. A. Patel, A. Mishchenko, A. S. Mayorov, C. R. Woods, J. R. Wallbank, M. Mucha-Kruczynski, B. A. Piot, M. Potemski, I. V. Grigorieva, K. S. Novoselov, F. Guinea, V. I. Fal’ko and A. K. Geim

Hofstadter’s butterfly and the fractal quantum Hall effect in moiré superlattices pp. 598-602

C. R. Dean, L. Wang, P. Maher, C. Forsythe, F. Ghahari, Y. Gao, J. Katoch, M. Ishigami, P. Moon, M. Koshino, T. Taniguchi, K. Watanabe, K. L. Shepard, J. Hone and P. Kim

Persistent export of 231Pa from the deep central Arctic Ocean over the past 35,000 years pp. 603-606

Sharon S. Hoffmann, Jerry F. McManus, William B. Curry and L. Susan Brown-Leger

Emergence of two types of terrestrial planet on solidification of magma ocean pp. 607-610

Keiko Hamano, Yutaka Abe and Hidenori Genda

Palaeontological evidence for an Oligocene divergence between Old World monkeys and apes pp. 611-614

Nancy J. Stevens, Erik R. Seiffert, Patrick M. O’Connor, Eric M. Roberts, Mark D. Schmitz, Cornelia Krause, Eric Gorscak, Sifa Ngasala, Tobin L. Hieronymus and Joseph Temu

Long-term warming restructures Arctic tundra without changing net soil carbon storage pp. 615-618

Seeta A. Sistla, John C. Moore, Rodney T. Simpson, Laura Gough, Gaius R. Shaver and Joshua P. Schimel

Synthetic analog computation in living cells pp. 619-623

Ramiz Daniel, Jacob R. Rubens, Rahul Sarpeshkar and Timothy K. Lu

BAF complexes facilitate decatenation of DNA by topoisomerase IIα pp. 624-627

Emily C. Dykhuizen, Diana C. Hargreaves, Erik L. Miller, Kairong Cui, Andrey Korshunov, Marcel Kool, Stefan Pfister, Yoon-Jae Cho, Keji Zhao and Gerald R. Crabtree

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning pp. 628-632

Timothy A. Sanders, Esther Llagostera and Maria Barna

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells pp. 633-637

Cosimo Commisso, Shawn M. Davidson, Rengin G. Soydaner-Azeloglu, Seth J. Parker, Jurre J. Kamphorst, Sean Hackett, Elda Grabocka, Michel Nofal, Jeffrey A. Drebin, Craig B. Thompson, Joshua D. Rabinowitz, Christian M. Metallo, Matthew G. Vander Heiden and Dafna Bar-Sagi

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling pp. 638-642

Gunther Zimmermann, Björn Papke, Shehab Ismail, Nachiket Vartak, Anchal Chandra, Maike Hoffmann, Stephan A. Hahn, Gemma Triola, Alfred Wittinghofer, Philippe I. H. Bastiaens and Herbert Waldmann

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics pp. 643-646

Gongpu Zhao, Juan R. Perilla, Ernest L. Yufenyuy, Xin Meng, Bo Chen, Jiying Ning, Jinwoo Ahn, Angela M. Gronenborn, Klaus Schulten, Christopher Aiken and Peijun Zhang

Crystal structure of a nitrate/nitrite exchanger pp. 647-651

Hongjin Zheng, Goragot Wisedchaisri and Tamir Gonen

Retraction Note: Branched tricarboxylic acid metabolism in Plasmodium falciparum pp. 652-652

Kellen L. Olszewski, Michael W. Mather, Joanne M. Morrisey, Benjamin A. Garcia, Akhil B. Vaidya, Joshua D. Rabinowitz and Manuel Llinás

Erratum: Basic amino-acid side chains regulate transmembrane integrin signalling pp. 652-652

Chungho Kim, Thomas Schmidt, Eun-Gyung Cho, Feng Ye, Tobias S. Ulmer and Mark H. Ginsberg

Technologies: The right tool pp. 653-655

Kelly Rae Chi

A time for peace pp. 658-658

S. R. Algernon

2013, volume 497, articles 7450

Sleep pp. S1-S1

Tony Scully

Structure: The anatomy of sleep pp. S2-S3

Mark Peplow

Neuroscience: Off to night school pp. S4-S5

Kerri Smith

Deprivation: A wake-up call pp. S6-S7

Elie Dolgin

Obesity: Heavy sleepers pp. S8-S9

Brian Owens

Chronobiology: Stepping out of time pp. S10-S12

Michael Eisenstein

Perspective: Casting light on sleep deficiency pp. S13-S13

Charles A. Czeisler

Mood disorders: The dark night pp. S14-S15

Sarah DeWeerdt

Insomnia: Chasing the dream pp. S16-S18

James Mitchell Crow

Neurodegeneration: Amyloid awakenings pp. S19-S20

Moheb Costandi

Pure hype of pure research helps no one pp. 411-411

Daniel Sarewitz

The wheels come off Kepler pp. 417-418

Ron Cowen

Log-jam in agency confirmations pp. 418-419

Lauren Morello

US budget cuts hit Earth monitoring pp. 419-420

Alexandra Witze

Russian academy awaits new head pp. 420-421

Quirin Schiermeier

A network to track Caribbean hazards pp. 421-422

Alexandra Witze

Graphene knock-offs probe ultrafast electronics pp. 422-423

Eugenie Samuel Reich

Voyager: Outward bound pp. 424-427

Alexandra Witze

The big fat truth pp. 428-430

Virginia Hughes

Arctic sea ice needs better forecasts pp. 431-433

Hajo Eicken

Six red flags for suspect work pp. 433-434

C. Glenn Begley

Drug discovery: Synthesized dreams pp. 435-436

Mike Jay

Ecology: Into the (re)wild pp. 436-437

Shahid Naeem

Statistics: Charting chance pp. 438-438

Anthony King

We need negative metrics too pp. 439-439

J. Britt Holbrook, Kelli R. Barr and Keith Wayne Brown

Campaign tactics and grants don't mix pp. 439-439

Victor Maojo, Juan Pazos and Casimir A. Kulikowski

Australian academy is fair to women pp. 439-439

Suzanne Cory

Economic modelling could aid brain map pp. 439-439

Ramy Arnaout

François Jacob (1920–2013) pp. 440-440

Michel Morange

Beneficial miscommunication pp. 442-443

Suzanne Wolff and Andrew Dillin

Two hosts, two structures pp. 443-444

Felix A. Rey

Tiny enzyme uses context to succeed pp. 445-446

Jimin Zheng and Zongchao Jia

Handedness detected by microwaves pp. 446-448

Laurence A. Nafie

When two is better than one pp. 448-449

Wencai Ren and Hui-Ming Cheng

Driving past four-stranded snags pp. 449-450

Sergei M. Mirkin

Mitonuclear protein imbalance as a conserved longevity mechanism pp. 451-457

Riekelt H. Houtkooper, Laurent Mouchiroud, Dongryeol Ryu, Norman Moullan, Elena Katsyuba, Graham Knott, Robert W. Williams and Johan Auwerx

Pif1 family helicases suppress genome instability at G-quadruplex motifs pp. 458-462

Katrin Paeschke, Matthew L. Bochman, P. Daniela Garcia, Petr Cejka, Katherine L. Friedman, Stephen C. Kowalczykowski and Virginia A. Zakian

Shear-driven dynamo waves at high magnetic Reynolds number pp. 463-465

S. M. Tobias and F. Cattaneo

Flux-freezing breakdown in high-conductivity magnetohydrodynamic turbulence pp. 466-469

Gregory Eyink, Ethan Vishniac, Cristian Lalescu, Hussein Aluie, Kalin Kanov, Kai Bürger, Randal Burns, Charles Meneveau and Alexander Szalay

All-angle negative refraction and active flat lensing of ultraviolet light pp. 470-474

Ting Xu, Amit Agrawal, Maxim Abashin, Kenneth J. Chau and Henri J. Lezec

Enantiomer-specific detection of chiral molecules via microwave spectroscopy pp. 475-477

David Patterson, Melanie Schnell and John M. Doyle

Weakened stratospheric quasibiennial oscillation driven by increased tropical mean upwelling pp. 478-481

Yoshio Kawatani and Kevin Hamilton

Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination pp. 482-485

Petr Znamenskiy and Anthony M. Zador

Non-redundant coding of aversive odours in the main olfactory pathway pp. 486-489

Adam Dewan, Rodrigo Pacifico, Ross Zhan, Dmitry Rinberg and Thomas Bozza

Sema3A regulates bone-mass accrual through sensory innervations pp. 490-493

Toru Fukuda, Shu Takeda, Ren Xu, Hiroki Ochi, Satoko Sunamura, Tsuyoshi Sato, Shinsuke Shibata, Yutaka Yoshida, Zirong Gu, Ayako Kimura, Chengshan Ma, Cheng Xu, Waka Bando, Koji Fujita, Kenichi Shinomiya, Takashi Hirai, Yoshinori Asou, Mitsuhiro Enomoto, Hideyuki Okano, Atsushi Okawa and Hiroshi Itoh

Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infection pp. 494-497

Jia Zhu, Tao Peng, Christine Johnston, Khamsone Phasouk, Angela S. Kask, Alexis Klock, Lei Jin, Kurt Diem, David M. Koelle, Anna Wald, Harlan Robins and Lawrence Corey

The TLR4 antagonist Eritoran protects mice from lethal influenza infection pp. 498-502

Kari Ann Shirey, Wendy Lai, Alison J. Scott, Michael Lipsky, Pragnesh Mistry, Lioubov M. Pletneva, Christopher L. Karp, Jaclyn McAlees, Theresa L. Gioannini, Jerrold Weiss, Wilbur H. Chen, Robert K. Ernst, Daniel P. Rossignol, Fabian Gusovsky, Jorge C. G. Blanco and Stefanie N. Vogel

The microRNA miR-235 couples blast-cell quiescence to the nutritional state pp. 503-506

Hidefumi Kasuga, Masamitsu Fukuyama, Aya Kitazawa, Kenji Kontani and Toshiaki Katada

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics pp. 507-511

Chin Yee Ho, Diana E. Jaalouk, Maria K. Vartiainen and Jan Lammerding

Reconfiguration of the proteasome during chaperone-mediated assembly pp. 512-516

Soyeon Park, Xueming Li, Ho Min Kim, Chingakham Ranjit Singh, Geng Tian, Martin A. Hoyt, Scott Lovell, Kevin P. Battaile, Michal Zolkiewski, Philip Coffino, Jeroen Roelofs, Yifan Cheng and Daniel Finley

Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits pp. 517-520

Unnur Styrkarsdottir, Gudmar Thorleifsson, Patrick Sulem, Daniel F. Gudbjartsson, Asgeir Sigurdsson, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Asmundur Oddsson, Agnar Helgason, Olafur T. Magnusson, G. Bragi Walters, Michael L. Frigge, Hafdis T. Helgadottir, Hrefna Johannsdottir, Kristin Bergsteinsdottir, Margret H. Ogmundsdottir, Jacqueline R. Center, Tuan V. Nguyen, John A. Eisman, Claus Christiansen, Erikur Steingrimsson, Jon G. Jonasson, Laufey Tryggvadottir, Gudmundur I. Eyjolfsson, Asgeir Theodors, Thorvaldur Jonsson, Thorvaldur Ingvarsson, Isleifur Olafsson, Thorunn Rafnar, Augustine Kong, Gunnar Sigurdsson, Gisli Masson, Unnur Thorsteinsdottir and Kari Stefansson

Crystal structure of the integral membrane diacylglycerol kinase pp. 521-524

Dianfan Li, Joseph A. Lyons, Valerie E. Pye, Lutz Vogeley, David Aragão, Colin P. Kenyon, Syed T. A. Shah, Christine Doherty, Margaret Aherne and Martin Caffrey

Travelling: Here, there and everywhere pp. 525-526

Neil Savage

Turning point: Joanna Wysocka pp. 527-527

Virginia Gewin

An alien named Tim pp. 530-530

Michael Haynes

2013, volume 497, articles 7449

Driving students into science is a fool’s errand pp. 289-289

Colin Macilwain

Human stem cells created by cloning pp. 295-296

David Cyranoski

Magnetar found at giant black hole pp. 296-297

Eugenie Samuel Reich

Chinese project probes the genetics of genius pp. 297-299

Ed Yong

Hawking decision fuels Israel debate pp. 299-300

Daniel Cressey

Meeting targets lab lapses pp. 300-301

Richard Van Noorden

Neanderthal culture: Old masters pp. 302-304

Tim Appenzeller

Invasive species: The 18-km2 rat trap pp. 306-308

Henry Nicholls

Don't bristle at blunders pp. 309-310

Mario Livio

The difficult art of giving pp. 311-312

William H. Schneider

Neuroscience: Losing the past pp. 313-314

Douwe Draaisma

Space exploration: Life on Mars pp. 314-315

Jim Bell

Books in brief pp. 315-315

Barbara Kiser

Q&A: Elephant man pp. 316-316

Laura Spinney

Social responsibility for new technologies pp. 317-317

Jacqueline McGlade, David Quist and David Gee

Preserve our digital heritage pp. 317-317

Ian Milligan

An innovation prize for clean cookstoves pp. 317-317

Ambuj D. Sagar and Kirk R. Smith

No mass strandings since sonar ban pp. 317-317

Antonio Fernández, Manuel Arbelo and Vidal Martín

Japan's work on ALMA telescope pp. 317-317

Masahiko Hayashi and Satoru Iguchi

Robert Edwards (1925–2013) pp. 318-318

Roger Gosden

Climate change at the dinner table pp. 320-321

Mark R. Payne

Bacterial communities as capitalist economies pp. 321-322

Ute Römling

Plumbing the depths of Uranus and Neptune pp. 323-324

Peter Read

Iron production electrified pp. 324-325

Derek Fray

Stuck between the teeth pp. 325-326

P. David Polly

Inferring ancient divergences requires genes with strong phylogenetic signals pp. 327-331

Leonidas Salichos and Antonis Rokas

Structural and molecular interrogation of intact biological systems pp. 332-337

Kwanghun Chung, Jenelle Wallace, Sung-Yon Kim, Sandhiya Kalyanasundaram, Aaron S. Andalman, Thomas J. Davidson, Julie J. Mirzabekov, Kelly A. Zalocusky, Joanna Mattis, Aleksandra K. Denisin, Sally Pak, Hannah Bernstein, Charu Ramakrishnan, Logan Grosenick, Viviana Gradinaru and Karl Deisseroth

Structure of the human smoothened receptor bound to an antitumour agent pp. 338-343

Chong Wang, Huixian Wu, Vsevolod Katritch, Gye Won Han, Xi-Ping Huang, Wei Liu, Fai Yiu Siu, Bryan L. Roth, Vadim Cherezov and Raymond C. Stevens

Atmospheric confinement of jet streams on Uranus and Neptune pp. 344-347

Yohai Kaspi, Adam P. Showman, William B. Hubbard, Oded Aharonson and Ravit Helled

An electrically pumped polariton laser pp. 348-352

Christian Schneider, Arash Rahimi-Iman, Na Young Kim, Julian Fischer, Ivan G. Savenko, Matthias Amthor, Matthias Lermer, Adriana Wolf, Lukas Worschech, Vladimir D. Kulakovskii, Ivan A. Shelykh, Martin Kamp, Stephan Reitzenstein, Alfred Forchel, Yoshihisa Yamamoto and Sven Höfling

A new anode material for oxygen evolution in molten oxide electrolysis pp. 353-356

Antoine Allanore, Lan Yin and Donald R. Sadoway

Deep fracture fluids isolated in the crust since the Precambrian era pp. 357-360

G. Holland, B. Sherwood Lollar, L. Li, G. Lacrampe-Couloume, G. F. Slater and C. J. Ballentine

Adaptive dynamics under development-based genotype–phenotype maps pp. 361-364

Isaac Salazar-Ciudad and Miquel Marín-Riera

Signature of ocean warming in global fisheries catch pp. 365-368

William W. L. Cheung, Reg Watson and Daniel Pauly

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4 pp. 369-373

Eric J. Benner, Dominic Luciano, Rebecca Jo, Khadar Abdi, Patricia Paez-Gonzalez, Huaxin Sheng, David S. Warner, Chunlei Liu, Cagla Eroglu and Chay T. Kuo

X-ray phase-contrast in vivo microtomography probes new aspects of Xenopus gastrulation pp. 374-377

Julian Moosmann, Alexey Ershov, Venera Altapova, Tilo Baumbach, Maneeshi S. Prasad, Carole LaBonne, Xianghui Xiao, Jubin Kashef and Ralf Hofmann

The shaping and functional consequences of the microRNA landscape in breast cancer pp. 378-382

Heidi Dvinge, Anna Git, Stefan Gräf, Mali Salmon-Divon, Christina Curtis, Andrea Sottoriva, Yongjun Zhao, Martin Hirst, Javier Armisen, Eric A. Miska, Suet-Feung Chin, Elena Provenzano, Gulisa Turashvili, Andrew Green, Ian Ellis, Sam Aparicio and Carlos Caldas

EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2 pp. 383-387

Jia Shen, Weiya Xia, Yekaterina B. Khotskaya, Longfei Huo, Kotaro Nakanishi, Seung-Oe Lim, Yi Du, Yan Wang, Wei-Chao Chang, Chung-Hsuan Chen, Jennifer L. Hsu, Yun Wu, Yung Carmen Lam, Brian P. James, Xiuping Liu, Chang-Gong Liu, Dinshaw J. Patel and Mien-Chie Hung

Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms pp. 388-391

Kun Zhao, Boo Shan Tseng, Bernard Beckerman, Fan Jin, Maxsim L. Gibiansky, Joe J. Harrison, Erik Luijten, Matthew R. Parsek and Gerard C. L. Wong

Receptor binding by a ferret-transmissible H5 avian influenza virus pp. 392-396

Xiaoli Xiong, Peter J. Coombs, Stephen R. Martin, Junfeng Liu, Haixia Xiao, John W. McCauley, Kathrin Locher, Philip A. Walker, Patrick J. Collins, Yoshihiro Kawaoka, John J. Skehel and Steven J. Gamblin

Working in Asia: The siren song of Singapore pp. 397-399

Quirin Schiermeier

Turning point: Laura Deming pp. 399-399

Karen Kaplan

The plague pp. 402-402

Ken Liu

2013, volume 497, articles 7448

China's citizens must act to save their environment pp. 159-159

Qiang Wang

US warheads to get a facelift pp. 165-166

Jeff Tollefson

Oceans under surveillance pp. 167-168

Quirin Schiermeier

US bill would keep helium store afloat pp. 168-169

Mark Peplow

Symmetry study deemed a fraud pp. 170-171

Eugenie Samuel Reich

Privacy protections: The genome hacker pp. 172-174

Erika Check Hayden

Neuroprosthetics: Once more, with feeling pp. 176-178

Roberta Kwok

A call for peace on climate and conflict pp. 179-180

Andrew R. Solow

A vision of our transport future pp. 181-182

Lawrence D. Burns

Free digital scans of human fossils pp. 183-183

Jean-Jacques Hublin

Philosophy: Deepities, cranes and skyhooks pp. 184-185

Melvin Konner

Books in brief pp. 185-185

Barbara Kiser

Data visualization: Drawing out the meaning pp. 186-186

Felice Frankel

Arts: Framing change pp. 187-187

Daniel Cressey

Overhaul pesticide testing on bees pp. 188-188

Axel Decourtye, Mickaël Henry and Nicolas Desneux

An open dialogue on solar engineering pp. 188-188

John Shepherd, Berhanu Abegaz and Jane Long

Oil-palm concerns in Brazilian Amazon pp. 188-188

Alexander C. Lees and Ima C. G. Vieira

Non-coding RNA foreseen 48 years ago pp. 188-188

Henry Harris

Exotic pear-shaped nuclei pp. 190-191

C. J. (Kim) Lister and Jonathan Butterworth

The cosmic web in focus pp. 191-192

Robert Braun

Security measures of a master regulator pp. 193-194

Dario R. Alessi and Yogesh Kulathu

Memory cells sound the alarm pp. 194-196

Jennifer E. Smith-Garvin and Luis J. Sigal

Death brings new life to muscle pp. 196-197

Shannon F. Yu and Mary K. Baylies

Inflammation links ageing to the brain pp. 197-198

Dana Gabuzda and Bruce A. Yankner

Studies of pear-shaped nuclei using accelerated radioactive beams pp. 199-204

L. P. Gaffney, P. A. Butler, M. Scheck, A. B. Hayes, F. Wenander, M. Albers, B. Bastin, C. Bauer, A. Blazhev, S. Bönig, N. Bree, J. Cederkäll, T. Chupp, D. Cline, T. E. Cocolios, T. Davinson, H. De Witte, J. Diriken, T. Grahn, A. Herzan, M. Huyse, D. G. Jenkins, D. T. Joss, N. Kesteloot, J. Konki, M. Kowalczyk, Th. Kröll, E. Kwan, R. Lutter, K. Moschner, P. Napiorkowski, J. Pakarinen, M. Pfeiffer, D. Radeck, P. Reiter, K. Reynders, S. V. Rigby, L. M. Robledo, M. Rudigier, S. Sambi, M. Seidlitz, B. Siebeck, T. Stora, P. Thoele, P. Van Duppen, M. J. Vermeulen, M. von Schmid, D. Voulot, N. Warr, K. Wimmer, K. Wrzosek-Lipska, C. Y. Wu and M. Zielinska

Hierarchy of orofacial rhythms revealed through whisking and breathing pp. 205-210

Jeffrey D. Moore, Martin Deschênes, Takahiro Furuta, Daniel Huber, Matthew C. Smear, Maxime Demers and David Kleinfeld

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH pp. 211-216

Guo Zhang, Juxue Li, Sudarshana Purkayastha, Yizhe Tang, Hai Zhang, Ye Yin, Bo Li, Gang Liu and Dongsheng Cai

mTOR kinase structure, mechanism and regulation pp. 217-223

Haijuan Yang, Derek G. Rudge, Joseph D. Koos, Bhamini Vaidialingam, Hyo J. Yang and Nikola P. Pavletich

Discrete clouds of neutral gas between the galaxies M31 and M33 pp. 224-226

Spencer A. Wolfe, D. J. Pisano, Felix J. Lockman, Stacy S. McGaugh and Edward J. Shaya

Bell violation using entangled photons without the fair-sampling assumption pp. 227-230

Marissa Giustina, Alexandra Mech, Sven Ramelow, Bernhard Wittmann, Johannes Kofler, Jörn Beyer, Adriana Lita, Brice Calkins, Thomas Gerrits, Sae Woo Nam, Rupert Ursin and Anton Zeilinger

Formation of a topological non-Fermi liquid in MnSi pp. 231-234

R. Ritz, M. Halder, M. Wagner, C. Franz, A. Bauer and C. Pfleiderer

Future sea-level rise from Greenland’s main outlet glaciers in a warming climate pp. 235-238

Faezeh M. Nick, Andreas Vieli, Morten Langer Andersen, Ian Joughin, Antony Payne, Tamsin L. Edwards, Frank Pattyn and Roderik S. W. van de Wal

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells pp. 239-243

Noushine Mossadegh-Keller, Sandrine Sarrazin, Prashanth K. Kandalla, Leon Espinosa, E. Richard Stanley, Stephen L. Nutt, Jordan Moore and Michael H. Sieweke

A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway pp. 244-248

Hao-Ming Chang, Robinson Triboulet, James E. Thornton and Richard I. Gregory

Meis1 regulates postnatal cardiomyocyte cell cycle arrest pp. 249-253

Ahmed I. Mahmoud, Fatih Kocabas, Shalini A. Muralidhar, Wataru Kimura, Ahmed S. Koura, Suwannee Thet, Enzo R. Porrello and Hesham A. Sadek

A CRISPR/Cas system mediates bacterial innate immune evasion and virulence pp. 254-257

Timothy R. Sampson, Sunil D. Saroj, Anna C. Llewellyn, Yih-Ling Tzeng and David S. Weiss

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota pp. 258-262

Anna Cebula, Michal Seweryn, Grzegorz A. Rempala, Simarjot Singh Pabla, Richard A. McIndoe, Timothy L. Denning, Lynn Bry, Piotr Kraj, Pawel Kisielow and Leszek Ignatowicz

Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion pp. 263-267

Amelia E. Hochreiter-Hufford, Chang Sup Lee, Jason M. Kinchen, Jennifer D. Sokolowski, Sanja Arandjelovic, Jarrod A. Call, Alexander L. Klibanov, Zhen Yan, James W. Mandell and Kodi S. Ravichandran

Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis pp. 268-271

Ke Xu, Minhua Zhang, Qin Zhao, Fang Yu, Hui Guo, Chengyuan Wang, Fangyuan He, Jianping Ding and Peng Zhang

Structure of a bacterial energy-coupling factor transporter pp. 272-276

Tingliang Wang, Guobin Fu, Xiaojing Pan, Jianping Wu, Xinqi Gong, Jiawei Wang and Yigong Shi

On my way to being a scientist pp. 277-278

Thomas M. Schofield

Turning point: Ben Novak pp. 279-279

Virginia Gewin

The front line pp. 282-282

Sylvia Spruck Wrigley

2013, volume 497, articles 7447

Australian science needs more female fellows pp. 7-7

Douglas Hilton

Global carbon dioxide levels near worrisome milestone pp. 13-14

Richard Monastersky

Flu papers spark row over credit for data pp. 14-15

Declan Butler and David Cyranoski

Disputed results a fresh blow for social psychology pp. 16-16

Alison Abbott

Transgenic salmon nears approval pp. 17-18

Heidi Ledford

Targeted drugs to tackle hepatitis C pp. 18-19

Beth Mole

Clinician to head Wellcome Trust pp. 19-19

Richard Van Noorden

Case studies: A hard look at GM crops pp. 24-26

Natasha Gilbert

Transgenics: A new breed pp. 27-29

Daniel Cressey

Africa and Asia need a rational debate on GM crops pp. 31-33

Christopher J. M. Whitty, Monty Jones, Alan Tollervey and Tim Wheeler

An experiment for the world pp. 33-35

Fusuo Zhang, Xinping Chen and Peter Vitousek

Psychiatry: A very sad story pp. 36-37

David Dobbs

Books in brief pp. 37-37

Barbara Kiser

Genetics: Wayward genes and grieving scientists pp. 38-38

Alison Abbott

Conservation: Storied rarities pp. 39-39

Emma Marris

Thirty years of transgenic plants pp. 40-40

Wim Grunewald, Jo Bury and Dirk Inzé

The high cost of overspecialization pp. 40-40

Xiaolei Huang, Gexia Qiao and Colin Favret

Journals should be clear on misconduct pp. 40-40

Xavier Bosch

Don't judge research on economics alone pp. 40-40

Thomas E. DeCoursey

Open-access boom in developing nations pp. 40-40

Jagadeesh Bayry

Navigation with a cognitive map pp. 42-43

Brandy Schmidt and A. David Redish

Small differences in sameness pp. 43-45

Alex N. Halliday

Active arrestin proteins crystallized pp. 45-46

Valentin Borshchevskiy and Georg Büldt

Single spins in silicon see the light pp. 46-47

Christoph D. Weis and Thomas Schenkel

Seeing the world through an insect's eyes pp. 47-48

Alexander Borst and Johannes Plett

The ends justify the means pp. 48-49

B. Franklin Pugh

Oxidation controls the DUB step pp. 49-50

Michael J. Clague

Globally networked risks and how to respond pp. 51-59

Dirk Helbing

Using membrane transporters to improve crops for sustainable food production pp. 60-66

Julian I. Schroeder, Emmanuel Delhaize, Wolf B. Frommer, Mary Lou Guerinot, Maria J. Harrison, Luis Herrera-Estrella, Tomoaki Horie, Leon V. Kochian, Rana Munns, Naoko K. Nishizawa, Yi-Fang Tsay and Dale Sanders

Integrated genomic characterization of endometrial carcinoma pp. 67-73

Douglas A. Levine

Hippocampal place-cell sequences depict future paths to remembered goals pp. 74-79

Brad E. Pfeiffer and David J. Foster

Structures of the human and Drosophila 80S ribosome pp. 80-85

Andreas M. Anger, Jean-Paul Armache, Otto Berninghausen, Michael Habeck, Marion Subklewe, Daniel N. Wilson and Roland Beckmann

Heralded entanglement between solid-state qubits separated by three metres pp. 86-90

H. Bernien, B. Hensen, W. Pfaff, G. Koolstra, M. S. Blok, L. Robledo, T. H. Taminiau, M. Markham, D. J. Twitchen, L. Childress and R. Hanson

Optical addressing of an individual erbium ion in silicon pp. 91-94

Chunming Yin, Milos Rancic, Gabriele G. de Boo, Nikolas Stavrias, Jeffrey C. McCallum, Matthew J. Sellars and Sven Rogge

Digital cameras with designs inspired by the arthropod eye pp. 95-99

Young Min Song, Yizhu Xie, Viktor Malyarchuk, Jianliang Xiao, Inhwa Jung, Ki-Joong Choi, Zhuangjian Liu, Hyunsung Park, Chaofeng Lu, Rak-Hwan Kim, Rui Li, Kenneth B. Crozier, Yonggang Huang and John A. Rogers

Long-term sedimentary recycling of rare sulphur isotope anomalies pp. 100-103

Christopher T. Reinhard, Noah J. Planavsky and Timothy W. Lyons

Linking the evolution of body shape and locomotor biomechanics in bird-line archosaurs pp. 104-107

Vivian Allen, Karl T. Bates, Zhiheng Li and John R. Hutchinson

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA pp. 108-112

Muhammed Murtaza, Sarah-Jane Dawson, Dana W. Y. Tsui, Davina Gale, Tim Forshew, Anna M. Piskorz, Christine Parkinson, Suet-Feung Chin, Zoya Kingsbury, Alvin S. C. Wong, Francesco Marass, Sean Humphray, James Hadfield, David Bentley, Tan Min Chin, James D. Brenton, Carlos Caldas and Nitzan Rosenfeld

Random convergence of olfactory inputs in the Drosophila mushroom body pp. 113-117

Sophie J. C. Caron, Vanessa Ruta, L. F. Abbott and Richard Axel

Tension sensing by Aurora B kinase is independent of survivin-based centromere localization pp. 118-121

Christopher S. Campbell and Arshad Desai

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX pp. 122-126

Myunggon Ko, Jungeun An, Hozefa S. Bandukwala, Lukas Chavez, Tarmo Äijö, William A. Pastor, Matthew F. Segal, Huiming Li, Kian Peng Koh, Harri Lähdesmäki, Patrick G. Hogan, L. Aravind and Anjana Rao

Extensive transcriptional heterogeneity revealed by isoform profiling pp. 127-131

Vicent Pelechano, Wu Wei and Lars M. Steinmetz

The catalytic mechanism for aerobic formation of methane by bacteria pp. 132-136

Siddhesh S. Kamat, Howard J. Williams, Lawrence J. Dangott, Mrinmoy Chakrabarti and Frank M. Raushel

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide pp. 137-141

Arun K. Shukla, Aashish Manglik, Andrew C. Kruse, Kunhong Xiao, Rosana I. Reis, Wei-Chou Tseng, Dean P. Staus, Daniel Hilger, Serdar Uysal, Li-Yin Huang, Marcin Paduch, Prachi Tripathi-Shukla, Akiko Koide, Shohei Koide, William I. Weis, Anthony A. Kossiakoff, Brian K. Kobilka and Robert J. Lefkowitz

Crystal structure of pre-activated arrestin p44 pp. 142-146

Yong Ju Kim, Klaus Peter Hofmann, Oliver P. Ernst, Patrick Scheerer, Hui-Woog Choe and Martha E. Sommer

Crowd-funding: Cash on demand pp. 147-149

Karen Kaplan

Turning point: Lucy Collinson pp. 149-149

Katharine Sanderson

Bee futures pp. 152-152

Vaughan Stanger