Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Jie Yin, Juan Carlos Mobarec, Peter Kolb and Daniel M. Rosenbaum ()
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Jie Yin: The University of Texas Southwestern Medical Center
Juan Carlos Mobarec: Philipps-University Marburg, 35032 Marburg, Germany
Peter Kolb: Philipps-University Marburg, 35032 Marburg, Germany
Daniel M. Rosenbaum: The University of Texas Southwestern Medical Center

Nature, 2015, vol. 519, issue 7542, 247-250

Abstract: The orexin system regulates sleep and arousal in humans, with orexin receptor antagonists becoming promising therapeutics for insomnia; now, the X-ray crystal structure of the human OX2 receptor in the presence of the insomnia drug suvorexant is solved.

Date: 2015
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DOI: 10.1038/nature14035

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