Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

Benjamin D. McNeil, Priyanka Pundir, Sonya Meeker, Liang Han, Bradley J. Undem, Marianna Kulka and Xinzhong Dong ()
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Benjamin D. McNeil: Center for Sensory Biology, Johns Hopkins University, School of Medicine
Priyanka Pundir: University of Alberta, Edmonton, Alberta T6G 2E1, Canada
Sonya Meeker: Johns Hopkins University, School of Medicine
Liang Han: Center for Sensory Biology, Johns Hopkins University, School of Medicine
Bradley J. Undem: Johns Hopkins University, School of Medicine
Marianna Kulka: University of Alberta, Edmonton, Alberta T6G 2E1, Canada
Xinzhong Dong: Center for Sensory Biology, Johns Hopkins University, School of Medicine

Nature, 2015, vol. 519, issue 7542, 237-241

Abstract: Cationic substances, including some drugs, can activate mast cells in an IgE-independent manner, leading to histamine release, inflammation and airway contraction; here, the G-protein-coupled receptor MrgprB2, the orthologue of human MRGPRX2, is shown to be the sole mast cell receptor for these substances in mice.

Date: 2015
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DOI: 10.1038/nature14022

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