N6-methyladenosine marks primary microRNAs for processing

Claudio R. Alarcón, Hyeseung Lee, Hani Goodarzi, Nils Halberg and Sohail F. Tavazoie ()
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Claudio R. Alarcón: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Hyeseung Lee: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Hani Goodarzi: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Nils Halberg: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Sohail F. Tavazoie: Laboratory of Systems Cancer Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA

Nature, 2015, vol. 519, issue 7544, 482-485

Abstract: The addition of the N6-methyladenosine (m6A) mark to primary microRNAs by METTL3 in mammalian cells is found to promote the recognition of these microRNA precursors by DGCR8, a component of the microprocessor complex.

Date: 2015
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DOI: 10.1038/nature14281

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