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2017, volume 552, articles 7685

Cancer immunotherapy pp. S61-S61

Eric Bender

The quest to extend the reach of checkpoint inhibitors in lung cancer pp. S62-S63

Karen Weintraub

Attack of the killer clones pp. S64-S66

Megan Scudellari

The benefits of immunotherapy combinations pp. S67-S69

Charles Schmidt

Cancer immunotherapy research round-up pp. S70-S71

Joana Osório

Making cancer immunotherapy a surer bet pp. S72-S73

Michael Eisenstein

The struggle to do no harm in clinical trials pp. S74-S75

Charles Schmidt

Calling cancer’s bluff with neoantigen vaccines pp. S76-S77

Sarah DeWeerdt

Drug pricing should depend on shared values pp. S78-S78

Scott Ramsey

A smart place to work pp. S107-S109

Brett Davis

Peer reviewers need more nurturing pp. 293-293

Richard Catlow

Rescued radar maps reveal Antarctica's past pp. 299-300

Alexandra Witze

Gene editing staves off deafness in mice pp. 300-301

Heidi Ledford

Could Bitcoin technology help science? pp. 301-302

Andy Extance

South Korean scientists eager for reactor restart pp. 302-302

David Cyranoski

2017 in news: The science events that shaped the year pp. 304-307

Ewen Callaway, Davide Castelvecchi, David Cyranoski, Elizabeth Gibney, Heidi Ledford, Jane J. Lee, Lauren Morello, Nicky Phillips, Quirin Schiermeier, Jeff Tollefson, Richard Van Noorden and Alexandra Witze

2017 in pictures: The best science images of the year pp. 308-313

Nisha Gaind

Nature’s 10 pp. 315-324

Heidi Ledford, Davide Castelvecchi, Elie Dolgin, Sara Reardon, Elizabeth Gibney, Nicky Phillips and Alexandra Witze

The case for technology investments in the environment pp. 325-328

Lucas N. Joppa

Science fiction when the future is now pp. 329-333

Lauren Beukes, Kim Stanley Robinson, Ken Liu, Hannu Rajaniemi, Alastair Reynolds and Aliette de Bodard

Why eavesdropping in open-plan spaces is good for your research pp. 334-334

Volker Heine

Parasites’ rights gaining ground pp. 334-334

Donald A. Windsor

A checklist to protect human rights in artificial-intelligence research pp. 334-334

Sumathy Ramesh

Train artificial intelligence to be fair to farming pp. 334-334

Yu-Pin Lin, Joy R. Petway and Josef Settele

India and Pakistan need to collaborate against pollution pp. 334-334

Muhammad Usman, Abdul Wakeel and Muhammad Farooq

Energy from thin air pp. 336-337

Don A. Cowan and Thulani P. Makhalanyane

The origins of memory T cells pp. 337-339

Kyla D. Omilusik and Ananda W. Goldrath

Martian water stored underground pp. 339-340

Tomohiro Usui

Tumour lymph vessels boost immunotherapy pp. 340-342

Christine Moussion and Shannon J. Turley

Specks of insight into Alzheimer’s disease pp. 342-343

Richard M. Ransohoff

Synthesis of E- and Z-trisubstituted alkenes by catalytic cross-metathesis pp. 347-354

Thach T. Nguyen, Ming Joo Koh, Tyler J. Mann, Richard R. Schrock and Amir H. Hoveyda

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease pp. 355-361

Carmen Venegas, Sathish Kumar, Bernardo S. Franklin, Tobias Dierkes, Rebecca Brinkschulte, Dario Tejera, Ana Vieira-Saecker, Stephanie Schwartz, Francesco Santarelli, Markus P. Kummer, Angelika Griep, Ellen Gelpi, Michael Beilharz, Dietmar Riedel, Douglas T. Golenbock, Matthias Geyer, Jochen Walter, Eicke Latz and Michael T. Heneka

Origin and differentiation of human memory CD8 T cells after vaccination pp. 362-367

Rama S. Akondy, Mark Fitch, Srilatha Edupuganti, Shu Yang, Haydn T. Kissick, Kelvin W. Li, Ben A. Youngblood, Hossam A. Abdelsamed, Donald J. McGuire, Kristen W. Cohen, Gabriela Alexe, Shashi Nagar, Megan M. McCausland, Satish Gupta, Pramila Tata, W. Nicholas Haining, M. Juliana McElrath, David Zhang, Bin Hu, William J. Greenleaf, Jorg J. Goronzy, Mark J. Mulligan, Marc Hellerstein and Rafi Ahmed

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40 pp. 368-373

Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J. Yang, Meredith Miller, Angela Yang, Ankita Dhar and Nikola P. Pavletich

Blazar spectral variability as explained by a twisted inhomogeneous jet pp. 374-377

C. M. Raiteri, M. Villata, J. A. Acosta-Pulido, I. Agudo, A. A. Arkharov, R. Bachev, G. V. Baida, E. Benítez, G. A. Borman, W. Boschin, V. Bozhilov, M. S. Butuzova, P. Calcidese, M. I. Carnerero, D. Carosati, C. Casadio, N. Castro-Segura, W.-P. Chen, G. Damljanovic, F. D’Ammando, A. Di Paola, J. Echevarría, N. V. Efimova, Sh. A. Ehgamberdiev, C. Espinosa, A. Fuentes, A. Giunta, J. L. Gómez, T. S. Grishina, M. A. Gurwell, D. Hiriart, H. Jermak, B. Jordan, S. G. Jorstad, M. Joshi, E. N. Kopatskaya, K. Kuratov, O. M. Kurtanidze, S. O. Kurtanidze, A. Lähteenmäki, V. M. Larionov, E. G. Larionova, L. V. Larionova, C. Lázaro, C. S. Lin, M. P. Malmrose, A. P. Marscher, K. Matsumoto, B. McBreen, R. Michel, B. Mihov, M. Minev, D. O. Mirzaqulov, A. A. Mokrushina, S. N. Molina, J. W. Moody, D. A. Morozova, S. V. Nazarov, M. G. Nikolashvili, J. M. Ohlert, D. N. Okhmat, E. Ovcharov, F. Pinna, T. A. Polakis, C. Protasio, T. Pursimo, F. J. Redondo-Lorenzo, N. Rizzi, G. Rodriguez-Coira, K. Sadakane, A. C. Sadun, M. R. Samal, S. S. Savchenko, E. Semkov, B. A. Skiff, L. Slavcheva-Mihova, P. S. Smith, I. A. Steele, A. Strigachev, J. Tammi, C. Thum, M. Tornikoski, Yu. V. Troitskaya, I. S. Troitsky, A. A. Vasilyev and O. Vince

A brief visit from a red and extremely elongated interstellar asteroid pp. 378-381

Karen J. Meech, Robert Weryk, Marco Micheli, Jan T. Kleyna, Olivier R. Hainaut, Robert Jedicke, Richard J. Wainscoat, Kenneth C. Chambers, Jacqueline V. Keane, Andreea Petric, Larry Denneau, Eugene Magnier, Travis Berger, Mark E. Huber, Heather Flewelling, Chris Waters, Eva Schunova-Lilly and Serge Chastel

Measurement of electrons from albedo neutron decay and neutron density in near-Earth space pp. 382-385

Xinlin Li, Richard Selesnick, Quintin Schiller, Kun Zhang, Hong Zhao, Daniel N. Baker and Michael A. Temerin

Discovery of a big void in Khufu’s Pyramid by observation of cosmic-ray muons pp. 386-390

Kunihiro Morishima, Mitsuaki Kuno, Akira Nishio, Nobuko Kitagawa, Yuta Manabe, Masaki Moto, Fumihiko Takasaki, Hirofumi Fujii, Kotaro Satoh, Hideyo Kodama, Kohei Hayashi, Shigeru Odaka, Sébastien Procureur, David Attié, Simon Bouteille, Denis Calvet, Christopher Filosa, Patrick Magnier, Irakli Mandjavidze, Marc Riallot, Benoit Marini, Pierre Gable, Yoshikatsu Date, Makiko Sugiura, Yasser Elshayeb, Tamer Elnady, Mustapha Ezzy, Emmanuel Guerriero, Vincent Steiger, Nicolas Serikoff, Jean-Baptiste Mouret, Bernard Charlès, Hany Helal and Mehdi Tayoubi

The divergent fates of primitive hydrospheric water on Earth and Mars pp. 391-394

Jon Wade, Brendan Dyck, Richard M. Palin, James D. P. Moore and Andrew J. Smye

Synchrotron scanning reveals amphibious ecomorphology in a new clade of bird-like dinosaurs pp. 395-399

Andrea Cau, Vincent Beyrand, Dennis F. A. E. Voeten, Vincent Fernandez, Paul Tafforeau, Koen Stein, Rinchen Barsbold, Khishigjav Tsogtbaatar, Philip J. Currie and Pascal Godefroit

Atmospheric trace gases support primary production in Antarctic desert surface soil pp. 400-403

Mukan Ji, Chris Greening, Inka Vanwonterghem, Carlo R. Carere, Sean K. Bay, Jason A. Steen, Kate Montgomery, Thomas Lines, John Beardall, Josie van Dorst, Ian Snape, Matthew B. Stott, Philip Hugenholtz and Belinda C. Ferrari

Effector CD8 T cells dedifferentiate into long-lived memory cells pp. 404-409

Ben Youngblood, J. Scott Hale, Haydn T. Kissick, Eunseon Ahn, Xiaojin Xu, Andreas Wieland, Koichi Araki, Erin E. West, Hazem E. Ghoneim, Yiping Fan, Pranay Dogra, Carl W. Davis, Bogumila T. Konieczny, Rustom Antia, Xiaodong Cheng and Rafi Ahmed

Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic pp. 410-414

Kangmin He, Robert Marsland, Srigokul Upadhyayula, Eli Song, Song Dang, Benjamin R. Capraro, Weiming Wang, Wesley Skillern, Raphael Gaudin, Minghe Ma and Tom Kirchhausen

Evolution of a designed protein assembly encapsulating its own RNA genome pp. 415-420

Gabriel L. Butterfield, Marc J. Lajoie, Heather H. Gustafson, Drew L. Sellers, Una Nattermann, Daniel Ellis, Jacob B. Bale, Sharon Ke, Garreck H. Lenz, Angelica Yehdego, Rashmi Ravichandran, Suzie H. Pun, Neil P. King and David Baker

Activation mechanism of the calcium-activated chloride channel TMEM16A revealed by cryo-EM pp. 421-425

Cristina Paulino, Valeria Kalienkova, Andy K. M. Lam, Yvonne Neldner and Raimund Dutzler

Cryo-EM structures of the TMEM16A calcium-activated chloride channel pp. 426-429

Shangyu Dang, Shengjie Feng, Jason Tien, Christian J. Peters, David Bulkley, Marco Lolicato, Jianhua Zhao, Kathrin Zuberbühler, Wenlei Ye, Lijun Qi, Tingxu Chen, Charles S. Craik, Yuh Nung Jan, Daniel L. Minor, Yifan Cheng and Lily Yeh Jan

Correction: Corrigendum: RNA m6A methylation regulates the ultraviolet-induced DNA damage response pp. 430-430

Yang Xiang, Benoit Laurent, Chih-Hung Hsu, Sigrid Nachtergaele, Zhike Lu, Wanqiang Sheng, Chuanyun Xu, Hao Chen, Jian Ouyang, Siqing Wang, Dominic Ling, Pang-Hung Hsu, Lee Zou, Ashwini Jambhekar, Chuan He and Yang Shi

Correction: Corrigendum: Mega-evolutionary dynamics of the adaptive radiation of birds pp. 430-430

Christopher R. Cooney, Jen A. Bright, Elliot J. R. Capp, Angela M. Chira, Emma C. Hughes, Christopher J. A. Moody, Lara O. Nouri, Zoë K. Varley and Gavin H. Thomas

Erratum: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity pp. 430-430

Shabnam Shalapour, Xue-Jia Lin, Ingmar N. Bastian, John Brain, Alastair D. Burt, Alexander A. Aksenov, Alison F. Vrbanac, Weihua Li, Andres Perkins, Takaji Matsutani, Zhenyu Zhong, Debanjan Dhar, Jose A. Navas-Molina, Jun Xu, Rohit Loomba, Michael Downes, Ruth T. Yu, Ronald M. Evans, Pieter C. Dorrestein, Rob Knight, Christopher Benner, Quentin M. Anstee and Michael Karin

Top ten tips to kick-start your career in 2018 pp. 431-432

Chris Woolston

The coupon pp. 434-434

Judy Helfrich

2017, volume 552, articles 7684

Spinal-cord injury: spurring regrowth pp. S49-S49

David Holmes

Repairing the neural highway pp. S50-S51

David Holmes

Chile’s chance to embrace science for the twenty-first century pp. S53-S55

Aleszu Bajak

New tricks from old dogs join the fight against ageing pp. S57-S59

Neil Savage

Zimbabwe’s new government must commit to science pp. 149-149

Dexter Tagwireyi

Nine researchers sue University of Rochester over sexual-harassment allegations pp. 155-156

Alexandra Witze

Tasmanian tiger genome offers clues to its extinction pp. 156-157

Ewen Callaway

Acupuncture in cancer study reignites debate about controversial technique pp. 157-158

Jo Marchant

US graduate students in uproar over proposed tax hike pp. 158-159

Helen Shen

Argentinian geoscientist faces criminal charges over glacier survey pp. 159-160

Jeff Tollefson and Emiliano Rodríguez Mega

The science that’s never been cited pp. 162-164

Richard Van Noorden

Deploy vaccines to fight superbugs pp. 165-167

Rino Rappuoli, David E. Bloom and Steve Black

Five priorities for weather and climate research pp. 168-170

Øystein Hov, Deon Terblanche, Gregory Carmichael, Sarah Jones, Paolo M. Ruti and Oksana Tarasova

Planetariums and the rise of spectacular science pp. 172-173

Marek Kukula

A manifesto for slow science, the biology of personal space, and an intimate look at the neuroscience of food: Books in brief pp. 173-173

Barbara Kiser

Lyme disease laid bare pp. 174-174

James G. Logan

Snow leopard conservation status is spot on pp. 175-175

Tom McCarthy

Pricing not enough for deep carbon cuts pp. 175-175

Michael Mehling and Endre Tvinnereim

How to spare half a planet pp. 175-175

Andrew Balmford and Rhys Green

Medical legacy of sanctions in Iran pp. 175-175

Reza Heidari, Mostafa Akbariqomi and Gholamreza Tavoosidana

Standardize future device connections for computers pp. 175-175

Ricardo Borges

Ronald Breslow (1931–2017) pp. 176-176

Virginia W. Cornish

Early embryos kept in check pp. 178-179

Julien G. Dumortier and Jean-Léon Maître

Stellar cannibalism in fits and starts pp. 179-180

Thomas Marsh

A dark side to omega-3 fatty acids pp. 180-181

Keisuke Yanagida and Timothy Hla

Longer life through an odd Pol enzyme pp. 182-183

Bruce A. Edgar and Savraj S. Grewal

Antarctic ice dynamics in warm climates pp. 183-184

Sarah Greenwood

Viruses hijack a long non-coding RNA pp. 184-185

Nicholas S. Heaton and Bryan R. Cullen

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity pp. 187-193

Vincenzo Sorrentino, Mario Romani, Laurent Mouchiroud, John S. Beck, Hongbo Zhang, Davide D’Amico, Norman Moullan, Francesca Potenza, Adrien W. Schmid, Solène Rietsch, Scott E. Counts and Johan Auwerx

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 pp. 194-199

Zdenek Skrott, Martin Mistrik, Klaus Kaae Andersen, Søren Friis, Dusana Majera, Jan Gursky, Tomas Ozdian, Jirina Bartkova, Zsofia Turi, Pavel Moudry, Marianne Kraus, Martina Michalova, Jana Vaclavkova, Petr Dzubak, Ivo Vrobel, Pavla Pouckova, Jindrich Sedlacek, Andrea Miklovicova, Anne Kutt, Jing Li, Jana Mattova, Christoph Driessen, Q. Ping Dou, Jørgen Olsen, Marian Hajduch, Boris Cvek, Raymond J. Deshaies and Jiri Bartek

Electron cryo-microscopy structure of a human TRPM4 channel pp. 200-204

Paige A. Winkler, Yihe Huang, Weinan Sun, Juan Du and Wei Lü

Structures of the calcium-activated, non-selective cation channel TRPM4 pp. 205-209

Jiangtao Guo, Ji She, Weizhong Zeng, Qingfeng Chen, Xiao-chen Bai and Youxing Jiang

Magnetically gated accretion in an accreting ‘non-magnetic’ white dwarf pp. 210-213

S. Scaringi, T. J. Maccarone, C. D’Angelo, C. Knigge and P. J. Groot

An electric-eel-inspired soft power source from stacked hydrogels pp. 214-218

Thomas B. H. Schroeder, Anirvan Guha, Aaron Lamoureux, Gloria VanRenterghem, David Sept, Max Shtein, Jerry Yang and Michael Mayer

Force loading explains spatial sensing of ligands by cells pp. 219-224

Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam and Pere Roca-Cusachs

Initiation and long-term instability of the East Antarctic Ice Sheet pp. 225-229

Sean P. S. Gulick, Amelia E. Shevenell, Aleksandr Montelli, Rodrigo Fernandez, Catherine Smith, Sophie Warny, Steven M. Bohaty, Charlotte Sjunneskog, Amy Leventer, Bruce Frederick and Donald D. Blankenship

Large emissions from floodplain trees close the Amazon methane budget pp. 230-234

Sunitha R. Pangala, Alex Enrich-Prast, Luana S. Basso, Roberta Bittencourt Peixoto, David Bastviken, Edward R. C. Hornibrook, Luciana V. Gatti, Humberto Marotta, Luana Silva Braucks Calazans, Cassia Mônica Sakuragui, Wanderley Rodrigues Bastos, Olaf Malm, Emanuel Gloor, John Bharat Miller and Vincent Gauci

A compositional tipping point governing the mobilization and eruption style of rhyolitic magma pp. 235-238

D. Di Genova, S. Kolzenburg, S. Wiesmaier, E. Dallanave, D. R. Neuville, K. U. Hess and D. B. Dingwell

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos pp. 239-243

Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska, Antonia Weberling, Gaelle Recher, Meng Zhu, Agnieszka Jedrusik, Liani G. Devito, Laila Noli, Iain C. Macaulay, Christa Buecker, Yakoub Khalaf, Dusko Ilic, Thierry Voet, John C. Marioni and Magdalena Zernicka-Goetz

Moving beyond microbiome-wide associations to causal microbe identification pp. 244-247

Neeraj K. Surana and Dennis L. Kasper

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy pp. 248-252

Jiong Hu, Sarah Dziumbla, Jihong Lin, Sofia-Iris Bibli, Sven Zukunft, Julian de Mos, Khader Awwad, Timo Frömel, Andreas Jungmann, Kavi Devraj, Zhixing Cheng, Liya Wang, Sascha Fauser, Charles G. Eberhart, Akrit Sodhi, Bruce D. Hammock, Stefan Liebner, Oliver J. Müller, Clemens Glaubitz, Hans-Peter Hammes, Rüdiger Popp and Ingrid Fleming

Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours pp. 253-257

J. Justin Milner, Clara Toma, Bingfei Yu, Kai Zhang, Kyla Omilusik, Anthony T. Phan, Dapeng Wang, Adam J. Getzler, Toan Nguyen, Shane Crotty, Wei Wang, Matthew E. Pipkin and Ananda W. Goldrath

A non-canonical Notch complex regulates adherens junctions and vascular barrier function pp. 258-262

William J. Polacheck, Matthew L. Kutys, Jinling Yang, Jeroen Eyckmans, Yinyu Wu, Hema Vasavada, Karen K. Hirschi and Christopher S. Chen

RNA polymerase III limits longevity downstream of TORC1 pp. 263-267

Danny Filer, Maximillian A. Thompson, Vakil Takhaveev, Adam J. Dobson, Ilektra Kotronaki, James W. M. Green, Matthias Heinemann, Jennifer M. A. Tullet and Nazif Alic

piRNA-mediated regulation of transposon alternative splicing in the soma and germ line pp. 268-272

Felipe Karam Teixeira, Martyna Okuniewska, Colin D. Malone, Rémi-Xavier Coux, Donald C. Rio and Ruth Lehmann

KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase pp. 273-277

Yugang Wang, Yusong R. Guo, Ke Liu, Zheng Yin, Rui Liu, Yan Xia, Lin Tan, Peiying Yang, Jong-Ho Lee, Xin-jian Li, David Hawke, Yanhua Zheng, Xu Qian, Jianxin Lyu, Jie He, Dongming Xing, Yizhi Jane Tao and Zhimin Lu

Erratum: Probabilistic reanalysis of twentieth-century sea-level rise pp. 278-278

Carling C. Hay, Eric Morrow, Robert Kopp and Jerry X. Mitrovica

Correction: Corrigendum: The 4D nucleome project pp. 278-278

Job Dekker, Andrew S. Belmont, Mitchell Guttman, Victor O. Leshyk, John T. Lis, Stavros Lomvardas, Leonid A. Mirny, Clodagh C. O’Shea, Peter J. Park, Bing Ren, Joan C. Ritland Politz, Jay Shendure and Sheng Zhong

Erratum: Early members of ‘living fossil’ lineage imply later origin of modern ray-finned fishes pp. 278-278

Sam Giles, Guang-Hui Xu, Thomas J. Near and Matt Friedman

How museum work can combine research and public engagement pp. 279-281

Amber Dance

Fifteen minutes pp. 284-284

Alex Shvartsman

2017, volume 552, articles 7683

Outsourcing discovery pp. S5-S5

Smriti Mallapaty

Wanted: academics wise to the needs of government pp. 7-7

Chris Tyler

Papers to patents pp. S10-S10

Ashish Arora, Sharon Belenzon and Andrea Patacconi

Industry links boost research output pp. S11-S13

Neil Savage

Archaeologists uneasy as Trump shrinks Bears Ears monument lands pp. 13-14

Cally Carswell

Huge haul of rare pterosaur eggs excites palaeontologists pp. 14-15

John Pickrell

Help wanted: industry seeks science alliances pp. S14-S15

Katharine Gammon

Bat cave solves mystery of deadly SARS virus — and suggests new outbreak could occur pp. 15-16

David Cyranoski

Scientists want in on humanity's next big space station pp. 16-17

Elizabeth Gibney

Hundreds of German universities set to lose access to Elsevier journals pp. 17-18

Quirin Schiermeier

Lost opportunities pp. S18-S18

Phillip Phan and Dean Wong

The labs that forge distant planets here on Earth pp. 20-22

Shannon Hall

Use machine learning to find energy materials pp. 23-27

Phil De Luna, Jennifer Wei, Yoshua Bengio, Alán Aspuru-Guzik and Edward Sargent

In good company pp. S24-S25

Elie Dolgin

Six principles for energy innovation pp. 25-27

Gabriel Chan, Anna P. Goldstein, Amitai Bin-Nun, Laura Diaz Anadon and Venkatesh Narayanamurti

First among equals pp. S26-S29

Mark Zastrow

The doubly dextrous physics of Enrico Fermi pp. 28-29

Catherine Westfall

How Viennese scientists fought the dogma, propaganda and prejudice of the 1930s pp. 29-30

Jordi Cat

Corporates make reluctant partners pp. S30-S32

Ichiko Fuyuno

Save Iran’s cheetah from extinction pp. 31-31

Jamshid Parchizadeh and Samual T. Williams

Celebrate results of German excellence initiative pp. 31-31

Inna Sokolova

Gauging the risk from US nuclear waste pp. 31-31

Rodney C. Ewing

Scrap very useless qualifiers in research papers pp. 31-31

Stephen K. Donovan

Frank Brown (1943-2017) pp. 32-32

Bernard Wood

DNA self-assembly scaled up pp. 34-35

Fei Zhang and Hao Yan

A tip of the hat to evolutionary change pp. 35-37

Charles R. Marshall

A steamy proposal for Martian clays pp. 37-38

Laura Schaefer

Vivid views of the PINK1 protein pp. 38-39

Salima Daou and Frank Sicheri

Two-dimensional tellurium pp. 40-41

Evan J. Reed

India’s commitment to science begins to pay off pp. S41-S43

T. V. Padma

The dark side of PD-1 receptor inhibition pp. 41-42

Aya Ludin and Leonard I. Zon

Quantum-teleportation experiments turn 20 pp. 42-43

Nicolas Gisin

Greater future global warming inferred from Earth’s recent energy budget pp. 45-50

Patrick T. Brown and Ken Caldeira

Carbon belts and chains aid nanotech resurgence pp. S45-S47

Tim Hornyak

Structure of PINK1 in complex with its substrate ubiquitin pp. 51-56

Alexander F. Schubert, Christina Gladkova, Els Pardon, Jane L. Wagstaff, Stefan M. V. Freund, Jan Steyaert, Sarah L. Maslen and David Komander

A transfer-RNA-derived small RNA regulates ribosome biogenesis pp. 57-62

Hak Kyun Kim, Gabriele Fuchs, Shengchun Wang, Wei Wei, Yue Zhang, Hyesuk Park, Biswajoy Roy-Chaudhuri, Pan Li, Jianpeng Xu, Kirk Chu, Feijie Zhang, Mei-Sze Chua, Samuel So, Qiangfeng Cliff Zhang, Peter Sarnow and Mark A. Kay

Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns pp. 67-71

Grigory Tikhomirov, Philip Petersen and Lulu Qian

Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components pp. 72-77

Luvena L. Ong, Nikita Hanikel, Omar K. Yaghi, Casey Grun, Maximilian T. Strauss, Patrick Bron, Josephine Lai-Kee-Him, Florian Schueder, Bei Wang, Pengfei Wang, Jocelyn Y. Kishi, Cameron Myhrvold, Allen Zhu, Ralf Jungmann, Gaetan Bellot, Yonggang Ke and Peng Yin

Gigadalton-scale shape-programmable DNA assemblies pp. 78-83

Klaus F. Wagenbauer, Christian Sigl and Hendrik Dietz

Biotechnological mass production of DNA origami pp. 84-87

Florian Praetorius, Benjamin Kick, Karl L. Behler, Maximilian N. Honemann, Dirk Weuster-Botz and Hendrik Dietz

Primordial clays on Mars formed beneath a steam or supercritical atmosphere pp. 88-91

Kevin M. Cannon, Stephen W. Parman and John F. Mustard

Reconciling taxon senescence with the Red Queen’s hypothesis pp. 92-95

Indrė Žliobaitė, Mikael Fortelius and Nils C. Stenseth

Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors pp. 101-105

Fumiji Saito, Kouyuki Hirayasu, Takeshi Satoh, Christian W. Wang, John Lusingu, Takao Arimori, Kyoko Shida, Nirianne Marie Q. Palacpac, Sawako Itagaki, Shiroh Iwanaga, Eizo Takashima, Takafumi Tsuboi, Masako Kohyama, Tadahiro Suenaga, Marco Colonna, Junichi Takagi, Thomas Lavstsen, Toshihiro Horii and Hisashi Arase

Maternal age generates phenotypic variation in Caenorhabditis elegans pp. 106-109

Marcos Francisco Perez, Mirko Francesconi, Cristina Hidalgo-Carcedo and Ben Lehner

IL-11 is a crucial determinant of cardiovascular fibrosis pp. 110-115

Sebastian Schafer, Sivakumar Viswanathan, Anissa A. Widjaja, Wei-Wen Lim, Aida Moreno-Moral, Daniel M. DeLaughter, Benjamin Ng, Giannino Patone, Kingsley Chow, Ester Khin, Jessie Tan, Sonia P. Chothani, Lei Ye, Owen J. L. Rackham, Nicole S. J. Ko, Norliza E. Sahib, Chee Jian Pua, Nicole T. G. Zhen, Chen Xie, Mao Wang, Henrike Maatz, Shiqi Lim, Kathrin Saar, Susanne Blachut, Enrico Petretto, Sabine Schmidt, Tracy Putoczki, Nuno Guimarães-Camboa, Hiroko Wakimoto, Sebastiaan van Heesch, Kristmundur Sigmundsson, See L. Lim, Jia L. Soon, Victor T. T. Chao, Yeow L. Chua, Teing E. Tan, Sylvia M. Evans, Yee J. Loh, Muhammad H. Jamal, Kim K. Ong, Kim C. Chua, Boon-Hean Ong, Mathew J. Chakaramakkil, Jonathan G. Seidman, Christine E. Seidman, Norbert Hubner, Kenny Y. K. Sin and Stuart A. Cook

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth pp. 116-120

Giovanni Germano, Simona Lamba, Giuseppe Rospo, Ludovic Barault, Alessandro Magrì, Federica Maione, Mariangela Russo, Giovanni Crisafulli, Alice Bartolini, Giulia Lerda, Giulia Siravegna, Benedetta Mussolin, Roberta Frapolli, Monica Montone, Federica Morano, Filippo de Braud, Nabil Amirouchene-Angelozzi, Silvia Marsoni, Maurizio D’Incalci, Armando Orlandi, Enrico Giraudo, Andrea Sartore-Bianchi, Salvatore Siena, Filippo Pietrantonio, Federica Di Nicolantonio and Alberto Bardelli

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis pp. 121-125

Tim Wartewig, Zsuzsanna Kurgyis, Selina Keppler, Konstanze Pechloff, Erik Hameister, Rupert Öllinger, Roman Maresch, Thorsten Buch, Katja Steiger, Christof Winter, Roland Rad and Jürgen Ruland

Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control pp. 126-131

Isaia Barbieri, Konstantinos Tzelepis, Luca Pandolfini, Junwei Shi, Gonzalo Millán-Zambrano, Samuel C. Robson, Demetrios Aspris, Valentina Migliori, Andrew J. Bannister, Namshik Han, Etienne De Braekeleer, Hannes Ponstingl, Alan Hendrick, Christopher R. Vakoc, George S. Vassiliou and Tony Kouzarides

Genetically programmed chiral organoborane synthesis pp. 132-136

S. B. Jennifer Kan, Xiongyi Huang, Yosephine Gumulya, Kai Chen and Frances H. Arnold

A test drive of a DNA-analysis toolkit in the cloud pp. 137-138

W. Wayt Gibbs

A celebration of Spain’s exemplary lab leaders pp. 139-140

Alison Abbott

Please consider my science-fiction story pp. 142-142

David G. Blake