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2015, volume 525, articles 7570

Cannabis pp. S1-S1

Michelle Grayson

The cannabis crop pp. S2-S3

Julie Gould

STAP cells are derived from ES cells pp. E4-E5

Daijiro Konno, Takeya Kasukawa, Kosuke Hashimoto, Takehiko Itoh, Taeko Suetsugu, Ikuo Miura, Shigeharu Wakana, Piero Carninci and Fumio Matsuzaki

Botany: The cultivation of weed pp. S4-S5

Lucas Laursen

Drug development: The treasure chest pp. S6-S8

Brian Owens

Failure to replicate the STAP cell phenomenon pp. E6-E9

Alejandro De Los Angeles, Francesco Ferrari, Yuko Fujiwara, Ronald Mathieu, Soohyun Lee, Semin Lee, Ho-Chou Tu, Samantha Ross, Stephanie Chou, Minh Nguyen, Zhaoting Wu, Thorold W. Theunissen, Benjamin E. Powell, Sumeth Imsoonthornruksa, Jiekai Chen, Marti Borkent, Vladislav Krupalnik, Ernesto Lujan, Marius Wernig, Jacob H. Hanna, Konrad Hochedlinger, Duanqing Pei, Rudolf Jaenisch, Hongkui Deng, Stuart H. Orkin, Peter J. Park and George Q. Daley

Perspective: Close the knowledge gap pp. S9-S9

Jonathan Page and Mark Ware

A potted history pp. S10-S11

Stephanie Pain

Israel: Research without prejudice pp. S12-S13

Emily Sohn

Perspective: Be clear about the real risks pp. S14-S14

Matthew Hill

Medical marijuana: Showdown at the cannabis corral pp. S15-S17

Michael Eisenstein

Cannabis: 4 big questions pp. S18-S18

Julie Gould

Make academic job advertisements fair to all pp. 427-427

Mathias Wullum Nielsen

A call to deal with the data deluge pp. 429-429

Chris Woolston

Lost generation looms as refugees miss university pp. 433-434

Declan Butler

UN approves global to-do list for next 15 years pp. 434-435

Jeff Tollefson

Brain stimulation in children spurs hope — and concern pp. 436-437

Linda Geddes

Canadian election spotlights scientists' frustrations pp. 437-437

Nicola Jones

Scripps Research Institute appoints leadership duo pp. 438-438

Erika Check Hayden

Indian ASTROSAT telescope set for global stardom pp. 438-439

T. V. Padma

Researchers wrestle with a privacy problem pp. 440-442

Erika Check Hayden

The hidden risks for ‘three-person’ babies pp. 444-446

Garry Hamilton

Energy: Reimagine fuel cells pp. 447-449

John P. Lemmon

Climate policy: Democracy is not an inconvenience pp. 449-450

Nico Stehr

Military science: Inventions of war pp. 451-452

Ann Finkbeiner

Space travel: When Soviets ruled the great beyond pp. 452-453

Tim Radford

Theatre: Lab's labour's lost pp. 454-454

Philip Ball

Popular uprising spreads science pp. 455-455

Muath Alduhishy and Mouhannad Malek

Citizen projects can minimize conflicts pp. 455-455

James W. Pearce-Higgins

Resolve ambiguities in China's emissions pp. 455-455

Fei Teng

Overhaul rules for hazardous chemicals pp. 455-455

Zhenwu Tang, Qifei Huang and Yufei Yang

Olympics will make water scarcity worse pp. 455-455

Hong Yang, Julian R. Thompson and Roger J. Flower

Crystals of a toxic core pp. 458-459

Michel Goedert and Yifan Cheng

Storms bring ocean nutrients to light pp. 460-461

Jaime Palter

A protein for healing infarcted hearts pp. 461-462

Gordana Vunjak-Novakovic

Neutrons with a twist pp. 462-463

Robert W. Boyd

Infection elevates diversity pp. 464-465

Aneil F. Agrawal

Monstrous galaxies unmasked pp. 465-466

Romeel Davé

The karma of oil palms pp. 466-467

Jerzy Paszkowski

Hallmarks of pluripotency pp. 469-478

Alejandro De Los Angeles, Francesco Ferrari, Ruibin Xi, Yuko Fujiwara, Nissim Benvenisty, Hongkui Deng, Konrad Hochedlinger, Rudolf Jaenisch, Soohyun Lee, Harry G. Leitch, M. William Lensch, Ernesto Lujan, Duanqing Pei, Janet Rossant, Marius Wernig, Peter J. Park and George Q. Daley

Epicardial FSTL1 reconstitution regenerates the adult mammalian heart pp. 479-485

Ke Wei, Vahid Serpooshan, Cecilia Hurtado, Marta Diez-Cuñado, Mingming Zhao, Sonomi Maruyama, Wenhong Zhu, Giovanni Fajardo, Michela Noseda, Kazuto Nakamura, Xueying Tian, Qiaozhen Liu, Andrew Wang, Yuka Matsuura, Paul Bushway, Wenqing Cai, Alex Savchenko, Morteza Mahmoudi, Michael D. Schneider, Maurice J. B. van den Hoff, Manish J. Butte, Phillip C. Yang, Kenneth Walsh, Bin Zhou, Daniel Bernstein, Mark Mercola and Pilar Ruiz-Lozano

Structure of the toxic core of α-synuclein from invisible crystals pp. 486-490

Jose A. Rodriguez, Magdalena I. Ivanova, Michael R. Sawaya, Duilio Cascio, Francis E. Reyes, Dan Shi, Smriti Sangwan, Elizabeth L. Guenther, Lisa M. Johnson, Meng Zhang, Lin Jiang, Mark A. Arbing, Brent L. Nannenga, Johan Hattne, Julian Whitelegge, Aaron S. Brewster, Marc Messerschmidt, Sébastien Boutet, Nicholas K. Sauter, Tamir Gonen and David S. Eisenberg

Structure of mammalian eIF3 in the context of the 43S preinitiation complex pp. 491-495

Amedee des Georges, Vidya Dhote, Lauriane Kuhn, Christopher U. T. Hellen, Tatyana V. Pestova, Joachim Frank and Yaser Hashem

The formation of submillimetre-bright galaxies from gas infall over a billion years pp. 496-499

Desika Narayanan, Matthew Turk, Robert Feldmann, Thomas Robitaille, Philip Hopkins, Robert Thompson, Christopher Hayward, David Ball, Claude-André Faucher-Giguère and Dušan Kereš

The diurnal cycle of water ice on comet 67P/Churyumov–Gerasimenko pp. 500-503

M. C. De Sanctis, F. Capaccioni, M. Ciarniello, G. Filacchione, M. Formisano, S. Mottola, A. Raponi, F. Tosi, D. Bockelée-Morvan, S. Erard, C. Leyrat, B. Schmitt, E. Ammannito, G. Arnold, M. A. Barucci, M. Combi, M. T. Capria, P. Cerroni, W.-H. Ip, E. Kuehrt, T. B. McCord, E. Palomba, P. Beck and E. Quirico

Controlling neutron orbital angular momentum pp. 504-506

Charles W. Clark, Roman Barankov, Michael G. Huber, Muhammad Arif, David G. Cory and Dmitry A. Pushin

A concise synthesis of (+)-batzelladine B from simple pyrrole-based starting materials pp. 507-510

Brendan T. Parr, Christos Economou and Seth B. Herzon

Lithospheric controls on magma composition along Earth’s longest continental hotspot track pp. 511-514

D. R. Davies, N. Rawlinson, G. Iaffaldano and I. H. Campbell

Novel competitors shape species’ responses to climate change pp. 515-518

Jake M. Alexander, Jeffrey M. Diez and Jonathan M. Levine

A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion pp. 519-522

Niv Scott, Matthias Prigge, Ofer Yizhar and Tali Kimchi

Cell-fate determination by ubiquitin-dependent regulation of translation pp. 523-527

Achim Werner, Shintaro Iwasaki, Colleen A. McGourty, Sofia Medina-Ruiz, Nia Teerikorpi, Indro Fedrigo, Nicholas T. Ingolia and Michael Rape

Neutrophil ageing is regulated by the microbiome pp. 528-532

Dachuan Zhang, Grace Chen, Deepa Manwani, Arthur Mortha, Chunliang Xu, Jeremiah J. Faith, Robert D. Burk, Yuya Kunisaki, Jung-Eun Jang, Christoph Scheiermann, Miriam Merad and Paul S. Frenette

Loss of Karma transposon methylation underlies the mantled somaclonal variant of oil palm pp. 533-537

Meilina Ong-Abdullah, Jared M. Ordway, Nan Jiang, Siew-Eng Ooi, Sau-Yee Kok, Norashikin Sarpan, Nuraziyan Azimi, Ahmad Tarmizi Hashim, Zamzuri Ishak, Samsul Kamal Rosli, Fadila Ahmad Malike, Nor Azwani Abu Bakar, Marhalil Marjuni, Norziha Abdullah, Zulkifli Yaakub, Mohd Din Amiruddin, Rajanaidu Nookiah, Rajinder Singh, Eng-Ti Leslie Low, Kuang-Lim Chan, Norazah Azizi, Steven W. Smith, Blaire Bacher, Muhammad A. Budiman, Andrew Van Brunt, Corey Wischmeyer, Melissa Beil, Michael Hogan, Nathan Lakey, Chin-Ching Lim, Xaviar Arulandoo, Choo-Kien Wong, Chin-Nee Choo, Wei-Chee Wong, Yen-Yen Kwan, Sharifah Shahrul Rabiah Syed Alwee, Ravigadevi Sambanthamurthi and Robert A. Martienssen

BET inhibitor resistance emerges from leukaemia stem cells pp. 538-542

Chun Yew Fong, Omer Gilan, Enid Y. N. Lam, Alan F. Rubin, Sarah Ftouni, Dean Tyler, Kym Stanley, Devbarna Sinha, Paul Yeh, Jessica Morison, George Giotopoulos, Dave Lugo, Philip Jeffrey, Stanley Chun-Wei Lee, Christopher Carpenter, Richard Gregory, Robert G. Ramsay, Steven W. Lane, Omar Abdel-Wahab, Tony Kouzarides, Ricky W. Johnstone, Sarah-Jane Dawson, Brian J. P. Huntly, Rab K. Prinjha, Anthony T. Papenfuss and Mark A. Dawson

Transcriptional plasticity promotes primary and acquired resistance to BET inhibition pp. 543-547

Philipp Rathert, Mareike Roth, Tobias Neumann, Felix Muerdter, Jae-Seok Roe, Matthias Muhar, Sumit Deswal, Sabine Cerny-Reiterer, Barbara Peter, Julian Jude, Thomas Hoffmann, Łukasz M. Boryń, Elin Axelsson, Norbert Schweifer, Ulrike Tontsch-Grunt, Lukas E. Dow, Davide Gianni, Mark Pearson, Peter Valent, Alexander Stark, Norbert Kraut, Christopher R. Vakoc and Johannes Zuber

Crystal structures of a double-barrelled fluoride ion channel pp. 548-551

Randy B. Stockbridge, Ludmila Kolmakova-Partensky, Tania Shane, Akiko Koide, Shohei Koide, Christopher Miller and Simon Newstead

Correction: Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome pp. 552-552

Jieqi Wang, Jan Eike Wegener, Teng-Wei Huang, Smitha Sripathy, Hector De Jesus-Cortes, Pin Xu, Stephanie Tran, Whitney Knobbe, Vid Leko, Jeremiah Britt, Ruth Starwalt, Latisha McDaniel, Chris S. Ward, Diana Parra, Benjamin Newcomb, Uyen Lao, Cynthia Nourigat, David A. Flowers, Sean Cullen, Nikolas L. Jorstad, Yue Yang, Lena Glaskova, Sébastien Vigneau, Julia Kozlitina, Michael J. Yetman, Joanna L. Jankowsky, Sybille D. Reichardt, Holger M. Reichardt, Jutta Gärtner, Marisa S. Bartolomei, Min Fang, Keith Loeb, C. Dirk Keene, Irwin Bernstein, Margaret Goodell, Daniel J. Brat, Peter Huppke, Jeffrey L. Neul, Antonio Bedalov and Andrew A. Pieper

Erratum: Structure of the TRPA1 ion channel suggests regulatory mechanisms pp. 552-552

Candice E. Paulsen, Jean-Paul Armache, Yuan Gao, Yifan Cheng and David Julius

Correction: Corrigendum: Eocene primates of South America and the African origins of New World monkeys pp. 552-552

Mariano Bond, Marcelo F. Tejedor, Kenneth E. Campbell, Laura Chornogubsky, Nelson Novo and Francisco Goin

Creative writing: A world of pure imagination pp. 553-555

Roberta Kwok

Trade talk: Medical liaison pp. 555-555

Monya Baker

Coin-operated dancer pp. 558-558

James Reinebold

2015, volume 525, articles 7569

Decompensated cirrhosis and microbiome interpretation pp. E1-E2

Jasmohan S. Bajaj, Naga S. Betrapally and Patrick M. Gillevet

Qin et al. reply pp. E2-E3

Nan Qin, Emmanuelle Le Chatelier, Jing Guo, Edi Prifti, Lanjuan Li and S. Dusko Ehrlich

Integration of social science into research is crucial pp. 291-291

Ana Viseu

If at first you don’t succeed, tweet it pp. 293-293

Chris Woolston

Crowdsourcing digs up an early human species pp. 297-298

Ewen Callaway

Africa braced for snakebite crisis pp. 299-299

Quirin Schiermeier

NIH disclosure rules falter pp. 300-301

Sara Reardon

Hunt for gravitational waves to resume after massive upgrade pp. 301-302

Davide Castelvecchi

Newfound meteor showers expand astronomical calendar pp. 302-303

Alexandra Witze

Interdisciplinary research by the numbers pp. 306-307

Richard Van Noorden

How to solve the world's biggest problems pp. 308-311

Heidi Ledford

Grant giving: Global funders to focus on interdisciplinarity pp. 313-315

Rick Rylance

Interdisciplinarity: How to catalyse collaboration pp. 315-317

Rebekah R. Brown, Ana Deletic and Tony H. F. Wong

Interdisciplinarity: Inside Manchester's 'arts lab' pp. 318-319

Peter E. Pormann

Anthropology: One-man multidisciplinarian pp. 319-320

Clare Pettitt

New environment law shows its fangs pp. 321-321

Dasheng Liu

Tailor checklists to clinical teams pp. 321-321

Thomas J. Cahill and Rod Stables

Mining shell waste will not be easy pp. 321-321

Hong-Wei Xiao, Zhen-Jiang Gao and A. S. Mujumdar

Seal of approval for ocean observations pp. 321-321

Chris E. Ostrander and Conrad C. Lautenbacher

Lack of help stymied community care pp. 321-321

Laura Spinney

Education reforms ring true 50 years on pp. 321-321

Barry S. Winkler

Forgetfulness illuminated pp. 324-325

Ju Lu and Yi Zuo

Tens of thousands of atoms replaced by one pp. 325-326

John Meurig Thomas

Perplexing effects of phenotypic plasticity pp. 326-327

Juha Merilä

Repositioned to kill stem cells pp. 328-329

Tessa Holyoake and David Vetrie

Charge topology in superconductors pp. 329-330

Erica W. Carlson

The death toll from air-pollution sources pp. 330-331

Michael Jerrett

Labelling and optical erasure of synaptic memory traces in the motor cortex pp. 333-338

Akiko Hayashi-Takagi, Sho Yagishita, Mayumi Nakamura, Fukutoshi Shirai, Yi I. Wu, Amanda L. Loshbaugh, Brian Kuhlman, Klaus M. Hahn and Haruo Kasai

Panorama of ancient metazoan macromolecular complexes pp. 339-344

Cuihong Wan, Blake Borgeson, Sadhna Phanse, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Bezginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, W. Brent Derry, Elisabeth R. Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte and Andrew Emili

The mechanism of DNA replication termination in vertebrates pp. 345-350

James M. Dewar, Magda Budzowska and Johannes C. Walter

Relativistic boost as the cause of periodicity in a massive black-hole binary candidate pp. 351-353

Daniel J. D'Orazio, Zoltán Haiman and David Schiminovich

Spawning rings of exceptional points out of Dirac cones pp. 354-358

Bo Zhen, Chia Wei Hsu, Yuichi Igarashi, Ling Lu, Ido Kaminer, Adi Pick, Song-Liang Chua, John D. Joannopoulos and Marin Soljačić

Inhomogeneity of charge-density-wave order and quenched disorder in a high-Tc superconductor pp. 359-362

G. Campi, A. Bianconi, N. Poccia, G. Bianconi, L. Barba, G. Arrighetti, D. Innocenti, J. Karpinski, N. D. Zhigadlo, S. M. Kazakov, M. Burghammer, M. v. Zimmermann, M. Sprung and A. Ricci

Designing switchable polarization and magnetization at room temperature in an oxide pp. 363-366

P. Mandal, M. J. Pitcher, J. Alaria, H. Niu, P. Borisov, P. Stamenov, J. B. Claridge and M. J. Rosseinsky

The contribution of outdoor air pollution sources to premature mortality on a global scale pp. 367-371

J. Lelieveld, J. S. Evans, M. Fnais, D. Giannadaki and A. Pozzer

Non-adaptive plasticity potentiates rapid adaptive evolution of gene expression in nature pp. 372-375

Cameron K. Ghalambor, Kim L. Hoke, Emily W. Ruell, Eva K. Fischer, David N. Reznick and Kimberly A. Hughes

A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defence pp. 376-379

Jakub Rajniak, Brenden Barco, Nicole K. Clay and Elizabeth S. Sattely

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists pp. 380-383

Stéphane Prost, Francis Relouzat, Marc Spentchian, Yasmine Ouzegdouh, Joseph Saliba, Gérald Massonnet, Jean-Paul Beressi, Els Verhoeyen, Victoria Raggueneau, Benjamin Maneglier, Sylvie Castaigne, Christine Chomienne, Stany Chrétien, Philippe Rousselot and Philippe Leboulch

The spliceosome is a therapeutic vulnerability in MYC-driven cancer pp. 384-388

Tiffany Y.-T. Hsu, Lukas M. Simon, Nicholas J. Neill, Richard Marcotte, Azin Sayad, Christopher S. Bland, Gloria V. Echeverria, Tingting Sun, Sarah J. Kurley, Siddhartha Tyagi, Kristen L. Karlin, Rocio Dominguez-Vidaña, Jessica D. Hartman, Alexander Renwick, Kathleen Scorsone, Ronald J. Bernardi, Samuel O. Skinner, Antrix Jain, Mayra Orellana, Chandraiah Lagisetti, Ido Golding, Sung Y. Jung, Joel R. Neilson, Xiang H.-F. Zhang, Thomas A. Cooper, Thomas R. Webb, Benjamin G. Neel, Chad A. Shaw and Thomas F. Westbrook

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6 pp. 389-393

Qian Zhang, Kai Zhao, Qicong Shen, Yanmei Han, Yan Gu, Xia Li, Dezhi Zhao, Yiqi Liu, Chunmei Wang, Xiang Zhang, Xiaoping Su, Juan Liu, Wei Ge, Ross L. Levine, Nan Li and Xuetao Cao

Replisome speed determines the efficiency of the Tus−Ter replication termination barrier pp. 394-398

Mohamed M. Elshenawy, Slobodan Jergic, Zhi-Qiang Xu, Mohamed A. Sobhy, Masateru Takahashi, Aaron J. Oakley, Nicholas E. Dixon and Samir M. Hamdan

Integrator mediates the biogenesis of enhancer RNAs pp. 399-403

Fan Lai, Alessandro Gardini, Anda Zhang and Ramin Shiekhattar

Crystal structure of the dynamin tetramer pp. 404-408

Thomas F. Reubold, Katja Faelber, Nuria Plattner, York Posor, Katharina Ketel, Ute Curth, Jeanette Schlegel, Roopsee Anand, Dietmar J. Manstein, Frank Noé, Volker Haucke, Oliver Daumke and Susanne Eschenburg

The cell menagerie: human immune profiling pp. 409-411

Marissa Fessenden

Work environment: When labs go bad pp. 413-415

Chris Woolston

Turning point: Martin Jinek pp. 415-415

Virginia Gewin

Wading into water pp. 418-418

Todd Honeycutt

2015, volume 525, articles 7568

Reproducibility will not cure what ails science pp. 159-159

Daniel Sarewitz

The journal of proposals, ideas, data and more pp. 161-161

Chris Woolston

Autopsies reveal signs of Alzheimer’s in growth-hormone patients pp. 165-166

Alison Abbott

US agencies plan research-ethics overhaul pp. 166-166

Heidi Ledford

Online security braces for quantum revolution pp. 167-168

Chris Cesare

Germany claims success for elite universities drive pp. 168-169

Quirin Schiermeier and Richard Van Noorden

Trillions of trees pp. 170-171

Rachel Ehrenberg

The revolution will not be crystallized: a new method sweeps through structural biology pp. 172-174

Ewen Callaway

Fishing for the first Americans pp. 176-178

Emma Marris

Climate change: Track urban emissions on a human scale pp. 179-181

Kevin Robert Gurney, Paty Romero-Lankao, Karen C. Seto, Lucy R. Hutyra, Riley Duren, Christopher Kennedy, Nancy B. Grimm, James R. Ehleringer, Peter Marcotullio, Sara Hughes, Stephanie Pincetl, Mikhail V. Chester, Daniel M. Runfola, Johannes J. Feddema and Joshua Sperling

Gender balance: Women are funded more fairly in social science pp. 181-183

Paul J. Boyle, Lucy K. Smith, Nicola J. Cooper, Kate S. Williams and Henrietta O'Connor

Genetics: Dawkins, redux pp. 184-185

Nathaniel Comfort

Books in brief pp. 185-185

Barbara Kiser

Q&A: The academic satirist pp. 186-186

Zoë Corbyn

Outdated listing puts species at risk pp. 187-187

Zhao-Min Zhou

Physicists' report on EU green electricity pp. 187-187

Jozef Ongena and Christophe Rossel

Laboratory seawater studies are justified pp. 187-187

Catriona L. Hurd

More extensive tests for e-cigarettes pp. 187-187

Frank Henkler and Andreas Luch

Oliver Sacks (1933–2015) pp. 188-188

Douwe Draaisma

Simple market models fail the test pp. 190-191

Alex Pentland

Countercurrents in lipid flow pp. 191-192

Anant K. Menon and Tim P. Levine

Amyloid-β pathology induced in humans pp. 193-194

Mathias Jucker and Lary C. Walker

Sea-spray particles cause freezing in clouds pp. 194-195

Lynn M. Russell

Glimpse into a primitive stellar nursery pp. 195-197

Adam Leroy

How to catch rare cell types pp. 197-198

Lu Wen and Fuchou Tang

A moving target pp. 198-199

Natalia L. Komarova

Mutant p53 and chromatin regulation pp. 199-200

Carol Prives and Scott W. Lowe

Mapping tree density at a global scale pp. 201-205

T. W. Crowther, H. B. Glick, K. R. Covey, C. Bettigole, D. S. Maynard, S. M. Thomas, J. R. Smith, G. Hintler, M. C. Duguid, G. Amatulli, M.-N. Tuanmu, W. Jetz, C. Salas, C. Stam, D. Piotto, R. Tavani, S. Green, G. Bruce, S. J. Williams, S. K. Wiser, M. O. Huber, G. M. Hengeveld, G.-J. Nabuurs, E. Tikhonova, P. Borchardt, C.-F. Li, L. W. Powrie, M. Fischer, A. Hemp, J. Homeier, P. Cho, A. C. Vibrans, P. M. Umunay, S. L. Piao, C. W. Rowe, M. S. Ashton, P. R. Crane and M. A. Bradford

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth pp. 206-211

Jiajun Zhu, Morgan A. Sammons, Greg Donahue, Zhixun Dou, Masoud Vedadi, Matthäus Getlik, Dalia Barsyte-Lovejoy, Rima Al-awar, Bryson W. Katona, Ali Shilatifard, Jing Huang, Xianxin Hua, Cheryl H. Arrowsmith and Shelley L. Berger

An atomic structure of human γ-secretase pp. 212-217

Xiao-chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H. W. Scheres and Yigong Shi

Dense cloud cores revealed by CO in the low metallicity dwarf galaxy WLM pp. 218-221

Monica Rubio, Bruce G. Elmegreen, Deidre A. Hunter, Elias Brinks, Juan R. Cortés and Phil Cigan

Quadrature squeezed photons from a two-level system pp. 222-225

Carsten H. H. Schulte, Jack Hansom, Alex E. Jones, Clemens Matthiesen, Claire Le Gall and Mete Atatüre

The most incompressible metal osmium at static pressures above 750 gigapascals pp. 226-229

L. Dubrovinsky, N. Dubrovinskaia, E. Bykova, M. Bykov, V. Prakapenka, C. Prescher, K. Glazyrin, H.-P. Liermann, M. Hanfland, M. Ekholm, Q. Feng, L. V. Pourovskii, M. I. Katsnelson, J. M. Wills and I. A. Abrikosov

Computational design of co-assembling protein–DNA nanowires pp. 230-233

Yun Mou, Jiun-Yann Yu, Timothy M. Wannier, Chin-Lin Guo and Stephen L. Mayo

A marine biogenic source of atmospheric ice-nucleating particles pp. 234-238

Theodore W. Wilson, Luis A. Ladino, Peter A. Alpert, Mark N. Breckels, Ian M. Brooks, Jo Browse, Susannah M. Burrows, Kenneth S. Carslaw, J. Alex Huffman, Christopher Judd, Wendy P. Kilthau, Ryan H. Mason, Gordon McFiggans, Lisa A. Miller, Juan J. Nájera, Elena Polishchuk, Stuart Rae, Corinne L. Schiller, Meng Si, Jesús Vergara Temprado, Thomas F. Whale, Jenny P. S. Wong, Oliver Wurl, Jacqueline D. Yakobi-Hancock, Jonathan P. D. Abbatt, Josephine Y. Aller, Allan K. Bertram, Daniel A. Knopf and Benjamin J. Murray

Evolutionary origin of the turtle skull pp. 239-242

G. S. Bever, Tyler R. Lyson, Daniel J. Field and Bhart-Anjan S. Bhullar

Arithmetic and local circuitry underlying dopamine prediction errors pp. 243-246

Neir Eshel, Michael Bukwich, Vinod Rao, Vivian Hemmelder, Ju Tian and Naoshige Uchida

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy pp. 247-250

Zane Jaunmuktane, Simon Mead, Matthew Ellis, Jonathan D. F. Wadsworth, Andrew J. Nicoll, Joanna Kenny, Francesca Launchbury, Jacqueline Linehan, Angela Richard-Loendt, A. Sarah Walker, Peter Rudge, John Collinge and Sebastian Brandner

Single-cell messenger RNA sequencing reveals rare intestinal cell types pp. 251-255

Dominic Grün, Anna Lyubimova, Lennart Kester, Kay Wiebrands, Onur Basak, Nobuo Sasaki, Hans Clevers and Alexander van Oudenaarden

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells pp. 256-260

Xin Ye, Wai Leong Tam, Tsukasa Shibue, Yasemin Kaygusuz, Ferenc Reinhardt, Elinor Ng Eaton and Robert A. Weinberg

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity pp. 261-264

Bartlomiej Waclaw, Ivana Bozic, Meredith E. Pittman, Ralph H. Hruban, Bert Vogelstein and Martin A. Nowak

Allosteric receptor activation by the plant peptide hormone phytosulfokine pp. 265-268

Jizong Wang, Hongju Li, Zhifu Han, Heqiao Zhang, Tong Wang, Guangzhong Lin, Junbiao Chang, Weicai Yang and Jijie Chai

Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling pp. 269-273

Feng Zhang, Jian Yao, Jiyuan Ke, Li Zhang, Vinh Q. Lam, Xiu-Fang Xin, X. Edward Zhou, Jian Chen, Joseph Brunzelle, Patrick R. Griffin, Mingguo Zhou, H. Eric Xu, Karsten Melcher and Sheng Yang He

Real-time observation of the initiation of RNA polymerase II transcription pp. 274-277

Furqan M. Fazal, Cong A. Meng, Kenji Murakami, Roger D. Kornberg and Steven M. Block

Correction: Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer pp. 278-278

Florian Muller, Simona Colla, Elisa Aquilanti, Veronica E. Manzo, Giannicola Genovese, Jaclyn Lee, Daniel Eisenson, Rujuta Narurkar, Pingna Deng, Luigi Nezi, Michelle Lee, Baoli Hu, Jian Hu, Ergun Sahin, Derrick Ong, Eliot Fletcher-Sananikone, Dennis Ho, Lawrence Kwong, Cameron Brennan, Y. Alan Wang, Lynda Chin and Ronald A. DePinho

Employee benefits: Plight of the postdoc pp. 279-281

Helen Shen

Trade talk: Fund manager pp. 281-281

Julie Gould

Neuraugment, verb pp. 284-284

Felicia Davin

2015, volume 525, articles 7567

Rejection of GM crops is not a failure for science pp. 7-7

Colin Macilwain

Lifetime collaborators reap the benefits pp. 9-9

Chris Woolston

Pluto snow forecast poses atmospheric conundrum pp. 13-14

Alexandra Witze

Quantum ‘spookiness’ passes toughest test yet pp. 14-15

Zeeya Merali

Next-generation X-ray source fires up pp. 15-16

Davide Castelvecchi

Giant study poses DNA data-sharing dilemma pp. 16-17

Sara Reardon

The tiniest Lego: a tale of nanoscale motors, rotors, switches and pumps pp. 18-21

Mark Peplow

Robust research: Institutions must do their part for reproducibility pp. 25-27

C. Glenn Begley, Alastair M. Buchan and Ulrich Dirnagl

Energy policy: Push renewables to spur carbon pricing pp. 27-29

Gernot Wagner, Tomas Kåberger, Susanna Olai, Michael Oppenheimer, Katherine Rittenhouse and Thomas Sterner

Computer science: Enchantress of abstraction pp. 30-31

Richard Holmes

Books in brief pp. 31-31

Barbara Kiser

Monitor ecosystem services from space pp. 33-33

Anna F. Cord, Ralf Seppelt and Woody Turner

Biodiversity on canal route already at risk pp. 33-33

Jeffrey K. McCrary

Offsets: Factor failure into protected areas pp. 33-33

Joseph M. Kiesecker, Bruce McKenney and Peter Kareiva

Galaxy γ-ray signal was not oversold pp. 33-33

Alex Geringer-Sameth

Problems at the nuclear pore pp. 36-37

Bennett W. Fox and Randal S. Tibbetts

Frictionless fluids from bacterial teamwork pp. 37-39

M. Cristina Marchetti

Global trends in plant naturalization pp. 39-40

Marcel Rejmánek

Extraordinarily conventional pp. 40-41

Igor I. Mazin

Location affects sporulation pp. 42-43

Beth A. Lazazzera and Diarmaid Hughes

The diversified economics of soil water pp. 43-44

Gabriel Bowen

Unequal opportunity during class switching pp. 44-45

Javier M. Di Noia

The quiet revolution of numerical weather prediction pp. 47-55

Peter Bauer, Alan Thorpe and Gilbert Brunet

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport pp. 56-61

Ke Zhang, Christopher J. Donnelly, Aaron R. Haeusler, Jonathan C. Grima, James B. Machamer, Peter Steinwald, Elizabeth L. Daley, Sean J. Miller, Kathleen M. Cunningham, Svetlana Vidensky, Saksham Gupta, Michael A. Thomas, Ingie Hong, Shu-Ling Chiu, Richard L. Huganir, Lyle W. Ostrow, Michael J. Matunis, Jiou Wang, Rita Sattler, Thomas E. Lloyd and Jeffrey D. Rothstein

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis pp. 62-67

Qiangjun Zhou, Ying Lai, Taulant Bacaj, Minglei Zhao, Artem Y. Lyubimov, Monarin Uervirojnangkoorn, Oliver B. Zeldin, Aaron S. Brewster, Nicholas K. Sauter, Aina E. Cohen, S. Michael Soltis, Roberto Alonso-Mori, Matthieu Chollet, Henrik T. Lemke, Richard A. Pfuetzner, Ucheor B. Choi, William I. Weis, Jiajie Diao, Thomas C. Südhof and Axel T. Brunger

Structural insights into the bacterial carbon–phosphorus lyase machinery pp. 68-72

Paulina Seweryn, Lan Bich Van, Morten Kjeldgaard, Christopher J. Russo, Lori A. Passmore, Bjarne Hove-Jensen, Bjarne Jochimsen and Ditlev E. Brodersen

Conventional superconductivity at 203 kelvin at high pressures in the sulfur hydride system pp. 73-76

A. P. Drozdov, M. I. Eremets, I. A. Troyan, V. Ksenofontov and S. I. Shylin

Negative refractive index and acoustic superlens from multiple scattering in single negative metamaterials pp. 77-81

Nadège Kaina, Fabrice Lemoult, Mathias Fink and Geoffroy Lerosey

Guiding the folding pathway of DNA origami pp. 82-86

Katherine E. Dunn, Frits Dannenberg, Thomas E. Ouldridge, Marta Kwiatkowska, Andrew J. Turberfield and Jonathan Bath

Alcohols as alkylating agents in heteroarene C–H functionalization pp. 87-90

Jian Jin and David W. C. MacMillan

Global separation of plant transpiration from groundwater and streamflow pp. 91-94

Jaivime Evaristo, Scott Jasechko and Jeffrey J. McDonnell

Broad plumes rooted at the base of the Earth's mantle beneath major hotspots pp. 95-99

Scott W. French and Barbara Romanowicz

Global exchange and accumulation of non-native plants pp. 100-103

Mark van Kleunen, Wayne Dawson, Franz Essl, Jan Pergl, Marten Winter, Ewald Weber, Holger Kreft, Patrick Weigelt, John Kartesz, Misako Nishino, Liubov A. Antonova, Julie F. Barcelona, Francisco J. Cabezas, Dairon Cárdenas, Juliana Cárdenas-Toro, Nicolás Castaño, Eduardo Chacón, Cyrille Chatelain, Aleksandr L. Ebel, Estrela Figueiredo, Nicol Fuentes, Quentin J. Groom, Lesley Henderson, Inderjit, Andrey Kupriyanov, Silvana Masciadri, Jan Meerman, Olga Morozova, Dietmar Moser, Daniel L. Nickrent, Annette Patzelt, Pieter B. Pelser, María P. Baptiste, Manop Poopath, Maria Schulze, Hanno Seebens, Wen-sheng Shu, Jacob Thomas, Mauricio Velayos, Jan J. Wieringa and Petr Pyšek

Genetic evidence for two founding populations of the Americas pp. 104-108

Pontus Skoglund, Swapan Mallick, Maria Cátira Bortolini, Niru Chennagiri, Tábita Hünemeier, Maria Luiza Petzl-Erler, Francisco Mauro Salzano, Nick Patterson and David Reich

Mutations in DCHS1 cause mitral valve prolapse pp. 109-113

Ronen Durst, Kimberly Sauls, David S. Peal, Annemarieke deVlaming, Katelynn Toomer, Maire Leyne, Monica Salani, Michael E. Talkowski, Harrison Brand, Maëlle Perrocheau, Charles Simpson, Christopher Jett, Matthew R. Stone, Florie Charles, Colby Chiang, Stacey N. Lynch, Nabila Bouatia-Naji, Francesca N. Delling, Lisa A. Freed, Christophe Tribouilloy, Thierry Le Tourneau, Hervé LeMarec, Leticia Fernandez-Friera, Jorge Solis, Daniel Trujillano, Stephan Ossowski, Xavier Estivill, Christian Dina, Patrick Bruneval, Adrian Chester, Jean-Jacques Schott, Kenneth D. Irvine, Yaopan Mao, Andy Wessels, Tahirali Motiwala, Michel Puceat, Yoshikazu Tsukasaki, Donald R. Menick, Harinath Kasiganesan, Xingju Nie, Ann-Marie Broome, Katherine Williams, Amanda Johnson, Roger R. Markwald, Xavier Jeunemaitre, Albert Hagege, Robert A. Levine, David J. Milan, Russell A. Norris and Susan A. Slaugenhaupt

PIK3CAH1047R induces multipotency and multi-lineage mammary tumours pp. 114-118

Shany Koren, Linsey Reavie, Joana Pinto Couto, Duvini De Silva, Michael B. Stadler, Tim Roloff, Adrian Britschgi, Tobias Eichlisberger, Hubertus Kohler, Olulanu Aina, Robert D. Cardiff and Mohamed Bentires-Alj

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity pp. 119-123

Alexandra Van Keymeulen, May Yin Lee, Marielle Ousset, Sylvain Brohée, Sandrine Rorive, Rajshekhar R. Giraddi, Aline Wuidart, Gaëlle Bouvencourt, Christine Dubois, Isabelle Salmon, Christos Sotiriou, Wayne A. Phillips and Cédric Blanpain

Regulation of mitochondrial morphology and function by stearoylation of TFR1 pp. 124-128

Deniz Senyilmaz, Sam Virtue, Xiaojun Xu, Chong Yew Tan, Julian L. Griffin, Aubry K. Miller, Antonio Vidal-Puig and Aurelio A. Teleman

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport pp. 129-133

Brian D. Freibaum, Yubing Lu, Rodrigo Lopez-Gonzalez, Nam Chul Kim, Sandra Almeida, Kyung-Ha Lee, Nisha Badders, Marc Valentine, Bruce L. Miller, Philip C. Wong, Leonard Petrucelli, Hong Joo Kim, Fen-Biao Gao and J. Paul Taylor

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching pp. 134-139

Junchao Dong, Rohit A. Panchakshari, Tingting Zhang, Yu Zhang, Jiazhi Hu, Sabrina A. Volpi, Robin M. Meyers, Yu-Jui Ho, Zhou Du, Davide F. Robbiani, Feilong Meng, Monica Gostissa, Michel C. Nussenzweig, John P. Manis and Frederick W. Alt

A four-helix bundle stores copper for methane oxidation pp. 140-143

Nicolas Vita, Semeli Platsaki, Arnaud Baslé, Stephen J. Allen, Neil G. Paterson, Andrew T. Crombie, J. Colin Murrell, Kevin J. Waldron and Christopher Dennison

Correction: Corrigendum: A diverse range of gene products are effectors of the type I interferon antiviral response pp. 144-144

John W. Schoggins, Sam J. Wilson, Maryline Panis, Mary Y. Murphy, Christopher T. Jones, Paul Bieniasz and Charles M. Rice

Correction: Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity pp. 144-144

John W. Schoggins, Donna A. MacDuff, Naoko Imanaka, Maria D. Gainey, Bimmi Shrestha, Jennifer L. Eitson, Katrina B. Mar, R. Blake Richardson, Alexander V. Ratushny, Vladimir Litvak, Rea Dabelic, Balaji Manicassamy, John D. Aitchison, Alan Aderem, Richard M. Elliott, Adolfo García-Sastre, Vincent Racaniello, Eric J. Snijder, Wayne M. Yokoyama, Michael S. Diamond, Herbert W. Virgin and Charles M. Rice

Correction: Corrigendum: Greenland supraglacial lake drainages triggered by hydrologically induced basal slip pp. 144-144

Laura A. Stevens, Mark D. Behn, Jeffrey J. McGuire, Sarah B. Das, Ian Joughin, Thomas Herring, David E. Shean and Matt A. King

Motion studies: See how they run pp. 145-146

Boer Deng

Internships: Mind wide open pp. 147-148

Paul Smaglik

Turning point: Anja Rammig pp. 149-149

Virginia Gewin

Time flies pp. 152-152

Carie Juettner