Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation

Yuka Morikawa, Todd Heallen, John Leach, Yang Xiao and James F. Martin ()
Additional contact information
Yuka Morikawa: Cardiomyocyte Renewal Laboratory, Texas Heart Institute
Todd Heallen: Cardiomyocyte Renewal Laboratory, Texas Heart Institute
John Leach: Baylor College of Medicine
Yang Xiao: Cardiomyocyte Renewal Laboratory, Texas Heart Institute
James F. Martin: Cardiomyocyte Renewal Laboratory, Texas Heart Institute

Nature, 2017, vol. 547, issue 7662, 227-231

Abstract: After injury in the heart, postnatal mouse hearts deficient in the Hippo pathway show efficient repair, and in the hearts of Mdx mice (a model of Duchenne muscular dystrophy) Hippo deficiency protects against overload-induced heart failure.

Date: 2017
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DOI: 10.1038/nature22979

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