Phase separation drives heterochromatin domain formation

Amy R. Strom, Alexander V. Emelyanov, Mustafa Mir, Dmitry V. Fyodorov, Xavier Darzacq and Gary H. Karpen ()
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Amy R. Strom: Lawrence Berkeley National Laboratory
Alexander V. Emelyanov: Albert Einstein College of Medicine
Mustafa Mir: University of California
Dmitry V. Fyodorov: Albert Einstein College of Medicine
Xavier Darzacq: University of California
Gary H. Karpen: Lawrence Berkeley National Laboratory

Nature, 2017, vol. 547, issue 7662, 241-245

Abstract: HP1a can nucleate into foci that display liquid properties during the early stages of heterochromatin domain formation in Drosophila embryos, suggesting that the repressive action of heterochromatin may be mediated in part by emergent properties of phase separation.

Date: 2017
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DOI: 10.1038/nature22989

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