Selective sp3 C–H alkylation via polarity-match-based cross-coupling

Chip Le, Yufan Liang, Ryan W. Evans, Ximing Li and David W. C. MacMillan ()
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Chip Le: Merck Center for Catalysis at Princeton University
Yufan Liang: Merck Center for Catalysis at Princeton University
Ryan W. Evans: Merck Center for Catalysis at Princeton University
Ximing Li: Merck Center for Catalysis at Princeton University
David W. C. MacMillan: Merck Center for Catalysis at Princeton University

Nature, 2017, vol. 547, issue 7661, 79-83

Abstract: Using a triple catalytic approach, a selective sp3 C–H alkylation is demonstrated that is applicable in late-stage functionalization of pharmaceutical compounds.

Date: 2017
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DOI: 10.1038/nature22813

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