mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Natalia Martín-Martín, Sonia Fernandez-Ruiz, James D. Sutherland, Michelle Clasquin, Julen Tomas-Cortazar, Jose Jimenez, Ines Torres, Phong Quang, Pilar Ximenez-Embun, Ruzica Bago, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Isabel Lacasa-Viscasillas, Miguel Unda, Verónica Torrano, Diana Cabrera, Sebastiaan M. van Liempd, Ylenia Cendon, Elena Castro, Stuart Murray, Ajinkya Revandkar, Andrea Alimonti, Yinan Zhang, Amelia Barnett, Gina Lein, David Pirman, Ana R. Cortazar, Leire Arreal, Ludmila Prudkin, Ianire Astobiza, Lorea Valcarcel-Jimenez, Patricia Zuñiga-García, Itziar Fernandez-Dominguez, Marco Piva, Alfredo Caro-Maldonado, Pilar Sánchez-Mosquera, Mireia Castillo-Martín, Violeta Serra, Naiara Beraza, Antonio Gentilella, George Thomas, Mikel Azkargorta, Felix Elortza, Rosa Farràs, David Olmos, Alejo Efeyan, Juan Anguita, Javier Muñoz, Juan M. Falcón-Pérez, Rosa Barrio, Teresa Macarulla, Jose M. Mato, Maria L. Martinez-Chantar, Carlos Cordon-Cardo, Ana M. Aransay, Kevin Marks, José Baselga, Josep Tabernero, Paolo Nuciforo, Brendan D. Manning, Katya Marjon and Arkaitz Carracedo ()
Additional contact information
Amaia Zabala-Letona: CIC bioGUNE, Bizkaia Technology Park
Amaia Arruabarrena-Aristorena: CIC bioGUNE, Bizkaia Technology Park
Natalia Martín-Martín: CIC bioGUNE, Bizkaia Technology Park
Sonia Fernandez-Ruiz: CIC bioGUNE, Bizkaia Technology Park
James D. Sutherland: CIC bioGUNE, Bizkaia Technology Park
Michelle Clasquin: AGIOS Pharmaceuticals
Julen Tomas-Cortazar: CIC bioGUNE, Bizkaia Technology Park
Jose Jimenez: Vall d’Hebron Institute of Oncology (VHIO), Universidad Autónoma de Barcelona
Ines Torres: Valld’Hebron Hospital, Universitat Autónoma de Barcelona
Phong Quang: AGIOS Pharmaceuticals
Pilar Ximenez-Embun: Spanish National Cancer Research Centre (CNIO)
Ruzica Bago: MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee
Aitziber Ugalde-Olano: Basurto University Hospital
Ana Loizaga-Iriarte: Basurto University Hospital
Isabel Lacasa-Viscasillas: Basurto University Hospital
Miguel Unda: Basurto University Hospital
Verónica Torrano: CIC bioGUNE, Bizkaia Technology Park
Diana Cabrera: CIC bioGUNE, Bizkaia Technology Park
Sebastiaan M. van Liempd: CIC bioGUNE, Bizkaia Technology Park
Ylenia Cendon: Spanish National Cancer Research Centre (CNIO)
Elena Castro: Spanish National Cancer Research Centre (CNIO)
Stuart Murray: AGIOS Pharmaceuticals
Ajinkya Revandkar: Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland (IOSI)
Andrea Alimonti: Institute of Oncology Research (IOR) and Oncology Institute of Southern Switzerland (IOSI)
Yinan Zhang: Harvard School of Public Health
Amelia Barnett: AGIOS Pharmaceuticals
Gina Lein: AGIOS Pharmaceuticals
David Pirman: AGIOS Pharmaceuticals
Ana R. Cortazar: CIC bioGUNE, Bizkaia Technology Park
Leire Arreal: CIC bioGUNE, Bizkaia Technology Park
Ludmila Prudkin: Vall d’Hebron Institute of Oncology (VHIO), Universidad Autónoma de Barcelona
Ianire Astobiza: CIC bioGUNE, Bizkaia Technology Park
Lorea Valcarcel-Jimenez: CIC bioGUNE, Bizkaia Technology Park
Patricia Zuñiga-García: CIC bioGUNE, Bizkaia Technology Park
Itziar Fernandez-Dominguez: CIC bioGUNE, Bizkaia Technology Park
Marco Piva: CIC bioGUNE, Bizkaia Technology Park
Alfredo Caro-Maldonado: CIC bioGUNE, Bizkaia Technology Park
Pilar Sánchez-Mosquera: CIC bioGUNE, Bizkaia Technology Park
Mireia Castillo-Martín: Icahn School of Medicine at Mount Sinai
Violeta Serra: CIBERONC, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5
Naiara Beraza: CIC bioGUNE, Bizkaia Technology Park
Antonio Gentilella: Laboratory of Metabolism and Cancer, Catalan Institute of Oncology, ICO, Bellvitge Biomedical Research Institute
George Thomas: Laboratory of Metabolism and Cancer, Catalan Institute of Oncology, ICO, Bellvitge Biomedical Research Institute
Mikel Azkargorta: CIC bioGUNE, Bizkaia Technology Park
Felix Elortza: CIC bioGUNE, Bizkaia Technology Park
Rosa Farràs: Centro de Investigación Príncipe Felipe
David Olmos: Spanish National Cancer Research Centre (CNIO)
Alejo Efeyan: Spanish National Cancer Research Centre (CNIO)
Juan Anguita: CIC bioGUNE, Bizkaia Technology Park
Javier Muñoz: Spanish National Cancer Research Centre (CNIO)
Juan M. Falcón-Pérez: CIC bioGUNE, Bizkaia Technology Park
Rosa Barrio: CIC bioGUNE, Bizkaia Technology Park
Teresa Macarulla: CIBERONC, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5
Jose M. Mato: CIC bioGUNE, Bizkaia Technology Park
Maria L. Martinez-Chantar: CIC bioGUNE, Bizkaia Technology Park
Carlos Cordon-Cardo: Icahn School of Medicine at Mount Sinai
Ana M. Aransay: CIC bioGUNE, Bizkaia Technology Park
Kevin Marks: AGIOS Pharmaceuticals
José Baselga: Human Oncology & Pathogenesis Program, Memorial Sloan-Kettering Cancer Center
Josep Tabernero: CIBERONC, Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5
Paolo Nuciforo: Vall d’Hebron Institute of Oncology (VHIO), Universidad Autónoma de Barcelona
Brendan D. Manning: Harvard School of Public Health
Katya Marjon: AGIOS Pharmaceuticals
Arkaitz Carracedo: CIC bioGUNE, Bizkaia Technology Park

Nature, 2017, vol. 547, issue 7661, 109-113

Abstract: mTOR complex 1 signalling regulates polyamine metabolism and thereby promotes tumorigenesis, through regulation of the stability of a key enzyme, AMD1.

Date: 2017
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DOI: 10.1038/nature22964

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